BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 1207807 Cc1nn(C)c2COC\C=C/Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C32H30ClN3O4/c1-20-28-26(35(2)34-20)19-39-17-6-5-16-36-30-24(14-15-25(33)29(28)30)23(31(36)32(37)38)12-8-18-40-27-13-7-10-21-9-3-4-11-22(21)27/h3-7,9-11,13-15H,8,12,16-19H2,1-2H3,(H,37,38)/b6-5- RJDONMRZHDZWMR-WAYWQWQTSA-N 572148 (rac)-(11Z)-4-chloro-1,3-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-1,10,13,15-tetrahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 1::US11478451, Example 1 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 6.10 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572148&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591086 473133220 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207810 Cc1nn(C)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C32H32ClN3O4/c1-20-28-26(35(2)34-20)19-39-17-6-5-16-36-30-24(14-15-25(33)29(28)30)23(31(36)32(37)38)12-8-18-40-27-13-7-10-21-9-3-4-11-22(21)27/h3-4,7,9-11,13-15H,5-6,8,12,16-19H2,1-2H3,(H,37,38) PPCSRTPOKGWSIX-UHFFFAOYSA-N 572149 US11447504, Example 2::US11447504, Example 3::US11447504, Example 4::US11478451, Example 4::rac-4-chloro-1,3-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-1,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.60 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572149&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591116 473133221 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207811 Cc1nn(C)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C32H32ClN3O4/c1-20-28-26(35(2)34-20)19-39-17-6-5-16-36-30-24(14-15-25(33)29(28)30)23(31(36)32(37)38)12-8-18-40-27-13-7-10-21-9-3-4-11-22(21)27/h3-4,7,9-11,13-15H,5-6,8,12,16-19H2,1-2H3,(H,37,38) PPCSRTPOKGWSIX-UHFFFAOYSA-N 572149 US11447504, Example 2::US11447504, Example 3::US11447504, Example 4::US11478451, Example 4::rac-4-chloro-1,3-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-1,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572149&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591116 473133221 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207814 Cc1nn(C)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C32H32ClN3O4/c1-20-28-26(35(2)34-20)19-39-17-6-5-16-36-30-24(14-15-25(33)29(28)30)23(31(36)32(37)38)12-8-18-40-27-13-7-10-21-9-3-4-11-22(21)27/h3-4,7,9-11,13-15H,5-6,8,12,16-19H2,1-2H3,(H,37,38) PPCSRTPOKGWSIX-UHFFFAOYSA-N 572149 US11447504, Example 2::US11447504, Example 3::US11447504, Example 4::US11478451, Example 4::rac-4-chloro-1,3-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-1,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 38.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572149&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591116 473133221 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207815 CCc1c-2c(CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H36ClFN4O3/c1-4-28-31-27(37-39(28)3)20-38(2)16-5-6-17-40-32-25(14-15-26(35)30(31)32)24(33(40)34(41)42)10-8-18-43-29-11-7-9-21-19-22(36)12-13-23(21)29/h7,9,11-15,19H,4-6,8,10,16-18,20H2,1-3H3,(H,41,42) BPPSKYUYBHETDL-UHFFFAOYSA-N 572152 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,14-dimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 5::US11447504, Example 6::US11447504, Example 7::US11478451, Example 7 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.20 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572152&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591250 473133222 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207816 CCc1c-2c(CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H36ClFN4O3/c1-4-28-31-27(37-39(28)3)20-38(2)16-5-6-17-40-32-25(14-15-26(35)30(31)32)24(33(40)34(41)42)10-8-18-43-29-11-7-9-21-19-22(36)12-13-23(21)29/h7,9,11-15,19H,4-6,8,10,16-18,20H2,1-3H3,(H,41,42) BPPSKYUYBHETDL-UHFFFAOYSA-N 572152 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,14-dimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 5::US11447504, Example 6::US11447504, Example 7::US11478451, Example 7 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.600 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572152&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591250 473133222 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207819 CCc1c-2c(CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H36ClFN4O3/c1-4-28-31-27(37-39(28)3)20-38(2)16-5-6-17-40-32-25(14-15-26(35)30(31)32)24(33(40)34(41)42)10-8-18-43-29-11-7-9-21-19-22(36)12-13-23(21)29/h7,9,11-15,19H,4-6,8,10,16-18,20H2,1-3H3,(H,41,42) BPPSKYUYBHETDL-UHFFFAOYSA-N 572152 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,14-dimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 5::US11447504, Example 6::US11447504, Example 7::US11478451, Example 7 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 33.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572152&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591250 473133222 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207820 Cc1nn(CCN2CCOCC2)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C37H41ClN4O5/c1-25-33-31(42(39-25)17-16-40-18-22-45-23-19-40)24-46-20-5-4-15-41-35-29(13-14-30(38)34(33)35)28(36(41)37(43)44)11-7-21-47-32-12-6-9-26-8-2-3-10-27(26)32/h2-3,6,8-10,12-14H,4-5,7,11,15-24H2,1H3,(H,43,44) CFEBGYDMHHPZMA-UHFFFAOYSA-N 572155 (rac)-4-chloro-3-ethyl-1-[2-(morpholin-4-yl)ethyl]-7-[3-(naphthalen-1-yloxy)propyl]-1,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 8::US11447504, Example 9 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.890 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572155&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 157561098 473133223 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207821 Cc1nn(CCN2CCOCC2)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C37H41ClN4O5/c1-25-33-31(42(39-25)17-16-40-18-22-45-23-19-40)24-46-20-5-4-15-41-35-29(13-14-30(38)34(33)35)28(36(41)37(43)44)11-7-21-47-32-12-6-9-26-8-2-3-10-27(26)32/h2-3,6,8-10,12-14H,4-5,7,11,15-24H2,1H3,(H,43,44) CFEBGYDMHHPZMA-UHFFFAOYSA-N 572155 (rac)-4-chloro-3-ethyl-1-[2-(morpholin-4-yl)ethyl]-7-[3-(naphthalen-1-yloxy)propyl]-1,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 8::US11447504, Example 9 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.470 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572155&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 157561098 473133223 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207824 CCc1nn(CCN2CCOCC2)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C38H43ClN4O5/c1-2-31-35-32(43(40-31)18-17-41-19-23-46-24-20-41)25-47-21-6-5-16-42-36-29(14-15-30(39)34(35)36)28(37(42)38(44)45)12-8-22-48-33-13-7-10-26-9-3-4-11-27(26)33/h3-4,7,9-11,13-15H,2,5-6,8,12,16-25H2,1H3,(H,44,45) WDKPDJPIUJQOAB-UHFFFAOYSA-N 572157 4-chloro-3-ethyl-1-[2-(morpholin-4-yl)ethyl]-7-[3-(naphthalen-1-yloxy)propyl]-1,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid-N-ethylethanamine Salt (Enantiomer 2)::US11447504, Example 10::US11478451, Example 10 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 12.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572157&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591160 473133224 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207825 CN1CCCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c(-c4c(C)n(C)nc4C1)c23 InChI=1S/C33H35ClN4O3/c1-21-29-27(35-37(21)3)20-36(2)17-6-7-18-38-31-25(15-16-26(34)30(29)31)24(32(38)33(39)40)13-9-19-41-28-14-8-11-22-10-4-5-12-23(22)28/h4-5,8,10-12,14-16H,6-7,9,13,17-20H2,1-3H3,(H,39,40) JFFOLBCOYWMQHS-UHFFFAOYSA-N 572158 (rac)-4-chloro-2,3,14-trimethyl-7-[3-(naphthalen-1-yloxy)propyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 11::US11478451, Example 11 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572158&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591225 473133225 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207826 CN1CCCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c(-c4c(C)n(C)nc4C1)c23 InChI=1S/C33H35ClN4O3/c1-21-29-27(35-37(21)3)20-36(2)17-6-7-18-38-31-25(15-16-26(34)30(29)31)24(32(38)33(39)40)13-9-19-41-28-14-8-11-22-10-4-5-12-23(22)28/h4-5,8,10-12,14-16H,6-7,9,13,17-20H2,1-3H3,(H,39,40) JFFOLBCOYWMQHS-UHFFFAOYSA-N 572159 (+)-4-chloro-2,3,14-trimethyl-7-[3-(naphthalen-1-yloxy) propyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid-N-ethylethanamine Salt (Enantiomer 1)::US11447504, Example 12 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.520 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572159&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591225 473133226 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207829 CN1CCCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c(-c4c(C)[nH]nc4C1)c23 InChI=1S/C32H33ClN4O3/c1-20-28-26(35-34-20)19-36(2)16-5-6-17-37-30-24(14-15-25(33)29(28)30)23(31(37)32(38)39)12-8-18-40-27-13-7-10-21-9-3-4-11-22(21)27/h3-4,7,9-11,13-15H,5-6,8,12,16-19H2,1-2H3,(H,34,35)(H,38,39) GELGKXVOWYYPCM-UHFFFAOYSA-N 572160 (−)-4-chloro-2,3,14-trimethyl-7-[3-(naphthalen-1-yloxy) propyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid-N-ethylethanamine Salt (Enantiomer 2)::US11447504, Example 13::US11478451, Example 13 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 26.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572160&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591720 473133227 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207830 Cc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H31ClFN3O4/c1-19-28-26(35-36(19)2)18-40-15-4-3-14-37-30-24(12-13-25(33)29(28)30)23(31(37)32(38)39)8-6-16-41-27-9-5-7-20-17-21(34)10-11-22(20)27/h5,7,9-13,17H,3-4,6,8,14-16,18H2,1-2H3,(H,38,39) NDWMVESOANHLBE-UHFFFAOYSA-N 572161 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 14::US11447504, Example 16::US11478451, Example 16 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.00 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572161&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591177 473133228 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207831 Cc1[nH]nc2COCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C31H29ClFN3O4/c1-18-27-25(35-34-18)17-39-14-3-2-13-36-29-23(11-12-24(32)28(27)29)22(30(36)31(37)38)7-5-15-40-26-8-4-6-19-16-20(33)9-10-21(19)26/h4,6,8-12,16H,2-3,5,7,13-15,17H2,1H3,(H,34,35)(H,37,38) FZKJBLJEXASDNO-UHFFFAOYSA-N 572162 (+)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid-N-ethylethanamine Salt (Enantiomer 1)::US11447504, Example 15::US11478451, Example 17 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.490 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572162&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591079 473133229 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207834 Cc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H31ClFN3O4/c1-19-28-26(35-36(19)2)18-40-15-4-3-14-37-30-24(12-13-25(33)29(28)30)23(31(37)32(38)39)8-6-16-41-27-9-5-7-20-17-21(34)10-11-22(20)27/h5,7,9-13,17H,3-4,6,8,14-16,18H2,1-2H3,(H,38,39) NDWMVESOANHLBE-UHFFFAOYSA-N 572161 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 14::US11447504, Example 16::US11478451, Example 16 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.660 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572161&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591177 473133228 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207837 Cc1[nH]nc2COCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C31H29ClFN3O4/c1-18-27-25(35-34-18)17-39-14-3-2-13-36-29-23(11-12-24(32)28(27)29)22(30(36)31(37)38)7-5-15-40-26-8-4-6-19-16-20(33)9-10-21(19)26/h4,6,8-12,16H,2-3,5,7,13-15,17H2,1H3,(H,34,35)(H,37,38) FZKJBLJEXASDNO-UHFFFAOYSA-N 572164 (−)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid-N-ethylethanamine Salt (Enantiomer 2)::US11447504, Example 17 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 5.20 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572164&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591079 473133230 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207838 CCc1c-2c(COC\C=C/Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H32ClN3O4/c1-3-27-30-26(35-36(27)2)20-40-18-7-6-17-37-31-24(15-16-25(34)29(30)31)23(32(37)33(38)39)13-9-19-41-28-14-8-11-21-10-4-5-12-22(21)28/h4-8,10-12,14-16H,3,9,13,17-20H2,1-2H3,(H,38,39)/b7-6- PYMQPCYJYGZZFS-SREVYHEPSA-N 572165 (rac)-(11 Z)-4-chloro-3-ethyl-2-methyl-7-[3-(naphthalen-1-yloxy)propyl]-2,10,13,15-tetrahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 18 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.30 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572165&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591275 473133231 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207841 CCc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H34ClN3O4/c1-3-27-30-26(35-36(27)2)20-40-18-7-6-17-37-31-24(15-16-25(34)29(30)31)23(32(37)33(38)39)13-9-19-41-28-14-8-11-21-10-4-5-12-22(21)28/h4-5,8,10-12,14-16H,3,6-7,9,13,17-20H2,1-2H3,(H,38,39) COJURVSFEDLRNW-UHFFFAOYSA-N 572166 (rac)-4-chloro-3-ethyl-2-methyl-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 19::US11447504, Example 20::US11447504, Example 21::US11447504, Example 25::US11478451, Example 21 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.850 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572166&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591254 473133232 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207842 CCc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H34ClN3O4/c1-3-27-30-26(35-36(27)2)20-40-18-7-6-17-37-31-24(15-16-25(34)29(30)31)23(32(37)33(38)39)13-9-19-41-28-14-8-11-21-10-4-5-12-22(21)28/h4-5,8,10-12,14-16H,3,6-7,9,13,17-20H2,1-2H3,(H,38,39) COJURVSFEDLRNW-UHFFFAOYSA-N 572166 (rac)-4-chloro-3-ethyl-2-methyl-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 19::US11447504, Example 20::US11447504, Example 21::US11447504, Example 25::US11478451, Example 21 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.590 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572166&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591254 473133232 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207845 CCc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H34ClN3O4/c1-3-27-30-26(35-36(27)2)20-40-18-7-6-17-37-31-24(15-16-25(34)29(30)31)23(32(37)33(38)39)13-9-19-41-28-14-8-11-21-10-4-5-12-22(21)28/h4-5,8,10-12,14-16H,3,6-7,9,13,17-20H2,1-2H3,(H,38,39) COJURVSFEDLRNW-UHFFFAOYSA-N 572166 (rac)-4-chloro-3-ethyl-2-methyl-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 19::US11447504, Example 20::US11447504, Example 21::US11447504, Example 25::US11478451, Example 21 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 8.90 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572166&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591254 473133232 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207846 CCc1c-2c(CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H37ClN4O3/c1-4-28-31-27(36-38(28)3)21-37(2)18-7-8-19-39-32-25(16-17-26(35)30(31)32)24(33(39)34(40)41)14-10-20-42-29-15-9-12-22-11-5-6-13-23(22)29/h5-6,9,11-13,15-17H,4,7-8,10,14,18-21H2,1-3H3,(H,40,41) SMIRFHPIIHOGEQ-UHFFFAOYSA-N 572169 (rac)-4-chloro-3-ethyl-2,14-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 22::US11447504, Example 23::US11447504, Example 24::US11478451, Example 24 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.50 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572169&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591133 473133233 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207847 CCc1c-2c(CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H37ClN4O3/c1-4-28-31-27(36-38(28)3)21-37(2)18-7-8-19-39-32-25(16-17-26(35)30(31)32)24(33(39)34(40)41)14-10-20-42-29-15-9-12-22-11-5-6-13-23(22)29/h5-6,9,11-13,15-17H,4,7-8,10,14,18-21H2,1-3H3,(H,40,41) SMIRFHPIIHOGEQ-UHFFFAOYSA-N 572169 (rac)-4-chloro-3-ethyl-2,14-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 22::US11447504, Example 23::US11447504, Example 24::US11478451, Example 24 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.450 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572169&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591133 473133233 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207850 CCc1c-2c(CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H37ClN4O3/c1-4-28-31-27(36-38(28)3)21-37(2)18-7-8-19-39-32-25(16-17-26(35)30(31)32)24(33(39)34(40)41)14-10-20-42-29-15-9-12-22-11-5-6-13-23(22)29/h5-6,9,11-13,15-17H,4,7-8,10,14,18-21H2,1-3H3,(H,40,41) SMIRFHPIIHOGEQ-UHFFFAOYSA-N 572169 (rac)-4-chloro-3-ethyl-2,14-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 22::US11447504, Example 23::US11447504, Example 24::US11478451, Example 24 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 15.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572169&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591133 473133233 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207851 CCc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H34ClN3O4/c1-3-27-30-26(35-36(27)2)20-40-18-7-6-17-37-31-24(15-16-25(34)29(30)31)23(32(37)33(38)39)13-9-19-41-28-14-8-11-21-10-4-5-12-22(21)28/h4-5,8,10-12,14-16H,3,6-7,9,13,17-20H2,1-2H3,(H,38,39) COJURVSFEDLRNW-UHFFFAOYSA-N 572166 (rac)-4-chloro-3-ethyl-2-methyl-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 19::US11447504, Example 20::US11447504, Example 21::US11447504, Example 25::US11478451, Example 21 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.20 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572166&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591254 473133232 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207852 Cc1[nH]nc2COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C31H30ClN3O4/c1-19-27-25(34-33-19)18-38-16-5-4-15-35-29-23(13-14-24(32)28(27)29)22(30(35)31(36)37)11-7-17-39-26-12-6-9-20-8-2-3-10-21(20)26/h2-3,6,8-10,12-14H,4-5,7,11,15-18H2,1H3,(H,33,34)(H,36,37) STPZDEATQDDZCR-UHFFFAOYSA-N 572173 4-chloro-2,3-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo-[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid-N-ethylethanamine Salt (Enantiomer 1)::US11447504, Example 26::US11447504, Example 27::US11478451, Example 27 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.690 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572173&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591331 473133234 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207855 Cc1[nH]nc2COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C31H30ClN3O4/c1-19-27-25(34-33-19)18-38-16-5-4-15-35-29-23(13-14-24(32)28(27)29)22(30(35)31(36)37)11-7-17-39-26-12-6-9-20-8-2-3-10-21(20)26/h2-3,6,8-10,12-14H,4-5,7,11,15-18H2,1H3,(H,33,34)(H,36,37) STPZDEATQDDZCR-UHFFFAOYSA-N 572173 4-chloro-2,3-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo-[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid-N-ethylethanamine Salt (Enantiomer 1)::US11447504, Example 26::US11447504, Example 27::US11478451, Example 27 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 18.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572173&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591331 473133234 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207856 Cc1c-2c(CNCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C31H31ClN4O3/c1-19-27-25(34-35(19)2)18-33-15-7-16-36-29-23(13-14-24(32)28(27)29)22(30(36)31(37)38)11-6-17-39-26-12-5-9-20-8-3-4-10-21(20)26/h3-5,8-10,12-14,33H,6-7,11,15-18H2,1-2H3,(H,37,38) UQDUQFWHFLOCHG-UHFFFAOYSA-N 572175 (rac)-12-chloro-10,11-dimethyl-1-[3-(naphthalen-1-yloxy)propyl]-4,5,6,7,8,10-hexahydropyrazolo[3′,4′:7,8][1,5]diazecino[9,10,1-hi]indole-2-carboxylic Acid-Formic Acid Salt::US11447504, Example 28::US11478451, Example 28 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.30 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572175&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 155123531 473133235 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207859 CN1CCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c(-c4c(C)n(C)nc4C1)c23 InChI=1S/C32H33ClN4O3/c1-20-28-26(34-36(20)3)19-35(2)16-8-17-37-30-24(14-15-25(33)29(28)30)23(31(37)32(38)39)12-7-18-40-27-13-6-10-21-9-4-5-11-22(21)27/h4-6,9-11,13-15H,7-8,12,16-19H2,1-3H3,(H,38,39) AZNRUVYELMSHOT-UHFFFAOYSA-N 572176 (rac)-12-chloro-7,10,11-trimethyl-1-[3-(naphthalen-1-yloxy)propyl]-4,5,6,7,8,10-hexahydropyrazolo[3′,4′:7,8][1,5]diazecino[9,10,1-hi]indole-2-carboxylic Acid::US11447504, Example 29::US11478451, Example 29 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.50 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572176&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591196 473133236 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207862 CN1CCCCn2c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c(-c4c(C)n(C)nc4C1)c23 InChI=1S/C33H34ClFN4O3/c1-20-29-27(36-38(20)3)19-37(2)15-4-5-16-39-31-25(13-14-26(34)30(29)31)24(32(39)33(40)41)9-7-17-42-28-10-6-8-21-18-22(35)11-12-23(21)28/h6,8,10-14,18H,4-5,7,9,15-17,19H2,1-3H3,(H,40,41) OGHDOPFGJXKBFT-UHFFFAOYSA-N 572177 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3,14-trimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 30::US11478451, Example 30 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.920 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572177&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591246 473133237 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207863 CN1CCCCn2c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c(-c4c(C)[nH]nc4C1)c23 InChI=1S/C32H32ClFN4O3/c1-19-28-26(36-35-19)18-37(2)14-3-4-15-38-30-24(12-13-25(33)29(28)30)23(31(38)32(39)40)8-6-16-41-27-9-5-7-20-17-21(34)10-11-22(20)27/h5,7,9-13,17H,3-4,6,8,14-16,18H2,1-2H3,(H,35,36)(H,39,40) MCNVWPUURUOIIZ-UHFFFAOYSA-N 572178 (+)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3,14-trimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid-N-ethylethanamine Salt (Enantiomer 1)::US11447504, Example 31::US11478451, Example 32 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.710 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572178&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591090 473133238 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207866 CN1CCCCn2c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c(-c4c(C)[nH]nc4C1)c23 InChI=1S/C32H32ClFN4O3/c1-19-28-26(36-35-19)18-37(2)14-3-4-15-38-30-24(12-13-25(33)29(28)30)23(31(38)32(39)40)8-6-16-41-27-9-5-7-20-17-21(34)10-11-22(20)27/h5,7,9-13,17H,3-4,6,8,14-16,18H2,1-2H3,(H,35,36)(H,39,40) MCNVWPUURUOIIZ-UHFFFAOYSA-N 572179 (−)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3,14-trimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid-N-ethylethanamine Salt (Enantiomer 2)::US11447504, Example 32 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 26.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572179&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591090 473133239 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207867 CCc1nn(C)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C33H33ClFN3O4/c1-3-26-30-27(37(2)36-26)19-41-16-5-4-15-38-31-24(13-14-25(34)29(30)31)23(32(38)33(39)40)9-7-17-42-28-10-6-8-20-18-21(35)11-12-22(20)28/h6,8,10-14,18H,3-5,7,9,15-17,19H2,1-2H3,(H,39,40) VDWYPXRLOOMXTJ-UHFFFAOYSA-N 572180 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-1-methyl-1,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 33::US11478451, Example 35 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.70 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572180&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591268 473133240 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207868 CCc1nn(C)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C33H33ClFN3O4/c1-3-26-30-27(37(2)36-26)19-41-16-5-4-15-38-31-24(13-14-25(34)29(30)31)23(32(38)33(39)40)9-7-17-42-28-10-6-8-20-18-21(35)11-12-22(20)28/h6,8,10-14,18H,3-5,7,9,15-17,19H2,1-2H3,(H,39,40) VDWYPXRLOOMXTJ-UHFFFAOYSA-N 572181 (+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-1-methyl-1,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 1)::US11447504, Example 34 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.590 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572181&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591268 473133241 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207871 CCc1nn(C)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C33H33ClFN3O4/c1-3-26-30-27(37(2)36-26)19-41-16-5-4-15-38-31-24(13-14-25(34)29(30)31)23(32(38)33(39)40)9-7-17-42-28-10-6-8-20-18-21(35)11-12-22(20)28/h6,8,10-14,18H,3-5,7,9,15-17,19H2,1-2H3,(H,39,40) VDWYPXRLOOMXTJ-UHFFFAOYSA-N 572182 (−)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-1-methyl-1,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 2)::US11447504, Example 35 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 22.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572182&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591268 473133242 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207872 CCc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H33ClFN3O4/c1-3-27-30-26(36-37(27)2)19-41-16-5-4-15-38-31-24(13-14-25(34)29(30)31)23(32(38)33(39)40)9-7-17-42-28-10-6-8-20-18-21(35)11-12-22(20)28/h6,8,10-14,18H,3-5,7,9,15-17,19H2,1-2H3,(H,39,40) DSRUJIWLAZNHGL-UHFFFAOYSA-N 572183 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 36::US11478451, Example 069 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.940 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572183&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591175 473133243 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207873 CCc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H33ClFN3O4/c1-3-27-30-26(36-37(27)2)19-41-16-5-4-15-38-31-24(13-14-25(34)29(30)31)23(32(38)33(39)40)9-7-17-42-28-10-6-8-20-18-21(35)11-12-22(20)28/h6,8,10-14,18H,3-5,7,9,15-17,19H2,1-2H3,(H,39,40) DSRUJIWLAZNHGL-UHFFFAOYSA-N 572184 (+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid-N-ethylethanamine Salt (Enantiomer 1)::US11447504, Example 37 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.780 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572184&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591175 473133244 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207876 CCc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H33ClFN3O4/c1-3-27-30-26(36-37(27)2)19-41-16-5-4-15-38-31-24(13-14-25(34)29(30)31)23(32(38)33(39)40)9-7-17-42-28-10-6-8-20-18-21(35)11-12-22(20)28/h6,8,10-14,18H,3-5,7,9,15-17,19H2,1-2H3,(H,39,40) DSRUJIWLAZNHGL-UHFFFAOYSA-N 572185 (−)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid-N-ethylethanamine Salt (Enantiomer 2)::US11447504, Example 38 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 16.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572185&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591175 473133245 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207877 CCc1nn(C)c2CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C34H36ClFN4O3/c1-4-27-31-28(39(3)37-27)20-38(2)16-5-6-17-40-32-25(14-15-26(35)30(31)32)24(33(40)34(41)42)10-8-18-43-29-11-7-9-21-19-22(36)12-13-23(21)29/h7,9,11-15,19H,4-6,8,10,16-18,20H2,1-3H3,(H,41,42) LFUKYUNPOGFDAD-UHFFFAOYSA-N 572186 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-1,14-dimethyl-10,11,12,13,14,15-hexahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 39::US11447504, Example 40::US11447504, Example 41::US11478451, Example 41 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.790 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572186&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591100 473133246 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207878 CCc1nn(C)c2CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C34H36ClFN4O3/c1-4-27-31-28(39(3)37-27)20-38(2)16-5-6-17-40-32-25(14-15-26(35)30(31)32)24(33(40)34(41)42)10-8-18-43-29-11-7-9-21-19-22(36)12-13-23(21)29/h7,9,11-15,19H,4-6,8,10,16-18,20H2,1-3H3,(H,41,42) LFUKYUNPOGFDAD-UHFFFAOYSA-N 572186 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-1,14-dimethyl-10,11,12,13,14,15-hexahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 39::US11447504, Example 40::US11447504, Example 41::US11478451, Example 41 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.30 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572186&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591100 473133246 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207881 CCc1nn(C)c2CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C34H36ClFN4O3/c1-4-27-31-28(39(3)37-27)20-38(2)16-5-6-17-40-32-25(14-15-26(35)30(31)32)24(33(40)34(41)42)10-8-18-43-29-11-7-9-21-19-22(36)12-13-23(21)29/h7,9,11-15,19H,4-6,8,10,16-18,20H2,1-3H3,(H,41,42) LFUKYUNPOGFDAD-UHFFFAOYSA-N 572186 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-1,14-dimethyl-10,11,12,13,14,15-hexahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 39::US11447504, Example 40::US11447504, Example 41::US11478451, Example 41 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 12.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572186&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591100 473133246 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207882 CCc1nn(CCN2CCOCC2)c2CN(C)C\C=C/Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C39H44ClN5O4/c1-3-32-36-33(45(41-32)20-19-43-21-24-48-25-22-43)26-42(2)17-6-7-18-44-37-30(15-16-31(40)35(36)37)29(38(44)39(46)47)13-9-23-49-34-14-8-11-27-10-4-5-12-28(27)34/h4-8,10-12,14-16H,3,9,13,17-26H2,1-2H3,(H,46,47)/b7-6- SJXJNUGYXIGETG-SREVYHEPSA-N 572189 (rac)-(11Z)-4-chloro-3-ethyl-14-methyl-1-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]-propyl}-10,13,14,15-tetrahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 42::US11447504, Example 43::US11447504, Example 44::US11478451, Example 44 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 4.00 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572189&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591324 473133247 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207883 CCc1nn(CCN2CCOCC2)c2CN(C)C\C=C/Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C39H44ClN5O4/c1-3-32-36-33(45(41-32)20-19-43-21-24-48-25-22-43)26-42(2)17-6-7-18-44-37-30(15-16-31(40)35(36)37)29(38(44)39(46)47)13-9-23-49-34-14-8-11-27-10-4-5-12-28(27)34/h4-8,10-12,14-16H,3,9,13,17-26H2,1-2H3,(H,46,47)/b7-6- SJXJNUGYXIGETG-SREVYHEPSA-N 572189 (rac)-(11Z)-4-chloro-3-ethyl-14-methyl-1-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]-propyl}-10,13,14,15-tetrahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 42::US11447504, Example 43::US11447504, Example 44::US11478451, Example 44 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.40 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572189&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591324 473133247 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207886 CCc1nn(CCN2CCOCC2)c2CN(C)C\C=C/Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C39H44ClN5O4/c1-3-32-36-33(45(41-32)20-19-43-21-24-48-25-22-43)26-42(2)17-6-7-18-44-37-30(15-16-31(40)35(36)37)29(38(44)39(46)47)13-9-23-49-34-14-8-11-27-10-4-5-12-28(27)34/h4-8,10-12,14-16H,3,9,13,17-26H2,1-2H3,(H,46,47)/b7-6- SJXJNUGYXIGETG-SREVYHEPSA-N 572189 (rac)-(11Z)-4-chloro-3-ethyl-14-methyl-1-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]-propyl}-10,13,14,15-tetrahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 42::US11447504, Example 43::US11447504, Example 44::US11478451, Example 44 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 41.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572189&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591324 473133247 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207887 CCc1nn(CCN2CCOCC2)c2CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C39H46ClN5O4/c1-3-32-36-33(45(41-32)20-19-43-21-24-48-25-22-43)26-42(2)17-6-7-18-44-37-30(15-16-31(40)35(36)37)29(38(44)39(46)47)13-9-23-49-34-14-8-11-27-10-4-5-12-28(27)34/h4-5,8,10-12,14-16H,3,6-7,9,13,17-26H2,1-2H3,(H,46,47) GHFRJMORTHPRRF-UHFFFAOYSA-N 572192 (rac)-4-chloro-3-ethyl-14-methyl-1-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 45::US11447504, Example 46::US11447504, Example 47::US11478451, Example 47 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.30 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572192&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591276 473133248 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207888 CCc1nn(CCN2CCOCC2)c2CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C39H46ClN5O4/c1-3-32-36-33(45(41-32)20-19-43-21-24-48-25-22-43)26-42(2)17-6-7-18-44-37-30(15-16-31(40)35(36)37)29(38(44)39(46)47)13-9-23-49-34-14-8-11-27-10-4-5-12-28(27)34/h4-5,8,10-12,14-16H,3,6-7,9,13,17-26H2,1-2H3,(H,46,47) GHFRJMORTHPRRF-UHFFFAOYSA-N 572192 (rac)-4-chloro-3-ethyl-14-methyl-1-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 45::US11447504, Example 46::US11447504, Example 47::US11478451, Example 47 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.710 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572192&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591276 473133248 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207891 CCc1nn(CCN2CCOCC2)c2CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C39H46ClN5O4/c1-3-32-36-33(45(41-32)20-19-43-21-24-48-25-22-43)26-42(2)17-6-7-18-44-37-30(15-16-31(40)35(36)37)29(38(44)39(46)47)13-9-23-49-34-14-8-11-27-10-4-5-12-28(27)34/h4-5,8,10-12,14-16H,3,6-7,9,13,17-26H2,1-2H3,(H,46,47) GHFRJMORTHPRRF-UHFFFAOYSA-N 572192 (rac)-4-chloro-3-ethyl-14-methyl-1-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 45::US11447504, Example 46::US11447504, Example 47::US11478451, Example 47 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 44.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572192&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591276 473133248 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207892 CN1CCN(CCCn2nc3COCCCCn4c(C(O)=O)c(CCCOc5cccc6ccccc56)c5ccc(Cl)c(-c3c2C)c45)CC1 InChI=1S/C39H46ClN5O4/c1-27-35-33(41-45(27)19-9-17-43-22-20-42(2)21-23-43)26-48-24-6-5-18-44-37-31(15-16-32(40)36(35)37)30(38(44)39(46)47)13-8-25-49-34-14-7-11-28-10-3-4-12-29(28)34/h3-4,7,10-12,14-16H,5-6,8-9,13,17-26H2,1-2H3,(H,46,47) DQGMLLGNPCATLY-UHFFFAOYSA-N 572195 (rac)-4-chloro-3-methyl-2-[3-(4-methylpiperazin-1-yl)propyl]-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 48::US11478451, Example 50 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.70 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572195&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591098 473133249 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207893 CN1CCN(CCCn2nc3COCCCCn4c(C(O)=O)c(CCCOc5cccc6ccccc56)c5ccc(Cl)c(-c3c2C)c45)CC1 InChI=1S/C39H46ClN5O4/c1-27-35-33(41-45(27)19-9-17-43-22-20-42(2)21-23-43)26-48-24-6-5-18-44-37-31(15-16-32(40)36(35)37)30(38(44)39(46)47)13-8-25-49-34-14-7-11-28-10-3-4-12-29(28)34/h3-4,7,10-12,14-16H,5-6,8-9,13,17-26H2,1-2H3,(H,46,47) DQGMLLGNPCATLY-UHFFFAOYSA-N 572196 (+)-4-chloro-3-methyl-2-[3-(4-methylpiperazin-1-yl)propyl]-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 1)::US11447504, Example 49 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.750 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572196&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591098 473133250 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207896 CN1CCN(CCCn2nc3COCCCCn4c(C(O)=O)c(CCCOc5cccc6ccccc56)c5ccc(Cl)c(-c3c2C)c45)CC1 InChI=1S/C39H46ClN5O4/c1-27-35-33(41-45(27)19-9-17-43-22-20-42(2)21-23-43)26-48-24-6-5-18-44-37-31(15-16-32(40)36(35)37)30(38(44)39(46)47)13-8-25-49-34-14-7-11-28-10-3-4-12-29(28)34/h3-4,7,10-12,14-16H,5-6,8-9,13,17-26H2,1-2H3,(H,46,47) DQGMLLGNPCATLY-UHFFFAOYSA-N 572197 (−)-4-chloro-3-methyl-2-[3-(4-methylpiperazin-1-yl)propyl]-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 2)::US11447504, Example 50 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 15.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572197&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591098 473133251 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207897 CCc1c-2c(CCCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H36ClN3O3/c1-3-28-31-27(36-37(28)2)16-6-4-5-9-20-38-32-25(18-19-26(35)30(31)32)24(33(38)34(39)40)15-11-21-41-29-17-10-13-22-12-7-8-14-23(22)29/h7-8,10,12-14,17-19H,3-6,9,11,15-16,20-21H2,1-2H3,(H,39,40) SSTSSUXFOIWKBG-UHFFFAOYSA-N 572198 (rac)-4-chloro-3-ethyl-2-methyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5]azacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 51::US11478451, Example 52 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 3.30 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572198&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591134 473133252 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207900 CCc1c-2c(CCCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H36ClN3O3/c1-3-28-31-27(36-37(28)2)16-6-4-5-9-20-38-32-25(18-19-26(35)30(31)32)24(33(38)34(39)40)15-11-21-41-29-17-10-13-22-12-7-8-14-23(22)29/h7-8,10,12-14,17-19H,3-6,9,11,15-16,20-21H2,1-2H3,(H,39,40) SSTSSUXFOIWKBG-UHFFFAOYSA-N 572199 (+)-4-chloro-3-ethyl-2-methyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5]azacycloundecino[3,2,1-hi]indole-8-carboxylic acid-N-ethylethanamine Salt—Enantiomer 1::US11447504, Example 52 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.870 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572199&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591134 473133253 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207901 CCc1c-2c(CCCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H36ClN3O3/c1-3-28-31-27(36-37(28)2)16-6-4-5-9-20-38-32-25(18-19-26(35)30(31)32)24(33(38)34(39)40)15-11-21-41-29-17-10-13-22-12-7-8-14-23(22)29/h7-8,10,12-14,17-19H,3-6,9,11,15-16,20-21H2,1-2H3,(H,39,40) SSTSSUXFOIWKBG-UHFFFAOYSA-N 572200 (−) 4-chloro-3-ethyl-2-methyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5]azacycloundecino[3,2,1-hi]indole-8-carboxylic acid-N-ethylethanamine Salt—Enantiomer 2::US11447504, Example 53 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 21.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572200&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591134 473133254 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207902 CCc1c-2c(CCCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H35ClFN3O3/c1-3-28-31-27(37-38(28)2)12-6-4-5-7-18-39-32-25(16-17-26(35)30(31)32)24(33(39)34(40)41)11-9-19-42-29-13-8-10-21-20-22(36)14-15-23(21)29/h8,10,13-17,20H,3-7,9,11-12,18-19H2,1-2H3,(H,40,41) OHARMQWZWCLEAS-UHFFFAOYSA-N 572201 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5]azacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 54::US11478451, Example 071 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.30 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572201&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591153 473133255 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207905 CCc1c-2c(COCC(F)(F)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H31ClF3N3O4/c1-3-26-29-25(38-39(26)2)17-43-18-33(36,37)13-14-40-30-23(11-12-24(34)28(29)30)22(31(40)32(41)42)7-5-15-44-27-8-4-6-19-16-20(35)9-10-21(19)27/h4,6,8-12,16H,3,5,7,13-15,17-18H2,1-2H3,(H,41,42) RVPQOBYZHGHWNE-UHFFFAOYSA-N 572202 (rac)-4-chloro-12,12-difluoro-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 55::US11478451, Example 086 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.30 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572202&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591253 473133256 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207908 Cc1c-2c(COCC(F)(F)CCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H30ClF2N3O4/c1-19-27-25(36-37(19)2)17-41-18-32(34,35)14-15-38-29-23(12-13-24(33)28(27)29)22(30(38)31(39)40)10-6-16-42-26-11-5-8-20-7-3-4-9-21(20)26/h3-5,7-9,11-13H,6,10,14-18H2,1-2H3,(H,39,40) BGHOHGRGKVVKET-UHFFFAOYSA-N 572203 4-chloro-12,12-difluoro-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid-N-ethylethanamine Salt—Enantiomer 1::US11447504, Example 56::US11447504, Example 57::US11478451, Example 57 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.820 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572203&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591179 473133257 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207909 Cc1c-2c(COCC(F)(F)CCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H30ClF2N3O4/c1-19-27-25(36-37(19)2)17-41-18-32(34,35)14-15-38-29-23(12-13-24(33)28(27)29)22(30(38)31(39)40)10-6-16-42-26-11-5-8-20-7-3-4-9-21(20)26/h3-5,7-9,11-13H,6,10,14-18H2,1-2H3,(H,39,40) BGHOHGRGKVVKET-UHFFFAOYSA-N 572203 4-chloro-12,12-difluoro-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid-N-ethylethanamine Salt—Enantiomer 1::US11447504, Example 56::US11447504, Example 57::US11478451, Example 57 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 23.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572203&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591179 473133257 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207910 Cc1c-2c(CN(CC(F)(F)F)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H33ClF4N4O3/c1-20-29-27(40-41(20)2)18-42(19-34(37,38)39)14-3-4-15-43-31-25(12-13-26(35)30(29)31)24(32(43)33(44)45)8-6-16-46-28-9-5-7-21-17-22(36)10-11-23(21)28/h5,7,9-13,17H,3-4,6,8,14-16,18-19H2,1-2H3,(H,44,45) RFZZMGINSPWQEQ-UHFFFAOYSA-N 572205 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-14-(2,2,2-trifluoroethyl)-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 58::US11447504, Example 59::US11447504, Example 60::US11478451, Example 60 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.50 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572205&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591124 473133258 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207913 Cc1c-2c(CN(CC(F)(F)F)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H33ClF4N4O3/c1-20-29-27(40-41(20)2)18-42(19-34(37,38)39)14-3-4-15-43-31-25(12-13-26(35)30(29)31)24(32(43)33(44)45)8-6-16-46-28-9-5-7-21-17-22(36)10-11-23(21)28/h5,7,9-13,17H,3-4,6,8,14-16,18-19H2,1-2H3,(H,44,45) RFZZMGINSPWQEQ-UHFFFAOYSA-N 572205 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-14-(2,2,2-trifluoroethyl)-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 58::US11447504, Example 59::US11447504, Example 60::US11478451, Example 60 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.50 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572205&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591124 473133258 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207914 Cc1c-2c(CN(CC(F)(F)F)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H33ClF4N4O3/c1-20-29-27(40-41(20)2)18-42(19-34(37,38)39)14-3-4-15-43-31-25(12-13-26(35)30(29)31)24(32(43)33(44)45)8-6-16-46-28-9-5-7-21-17-22(36)10-11-23(21)28/h5,7,9-13,17H,3-4,6,8,14-16,18-19H2,1-2H3,(H,44,45) RFZZMGINSPWQEQ-UHFFFAOYSA-N 572205 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-14-(2,2,2-trifluoroethyl)-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 58::US11447504, Example 59::US11447504, Example 60::US11478451, Example 60 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 50.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572205&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591124 473133258 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207915 CCc1c-2c(CN(CC(F)(F)F)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C35H35ClF4N4O3/c1-3-28-31-27(41-42(28)2)19-43(20-35(38,39)40)15-4-5-16-44-32-25(13-14-26(36)30(31)32)24(33(44)34(45)46)9-7-17-47-29-10-6-8-21-18-22(37)11-12-23(21)29/h6,8,10-14,18H,3-5,7,9,15-17,19-20H2,1-2H3,(H,45,46) SOQSAVNRWHIOGH-UHFFFAOYSA-N 572208 (rac) 4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-14-(2,2,2-trifluoroethyl)-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 61::US11447504, Example 62::US11478451, Example 61 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.40 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572208&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591302 473133259 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207916 CCc1c-2c(CN(CC(F)(F)F)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C35H35ClF4N4O3/c1-3-28-31-27(41-42(28)2)19-43(20-35(38,39)40)15-4-5-16-44-32-25(13-14-26(36)30(31)32)24(33(44)34(45)46)9-7-17-47-29-10-6-8-21-18-22(37)11-12-23(21)29/h6,8,10-14,18H,3-5,7,9,15-17,19-20H2,1-2H3,(H,45,46) SOQSAVNRWHIOGH-UHFFFAOYSA-N 572208 (rac) 4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-14-(2,2,2-trifluoroethyl)-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 61::US11447504, Example 62::US11478451, Example 61 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.70 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572208&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591302 473133259 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207917 Cc1c-2c(COCC3CCC3Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H34ClN3O4/c1-20-30-28(36-37(20)2)19-41-18-23-13-12-22(23)17-38-32-26(14-15-27(35)31(30)32)25(33(38)34(39)40)10-6-16-42-29-11-5-8-21-7-3-4-9-24(21)29/h3-5,7-9,11,14-15,22-23H,6,10,12-13,16-19H2,1-2H3,(H,39,40) UXSFIMYRQOIGPQ-UHFFFAOYSA-N 572210 (9aS,11 aR)-3-chloro-4,5-dimethyl-15-{3-[(naphthalen-1-yl)oxy]propyl}-5,7,9,9a, 10,11,11a, 12-octahydrocyclobuta[3,4]pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-14-carboxylic Acid—Stereoisomer 1::US11447504, Example 63::US11447504, Example 64::US11478451, Example 081 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.50 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572210&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591248 473133260 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207918 Cc1c-2c(COCC3CCC3Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H34ClN3O4/c1-20-30-28(36-37(20)2)19-41-18-23-13-12-22(23)17-38-32-26(14-15-27(35)31(30)32)25(33(38)34(39)40)10-6-16-42-29-11-5-8-21-7-3-4-9-24(21)29/h3-5,7-9,11,14-15,22-23H,6,10,12-13,16-19H2,1-2H3,(H,39,40) UXSFIMYRQOIGPQ-UHFFFAOYSA-N 572210 (9aS,11 aR)-3-chloro-4,5-dimethyl-15-{3-[(naphthalen-1-yl)oxy]propyl}-5,7,9,9a, 10,11,11a, 12-octahydrocyclobuta[3,4]pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-14-carboxylic Acid—Stereoisomer 1::US11447504, Example 63::US11447504, Example 64::US11478451, Example 081 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 4.90 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572210&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591248 473133260 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207919 Cc1c-2c(COCC3CC3Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H32ClN3O4/c1-19-29-27(35-36(19)2)18-40-17-22-15-21(22)16-37-31-25(12-13-26(34)30(29)31)24(32(37)33(38)39)10-6-14-41-28-11-5-8-20-7-3-4-9-23(20)28/h3-5,7-9,11-13,21-22H,6,10,14-18H2,1-2H3,(H,38,39) NAMHEZLSLWIGJK-UHFFFAOYSA-N 572212 (9aS,10aR or 9aR, 10aS)-3-chloro-4,5-dimethyl-14-{3-[(naphthalen-1-yl)oxy]propyl}-5,7,9a, 10,10a, 11-hexahydro-9H-cyclopropa[3,4]pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino-[8,7,6-hi]indole-13-carboxylic Acid—Stereoisomer 1::US11447504, Example 65::US11447504, Example 66::US11478451, Example 083 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.920 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572212&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591299 473133261 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207920 Cc1c-2c(COCC3CC3Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H32ClN3O4/c1-19-29-27(35-36(19)2)18-40-17-22-15-21(22)16-37-31-25(12-13-26(34)30(29)31)24(32(37)33(38)39)10-6-14-41-28-11-5-8-20-7-3-4-9-23(20)28/h3-5,7-9,11-13,21-22H,6,10,14-18H2,1-2H3,(H,38,39) NAMHEZLSLWIGJK-UHFFFAOYSA-N 572212 (9aS,10aR or 9aR, 10aS)-3-chloro-4,5-dimethyl-14-{3-[(naphthalen-1-yl)oxy]propyl}-5,7,9a, 10,10a, 11-hexahydro-9H-cyclopropa[3,4]pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino-[8,7,6-hi]indole-13-carboxylic Acid—Stereoisomer 1::US11447504, Example 65::US11447504, Example 66::US11478451, Example 083 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.70 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572212&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591299 473133261 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207921 Cc1nn(C)c2N(Cc3ccccc3)CCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4cccc(-c12)c34 InChI=1S/C38H38N4O3/c1-26-34-32-19-11-18-30-31(20-12-24-45-33-21-10-16-28-15-6-7-17-29(28)33)36(38(43)44)42(35(30)32)23-9-8-22-41(37(34)40(2)39-26)25-27-13-4-3-5-14-27/h3-7,10-11,13-19,21H,8-9,12,20,22-25H2,1-2H3,(H,43,44) GKGARWQHJPRBIZ-UHFFFAOYSA-N 572214 (rac)-8-benzyl-9,11-dimethyl-1-[3-(1-naphthyloxy)propyl]-4,5,6,7,8,9-hexahydropyrazolo[4′,3′:4,5][1,6]diazecino[3,2,1-hi]indole-2-carboxylic Acid (Example 002) and (rac)-9,11-dimethyl-1-[3-(1-naphthyloxy)propyl]-4,5,6,7,8,9-hexahydropyrazolo[4′,3′:4,5][1,6]diazecino[3,2,1-hi]indole-2-carboxylic Acid (Example 003)::US11447504, Example 69 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 350 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572214&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 132143525 473133262 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207922 Cc1nn(C)c2NCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4cccc(-c12)c34 InChI=1S/C31H32N4O3/c1-20-27-25-14-8-13-23-24(15-9-19-38-26-16-7-11-21-10-3-4-12-22(21)26)29(31(36)37)35(28(23)25)18-6-5-17-32-30(27)34(2)33-20/h3-4,7-8,10-14,16,32H,5-6,9,15,17-19H2,1-2H3,(H,36,37) OAEVSBBSVICKIC-UHFFFAOYSA-N 572215 US11447504, Example 70 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 43.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572215&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 137251886 473133263 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207923 CN1CCCCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c(-c4c(C)n(C)nc14)c23 InChI=1S/C33H35ClN4O3/c1-21-28-29-26(34)17-16-25-24(14-10-20-41-27-15-9-12-22-11-5-6-13-23(22)27)31(33(39)40)38(30(25)29)19-8-4-7-18-36(2)32(28)35-37(21)3/h5-6,9,11-13,15-17H,4,7-8,10,14,18-20H2,1-3H3,(H,39,40) CGMPYXJHHLNZIS-UHFFFAOYSA-N 572216 (rac)-4-chloro-2,3,15-trimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5][1,6]diazacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 71::US11447504, Example 72::US11447504, Example 73 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.20 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572216&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591725 473133264 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207926 CN1CCCCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c(-c4c(C)n(C)nc14)c23 InChI=1S/C33H35ClN4O3/c1-21-28-29-26(34)17-16-25-24(14-10-20-41-27-15-9-12-22-11-5-6-13-23(22)27)31(33(39)40)38(30(25)29)19-8-4-7-18-36(2)32(28)35-37(21)3/h5-6,9,11-13,15-17H,4,7-8,10,14,18-20H2,1-3H3,(H,39,40) CGMPYXJHHLNZIS-UHFFFAOYSA-N 572216 (rac)-4-chloro-2,3,15-trimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5][1,6]diazacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 71::US11447504, Example 72::US11447504, Example 73 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.960 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572216&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591725 473133264 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207927 CN1CCCCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c(-c4c(C)n(C)nc14)c23 InChI=1S/C33H35ClN4O3/c1-21-28-29-26(34)17-16-25-24(14-10-20-41-27-15-9-12-22-11-5-6-13-23(22)27)31(33(39)40)38(30(25)29)19-8-4-7-18-36(2)32(28)35-37(21)3/h5-6,9,11-13,15-17H,4,7-8,10,14,18-20H2,1-3H3,(H,39,40) CGMPYXJHHLNZIS-UHFFFAOYSA-N 572216 (rac)-4-chloro-2,3,15-trimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5][1,6]diazacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 71::US11447504, Example 72::US11447504, Example 73 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 16.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572216&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591725 473133264 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207930 CN1CCCCCn2c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c(-c4c(C)n(C)nc14)c23 InChI=1S/C33H34ClFN4O3/c1-20-28-29-26(34)15-14-25-24(10-8-18-42-27-11-7-9-21-19-22(35)12-13-23(21)27)31(33(40)41)39(30(25)29)17-6-4-5-16-37(2)32(28)36-38(20)3/h7,9,11-15,19H,4-6,8,10,16-18H2,1-3H3,(H,40,41) OLJSHGSMKXGVPK-UHFFFAOYSA-N 572219 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3,15-trimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5][1,6]diazacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 74::US11447504, Example 75::US11447504, Example 76 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.30 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572219&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591736 473133265 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207933 CN1CCCCCn2c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c(-c4c(C)n(C)nc14)c23 InChI=1S/C33H34ClFN4O3/c1-20-28-29-26(34)15-14-25-24(10-8-18-42-27-11-7-9-21-19-22(35)12-13-23(21)27)31(33(40)41)39(30(25)29)17-6-4-5-16-37(2)32(28)36-38(20)3/h7,9,11-15,19H,4-6,8,10,16-18H2,1-3H3,(H,40,41) OLJSHGSMKXGVPK-UHFFFAOYSA-N 572219 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3,15-trimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5][1,6]diazacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 74::US11447504, Example 75::US11447504, Example 76 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.700 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572219&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591736 473133265 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207936 CN1CCCCCn2c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c(-c4c(C)n(C)nc14)c23 InChI=1S/C33H34ClFN4O3/c1-20-28-29-26(34)15-14-25-24(10-8-18-42-27-11-7-9-21-19-22(35)12-13-23(21)27)31(33(40)41)39(30(25)29)17-6-4-5-16-37(2)32(28)36-38(20)3/h7,9,11-15,19H,4-6,8,10,16-18H2,1-3H3,(H,40,41) OLJSHGSMKXGVPK-UHFFFAOYSA-N 572219 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3,15-trimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5][1,6]diazacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 74::US11447504, Example 75::US11447504, Example 76 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 7.90 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572219&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591736 473133265 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207939 CCc1c-2c(nn1C)N(C)CCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C34H36ClFN4O3/c1-4-27-30-29-26(35)16-15-25-24(11-9-19-43-28-12-8-10-21-20-22(36)13-14-23(21)28)32(34(41)42)40(31(25)29)18-7-5-6-17-38(2)33(30)37-39(27)3/h8,10,12-16,20H,4-7,9,11,17-19H2,1-3H3,(H,41,42) ADXFNSVYTPLASR-UHFFFAOYSA-N 572222 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,15-dimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5][1,6]diazacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 77::US11447504, Example 78::US11447504, Example 79 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572222&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591768 473133266 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207942 CCc1c-2c(nn1C)N(C)CCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C34H36ClFN4O3/c1-4-27-30-29-26(35)16-15-25-24(11-9-19-43-28-12-8-10-21-20-22(36)13-14-23(21)28)32(34(41)42)40(31(25)29)18-7-5-6-17-38(2)33(30)37-39(27)3/h8,10,12-16,20H,4-7,9,11,17-19H2,1-3H3,(H,41,42) ADXFNSVYTPLASR-UHFFFAOYSA-N 572222 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,15-dimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5][1,6]diazacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 77::US11447504, Example 78::US11447504, Example 79 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.10 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572222&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591768 473133266 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207945 CCc1c-2c(nn1C)N(C)CCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C34H36ClFN4O3/c1-4-27-30-29-26(35)16-15-25-24(11-9-19-43-28-12-8-10-21-20-22(36)13-14-23(21)28)32(34(41)42)40(31(25)29)18-7-5-6-17-38(2)33(30)37-39(27)3/h8,10,12-16,20H,4-7,9,11,17-19H2,1-3H3,(H,41,42) ADXFNSVYTPLASR-UHFFFAOYSA-N 572222 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,15-dimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5][1,6]diazacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 77::US11447504, Example 78::US11447504, Example 79 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 6.40 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572222&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591768 473133266 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207948 CCc1c-2c(nn1C)N(CCC1CCOCC1)CCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H46ClFN4O4/c1-3-33-36-35-32(41)15-14-31-30(10-8-22-50-34-11-7-9-27-25-28(42)12-13-29(27)34)38(40(47)48)46(37(31)35)20-6-4-5-19-45(39(36)43-44(33)2)21-16-26-17-23-49-24-18-26/h7,9,11-15,25-26H,3-6,8,10,16-24H2,1-2H3,(H,47,48) HHGPCAJGMHOKIL-UHFFFAOYSA-N 572225 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(oxan-4-yl)ethyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5][1,6]diazacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 80::US11447504, Example 81::US11447504, Example 82 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.00 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572225&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591741 473133267 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207949 CCc1c-2c(nn1C)N(CCC1CCOCC1)CCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H46ClFN4O4/c1-3-33-36-35-32(41)15-14-31-30(10-8-22-50-34-11-7-9-27-25-28(42)12-13-29(27)34)38(40(47)48)46(37(31)35)20-6-4-5-19-45(39(36)43-44(33)2)21-16-26-17-23-49-24-18-26/h7,9,11-15,25-26H,3-6,8,10,16-24H2,1-2H3,(H,47,48) HHGPCAJGMHOKIL-UHFFFAOYSA-N 572225 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(oxan-4-yl)ethyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5][1,6]diazacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 80::US11447504, Example 81::US11447504, Example 82 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572225&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591741 473133267 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207950 CCc1c-2c(nn1C)N(CCC1CCOCC1)CCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H46ClFN4O4/c1-3-33-36-35-32(41)15-14-31-30(10-8-22-50-34-11-7-9-27-25-28(42)12-13-29(27)34)38(40(47)48)46(37(31)35)20-6-4-5-19-45(39(36)43-44(33)2)21-16-26-17-23-49-24-18-26/h7,9,11-15,25-26H,3-6,8,10,16-24H2,1-2H3,(H,47,48) HHGPCAJGMHOKIL-UHFFFAOYSA-N 572225 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(oxan-4-yl)ethyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5][1,6]diazacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 80::US11447504, Example 81::US11447504, Example 82 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 140 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572225&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591741 473133267 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207951 Cc1c-2c(OCCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H31ClFN3O4/c1-19-27-28-25(33)14-13-24-23(9-7-17-40-26-10-6-8-20-18-21(34)11-12-22(20)26)30(32(38)39)37(29(24)28)15-4-3-5-16-41-31(27)35-36(19)2/h6,8,10-14,18H,3-5,7,9,15-17H2,1-2H3,(H,38,39) OMYQPDVOHAOLPZ-UHFFFAOYSA-N 572228 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-11,12,13,14-tetrahydro-2H,10H-pyrazolo[3′,4′:2,3][1,6]oxazacycloundecino[4,5,6-hi]indole-8-carboxylic Acid::US11447504, Example 83::US11447504, Example 84::US11447504, Example 85 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 4.50 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572228&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591717 473133268 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207952 Cc1c-2c(OCCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H31ClFN3O4/c1-19-27-28-25(33)14-13-24-23(9-7-17-40-26-10-6-8-20-18-21(34)11-12-22(20)26)30(32(38)39)37(29(24)28)15-4-3-5-16-41-31(27)35-36(19)2/h6,8,10-14,18H,3-5,7,9,15-17H2,1-2H3,(H,38,39) OMYQPDVOHAOLPZ-UHFFFAOYSA-N 572228 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-11,12,13,14-tetrahydro-2H,10H-pyrazolo[3′,4′:2,3][1,6]oxazacycloundecino[4,5,6-hi]indole-8-carboxylic Acid::US11447504, Example 83::US11447504, Example 84::US11447504, Example 85 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.90 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572228&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591717 473133268 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1207953 Cc1c-2c(OCCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H31ClFN3O4/c1-19-27-28-25(33)14-13-24-23(9-7-17-40-26-10-6-8-20-18-21(34)11-12-22(20)26)30(32(38)39)37(29(24)28)15-4-3-5-16-41-31(27)35-36(19)2/h6,8,10-14,18H,3-5,7,9,15-17H2,1-2H3,(H,38,39) OMYQPDVOHAOLPZ-UHFFFAOYSA-N 572228 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-11,12,13,14-tetrahydro-2H,10H-pyrazolo[3′,4′:2,3][1,6]oxazacycloundecino[4,5,6-hi]indole-8-carboxylic Acid::US11447504, Example 83::US11447504, Example 84::US11447504, Example 85 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 53.0 US Patent 10.7270/Q2057K58 aid1806828 US11447504 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Mortier, JX; McCarren, PR; Serrano-Wu, MH; Lemke, C; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572228&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591717 473133268 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206663 CC1OCCCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3cccc(-c4c(C)n(C)nc14)c23 InChI=1S/C33H35N3O4/c1-21-29-27-15-9-14-25-26(16-10-20-40-28-17-8-12-23-11-4-5-13-24(23)28)32(33(37)38)36(31(25)27)18-6-7-19-39-22(2)30(29)34-35(21)3/h4-5,8-9,11-15,17,22H,6-7,10,16,18-20H2,1-3H3,(H,37,38) GSHPRFUNVKYWPO-UHFFFAOYSA-N 571437 (rac)-2,3,15-trimethyl-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Mixture of Stereoisomers)::US11440923, Example 1::US11440923, Example 2::US11440923, Example 3 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.20 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571437&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591936 473132600 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206666 CC1OCCCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3cccc(-c4c(C)n(C)nc14)c23 InChI=1S/C33H35N3O4/c1-21-29-27-15-9-14-25-26(16-10-20-40-28-17-8-12-23-11-4-5-13-24(23)28)32(33(37)38)36(31(25)27)18-6-7-19-39-22(2)30(29)34-35(21)3/h4-5,8-9,11-15,17,22H,6-7,10,16,18-20H2,1-3H3,(H,37,38) GSHPRFUNVKYWPO-UHFFFAOYSA-N 571437 (rac)-2,3,15-trimethyl-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Mixture of Stereoisomers)::US11440923, Example 1::US11440923, Example 2::US11440923, Example 3 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.20 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571437&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591936 473132600 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206669 CC1OCCCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3cccc(-c4c(C)n(C)nc14)c23 InChI=1S/C33H35N3O4/c1-21-29-27-15-9-14-25-26(16-10-20-40-28-17-8-12-23-11-4-5-13-24(23)28)32(33(37)38)36(31(25)27)18-6-7-19-39-22(2)30(29)34-35(21)3/h4-5,8-9,11-15,17,22H,6-7,10,16,18-20H2,1-3H3,(H,37,38) GSHPRFUNVKYWPO-UHFFFAOYSA-N 571437 (rac)-2,3,15-trimethyl-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Mixture of Stereoisomers)::US11440923, Example 1::US11440923, Example 2::US11440923, Example 3 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 22.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571437 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571437&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591936 473132600 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206672 Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3cccc-2c13 InChI=1S/C38H44N4O5/c1-26-34-31-14-8-13-29-30(15-9-23-46-32-16-7-11-27-10-3-4-12-28(27)32)37(38(43)44)42(36(29)31)18-5-6-22-47-33(35(34)39-40(26)2)17-19-41-20-24-45-25-21-41/h3-4,7-8,10-14,16,33H,5-6,9,15,17-25H2,1-2H3,(H,43,44) XIDPTYAUKDEXAO-UHFFFAOYSA-N 571440 (rac)-2,3-dimethyl-15-[2-(morpholin-4-yl)ethyl]-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Mixture of Stereoisomers)::US11440923, Example 4::US11440923, Example 5::US11440923, Example 6 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571440&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591921 473132601 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206673 Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3cccc-2c13 InChI=1S/C38H44N4O5/c1-26-34-31-14-8-13-29-30(15-9-23-46-32-16-7-11-27-10-3-4-12-28(27)32)37(38(43)44)42(36(29)31)18-5-6-22-47-33(35(34)39-40(26)2)17-19-41-20-24-45-25-21-41/h3-4,7-8,10-14,16,33H,5-6,9,15,17-25H2,1-2H3,(H,43,44) XIDPTYAUKDEXAO-UHFFFAOYSA-N 571440 (rac)-2,3-dimethyl-15-[2-(morpholin-4-yl)ethyl]-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Mixture of Stereoisomers)::US11440923, Example 4::US11440923, Example 5::US11440923, Example 6 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.20 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571440&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591921 473132601 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206674 Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3cccc-2c13 InChI=1S/C38H44N4O5/c1-26-34-31-14-8-13-29-30(15-9-23-46-32-16-7-11-27-10-3-4-12-28(27)32)37(38(43)44)42(36(29)31)18-5-6-22-47-33(35(34)39-40(26)2)17-19-41-20-24-45-25-21-41/h3-4,7-8,10-14,16,33H,5-6,9,15,17-25H2,1-2H3,(H,43,44) XIDPTYAUKDEXAO-UHFFFAOYSA-N 571440 (rac)-2,3-dimethyl-15-[2-(morpholin-4-yl)ethyl]-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Mixture of Stereoisomers)::US11440923, Example 4::US11440923, Example 5::US11440923, Example 6 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 51.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571440 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571440&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591921 473132601 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206677 Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(F)c-2c13 InChI=1S/C38H43FN4O5/c1-25-33-34-30(39)15-14-29-28(12-8-22-47-31-13-7-10-26-9-3-4-11-27(26)31)37(38(44)45)43(36(29)34)17-5-6-21-48-32(35(33)40-41(25)2)16-18-42-19-23-46-24-20-42/h3-4,7,9-11,13-15,32H,5-6,8,12,16-24H2,1-2H3,(H,44,45) RDZMVGOZFDLRGC-UHFFFAOYSA-N 571443 (rac)-4-fluoro-2,3-dimethyl-15-[2-(morpholin-4-yl)ethyl]-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 7::US11440923, Example 8::US11440923, Example 9 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.660 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571443&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591860 473132602 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206680 Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(F)c-2c13 InChI=1S/C38H43FN4O5/c1-25-33-34-30(39)15-14-29-28(12-8-22-47-31-13-7-10-26-9-3-4-11-27(26)31)37(38(44)45)43(36(29)34)17-5-6-21-48-32(35(33)40-41(25)2)16-18-42-19-23-46-24-20-42/h3-4,7,9-11,13-15,32H,5-6,8,12,16-24H2,1-2H3,(H,44,45) RDZMVGOZFDLRGC-UHFFFAOYSA-N 571443 (rac)-4-fluoro-2,3-dimethyl-15-[2-(morpholin-4-yl)ethyl]-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 7::US11440923, Example 8::US11440923, Example 9 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.570 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571443&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591860 473132602 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206681 Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(F)c-2c13 InChI=1S/C38H43FN4O5/c1-25-33-34-30(39)15-14-29-28(12-8-22-47-31-13-7-10-26-9-3-4-11-27(26)31)37(38(44)45)43(36(29)34)17-5-6-21-48-32(35(33)40-41(25)2)16-18-42-19-23-46-24-20-42/h3-4,7,9-11,13-15,32H,5-6,8,12,16-24H2,1-2H3,(H,44,45) RDZMVGOZFDLRGC-UHFFFAOYSA-N 571443 (rac)-4-fluoro-2,3-dimethyl-15-[2-(morpholin-4-yl)ethyl]-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 7::US11440923, Example 8::US11440923, Example 9 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 58.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571443&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591860 473132602 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206684 CCc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(F)c-2c13 InChI=1S/C39H45FN4O5/c1-3-31-35-34-30(40)16-15-29-28(13-9-23-48-32-14-8-11-26-10-4-5-12-27(26)32)38(39(45)46)44(37(29)34)18-6-7-22-49-33(36(35)41-42(31)2)17-19-43-20-24-47-25-21-43/h4-5,8,10-12,14-16,33H,3,6-7,9,13,17-25H2,1-2H3,(H,45,46) AISBLTHXOXGMSY-UHFFFAOYSA-N 571446 (rac)-3-ethyl-4-fluoro-2-methyl-15-[2-(morpholin-4-yl)ethyl]-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 10::US11440923, Example 11::US11440923, Example 12 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.720 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571446&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591905 473132603 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206687 CCc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(F)c-2c13 InChI=1S/C39H45FN4O5/c1-3-31-35-34-30(40)16-15-29-28(13-9-23-48-32-14-8-11-26-10-4-5-12-27(26)32)38(39(45)46)44(37(29)34)18-6-7-22-49-33(36(35)41-42(31)2)17-19-43-20-24-47-25-21-43/h4-5,8,10-12,14-16,33H,3,6-7,9,13,17-25H2,1-2H3,(H,45,46) AISBLTHXOXGMSY-UHFFFAOYSA-N 571446 (rac)-3-ethyl-4-fluoro-2-methyl-15-[2-(morpholin-4-yl)ethyl]-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 10::US11440923, Example 11::US11440923, Example 12 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.540 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571446&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591905 473132603 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206688 CCc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(F)c-2c13 InChI=1S/C39H45FN4O5/c1-3-31-35-34-30(40)16-15-29-28(13-9-23-48-32-14-8-11-26-10-4-5-12-27(26)32)38(39(45)46)44(37(29)34)18-6-7-22-49-33(36(35)41-42(31)2)17-19-43-20-24-47-25-21-43/h4-5,8,10-12,14-16,33H,3,6-7,9,13,17-25H2,1-2H3,(H,45,46) AISBLTHXOXGMSY-UHFFFAOYSA-N 571446 (rac)-3-ethyl-4-fluoro-2-methyl-15-[2-(morpholin-4-yl)ethyl]-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 10::US11440923, Example 11::US11440923, Example 12 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 40.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571446&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591905 473132603 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206691 Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13 InChI=1S/C38H43ClN4O5/c1-25-33-34-30(39)15-14-29-28(12-8-22-47-31-13-7-10-26-9-3-4-11-27(26)31)37(38(44)45)43(36(29)34)17-5-6-21-48-32(35(33)40-41(25)2)16-18-42-19-23-46-24-20-42/h3-4,7,9-11,13-15,32H,5-6,8,12,16-24H2,1-2H3,(H,44,45) UMIMWGJEBPFPIS-UHFFFAOYSA-N 571449 (rac)-4-chloro-2,3-dimethyl-15-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 13::US11440923, Example 14::US11440923, Example 15 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.60 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571449&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591949 473132604 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206694 Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13 InChI=1S/C38H43ClN4O5/c1-25-33-34-30(39)15-14-29-28(12-8-22-47-31-13-7-10-26-9-3-4-11-27(26)31)37(38(44)45)43(36(29)34)17-5-6-21-48-32(35(33)40-41(25)2)16-18-42-19-23-46-24-20-42/h3-4,7,9-11,13-15,32H,5-6,8,12,16-24H2,1-2H3,(H,44,45) UMIMWGJEBPFPIS-UHFFFAOYSA-N 571449 (rac)-4-chloro-2,3-dimethyl-15-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 13::US11440923, Example 14::US11440923, Example 15 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.530 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571449&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591949 473132604 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206697 Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13 InChI=1S/C38H43ClN4O5/c1-25-33-34-30(39)15-14-29-28(12-8-22-47-31-13-7-10-26-9-3-4-11-27(26)31)37(38(44)45)43(36(29)34)17-5-6-21-48-32(35(33)40-41(25)2)16-18-42-19-23-46-24-20-42/h3-4,7,9-11,13-15,32H,5-6,8,12,16-24H2,1-2H3,(H,44,45) UMIMWGJEBPFPIS-UHFFFAOYSA-N 571449 (rac)-4-chloro-2,3-dimethyl-15-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 13::US11440923, Example 14::US11440923, Example 15 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 65.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571449&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591949 473132604 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206700 Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C38H42ClFN4O5/c1-24-33-34-30(39)13-12-29-28(8-6-20-48-31-9-5-7-25-23-26(40)10-11-27(25)31)37(38(45)46)44(36(29)34)15-3-4-19-49-32(35(33)41-42(24)2)14-16-43-17-21-47-22-18-43/h5,7,9-13,23,32H,3-4,6,8,14-22H2,1-2H3,(H,45,46) CJILTEZPSOPNKJ-UHFFFAOYSA-N 571452 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 16::US11440923, Example 17::US11440923, Example 18 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.00 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571452&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591796 473132605 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206703 Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C38H42ClFN4O5/c1-24-33-34-30(39)13-12-29-28(8-6-20-48-31-9-5-7-25-23-26(40)10-11-27(25)31)37(38(45)46)44(36(29)34)15-3-4-19-49-32(35(33)41-42(24)2)14-16-43-17-21-47-22-18-43/h5,7,9-13,23,32H,3-4,6,8,14-22H2,1-2H3,(H,45,46) CJILTEZPSOPNKJ-UHFFFAOYSA-N 571452 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 16::US11440923, Example 17::US11440923, Example 18 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.20 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571452&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591796 473132605 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206706 Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C38H42ClFN4O5/c1-24-33-34-30(39)13-12-29-28(8-6-20-48-31-9-5-7-25-23-26(40)10-11-27(25)31)37(38(45)46)44(36(29)34)15-3-4-19-49-32(35(33)41-42(24)2)14-16-43-17-21-47-22-18-43/h5,7,9-13,23,32H,3-4,6,8,14-22H2,1-2H3,(H,45,46) CJILTEZPSOPNKJ-UHFFFAOYSA-N 571452 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 16::US11440923, Example 17::US11440923, Example 18 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 42.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571452&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591796 473132605 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206709 Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(F)c-2c13 InChI=1S/C38H42F2N4O5/c1-24-33-34-30(40)13-12-29-28(8-6-20-48-31-9-5-7-25-23-26(39)10-11-27(25)31)37(38(45)46)44(36(29)34)15-3-4-19-49-32(35(33)41-42(24)2)14-16-43-17-21-47-22-18-43/h5,7,9-13,23,32H,3-4,6,8,14-22H2,1-2H3,(H,45,46) LGBQURTUDABKTP-UHFFFAOYSA-N 571455 (rac)-4-fluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 19::US11440923, Example 20::US11440923, Example 21 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.60 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571455&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591870 473132606 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206712 Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(F)c-2c13 InChI=1S/C38H42F2N4O5/c1-24-33-34-30(40)13-12-29-28(8-6-20-48-31-9-5-7-25-23-26(39)10-11-27(25)31)37(38(45)46)44(36(29)34)15-3-4-19-49-32(35(33)41-42(24)2)14-16-43-17-21-47-22-18-43/h5,7,9-13,23,32H,3-4,6,8,14-22H2,1-2H3,(H,45,46) LGBQURTUDABKTP-UHFFFAOYSA-N 571455 (rac)-4-fluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 19::US11440923, Example 20::US11440923, Example 21 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.790 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571455&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591870 473132606 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206715 Cc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(F)c-2c13 InChI=1S/C38H42F2N4O5/c1-24-33-34-30(40)13-12-29-28(8-6-20-48-31-9-5-7-25-23-26(39)10-11-27(25)31)37(38(45)46)44(36(29)34)15-3-4-19-49-32(35(33)41-42(24)2)14-16-43-17-21-47-22-18-43/h5,7,9-13,23,32H,3-4,6,8,14-22H2,1-2H3,(H,45,46) LGBQURTUDABKTP-UHFFFAOYSA-N 571455 (rac)-4-fluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 19::US11440923, Example 20::US11440923, Example 21 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 160 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571455&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591870 473132606 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206718 CCc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C39H44ClFN4O5/c1-3-31-35-34-30(40)14-13-29-28(9-7-21-49-32-10-6-8-25-24-26(41)11-12-27(25)32)38(39(46)47)45(37(29)34)16-4-5-20-50-33(36(35)42-43(31)2)15-17-44-18-22-48-23-19-44/h6,8,10-14,24,33H,3-5,7,9,15-23H2,1-2H3,(H,46,47) RQXSLNDYCDRXAC-UHFFFAOYSA-N 571458 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 22 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.50 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571458&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591896 473132607 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206721 CCc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C39H44ClFN4O5/c1-3-31-35-34-30(40)14-13-29-28(9-7-21-49-32-10-6-8-25-24-26(41)11-12-27(25)32)38(39(46)47)45(37(29)34)16-4-5-20-50-33(36(35)42-43(31)2)15-17-44-18-22-48-23-19-44/h6,8,10-14,24,33H,3-5,7,9,15-23H2,1-2H3,(H,46,47) RQXSLNDYCDRXAC-UHFFFAOYSA-N 571459 (+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine (Enantiomer 1)::US11440923, Example 23 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.630 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571459&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591896 473132608 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206724 CCc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C39H44ClFN4O5/c1-3-31-35-34-30(40)14-13-29-28(9-7-21-49-32-10-6-8-25-24-26(41)11-12-27(25)32)38(39(46)47)45(37(29)34)16-4-5-20-50-33(36(35)42-43(31)2)15-17-44-18-22-48-23-19-44/h6,8,10-14,24,33H,3-5,7,9,15-23H2,1-2H3,(H,46,47) RQXSLNDYCDRXAC-UHFFFAOYSA-N 571460 (−)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid—N-ethylethanamine (Enantiomer 2)::US11440923, Example 24 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 28.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571460 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571460&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591896 473132609 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206727 CCC1OCCCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c(-c4c(C)n(C)nc14)c23 InChI=1S/C34H36ClN3O4/c1-4-27-31-29(21(2)37(3)36-31)30-26(35)17-16-25-24(33(34(39)40)38(32(25)30)18-7-8-19-41-27)14-10-20-42-28-15-9-12-22-11-5-6-13-23(22)28/h5-6,9,11-13,15-17,27H,4,7-8,10,14,18-20H2,1-3H3,(H,39,40) SRCCZISYAVXKLD-UHFFFAOYSA-N 571461 (rac)-4-chloro-15-ethyl-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 25 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.90 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571461&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591850 473132610 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206730 Cc1c-2c(nn1C)C(CCO)OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13 InChI=1S/C34H36ClN3O5/c1-21-29-30-26(35)15-14-25-24(12-8-20-42-27-13-7-10-22-9-3-4-11-23(22)27)33(34(40)41)38(32(25)30)17-5-6-19-43-28(16-18-39)31(29)36-37(21)2/h3-4,7,9-11,13-15,28,39H,5-6,8,12,16-20H2,1-2H3,(H,40,41) BEVCGKXTXMHMFO-UHFFFAOYSA-N 571462 (rac)-4-chloro-15-(2-hydroxyethyl)-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 26 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571462 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571462&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591807 473132611 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206733 CCc1c-2c(nn1C)C(OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13)C(F)(F)F InChI=1S/C34H33ClF3N3O4/c1-3-25-28-27-24(35)16-15-23-22(13-9-19-44-26-14-8-11-20-10-4-5-12-21(20)26)31(33(42)43)41(30(23)27)17-6-7-18-45-32(34(36,37)38)29(28)39-40(25)2/h4-5,8,10-12,14-16,32H,3,6-7,9,13,17-19H2,1-2H3,(H,42,43) LFBYVLSJEJBMEJ-UHFFFAOYSA-N 571463 (rac)-4-Chloro-3-ethyl-2-methyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-15-(trifluoromethyl)-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 27 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 3.80 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571463&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591925 473132612 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206736 Cc1c-2c(nn1C)C(OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13)C1CC1 InChI=1S/C35H36ClN3O4/c1-21-29-30-27(36)17-16-26-25(12-8-20-42-28-13-7-10-22-9-3-4-11-24(22)28)33(35(40)41)39(32(26)30)18-5-6-19-43-34(23-14-15-23)31(29)37-38(21)2/h3-4,7,9-11,13,16-17,23,34H,5-6,8,12,14-15,18-20H2,1-2H3,(H,40,41) ZYTWBPWAQMGSAQ-UHFFFAOYSA-N 571464 (rac)-4-Chloro-15-cyclopropyl-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 28 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571464 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571464&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591928 473132613 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206739 CCC1OCCCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c(-c4c(C)n(C)nc14)c23 InChI=1S/C34H36ClN3O4/c1-4-27-31-29(21(2)37(3)36-31)30-26(35)17-16-25-24(33(34(39)40)38(32(25)30)18-7-8-19-41-27)14-10-20-42-28-15-9-12-22-11-5-6-13-23(22)28/h5-6,9,11-13,15-17,27H,4,7-8,10,14,18-20H2,1-3H3,(H,39,40) SRCCZISYAVXKLD-UHFFFAOYSA-N 571465 (+)-4-chloro-15-ethyl-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 1)::US11440923, Example 29 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.00 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571465 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571465&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591850 473132614 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206742 CCC1OCCCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c(-c4c(C)n(C)nc14)c23 InChI=1S/C34H36ClN3O4/c1-4-27-31-29(21(2)37(3)36-31)30-26(35)17-16-25-24(33(34(39)40)38(32(25)30)18-7-8-19-41-27)14-10-20-42-28-15-9-12-22-11-5-6-13-23(22)28/h5-6,9,11-13,15-17,27H,4,7-8,10,14,18-20H2,1-3H3,(H,39,40) SRCCZISYAVXKLD-UHFFFAOYSA-N 571466 (−)-4-chloro-15-ethyl-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 2)::US11440923, Example 30 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 200 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571466 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571466&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591850 473132615 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206745 Cc1c-2c(nn1C)C(CCO)OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13 InChI=1S/C34H36ClN3O5/c1-21-29-30-26(35)15-14-25-24(12-8-20-42-27-13-7-10-22-9-3-4-11-23(22)27)33(34(40)41)38(32(25)30)17-5-6-19-43-28(16-18-39)31(29)36-37(21)2/h3-4,7,9-11,13-15,28,39H,5-6,8,12,16-20H2,1-2H3,(H,40,41) BEVCGKXTXMHMFO-UHFFFAOYSA-N 571467 (+)-4-chloro-15-(2-hydroxyethyl)-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 1)::US11440923, Example 31 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.260 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571467 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571467&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591807 473132616 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206748 Cc1c-2c(nn1C)C(CCO)OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13 InChI=1S/C34H36ClN3O5/c1-21-29-30-26(35)15-14-25-24(12-8-20-42-27-13-7-10-22-9-3-4-11-23(22)27)33(34(40)41)38(32(25)30)17-5-6-19-43-28(16-18-39)31(29)36-37(21)2/h3-4,7,9-11,13-15,28,39H,5-6,8,12,16-20H2,1-2H3,(H,40,41) BEVCGKXTXMHMFO-UHFFFAOYSA-N 571468 (−)-4-chloro-15-(2-hydroxyethyl)-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 2)::US11440923, Example 32 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 75.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571468 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571468&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591807 473132617 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206751 CCc1c-2c(nn1C)C(OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13)C(F)(F)F InChI=1S/C34H33ClF3N3O4/c1-3-25-28-27-24(35)16-15-23-22(13-9-19-44-26-14-8-11-20-10-4-5-12-21(20)26)31(33(42)43)41(30(23)27)17-6-7-18-45-32(34(36,37)38)29(28)39-40(25)2/h4-5,8,10-12,14-16,32H,3,6-7,9,13,17-19H2,1-2H3,(H,42,43) LFBYVLSJEJBMEJ-UHFFFAOYSA-N 571469 (+)-4-chloro-3-ethyl-2-methyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-15-(trifluoromethyl)-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 1)::US11440923, Example 33 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.10 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571469 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571469&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591925 473132618 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206754 CCc1c-2c(nn1C)C(OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13)C(F)(F)F InChI=1S/C34H33ClF3N3O4/c1-3-25-28-27-24(35)16-15-23-22(13-9-19-44-26-14-8-11-20-10-4-5-12-21(20)26)31(33(42)43)41(30(23)27)17-6-7-18-45-32(34(36,37)38)29(28)39-40(25)2/h4-5,8,10-12,14-16,32H,3,6-7,9,13,17-19H2,1-2H3,(H,42,43) LFBYVLSJEJBMEJ-UHFFFAOYSA-N 571470 (−)-4-chloro-3-ethyl-2-methyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-15-(trifluoromethyl)-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 2)::US11440923, Example 34 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 370 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571470 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571470&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591925 473132619 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206757 Cc1c-2c(nn1C)C(OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13)C1CC1 InChI=1S/C35H36ClN3O4/c1-21-29-30-27(36)17-16-26-25(12-8-20-42-28-13-7-10-22-9-3-4-11-24(22)28)33(35(40)41)39(32(26)30)18-5-6-19-43-34(23-14-15-23)31(29)37-38(21)2/h3-4,7,9-11,13,16-17,23,34H,5-6,8,12,14-15,18-20H2,1-2H3,(H,40,41) ZYTWBPWAQMGSAQ-UHFFFAOYSA-N 571471 (+)-4-chloro-15-cyclopropyl-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid N-ethylethanamine Salt (Enantiomer 1)::US11440923, Example 35 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.730 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571471 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571471&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591928 473132620 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206760 Cc1c-2c(nn1C)C(OCCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13)C1CC1 InChI=1S/C35H36ClN3O4/c1-21-29-30-27(36)17-16-26-25(12-8-20-42-28-13-7-10-22-9-3-4-11-24(22)28)33(35(40)41)39(32(26)30)18-5-6-19-43-34(23-14-15-23)31(29)37-38(21)2/h3-4,7,9-11,13,16-17,23,34H,5-6,8,12,14-15,18-20H2,1-2H3,(H,40,41) ZYTWBPWAQMGSAQ-UHFFFAOYSA-N 571472 (−)-4-chloro-15-cyclopropyl-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid N-ethylethanamine Salt (Enantiomer 2)::US11440923, Example 36 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 280 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571472 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571472&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591928 473132621 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206763 COCCC1OCCCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c(-c4c(C)n(C)nc14)c23 InChI=1S/C35H38ClN3O5/c1-22-30-31-27(36)16-15-26-25(13-9-20-43-28-14-8-11-23-10-4-5-12-24(23)28)34(35(40)41)39(33(26)31)18-6-7-19-44-29(17-21-42-3)32(30)37-38(22)2/h4-5,8,10-12,14-16,29H,6-7,9,13,17-21H2,1-3H3,(H,40,41) UGRSAOFGYCVXJI-UHFFFAOYSA-N 571473 (rac)-4-chloro-(15-rac)-(2-methoxyethyl)-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 37 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.480 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571473&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591855 473132622 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206766 CCc1c-2c(nn1C)C(OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13)C1CC1 InChI=1S/C36H37ClFN3O4/c1-3-28-31-30-27(37)16-15-26-25(9-7-19-44-29-10-6-8-22-20-23(38)13-14-24(22)29)34(36(42)43)41(33(26)30)17-4-5-18-45-35(21-11-12-21)32(31)39-40(28)2/h6,8,10,13-16,20-21,35H,3-5,7,9,11-12,17-19H2,1-2H3,(H,42,43) YJGZWMUDDMXOHU-UHFFFAOYSA-N 571474 (rac)-4-chloro-(15-rac)-cyclopropyl-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 38 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.30 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571474&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591826 473132623 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206769 CCc1c-2c(nn1C)C(OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13)C1CC1 InChI=1S/C36H37ClFN3O4/c1-3-28-31-30-27(37)16-15-26-25(9-7-19-44-29-10-6-8-22-20-23(38)13-14-24(22)29)34(36(42)43)41(33(26)30)17-4-5-18-45-35(21-11-12-21)32(31)39-40(28)2/h6,8,10,13-16,20-21,35H,3-5,7,9,11-12,17-19H2,1-2H3,(H,42,43) YJGZWMUDDMXOHU-UHFFFAOYSA-N 571475 (+)-4-chloro-15-cyclopropyl-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 1)::US11440923, Example 39 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.720 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571475 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571475&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591826 473132624 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206772 CCc1c-2c(nn1C)C(OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13)C1CC1 InChI=1S/C36H37ClFN3O4/c1-3-28-31-30-27(37)16-15-26-25(9-7-19-44-29-10-6-8-22-20-23(38)13-14-24(22)29)34(36(42)43)41(33(26)30)17-4-5-18-45-35(21-11-12-21)32(31)39-40(28)2/h6,8,10,13-16,20-21,35H,3-5,7,9,11-12,17-19H2,1-2H3,(H,42,43) YJGZWMUDDMXOHU-UHFFFAOYSA-N 571476 (−)-4-chloro-15-cyclopropyl-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 2)::US11440923, Example 40 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 48.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571476 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571476&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591826 473132625 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206775 CCc1c-2c(nn1C)C(CCOC)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C36H39ClFN3O5/c1-4-28-32-31-27(37)15-14-26-25(10-8-19-45-29-11-7-9-22-21-23(38)12-13-24(22)29)35(36(42)43)41(34(26)31)17-5-6-18-46-30(16-20-44-3)33(32)39-40(28)2/h7,9,11-15,21,30H,4-6,8,10,16-20H2,1-3H3,(H,42,43) ULHMAHZGCJFFEN-UHFFFAOYSA-N 571477 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-(15-rac)-(2-methoxyethyl)-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 41 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.520 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571477 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571477&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591893 473132626 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206778 CCc1c-2c(nn1C)C(CCOC)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C36H39ClFN3O5/c1-4-28-32-31-27(37)15-14-26-25(10-8-19-45-29-11-7-9-22-21-23(38)12-13-24(22)29)35(36(42)43)41(34(26)31)17-5-6-18-46-30(16-20-44-3)33(32)39-40(28)2/h7,9,11-15,21,30H,4-6,8,10,16-20H2,1-3H3,(H,42,43) ULHMAHZGCJFFEN-UHFFFAOYSA-N 571478 (+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-15-(2-methoxyethyl)-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 1)::US11440923, Example 42 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.330 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571478 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571478&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591893 473132627 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206781 CCc1c-2c(nn1C)C(CCOC)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C36H39ClFN3O5/c1-4-28-32-31-27(37)15-14-26-25(10-8-19-45-29-11-7-9-22-21-23(38)12-13-24(22)29)35(36(42)43)41(34(26)31)17-5-6-18-46-30(16-20-44-3)33(32)39-40(28)2/h7,9,11-15,21,30H,4-6,8,10,16-20H2,1-3H3,(H,42,43) ULHMAHZGCJFFEN-UHFFFAOYSA-N 571479 (−)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-15-(2-methoxyethyl)-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 2)::US11440923, Example 43 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 88.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571479 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571479&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591893 473132628 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206784 CCc1c-2c(nn1C)C(CCO)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C35H37ClFN3O5/c1-3-27-31-30-26(36)14-13-25-24(9-7-19-44-28-10-6-8-21-20-22(37)11-12-23(21)28)34(35(42)43)40(33(25)30)16-4-5-18-45-29(15-17-41)32(31)38-39(27)2/h6,8,10-14,20,29,41H,3-5,7,9,15-19H2,1-2H3,(H,42,43) YBBZCAXSRUNKMD-UHFFFAOYSA-N 571480 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-(15-rac)-(2-hydroxyethyl)-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 44 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.390 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571480&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591816 473132629 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206787 CCc1c-2c(nn1C)C(CCO)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C35H37ClFN3O5/c1-3-27-31-30-26(36)14-13-25-24(9-7-19-44-28-10-6-8-21-20-22(37)11-12-23(21)28)34(35(42)43)40(33(25)30)16-4-5-18-45-29(15-17-41)32(31)38-39(27)2/h6,8,10-14,20,29,41H,3-5,7,9,15-19H2,1-2H3,(H,42,43) YBBZCAXSRUNKMD-UHFFFAOYSA-N 571481 (+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-15-(2-hydroxyethyl)-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 1)::US11440923, Example 45 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.550 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571481 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571481&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591816 473132630 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206790 CCc1c-2c(nn1C)C(CCO)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C35H37ClFN3O5/c1-3-27-31-30-26(36)14-13-25-24(9-7-19-44-28-10-6-8-21-20-22(37)11-12-23(21)28)34(35(42)43)40(33(25)30)16-4-5-18-45-29(15-17-41)32(31)38-39(27)2/h6,8,10-14,20,29,41H,3-5,7,9,15-19H2,1-2H3,(H,42,43) YBBZCAXSRUNKMD-UHFFFAOYSA-N 571482 (−)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-15-(2-hydroxyethyl)-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 2)::US11440923, Example 46 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 36.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571482 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571482&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591816 473132631 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206793 CCc1c-2c(nn1C)[C@@H](CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C39H44ClFN4O5/c1-3-31-35-34-30(40)14-13-29-28(9-7-21-49-32-10-6-8-25-24-26(41)11-12-27(25)32)38(39(46)47)45(37(29)34)16-4-5-20-50-33(36(35)42-43(31)2)15-17-44-18-22-48-23-19-44/h6,8,10-14,24,33H,3-5,7,9,15-23H2,1-2H3,(H,46,47)/t33-/m1/s1 RQXSLNDYCDRXAC-MGBGTMOVSA-N 571483 (+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-(15R)-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 47 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.370 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571483 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571483&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591867 473132632 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206796 CCc1c-2c(nn1C)[C@@H](CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C39H44ClFN4O5/c1-3-31-35-34-30(40)14-13-29-28(9-7-21-49-32-10-6-8-25-24-26(41)11-12-27(25)32)38(39(46)47)45(37(29)34)16-4-5-20-50-33(36(35)42-43(31)2)15-17-44-18-22-48-23-19-44/h6,8,10-14,24,33H,3-5,7,9,15-23H2,1-2H3,(H,46,47)/t33-/m1/s1 RQXSLNDYCDRXAC-MGBGTMOVSA-N 571484 (15R)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt::US11440923, Example 48 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 3.60 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571484 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571484&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591867 473132633 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206797 CCc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(F)c-2c13 InChI=1S/C39H44F2N4O5/c1-3-31-35-34-30(41)14-13-29-28(9-7-21-49-32-10-6-8-25-24-26(40)11-12-27(25)32)38(39(46)47)45(37(29)34)16-4-5-20-50-33(36(35)42-43(31)2)15-17-44-18-22-48-23-19-44/h6,8,10-14,24,33H,3-5,7,9,15-23H2,1-2H3,(H,46,47) SJDMDUULGAVTFD-UHFFFAOYSA-N 571485 (rac)-3-Ethyl-4-fluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-(15-rac)-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 49 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.850 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571485 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571485&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591976 473132634 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206800 CCc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(F)c-2c13 InChI=1S/C39H44F2N4O5/c1-3-31-35-34-30(41)14-13-29-28(9-7-21-49-32-10-6-8-25-24-26(40)11-12-27(25)32)38(39(46)47)45(37(29)34)16-4-5-20-50-33(36(35)42-43(31)2)15-17-44-18-22-48-23-19-44/h6,8,10-14,24,33H,3-5,7,9,15-23H2,1-2H3,(H,46,47) SJDMDUULGAVTFD-UHFFFAOYSA-N 571486 (+)-3-ethyl-4-fluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 1)::US11440923, Example 50 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.480 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571486 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571486&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591976 473132635 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206803 CCc1c-2c(nn1C)C(CCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(F)c-2c13 InChI=1S/C39H44F2N4O5/c1-3-31-35-34-30(41)14-13-29-28(9-7-21-49-32-10-6-8-25-24-26(40)11-12-27(25)32)38(39(46)47)45(37(29)34)16-4-5-20-50-33(36(35)42-43(31)2)15-17-44-18-22-48-23-19-44/h6,8,10-14,24,33H,3-5,7,9,15-23H2,1-2H3,(H,46,47) SJDMDUULGAVTFD-UHFFFAOYSA-N 571487 (−)-3-ethyl-4-fluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 2)::US11440923, Example 51 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 60.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571487 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571487&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591976 473132636 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206806 CCc1c-2c(nn1C)C(CC(C)(C)O)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C37H41ClFN3O5/c1-5-28-32-31-27(38)16-15-26-25(11-9-19-46-29-12-8-10-22-20-23(39)13-14-24(22)29)35(36(43)44)42(34(26)31)17-6-7-18-47-30(21-37(2,3)45)33(32)40-41(28)4/h8,10,12-16,20,30,45H,5-7,9,11,17-19,21H2,1-4H3,(H,43,44) URSSGZZZWGELEI-UHFFFAOYSA-N 571488 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-(15-rac)-(2-hydroxy-2-methylpropyl)-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 52 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.880 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571488 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571488&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591853 473132637 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206809 CCc1c-2c(nn1C)C(CC(C)(C)O)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C37H41ClFN3O5/c1-5-28-32-31-27(38)16-15-26-25(11-9-19-46-29-12-8-10-22-20-23(39)13-14-24(22)29)35(36(43)44)42(34(26)31)17-6-7-18-47-30(21-37(2,3)45)33(32)40-41(28)4/h8,10,12-16,20,30,45H,5-7,9,11,17-19,21H2,1-4H3,(H,43,44) URSSGZZZWGELEI-UHFFFAOYSA-N 571489 (+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-15-(2-hydroxy-2-methylpropyl)-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 1)::US11440923, Example 53 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.410 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571489 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571489&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591853 473132638 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206812 CCc1c-2c(nn1C)C(CC(C)(C)O)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C37H41ClFN3O5/c1-5-28-32-31-27(38)16-15-26-25(11-9-19-46-29-12-8-10-22-20-23(39)13-14-24(22)29)35(36(43)44)42(34(26)31)17-6-7-18-47-30(21-37(2,3)45)33(32)40-41(28)4/h8,10,12-16,20,30,45H,5-7,9,11,17-19,21H2,1-4H3,(H,43,44) URSSGZZZWGELEI-UHFFFAOYSA-N 571490 (−)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-15-(2-hydroxy-2-methylpropyl)-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 21::US11440923, Example 54 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 47.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571490 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571490&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591853 473132639 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206815 CCc1c-2c(nn1C)C(CCN1CCC(F)(F)C1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C39H42ClF3N4O4/c1-3-30-34-33-29(40)14-13-28-27(9-7-21-50-31-10-6-8-24-22-25(41)11-12-26(24)31)37(38(48)49)47(36(28)33)17-4-5-20-51-32(35(34)44-45(30)2)15-18-46-19-16-39(42,43)23-46/h6,8,10-14,22,32H,3-5,7,9,15-21,23H2,1-2H3,(H,48,49) AGJFZNQFGUFEFK-UHFFFAOYSA-N 571491 (rac)-4-chloro-(15-rac)-[2-(3,3-difluoropyrrolidin-1-yl)ethyl]-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid—2-hydroxypropane-1,2,3-tricarboxylic Acid Salt::US11440923, Example 55::US11440923, Example 56::US11440923, Example 57::US11440923, Example 58 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.780 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571491&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591910 473132640 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206818 CCc1c-2c(nn1C)C(CCN1CCC(F)(F)C1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C39H42ClF3N4O4/c1-3-30-34-33-29(40)14-13-28-27(9-7-21-50-31-10-6-8-24-22-25(41)11-12-26(24)31)37(38(48)49)47(36(28)33)17-4-5-20-51-32(35(34)44-45(30)2)15-18-46-19-16-39(42,43)23-46/h6,8,10-14,22,32H,3-5,7,9,15-21,23H2,1-2H3,(H,48,49) AGJFZNQFGUFEFK-UHFFFAOYSA-N 571491 (rac)-4-chloro-(15-rac)-[2-(3,3-difluoropyrrolidin-1-yl)ethyl]-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid—2-hydroxypropane-1,2,3-tricarboxylic Acid Salt::US11440923, Example 55::US11440923, Example 56::US11440923, Example 57::US11440923, Example 58 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.840 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571491&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591910 473132640 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206821 CCc1c-2c(nn1C)C(CCN1CCC(F)(F)C1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C39H42ClF3N4O4/c1-3-30-34-33-29(40)14-13-28-27(9-7-21-50-31-10-6-8-24-22-25(41)11-12-26(24)31)37(38(48)49)47(36(28)33)17-4-5-20-51-32(35(34)44-45(30)2)15-18-46-19-16-39(42,43)23-46/h6,8,10-14,22,32H,3-5,7,9,15-21,23H2,1-2H3,(H,48,49) AGJFZNQFGUFEFK-UHFFFAOYSA-N 571491 (rac)-4-chloro-(15-rac)-[2-(3,3-difluoropyrrolidin-1-yl)ethyl]-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid—2-hydroxypropane-1,2,3-tricarboxylic Acid Salt::US11440923, Example 55::US11440923, Example 56::US11440923, Example 57::US11440923, Example 58 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 160 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571491&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591910 473132640 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206824 CCc1c-2c(nn1C)C(CCN1CCC(F)(F)C1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C39H42ClF3N4O4/c1-3-30-34-33-29(40)14-13-28-27(9-7-21-50-31-10-6-8-24-22-25(41)11-12-26(24)31)37(38(48)49)47(36(28)33)17-4-5-20-51-32(35(34)44-45(30)2)15-18-46-19-16-39(42,43)23-46/h6,8,10-14,22,32H,3-5,7,9,15-21,23H2,1-2H3,(H,48,49) AGJFZNQFGUFEFK-UHFFFAOYSA-N 571491 (rac)-4-chloro-(15-rac)-[2-(3,3-difluoropyrrolidin-1-yl)ethyl]-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid—2-hydroxypropane-1,2,3-tricarboxylic Acid Salt::US11440923, Example 55::US11440923, Example 56::US11440923, Example 57::US11440923, Example 58 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.780 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571491 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571491&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591910 473132640 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206825 CCc1c-2c(nn1C)C(OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13)c1ccccc1 InChI=1S/C39H37ClFN3O4/c1-3-31-34-33-30(40)19-18-29-28(14-10-22-47-32-15-9-13-25-23-26(41)16-17-27(25)32)37(39(45)46)44(36(29)33)20-7-8-21-48-38(35(34)42-43(31)2)24-11-5-4-6-12-24/h4-6,9,11-13,15-19,23,38H,3,7-8,10,14,20-22H2,1-2H3,(H,45,46) RJNIBEXFQRAROW-UHFFFAOYSA-N 571495 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-(15-rac)-phenyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 59 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.70 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571495 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571495&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591970 473132641 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206828 CCc1c-2c(nn1C)C(CCC1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H45ClFN3O5/c1-3-32-36-35-31(41)15-14-30-29(9-7-21-49-33-10-6-8-26-24-27(42)12-13-28(26)33)39(40(46)47)45(38(30)35)19-4-5-20-50-34(37(36)43-44(32)2)16-11-25-17-22-48-23-18-25/h6,8,10,12-15,24-25,34H,3-5,7,9,11,16-23H2,1-2H3,(H,46,47) VHMBNLMVMVJRRL-UHFFFAOYSA-N 571496 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-(15-rac)-[2-(oxan-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 60 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.690 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571496 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571496&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591922 473132642 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206831 CCc1c-2c(nn1C)C(CCC1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H45ClFN3O5/c1-3-32-36-35-31(41)15-14-30-29(9-7-21-49-33-10-6-8-26-24-27(42)12-13-28(26)33)39(40(46)47)45(38(30)35)19-4-5-20-50-34(37(36)43-44(32)2)16-11-25-17-22-48-23-18-25/h6,8,10,12-15,24-25,34H,3-5,7,9,11,16-23H2,1-2H3,(H,46,47) VHMBNLMVMVJRRL-UHFFFAOYSA-N 571497 4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(oxan-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 1)::US11440923, Example 61 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.460 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571497 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571497&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591922 473132643 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206832 CCc1c-2c(nn1C)C(CCC1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H45ClFN3O5/c1-3-32-36-35-31(41)15-14-30-29(9-7-21-49-33-10-6-8-26-24-27(42)12-13-28(26)33)39(40(46)47)45(38(30)35)19-4-5-20-50-34(37(36)43-44(32)2)16-11-25-17-22-48-23-18-25/h6,8,10,12-15,24-25,34H,3-5,7,9,11,16-23H2,1-2H3,(H,46,47) VHMBNLMVMVJRRL-UHFFFAOYSA-N 571498 (−)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(oxan-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 2)::US11440923, Example 62 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 120 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571498 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571498&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591922 473132644 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206835 CCc1c-2c(nn1C)C(CCC1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H45ClFN3O5/c1-3-32-36-35-31(41)15-14-30-29(9-7-21-49-33-10-6-8-26-24-27(42)12-13-28(26)33)39(40(46)47)45(38(30)35)19-4-5-20-50-34(37(36)43-44(32)2)16-11-25-17-22-48-23-18-25/h6,8,10,12-15,24-25,34H,3-5,7,9,11,16-23H2,1-2H3,(H,46,47) VHMBNLMVMVJRRL-UHFFFAOYSA-N 571499 (+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(oxan-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 1)::US11440923, Example 63 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.880 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571499&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591922 473132645 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206836 CCc1c-2c(nn1C)C(CCC1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H45ClFN3O5/c1-3-32-36-35-31(41)15-14-30-29(9-7-21-49-33-10-6-8-26-24-27(42)12-13-28(26)33)39(40(46)47)45(38(30)35)19-4-5-20-50-34(37(36)43-44(32)2)16-11-25-17-22-48-23-18-25/h6,8,10,12-15,24-25,34H,3-5,7,9,11,16-23H2,1-2H3,(H,46,47) VHMBNLMVMVJRRL-UHFFFAOYSA-N 571500 (−)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(oxan-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 2)::US11440923, Example 64 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 47.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571500 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571500&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591922 473132646 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206837 CCc1c-2c(nn1C)C(CCCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H46ClFN4O5/c1-3-32-36-35-31(41)16-15-30-29(10-8-22-50-33-11-6-9-26-25-27(42)13-14-28(26)33)39(40(47)48)46(38(30)35)18-4-5-21-51-34(37(36)43-44(32)2)12-7-17-45-19-23-49-24-20-45/h6,9,11,13-16,25,34H,3-5,7-8,10,12,17-24H2,1-2H3,(H,47,48) IXLRDTNFEZCJQJ-UHFFFAOYSA-N 571501 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-(15-rac)-[3-(morpholin-4-yl)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 65 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.30 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571501 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571501&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591812 473133560 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206840 CCc1c-2c(nn1C)C(CCCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H46ClFN4O5/c1-3-32-36-35-31(41)16-15-30-29(10-8-22-50-33-11-6-9-26-25-27(42)13-14-28(26)33)39(40(47)48)46(38(30)35)18-4-5-21-51-34(37(36)43-44(32)2)12-7-17-45-19-23-49-24-20-45/h6,9,11,13-16,25,34H,3-5,7-8,10,12,17-24H2,1-2H3,(H,47,48) IXLRDTNFEZCJQJ-UHFFFAOYSA-N 571502 (+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[3-(morpholin-4-yl)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 1)::US11440923, Example 66 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.540 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571502 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571502&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591812 473132647 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206841 CCc1c-2c(nn1C)C(CCCN1CCOCC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H46ClFN4O5/c1-3-32-36-35-31(41)16-15-30-29(10-8-22-50-33-11-6-9-26-25-27(42)13-14-28(26)33)39(40(47)48)46(38(30)35)18-4-5-21-51-34(37(36)43-44(32)2)12-7-17-45-19-23-49-24-20-45/h6,9,11,13-16,25,34H,3-5,7-8,10,12,17-24H2,1-2H3,(H,47,48) IXLRDTNFEZCJQJ-UHFFFAOYSA-N 571503 (−)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[3-(morpholin-4-yl) propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 2)::US11440923, Example 67 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 7.80 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571503&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591812 473132648 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206842 CCc1c-2c(nn1C)C(CCN1CCN(C)CC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H47ClFN5O4/c1-4-32-36-35-31(41)15-14-30-29(10-8-24-50-33-11-7-9-26-25-27(42)12-13-28(26)33)39(40(48)49)47(38(30)35)17-5-6-23-51-34(37(36)43-45(32)3)16-18-46-21-19-44(2)20-22-46/h7,9,11-15,25,34H,4-6,8,10,16-24H2,1-3H3,(H,48,49) ANVXUAKZIQJQID-UHFFFAOYSA-N 571504 4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-(15-rac)-[2-(4-methylpiperazin-1-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Mixture 1 of Stereoisomers)::US11440923, Example 68 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.30 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571504&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591788 473132649 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206845 CCc1c-2c(nn1C)C(CCN1CCN(C)CC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H47ClFN5O4/c1-4-32-36-35-31(41)15-14-30-29(10-8-24-50-33-11-7-9-26-25-27(42)12-13-28(26)33)39(40(48)49)47(38(30)35)17-5-6-23-51-34(37(36)43-45(32)3)16-18-46-21-19-44(2)20-22-46/h7,9,11-15,25,34H,4-6,8,10,16-24H2,1-3H3,(H,48,49) ANVXUAKZIQJQID-UHFFFAOYSA-N 571505 (+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(4-methylpiperazin-1-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Stereoisomer 1)::US11440923, Example 69 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.800 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571505&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591788 473132650 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206846 CCc1c-2c(nn1C)C(CCN1CCN(C)CC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H47ClFN5O4/c1-4-32-36-35-31(41)15-14-30-29(10-8-24-50-33-11-7-9-26-25-27(42)12-13-28(26)33)39(40(48)49)47(38(30)35)17-5-6-23-51-34(37(36)43-45(32)3)16-18-46-21-19-44(2)20-22-46/h7,9,11-15,25,34H,4-6,8,10,16-24H2,1-3H3,(H,48,49) ANVXUAKZIQJQID-UHFFFAOYSA-N 571506 (+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(4-methylpiperazin-1-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Stereoisomer 2)::US11440923, Example 70 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 68.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571506&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591788 473132651 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206847 CCc1c-2c(nn1C)C(CCN1CCN(C)CC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H47ClFN5O4/c1-4-32-36-35-31(41)15-14-30-29(10-8-24-50-33-11-7-9-26-25-27(42)12-13-28(26)33)39(40(48)49)47(38(30)35)17-5-6-23-51-34(37(36)43-45(32)3)16-18-46-21-19-44(2)20-22-46/h7,9,11-15,25,34H,4-6,8,10,16-24H2,1-3H3,(H,48,49) ANVXUAKZIQJQID-UHFFFAOYSA-N 571507 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-(15-rac)-[2-(4-methylpiperazin-1-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Mixture 2 Od Stereoisomers)::US11440923, Example 71 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.00 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571507&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591788 473132652 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206850 CCc1c-2c(nn1C)C(CCN1CCN(C)CC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H47ClFN5O4/c1-4-32-36-35-31(41)15-14-30-29(10-8-24-50-33-11-7-9-26-25-27(42)12-13-28(26)33)39(40(48)49)47(38(30)35)17-5-6-23-51-34(37(36)43-45(32)3)16-18-46-21-19-44(2)20-22-46/h7,9,11-15,25,34H,4-6,8,10,16-24H2,1-3H3,(H,48,49) ANVXUAKZIQJQID-UHFFFAOYSA-N 571508 (−)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(4-methylpiperazin-1-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Stereoisomer 3)::US11440923, Example 72 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571508&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591788 473132653 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206851 CCc1c-2c(nn1C)C(CCN1CCN(C)CC1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H47ClFN5O4/c1-4-32-36-35-31(41)15-14-30-29(10-8-24-50-33-11-7-9-26-25-27(42)12-13-28(26)33)39(40(48)49)47(38(30)35)17-5-6-23-51-34(37(36)43-45(32)3)16-18-46-21-19-44(2)20-22-46/h7,9,11-15,25,34H,4-6,8,10,16-24H2,1-3H3,(H,48,49) ANVXUAKZIQJQID-UHFFFAOYSA-N 571509 (−)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(4-methylpiperazin-1-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Stereoisomer 4)::US11440923, Example 73 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 13.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571509&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591788 473132654 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206852 CCc1c-2c(nn1C)C(CCC(C)(C)O)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C38H43ClFN3O5/c1-5-29-33-32-28(39)16-15-27-26(11-9-21-47-30-12-8-10-23-22-24(40)13-14-25(23)30)36(37(44)45)43(35(27)32)19-6-7-20-48-31(17-18-38(2,3)46)34(33)41-42(29)4/h8,10,12-16,22,31,46H,5-7,9,11,17-21H2,1-4H3,(H,44,45) SNUPARNCTJQMEM-UHFFFAOYSA-N 571510 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-(15-rac)-(3-hydroxy-3-methylbutyl)-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 74 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.00 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571510&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591959 473132655 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206855 CCc1c-2c(nn1C)C(CCC(C)(C)O)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C38H43ClFN3O5/c1-5-29-33-32-28(39)16-15-27-26(11-9-21-47-30-12-8-10-23-22-24(40)13-14-25(23)30)36(37(44)45)43(35(27)32)19-6-7-20-48-31(17-18-38(2,3)46)34(33)41-42(29)4/h8,10,12-16,22,31,46H,5-7,9,11,17-21H2,1-4H3,(H,44,45) SNUPARNCTJQMEM-UHFFFAOYSA-N 571511 (+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-15-(3-hydroxy-3-methylbutyl)-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 1)::US11440923, Example 75 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.370 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571511&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591959 473132656 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206856 CCc1c-2c(nn1C)C(CCC(C)(C)O)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C38H43ClFN3O5/c1-5-29-33-32-28(39)16-15-27-26(11-9-21-47-30-12-8-10-23-22-24(40)13-14-25(23)30)36(37(44)45)43(35(27)32)19-6-7-20-48-31(17-18-38(2,3)46)34(33)41-42(29)4/h8,10,12-16,22,31,46H,5-7,9,11,17-21H2,1-4H3,(H,44,45) SNUPARNCTJQMEM-UHFFFAOYSA-N 571512 (−)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-15-(3-hydroxy-3-methylbutyl)-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 2)::US11440923, Example 76 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 90.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571512&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591959 473132657 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206857 CCc1c-2c(nn1C)C(CCN1CC(F)(F)C1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C38H40ClF3N4O4/c1-3-29-33-32-28(39)14-13-27-26(9-7-19-49-30-10-6-8-23-20-24(40)11-12-25(23)30)36(37(47)48)46(35(27)32)16-4-5-18-50-31(34(33)43-44(29)2)15-17-45-21-38(41,42)22-45/h6,8,10-14,20,31H,3-5,7,9,15-19,21-22H2,1-2H3,(H,47,48) JZYOIBXKSDWGOE-UHFFFAOYSA-N 571513 (rac)-4-chloro-(15-rac)-[2-(3,3-difluoroazetidin-1-yl)ethyl]-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 77 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.70 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571513&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591849 473132658 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206858 CCc1c-2c(nn1C)C(CCN1CC(F)(F)C1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C38H40ClF3N4O4/c1-3-29-33-32-28(39)14-13-27-26(9-7-19-49-30-10-6-8-23-20-24(40)11-12-25(23)30)36(37(47)48)46(35(27)32)16-4-5-18-50-31(34(33)43-44(29)2)15-17-45-21-38(41,42)22-45/h6,8,10-14,20,31H,3-5,7,9,15-19,21-22H2,1-2H3,(H,47,48) JZYOIBXKSDWGOE-UHFFFAOYSA-N 571514 (+)-4-chloro-15-[2-(3,3-difluoroazetidin-1-yl)ethyl]-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 1)::US11440923, Example 78 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.420 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571514&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591849 473132659 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206859 CCc1c-2c(nn1C)C(CCN1CC(F)(F)C1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C38H40ClF3N4O4/c1-3-29-33-32-28(39)14-13-27-26(9-7-19-49-30-10-6-8-23-20-24(40)11-12-25(23)30)36(37(47)48)46(35(27)32)16-4-5-18-50-31(34(33)43-44(29)2)15-17-45-21-38(41,42)22-45/h6,8,10-14,20,31H,3-5,7,9,15-19,21-22H2,1-2H3,(H,47,48) JZYOIBXKSDWGOE-UHFFFAOYSA-N 571515 (−)-4-chloro-15-[2-(3,3-difluoroazetidin-1-yl)ethyl]-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid—N-ethylethanamine Salt (Enantiomer 2)::US11440923, Example 79 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 14.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571515&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591849 473132660 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206860 CCc1c-2c(nn1C)C(CCN(C)OC)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C37H42ClFN4O5/c1-5-29-33-32-28(38)16-15-27-26(11-9-21-47-30-12-8-10-23-22-24(39)13-14-25(23)30)36(37(44)45)43(35(27)32)18-6-7-20-48-31(17-19-41(2)46-4)34(33)40-42(29)3/h8,10,12-16,22,31H,5-7,9,11,17-21H2,1-4H3,(H,44,45) RBVKBBSZJHQGPO-UHFFFAOYSA-N 571516 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-(15-rac)-{2-[methoxy(methyl)amino]ethyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 80 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 3.50 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571516&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591890 473132661 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206861 CCc1c-2c(nn1C)C(CCN(C)C)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C37H42ClFN4O4/c1-5-29-33-32-28(38)16-15-27-26(11-9-21-46-30-12-8-10-23-22-24(39)13-14-25(23)30)36(37(44)45)43(35(27)32)18-6-7-20-47-31(17-19-41(2)3)34(33)40-42(29)4/h8,10,12-16,22,31H,5-7,9,11,17-21H2,1-4H3,(H,44,45) IDDPEDPZMHSKMH-UHFFFAOYSA-N 571517 4-chloro-15-[2-(dimethylamino)ethyl]-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Stereoisomer 1)::US11440923, Example 82::US11440923, Example 83::US11440923, Example 84::US11440923, Example 85 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 42.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571517&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 155123493 473132662 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206862 CCc1c-2c(nn1C)C(CCN(C)C)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C37H42ClFN4O4/c1-5-29-33-32-28(38)16-15-27-26(11-9-21-46-30-12-8-10-23-22-24(39)13-14-25(23)30)36(37(44)45)43(35(27)32)18-6-7-20-47-31(17-19-41(2)3)34(33)40-42(29)4/h8,10,12-16,22,31H,5-7,9,11,17-21H2,1-4H3,(H,44,45) IDDPEDPZMHSKMH-UHFFFAOYSA-N 571517 4-chloro-15-[2-(dimethylamino)ethyl]-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Stereoisomer 1)::US11440923, Example 82::US11440923, Example 83::US11440923, Example 84::US11440923, Example 85 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571517&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 155123493 473132662 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206863 CCc1c-2c(nn1C)C(CCN(C)C)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C37H42ClFN4O4/c1-5-29-33-32-28(38)16-15-27-26(11-9-21-46-30-12-8-10-23-22-24(39)13-14-25(23)30)36(37(44)45)43(35(27)32)18-6-7-20-47-31(17-19-41(2)3)34(33)40-42(29)4/h8,10,12-16,22,31H,5-7,9,11,17-21H2,1-4H3,(H,44,45) IDDPEDPZMHSKMH-UHFFFAOYSA-N 571517 4-chloro-15-[2-(dimethylamino)ethyl]-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Stereoisomer 1)::US11440923, Example 82::US11440923, Example 83::US11440923, Example 84::US11440923, Example 85 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 16.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571517&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 155123493 473132662 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206864 CCc1c-2c(nn1C)C(CCN(C)C)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C37H42ClFN4O4/c1-5-29-33-32-28(38)16-15-27-26(11-9-21-46-30-12-8-10-23-22-24(39)13-14-25(23)30)36(37(44)45)43(35(27)32)18-6-7-20-47-31(17-19-41(2)3)34(33)40-42(29)4/h8,10,12-16,22,31H,5-7,9,11,17-21H2,1-4H3,(H,44,45) IDDPEDPZMHSKMH-UHFFFAOYSA-N 571517 4-chloro-15-[2-(dimethylamino)ethyl]-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Stereoisomer 1)::US11440923, Example 82::US11440923, Example 83::US11440923, Example 84::US11440923, Example 85 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 3.90 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571517&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 155123493 473132662 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206865 CCc1c-2c(nn1C)C(CCN1CCOCC1)OCC(F)(F)CCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C39H42ClF3N4O5/c1-3-30-34-33-29(40)12-11-28-27(7-5-19-51-31-8-4-6-24-22-25(41)9-10-26(24)31)37(38(48)49)47(36(28)33)16-14-39(42,43)23-52-32(35(34)44-45(30)2)13-15-46-17-20-50-21-18-46/h4,6,8-12,22,32H,3,5,7,13-21,23H2,1-2H3,(H,48,49) DLLSKPFENYULCW-UHFFFAOYSA-N 571521 4-chloro-3-ethyl-12,12-difluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Mixture of Stereoisomers 1)::US11440923, Example 86 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.60 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571521&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591950 473132663 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206866 CCc1c-2c(nn1C)C(CCN1CCOCC1)OCC(F)(F)CCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C39H42ClF3N4O5/c1-3-30-34-33-29(40)12-11-28-27(7-5-19-51-31-8-4-6-24-22-25(41)9-10-26(24)31)37(38(48)49)47(36(28)33)16-14-39(42,43)23-52-32(35(34)44-45(30)2)13-15-46-17-20-50-21-18-46/h4,6,8-12,22,32H,3,5,7,13-21,23H2,1-2H3,(H,48,49) DLLSKPFENYULCW-UHFFFAOYSA-N 571522 (+)-4-chloro-3-ethyl-12,12-difluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 1)::US11440923, Example 87 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.530 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571522 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571522&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591950 473132664 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206867 CCc1c-2c(nn1C)C(CCN1CCOCC1)OCC(F)(F)CCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C39H42ClF3N4O5/c1-3-30-34-33-29(40)12-11-28-27(7-5-19-51-31-8-4-6-24-22-25(41)9-10-26(24)31)37(38(48)49)47(36(28)33)16-14-39(42,43)23-52-32(35(34)44-45(30)2)13-15-46-17-20-50-21-18-46/h4,6,8-12,22,32H,3,5,7,13-21,23H2,1-2H3,(H,48,49) DLLSKPFENYULCW-UHFFFAOYSA-N 571523 (−)-4-chloro-3-ethyl-12,12-difluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 2)::US11440923, Example 88 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 17.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571523 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571523&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591950 473132665 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206868 CCc1c-2c(nn1C)C(CCN1CCOCC1)OCC(F)(F)CCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C39H42ClF3N4O5/c1-3-30-34-33-29(40)12-11-28-27(7-5-19-51-31-8-4-6-24-22-25(41)9-10-26(24)31)37(38(48)49)47(36(28)33)16-14-39(42,43)23-52-32(35(34)44-45(30)2)13-15-46-17-20-50-21-18-46/h4,6,8-12,22,32H,3,5,7,13-21,23H2,1-2H3,(H,48,49) DLLSKPFENYULCW-UHFFFAOYSA-N 571524 4-chloro-3-ethyl-12,12-difluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Mixture of Stereoisomers 2)::US11440923, Example 89 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.00 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571524 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571524&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591950 473132666 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206869 CCc1c-2c(nn1C)C(CCN1CCOCC1)OCC(F)(F)CCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C39H42ClF3N4O5/c1-3-30-34-33-29(40)12-11-28-27(7-5-19-51-31-8-4-6-24-22-25(41)9-10-26(24)31)37(38(48)49)47(36(28)33)16-14-39(42,43)23-52-32(35(34)44-45(30)2)13-15-46-17-20-50-21-18-46/h4,6,8-12,22,32H,3,5,7,13-21,23H2,1-2H3,(H,48,49) DLLSKPFENYULCW-UHFFFAOYSA-N 571525 (+)-4-chloro-3-ethyl-12,12-difluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 3)::US11440923, Example 90 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.460 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571525 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571525&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591950 473132667 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206870 CCc1c-2c(nn1C)C(CCN1CCOCC1)OCC(F)(F)CCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C39H42ClF3N4O5/c1-3-30-34-33-29(40)12-11-28-27(7-5-19-51-31-8-4-6-24-22-25(41)9-10-26(24)31)37(38(48)49)47(36(28)33)16-14-39(42,43)23-52-32(35(34)44-45(30)2)13-15-46-17-20-50-21-18-46/h4,6,8-12,22,32H,3,5,7,13-21,23H2,1-2H3,(H,48,49) DLLSKPFENYULCW-UHFFFAOYSA-N 571526 (−)-4-chloro-3-ethyl-12,12-difluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-15-[2-(morpholin-4-yl)ethyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid (Enantiomer 4)::US11440923, Example 91 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 20.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571526 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571526&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591950 473132668 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206871 CCc1c-2c(nn1C)C(Cc1ccccc1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H39ClFN3O4/c1-3-32-36-35-31(41)19-18-30-29(14-10-22-48-33-15-9-13-26-24-27(42)16-17-28(26)33)39(40(46)47)45(38(30)35)20-7-8-21-49-34(37(36)43-44(32)2)23-25-11-5-4-6-12-25/h4-6,9,11-13,15-19,24,34H,3,7-8,10,14,20-23H2,1-2H3,(H,46,47) MPYDWEGXMHLZSW-UHFFFAOYSA-N 571527 (rac)-(rac-15)-benzyl-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 92 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 3.20 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571527 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571527&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591940 473132669 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206874 CCc1c-2c(nn1C)C(CCN1CCOCC1)N(C)CCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H47ClFN5O4/c1-4-32-36-35-31(41)15-14-30-29(10-8-22-51-34-11-7-9-26-25-27(42)12-13-28(26)34)39(40(48)49)47(38(30)35)18-6-5-17-44(2)33(37(36)43-45(32)3)16-19-46-20-23-50-24-21-46/h7,9,11-15,25,33H,4-6,8,10,16-24H2,1-3H3,(H,48,49) DKEGORYWTLFZBI-UHFFFAOYSA-N 571528 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2,14-dimethyl-(15-rac)-[2-(morpholin-4-yl)ethyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid—Racemate 1::US11440923, Example 101::US11440923, Example 93::US11440923, Example 94::US11440923, Example 95::US11440923, Example 96::US11440923, Example 97::US11440923, Example 98 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571528&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591973 473132670 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206875 CCc1c-2c(nn1C)C(CCN1CCOCC1)N(C)CCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H47ClFN5O4/c1-4-32-36-35-31(41)15-14-30-29(10-8-22-51-34-11-7-9-26-25-27(42)12-13-28(26)34)39(40(48)49)47(38(30)35)18-6-5-17-44(2)33(37(36)43-45(32)3)16-19-46-20-23-50-24-21-46/h7,9,11-15,25,33H,4-6,8,10,16-24H2,1-3H3,(H,48,49) DKEGORYWTLFZBI-UHFFFAOYSA-N 571528 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2,14-dimethyl-(15-rac)-[2-(morpholin-4-yl)ethyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid—Racemate 1::US11440923, Example 101::US11440923, Example 93::US11440923, Example 94::US11440923, Example 95::US11440923, Example 96::US11440923, Example 97::US11440923, Example 98 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.640 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571528&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591973 473132670 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206876 CCc1c-2c(nn1C)C(CCN1CCOCC1)N(C)CCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H47ClFN5O4/c1-4-32-36-35-31(41)15-14-30-29(10-8-22-51-34-11-7-9-26-25-27(42)12-13-28(26)34)39(40(48)49)47(38(30)35)18-6-5-17-44(2)33(37(36)43-45(32)3)16-19-46-20-23-50-24-21-46/h7,9,11-15,25,33H,4-6,8,10,16-24H2,1-3H3,(H,48,49) DKEGORYWTLFZBI-UHFFFAOYSA-N 571528 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2,14-dimethyl-(15-rac)-[2-(morpholin-4-yl)ethyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid—Racemate 1::US11440923, Example 101::US11440923, Example 93::US11440923, Example 94::US11440923, Example 95::US11440923, Example 96::US11440923, Example 97::US11440923, Example 98 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 34.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571528&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591973 473132670 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206877 CCc1c-2c(nn1C)C(CCN1CCOCC1)N(C)CCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H47ClFN5O4/c1-4-32-36-35-31(41)15-14-30-29(10-8-22-51-34-11-7-9-26-25-27(42)12-13-28(26)34)39(40(48)49)47(38(30)35)18-6-5-17-44(2)33(37(36)43-45(32)3)16-19-46-20-23-50-24-21-46/h7,9,11-15,25,33H,4-6,8,10,16-24H2,1-3H3,(H,48,49) DKEGORYWTLFZBI-UHFFFAOYSA-N 571528 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2,14-dimethyl-(15-rac)-[2-(morpholin-4-yl)ethyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid—Racemate 1::US11440923, Example 101::US11440923, Example 93::US11440923, Example 94::US11440923, Example 95::US11440923, Example 96::US11440923, Example 97::US11440923, Example 98 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.950 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571528&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591973 473132670 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206878 CCc1c-2c(nn1C)C(CCN1CCOCC1)N(C)CCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H47ClFN5O4/c1-4-32-36-35-31(41)15-14-30-29(10-8-22-51-34-11-7-9-26-25-27(42)12-13-28(26)34)39(40(48)49)47(38(30)35)18-6-5-17-44(2)33(37(36)43-45(32)3)16-19-46-20-23-50-24-21-46/h7,9,11-15,25,33H,4-6,8,10,16-24H2,1-3H3,(H,48,49) DKEGORYWTLFZBI-UHFFFAOYSA-N 571528 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2,14-dimethyl-(15-rac)-[2-(morpholin-4-yl)ethyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid—Racemate 1::US11440923, Example 101::US11440923, Example 93::US11440923, Example 94::US11440923, Example 95::US11440923, Example 96::US11440923, Example 97::US11440923, Example 98 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.600 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571528&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591973 473132670 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206879 CCc1c-2c(nn1C)C(CCN1CCOCC1)N(C)CCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H47ClFN5O4/c1-4-32-36-35-31(41)15-14-30-29(10-8-22-51-34-11-7-9-26-25-27(42)12-13-28(26)34)39(40(48)49)47(38(30)35)18-6-5-17-44(2)33(37(36)43-45(32)3)16-19-46-20-23-50-24-21-46/h7,9,11-15,25,33H,4-6,8,10,16-24H2,1-3H3,(H,48,49) DKEGORYWTLFZBI-UHFFFAOYSA-N 571528 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2,14-dimethyl-(15-rac)-[2-(morpholin-4-yl)ethyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid—Racemate 1::US11440923, Example 101::US11440923, Example 93::US11440923, Example 94::US11440923, Example 95::US11440923, Example 96::US11440923, Example 97::US11440923, Example 98 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 32.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571528&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591973 473132670 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206880 CCc1c-2c(nn1C)C(CCN1CCOCC1)N(C)CCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H48ClN5O4/c1-4-32-36-35-31(41)17-16-30-29(14-10-24-50-34-15-9-12-27-11-5-6-13-28(27)34)39(40(47)48)46(38(30)35)20-8-7-19-43(2)33(37(36)42-44(32)3)18-21-45-22-25-49-26-23-45/h5-6,9,11-13,15-17,33H,4,7-8,10,14,18-26H2,1-3H3,(H,47,48) VSCAQHKPSYCRGF-UHFFFAOYSA-N 571534 (rac)-4-chloro-3-ethyl-2,14-dimethyl-(15-rac)-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic::US11440923, Example 100::US11440923, Example 99 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571534&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591966 473132671 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206881 CCc1c-2c(nn1C)C(CCN1CCOCC1)N(C)CCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H48ClN5O4/c1-4-32-36-35-31(41)17-16-30-29(14-10-24-50-34-15-9-12-27-11-5-6-13-28(27)34)39(40(47)48)46(38(30)35)20-8-7-19-43(2)33(37(36)42-44(32)3)18-21-45-22-25-49-26-23-45/h5-6,9,11-13,15-17,33H,4,7-8,10,14,18-26H2,1-3H3,(H,47,48) VSCAQHKPSYCRGF-UHFFFAOYSA-N 571534 (rac)-4-chloro-3-ethyl-2,14-dimethyl-(15-rac)-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic::US11440923, Example 100::US11440923, Example 99 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.60 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571534 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571534&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591966 473132671 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206882 CCc1c-2c(nn1C)C(CCN1CCOCC1)N(C)CCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C40H47ClFN5O4/c1-4-32-36-35-31(41)15-14-30-29(10-8-22-51-34-11-7-9-26-25-27(42)12-13-28(26)34)39(40(48)49)47(38(30)35)18-6-5-17-44(2)33(37(36)43-45(32)3)16-19-46-20-23-50-24-21-46/h7,9,11-15,25,33H,4-6,8,10,16-24H2,1-3H3,(H,48,49) DKEGORYWTLFZBI-UHFFFAOYSA-N 571528 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2,14-dimethyl-(15-rac)-[2-(morpholin-4-yl)ethyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid—Racemate 1::US11440923, Example 101::US11440923, Example 93::US11440923, Example 94::US11440923, Example 95::US11440923, Example 96::US11440923, Example 97::US11440923, Example 98 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.80 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571528 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571528&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591973 473132670 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206883 CCc1c-2c(nn1C)C1CCCCN1CCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13 InChI=1S/C37H41ClN4O3/c1-3-29-33-32-28(38)19-18-27-26(15-11-23-45-31-17-10-13-24-12-4-5-14-25(24)31)36(37(43)44)42(35(27)32)22-9-8-21-41-20-7-6-16-30(41)34(33)39-40(29)2/h4-5,10,12-14,17-19,30H,3,6-9,11,15-16,20-23H2,1-2H3,(H,43,44) AOBVUBMWZIKPMN-UHFFFAOYSA-N 571537 (rac)-18-chloro-1-ethyl-2-methyl-15-[3-(1-naphthyloxy)propyl]-2,3b,4,5,6,7,9,10,11,12-decahydropyrazolo[3′,4′:8,9]pyrido[1′,2′:6,7][1,6]diazacycloundecino[10,11,1-hi]indole-14-carboxylic Acid (Isomer 1)::US11440923, Example 102::US11440923, Example 103 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.40 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571537&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591835 473132672 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206884 CCc1c-2c(nn1C)C1CCCCN1CCCCn1c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c-2c13 InChI=1S/C37H41ClN4O3/c1-3-29-33-32-28(38)19-18-27-26(15-11-23-45-31-17-10-13-24-12-4-5-14-25(24)31)36(37(43)44)42(35(27)32)22-9-8-21-41-20-7-6-16-30(41)34(33)39-40(29)2/h4-5,10,12-14,17-19,30H,3,6-9,11,15-16,20-23H2,1-2H3,(H,43,44) AOBVUBMWZIKPMN-UHFFFAOYSA-N 571537 (rac)-18-chloro-1-ethyl-2-methyl-15-[3-(1-naphthyloxy)propyl]-2,3b,4,5,6,7,9,10,11,12-decahydropyrazolo[3′,4′:8,9]pyrido[1′,2′:6,7][1,6]diazacycloundecino[10,11,1-hi]indole-14-carboxylic Acid (Isomer 1)::US11440923, Example 102::US11440923, Example 103 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.940 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571537 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571537&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591835 473132672 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206885 CCc1c-2c(nn1C)C1CCCN1CCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C36H38ClFN4O3/c1-3-28-32-31-27(37)16-15-26-25(10-8-20-45-30-12-6-9-22-21-23(38)13-14-24(22)30)35(36(43)44)42(34(26)31)19-5-4-17-41-18-7-11-29(41)33(32)39-40(28)2/h6,9,12-16,21,29H,3-5,7-8,10-11,17-20H2,1-2H3,(H,43,44) AGLLPJYSQPPHJN-UHFFFAOYSA-N 571539 (rac)-17-chloro-1-ethyl-14-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-3b,4,5,6,8,9,10,11-octahydro-2H-pyrazolo[3′,4′:8,9]pyrrolo[1′,2′:6,7][1,6]diazacycloundecino[10,11,1-hi]indole-13-carboxylic Acid (Isomer 1, Diasteromer of Example 107)::US11440923, Example 104 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 0.880 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571539 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571539&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591828 473132673 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206886 CCc1c-2c(nn1C)C1CCCN1CCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C36H38ClFN4O3/c1-3-28-32-31-27(37)16-15-26-25(10-8-20-45-30-12-6-9-22-21-23(38)13-14-24(22)30)35(36(43)44)42(34(26)31)19-5-4-17-41-18-7-11-29(41)33(32)39-40(28)2/h6,9,12-16,21,29H,3-5,7-8,10-11,17-20H2,1-2H3,(H,43,44) AGLLPJYSQPPHJN-UHFFFAOYSA-N 571540 (+)-17-chloro-1-ethyl-14-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-3b,4,5,6,8,9,10,11-octahydro-2H-pyrazolo[3′,4′:8,9]pyrrolo[1′,2′:6,7][1,6]diazacycloundecino[10,11,1-hi]indole-13-carboxylic Acid (Enantiomer 1)::US11440923, Example 105 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571540&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591828 473132674 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206887 CCc1c-2c(nn1C)C1CCCN1CCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C36H38ClFN4O3/c1-3-28-32-31-27(37)16-15-26-25(10-8-20-45-30-12-6-9-22-21-23(38)13-14-24(22)30)35(36(43)44)42(34(26)31)19-5-4-17-41-18-7-11-29(41)33(32)39-40(28)2/h6,9,12-16,21,29H,3-5,7-8,10-11,17-20H2,1-2H3,(H,43,44) AGLLPJYSQPPHJN-UHFFFAOYSA-N 571541 (−)-17-chloro-1-ethyl-14-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-3b,4,5,6,8,9,10,11-octahydro-2H-pyrazolo[3′,4′:8,9]pyrrolo[1′,2′:6,7][1,6]diazacycloundecino[10,11,1-hi]indole-13-carboxylic Acid (Enantiomer 2)::US11440923, Example 106 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 17.0 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571541 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571541&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591828 473132675 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206888 CCc1c-2c(nn1C)C1CCCN1CCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C36H38ClFN4O3/c1-3-28-32-31-27(37)16-15-26-25(10-8-20-45-30-12-6-9-22-21-23(38)13-14-24(22)30)35(36(43)44)42(34(26)31)19-5-4-17-41-18-7-11-29(41)33(32)39-40(28)2/h6,9,12-16,21,29H,3-5,7-8,10-11,17-20H2,1-2H3,(H,43,44) AGLLPJYSQPPHJN-UHFFFAOYSA-N 571542 (rac)-17-chloro-1-ethyl-14-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-3b,4,5,6,8,9,10,11-octahydro-2H-pyrazolo[3′,4′:8,9]pyrrolo[1′,2′:6,7][1,6]diazacycloundecino[10,11,1-hi]indole-13-carboxylic Acid (Isomer 2, Diastereomer of Example 104)::US11440923, Example 107 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571542 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571542&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591828 473132676 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1206889 CCc1c-2c(nn1C)C(CCN1CC(F)C1)OCCCCn1c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c-2c13 InChI=1S/C38H41ClF2N4O4/c1-3-30-34-33-29(39)14-13-28-27(9-7-19-48-31-10-6-8-23-20-24(40)11-12-26(23)31)37(38(46)47)45(36(28)33)16-4-5-18-49-32(35(34)42-43(30)2)15-17-44-21-25(41)22-44/h6,8,10-14,20,25,32H,3-5,7,9,15-19,21-22H2,1-2H3,(H,46,47) SOTBKPIWLHXQGJ-UHFFFAOYSA-N 571543 (rac)-4-chloro-3-ethyl-15-[2-(rac)-(3-fluoroazetidin-1-yl)ethyl]-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11440923, Example 108 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.20 US Patent 10.7270/Q2J38WT5 aid1806812 US11440923 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Monning, U; Nowak-Reppel, K; Wittrock, S; McKinney, D; Serrano-Wu, MH; Lemke, C; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA TBA http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=571543 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=571543&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591838 473132677 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218240 CCc1c-2c(CN(C)CCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H34ClFN4O3/c1-4-27-30-26(36-38(27)3)19-37(2)15-7-16-39-31-24(13-14-25(34)29(30)31)23(32(39)33(40)41)9-6-17-42-28-10-5-8-20-18-21(35)11-12-22(20)28/h5,8,10-14,18H,4,6-7,9,15-17,19H2,1-3H3,(H,40,41) SBCOOYGIYRFUJP-UHFFFAOYSA-N 577709 (−)-2-chloro-11-ethyl-1-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-7,10-dimethyl-4,5,6,7,8,10-hexahydropyrazolo[3′,4′:7,8][1,5]diazecino[9,10,1-hi]indole-2-carboxylic acid salt (Enantiomer 2)::US11478451, Example 114 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 7.40 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577709 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577709&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591135 474499870 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218245 CCc1c-2c(CCCN(C)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H36ClFN4O3/c1-4-28-31-27(37-39(28)3)10-6-16-38(2)17-18-40-32-25(14-15-26(35)30(31)32)24(33(40)34(41)42)9-7-19-43-29-11-5-8-21-20-22(36)12-13-23(21)29/h5,8,11-15,20H,4,6-7,9-10,16-19H2,1-3H3,(H,41,42) FPOLKHIRETYZKM-UHFFFAOYSA-N 577711 (+)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,12-dimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,4]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid (Enantiomer 1)::US11478451, Example 116 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577711 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577711&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591284 474499872 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218248 CCc1c-2c(CCCN(C)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H36ClFN4O3/c1-4-28-31-27(37-39(28)3)10-6-16-38(2)17-18-40-32-25(14-15-26(35)30(31)32)24(33(40)34(41)42)9-7-19-43-29-11-5-8-21-20-22(36)12-13-23(21)29/h5,8,11-15,20H,4,6-7,9-10,16-19H2,1-3H3,(H,41,42) FPOLKHIRETYZKM-UHFFFAOYSA-N 577712 (−)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,12-dimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,4]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid (Enantiomer 2)::US11478451, Example 117 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 6.70 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577712 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577712&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591284 474499873 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218251 CCc1c-2c(CCCN(CC(F)F)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C35H36ClF3N4O3/c1-3-28-32-27(40-41(28)2)9-5-15-42(20-30(38)39)16-17-43-33-25(13-14-26(36)31(32)33)24(34(43)35(44)45)8-6-18-46-29-10-4-7-21-19-22(37)11-12-23(21)29/h4,7,10-14,19,30H,3,5-6,8-9,15-18,20H2,1-2H3,(H,44,45) VIYPHNLFAISCNM-UHFFFAOYSA-N 577713 (rac)-4-chloro-12-(2,2-difluoroethyl)-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,4]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 118::US11478451, Example 120 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.30 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577713&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591239 474499874 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218254 CCc1c-2c(CCCN(CC(F)F)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C35H36ClF3N4O3/c1-3-28-32-27(40-41(28)2)9-5-15-42(20-30(38)39)16-17-43-33-25(13-14-26(36)31(32)33)24(34(43)35(44)45)8-6-18-46-29-10-4-7-21-19-22(37)11-12-23(21)29/h4,7,10-14,19,30H,3,5-6,8-9,15-18,20H2,1-2H3,(H,44,45) VIYPHNLFAISCNM-UHFFFAOYSA-N 577713 (rac)-4-chloro-12-(2,2-difluoroethyl)-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,4]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 118::US11478451, Example 120 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 39.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577713 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577713&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591239 474499874 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218257 CCc1c-2c(CCCN(CCCCOC(C)=O)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C39H44ClFN4O5/c1-4-33-36-32(42-43(33)3)12-8-19-44(18-5-6-22-49-25(2)46)20-21-45-37-30(16-17-31(40)35(36)37)29(38(45)39(47)48)11-9-23-50-34-13-7-10-26-24-27(41)14-15-28(26)34/h7,10,13-17,24H,4-6,8-9,11-12,18-23H2,1-3H3,(H,47,48) VMLMIPYHDLPWFQ-UHFFFAOYSA-N 577715 (rac)-12-(4-acetoxybutyl)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,4]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 121 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 3.10 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577715 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577715&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591267 474499875 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218260 CCc1c-2c(CCCN(CCCCO)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C37H42ClFN4O4/c1-3-31-34-30(40-41(31)2)11-7-18-42(17-4-5-21-44)19-20-43-35-28(15-16-29(38)33(34)35)27(36(43)37(45)46)10-8-22-47-32-12-6-9-24-23-25(39)13-14-26(24)32/h6,9,12-16,23,44H,3-5,7-8,10-11,17-22H2,1-2H3,(H,45,46) NTVJBMGQNBWXBH-UHFFFAOYSA-N 577716 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-12-(4-hydroxybutyl)-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,4]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 122 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.10 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577716 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577716&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591220 474499876 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218263 CCc1c-2c(CCCN(CC(F)(F)C(F)F)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C36H36ClF5N4O3/c1-3-28-31-27(43-44(28)2)9-5-15-45(20-36(41,42)35(39)40)16-17-46-32-25(13-14-26(37)30(31)32)24(33(46)34(47)48)8-6-18-49-29-10-4-7-21-19-22(38)11-12-23(21)29/h4,7,10-14,19,35H,3,5-6,8-9,15-18,20H2,1-2H3,(H,47,48) DRNIXHSDQJHFDF-UHFFFAOYSA-N 577717 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2-methyl-12-(2,2,3,3-tetrafluoropropyl)-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,4]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 123 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 5.60 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577717 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577717&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591231 474499877 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218266 CCc1c-2c(CCCOCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H33ClFN3O4/c1-3-27-30-26(36-37(27)2)9-6-16-41-18-15-38-31-24(13-14-25(34)29(30)31)23(32(38)33(39)40)8-5-17-42-28-10-4-7-20-19-21(35)11-12-22(20)28/h4,7,10-14,19H,3,5-6,8-9,15-18H2,1-2H3,(H,39,40) MENDZIZPQZNJFU-UHFFFAOYSA-N 577718 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2-methyl-2,10,11,13,14,15-hexahydropyrazolo[4′,3′:7,8][1,4]oxazacycloundecino[6,5,4-hi]indole-8-carboxylic acid::US11478451, Example 124 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.20 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577718 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577718&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591121 474499878 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218269 CCc1nn(C)c2CCCOCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C33H33ClFN3O4/c1-3-26-30-27(37(2)36-26)9-6-16-41-18-15-38-31-24(13-14-25(34)29(30)31)23(32(38)33(39)40)8-5-17-42-28-10-4-7-20-19-21(35)11-12-22(20)28/h4,7,10-14,19H,3,5-6,8-9,15-18H2,1-2H3,(H,39,40) UHVHAZALLKRBMD-UHFFFAOYSA-N 577719 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-1-methyl-1,10,11,13,14,15-hexahydropyrazolo[4′,3′:7,8][1,4]oxazacycloundecino[6,5,4-hi]indole-8-carboxylic acid::US11478451, Example 125 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.40 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577719 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577719&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591078 474499879 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218272 CCc1c-2c(CN(C)CC(F)(F)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H34ClF3N4O3/c1-4-27-30-26(39-41(27)3)18-40(2)19-34(37,38)14-15-42-31-24(12-13-25(35)29(30)31)23(32(42)33(43)44)8-6-16-45-28-9-5-7-20-17-21(36)10-11-22(20)28/h5,7,9-13,17H,4,6,8,14-16,18-19H2,1-3H3,(H,43,44) YZYMZHBSKWEGRE-UHFFFAOYSA-N 577720 (rac)-4-Chloro-3-ethyl-12,12-difluoro-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2,14-dimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indol-14-ium-8-carboxylate::US11478451, Example 126::US11478451, Example 127::US11478451, Example 128 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.20 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577720&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591333 474499880 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218275 CCc1c-2c(CN(C)CC(F)(F)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H34ClF3N4O3/c1-4-27-30-26(39-41(27)3)18-40(2)19-34(37,38)14-15-42-31-24(12-13-25(35)29(30)31)23(32(42)33(43)44)8-6-16-45-28-9-5-7-20-17-21(36)10-11-22(20)28/h5,7,9-13,17H,4,6,8,14-16,18-19H2,1-3H3,(H,43,44) YZYMZHBSKWEGRE-UHFFFAOYSA-N 577720 (rac)-4-Chloro-3-ethyl-12,12-difluoro-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2,14-dimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indol-14-ium-8-carboxylate::US11478451, Example 126::US11478451, Example 127::US11478451, Example 128 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.00 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577720&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591333 474499880 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218276 CCc1c-2c(CN(C)CC(F)(F)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H34ClF3N4O3/c1-4-27-30-26(39-41(27)3)18-40(2)19-34(37,38)14-15-42-31-24(12-13-25(35)29(30)31)23(32(42)33(43)44)8-6-16-45-28-9-5-7-20-17-21(36)10-11-22(20)28/h5,7,9-13,17H,4,6,8,14-16,18-19H2,1-3H3,(H,43,44) YZYMZHBSKWEGRE-UHFFFAOYSA-N 577720 (rac)-4-Chloro-3-ethyl-12,12-difluoro-7-{3-[(6-fluoro-1-naphthyl)oxy]propyl}-2,14-dimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indol-14-ium-8-carboxylate::US11478451, Example 126::US11478451, Example 127::US11478451, Example 128 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 15.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577720 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577720&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591333 474499880 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218277 CCc1c-2c(CN(C)CCC(F)(F)Cn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H34ClF3N4O3/c1-4-27-30-26(39-41(27)3)18-40(2)15-14-34(37,38)19-42-31-24(12-13-25(35)29(30)31)23(32(42)33(43)44)8-6-16-45-28-9-5-7-20-17-21(36)10-11-22(20)28/h5,7,9-13,17H,4,6,8,14-16,18-19H2,1-3H3,(H,43,44) JNJJNEKBXXZGON-UHFFFAOYSA-N 577723 (rac)-4-chloro-3-ethyl-11,11-difluoro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,14-dimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 129 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 3.10 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577723 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577723&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591320 474499881 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218280 CCc1c-2c(CNCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H34ClFN4O3/c1-3-27-30-26(37-38(27)2)19-36-15-4-5-16-39-31-24(13-14-25(34)29(30)31)23(32(39)33(40)41)9-7-17-42-28-10-6-8-20-18-21(35)11-12-22(20)28/h6,8,10-14,18,36H,3-5,7,9,15-17,19H2,1-2H3,(H,40,41) GQUYSLKMKGCSSK-UHFFFAOYSA-N 577724 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 130 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.40 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577724 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577724&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591084 474499882 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218283 CCc1c-2c(CN(CCOC)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C36H40ClFN4O4/c1-4-30-33-29(39-40(30)2)22-41(18-20-45-3)16-5-6-17-42-34-27(14-15-28(37)32(33)34)26(35(42)36(43)44)10-8-19-46-31-11-7-9-23-21-24(38)12-13-25(23)31/h7,9,11-15,21H,4-6,8,10,16-20,22H2,1-3H3,(H,43,44) FSDBDUGRFNHSHC-UHFFFAOYSA-N 577725 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-14-(2-methoxyethyl)-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 131::US11478451, Example 132 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577725&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591322 474499883 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218286 CCc1c-2c(CN(CCOC)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C36H40ClFN4O4/c1-4-30-33-29(39-40(30)2)22-41(18-20-45-3)16-5-6-17-42-34-27(14-15-28(37)32(33)34)26(35(42)36(43)44)10-8-19-46-31-11-7-9-23-21-24(38)12-13-25(23)31/h7,9,11-15,21H,4-6,8,10,16-20,22H2,1-3H3,(H,43,44) FSDBDUGRFNHSHC-UHFFFAOYSA-N 577725 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-14-(2-methoxyethyl)-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 131::US11478451, Example 132 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 23.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577725 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577725&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591322 474499883 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218287 CCc1c-2c(CN(CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)C(=O)OCCOC)nn1C InChI=1S/C37H40ClFN4O6/c1-4-30-33-29(40-41(30)2)22-42(37(46)49-20-19-47-3)16-5-6-17-43-34-27(14-15-28(38)32(33)34)26(35(43)36(44)45)10-8-18-48-31-11-7-9-23-21-24(39)12-13-25(23)31/h7,9,11-15,21H,4-6,8,10,16-20,22H2,1-3H3,(H,44,45) VNVHSUQCALEXSI-UHFFFAOYSA-N 577727 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-14-[(2-methoxyethoxy)carbonyl]-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 134 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.60 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577727 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577727&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591307 474499884 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218290 CCc1c-2c(CN(CCC3CCOCC3)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C40H46ClFN4O4/c1-3-34-37-33(43-44(34)2)25-45(20-15-26-16-22-49-23-17-26)18-4-5-19-46-38-31(13-14-32(41)36(37)38)30(39(46)40(47)48)9-7-21-50-35-10-6-8-27-24-28(42)11-12-29(27)35/h6,8,10-14,24,26H,3-5,7,9,15-23,25H2,1-2H3,(H,47,48) GFBBKAVUWIQWMC-UHFFFAOYSA-N 577728 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-14-[2-(oxan-4-yl)ethyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 135::US11478451, Example 137 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.70 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577728&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591180 474499885 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218293 CCc1c-2c(CN(CCC3CCOCC3)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C40H46ClFN4O4/c1-3-34-37-33(43-44(34)2)25-45(20-15-26-16-22-49-23-17-26)18-4-5-19-46-38-31(13-14-32(41)36(37)38)30(39(46)40(47)48)9-7-21-50-35-10-6-8-27-24-28(42)11-12-29(27)35/h6,8,10-14,24,26H,3-5,7,9,15-23,25H2,1-2H3,(H,47,48) GFBBKAVUWIQWMC-UHFFFAOYSA-N 577728 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-14-[2-(oxan-4-yl)ethyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 135::US11478451, Example 137 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 52.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577728 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577728&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591180 474499885 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218294 CCc1c-2c(CN(CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)C(=O)OCCC2CCOCC2)nn1C InChI=1S/C41H46ClFN4O6/c1-3-34-37-33(44-45(34)2)25-46(41(50)53-23-17-26-15-21-51-22-16-26)18-4-5-19-47-38-31(13-14-32(42)36(37)38)30(39(47)40(48)49)9-7-20-52-35-10-6-8-27-24-28(43)11-12-29(27)35/h6,8,10-14,24,26H,3-5,7,9,15-23,25H2,1-2H3,(H,48,49) ISUPITFQRXTUBF-UHFFFAOYSA-N 577730 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-14-{[2-(oxan-4-yl)ethoxy]carbonyl}-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 138 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 3.60 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577730&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591321 474499886 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218297 CCc1c-2c(CN(CCCO)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C36H40ClFN4O4/c1-3-30-33-29(39-40(30)2)22-41(17-8-19-43)16-4-5-18-42-34-27(14-15-28(37)32(33)34)26(35(42)36(44)45)10-7-20-46-31-11-6-9-23-21-24(38)12-13-25(23)31/h6,9,11-15,21,43H,3-5,7-8,10,16-20,22H2,1-2H3,(H,44,45) LKHKVFNADZMDJC-UHFFFAOYSA-N 577731 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-14-(3-hydroxypropyl)-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 139 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.00 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577731 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577731&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591171 474499887 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218300 CCc1c-2c(CN(CCC(C)(C)O)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C38H44ClFN4O4/c1-5-31-34-30(41-42(31)4)23-43(20-17-38(2,3)47)18-6-7-19-44-35-28(15-16-29(39)33(34)35)27(36(44)37(45)46)11-9-21-48-32-12-8-10-24-22-25(40)13-14-26(24)32/h8,10,12-16,22,47H,5-7,9,11,17-21,23H2,1-4H3,(H,45,46) QFHUAJLMTZLYGS-UHFFFAOYSA-N 577732 4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-14-(3-hydroxy-3-methylbutyl)-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid (Enantiomer 2)::US11478451, Example 141::US11478451, Example 143 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 15.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577732&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591173 474499888 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218301 CCc1c-2c(CN(CCC(C)(C)O)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C38H44ClFN4O4/c1-5-31-34-30(41-42(31)4)23-43(20-17-38(2,3)47)18-6-7-19-44-35-28(15-16-29(39)33(34)35)27(36(44)37(45)46)11-9-21-48-32-12-8-10-24-22-25(40)13-14-26(24)32/h8,10,12-16,22,47H,5-7,9,11,17-21,23H2,1-4H3,(H,45,46) QFHUAJLMTZLYGS-UHFFFAOYSA-N 577732 4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-14-(3-hydroxy-3-methylbutyl)-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid (Enantiomer 2)::US11478451, Example 141::US11478451, Example 143 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 62.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577732 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577732&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591173 474499888 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1217948 Cc1nn(C)c2COC\C=C/Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C32H30ClN3O4/c1-20-28-26(35(2)34-20)19-39-17-6-5-16-36-30-24(14-15-25(33)29(28)30)23(31(36)32(37)38)12-8-18-40-27-13-7-10-21-9-3-4-11-22(21)27/h3-7,9-11,13-15H,8,12,16-19H2,1-2H3,(H,37,38)/b6-5- RJDONMRZHDZWMR-WAYWQWQTSA-N 572148 (rac)-(11Z)-4-chloro-1,3-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-1,10,13,15-tetrahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 1::US11478451, Example 1 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 6.10 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572148 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572148&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591086 473133220 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1217951 Cc1nn(C)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C32H32ClN3O4/c1-20-28-26(35(2)34-20)19-39-17-6-5-16-36-30-24(14-15-25(33)29(28)30)23(31(36)32(37)38)12-8-18-40-27-13-7-10-21-9-3-4-11-22(21)27/h3-4,7,9-11,13-15H,5-6,8,12,16-19H2,1-2H3,(H,37,38) PPCSRTPOKGWSIX-UHFFFAOYSA-N 572149 US11447504, Example 2::US11447504, Example 3::US11447504, Example 4::US11478451, Example 4::rac-4-chloro-1,3-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-1,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.60 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572149&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591116 473133221 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1217954 Cc1nn(C)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C32H32ClN3O4/c1-20-28-26(35(2)34-20)19-39-17-6-5-16-36-30-24(14-15-25(33)29(28)30)23(31(36)32(37)38)12-8-18-40-27-13-7-10-21-9-3-4-11-22(21)27/h3-4,7,9-11,13-15H,5-6,8,12,16-19H2,1-2H3,(H,37,38) PPCSRTPOKGWSIX-UHFFFAOYSA-N 572149 US11447504, Example 2::US11447504, Example 3::US11447504, Example 4::US11478451, Example 4::rac-4-chloro-1,3-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-1,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572149&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591116 473133221 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1217957 Cc1nn(C)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C32H32ClN3O4/c1-20-28-26(35(2)34-20)19-39-17-6-5-16-36-30-24(14-15-25(33)29(28)30)23(31(36)32(37)38)12-8-18-40-27-13-7-10-21-9-3-4-11-22(21)27/h3-4,7,9-11,13-15H,5-6,8,12,16-19H2,1-2H3,(H,37,38) PPCSRTPOKGWSIX-UHFFFAOYSA-N 572149 US11447504, Example 2::US11447504, Example 3::US11447504, Example 4::US11478451, Example 4::rac-4-chloro-1,3-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-1,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 38.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572149 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572149&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591116 473133221 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1217960 CCc1c-2c(CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H36ClFN4O3/c1-4-28-31-27(37-39(28)3)20-38(2)16-5-6-17-40-32-25(14-15-26(35)30(31)32)24(33(40)34(41)42)10-8-18-43-29-11-7-9-21-19-22(36)12-13-23(21)29/h7,9,11-15,19H,4-6,8,10,16-18,20H2,1-3H3,(H,41,42) BPPSKYUYBHETDL-UHFFFAOYSA-N 572152 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,14-dimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 5::US11447504, Example 6::US11447504, Example 7::US11478451, Example 7 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.20 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572152&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591250 473133222 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1217965 CCc1c-2c(CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H36ClFN4O3/c1-4-28-31-27(37-39(28)3)20-38(2)16-5-6-17-40-32-25(14-15-26(35)30(31)32)24(33(40)34(41)42)10-8-18-43-29-11-7-9-21-19-22(36)12-13-23(21)29/h7,9,11-15,19H,4-6,8,10,16-18,20H2,1-3H3,(H,41,42) BPPSKYUYBHETDL-UHFFFAOYSA-N 572152 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,14-dimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 5::US11447504, Example 6::US11447504, Example 7::US11478451, Example 7 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 17.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572152&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591250 473133222 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1217972 CCc1nn(CCN2CCOCC2)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C38H43ClN4O5/c1-2-31-35-32(43(40-31)18-17-41-19-23-46-24-20-41)25-47-21-6-5-16-42-36-29(14-15-30(39)34(35)36)28(37(42)38(44)45)12-8-22-48-33-13-7-10-26-9-3-4-11-27(26)33/h3-4,7,9-11,13-15H,2,5-6,8,12,16-25H2,1H3,(H,44,45) WDKPDJPIUJQOAB-UHFFFAOYSA-N 572157 4-chloro-3-ethyl-1-[2-(morpholin-4-yl)ethyl]-7-[3-(naphthalen-1-yloxy)propyl]-1,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid-N-ethylethanamine Salt (Enantiomer 2)::US11447504, Example 10::US11478451, Example 10 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 12.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572157&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591160 473133224 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1217975 CN1CCCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c(-c4c(C)n(C)nc4C1)c23 InChI=1S/C33H35ClN4O3/c1-21-29-27(35-37(21)3)20-36(2)17-6-7-18-38-31-25(15-16-26(34)30(29)31)24(32(38)33(39)40)13-9-19-41-28-14-8-11-22-10-4-5-12-23(22)28/h4-5,8,10-12,14-16H,6-7,9,13,17-20H2,1-3H3,(H,39,40) JFFOLBCOYWMQHS-UHFFFAOYSA-N 572158 (rac)-4-chloro-2,3,14-trimethyl-7-[3-(naphthalen-1-yloxy)propyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 11::US11478451, Example 11 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572158&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591225 473133225 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1217980 CN1CCCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c(-c4c(C)[nH]nc4C1)c23 InChI=1S/C32H33ClN4O3/c1-20-28-26(35-34-20)19-36(2)16-5-6-17-37-30-24(14-15-25(33)29(28)30)23(31(37)32(38)39)12-8-18-40-27-13-7-10-21-9-3-4-11-22(21)27/h3-4,7,9-11,13-15H,5-6,8,12,16-19H2,1-2H3,(H,34,35)(H,38,39) GELGKXVOWYYPCM-UHFFFAOYSA-N 572160 (−)-4-chloro-2,3,14-trimethyl-7-[3-(naphthalen-1-yloxy) propyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid-N-ethylethanamine Salt (Enantiomer 2)::US11447504, Example 13::US11478451, Example 13 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 26.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572160 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572160&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591720 473133227 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1217983 Cc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H31ClFN3O4/c1-19-28-26(35-36(19)2)18-40-15-4-3-14-37-30-24(12-13-25(33)29(28)30)23(31(37)32(38)39)8-6-16-41-27-9-5-7-20-17-21(34)10-11-22(20)27/h5,7,9-13,17H,3-4,6,8,14-16,18H2,1-2H3,(H,38,39) NDWMVESOANHLBE-UHFFFAOYSA-N 572161 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 14::US11447504, Example 16::US11478451, Example 16 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.00 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572161&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591177 473133228 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1217988 Cc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H31ClFN3O4/c1-19-28-26(35-36(19)2)18-40-15-4-3-14-37-30-24(12-13-25(33)29(28)30)23(31(37)32(38)39)8-6-16-41-27-9-5-7-20-17-21(34)10-11-22(20)27/h5,7,9-13,17H,3-4,6,8,14-16,18H2,1-2H3,(H,38,39) NDWMVESOANHLBE-UHFFFAOYSA-N 572161 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 14::US11447504, Example 16::US11478451, Example 16 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 5.20 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572161&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591177 473133228 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1217993 CCc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H34ClN3O4/c1-3-27-30-26(35-36(27)2)20-40-18-7-6-17-37-31-24(15-16-25(34)29(30)31)23(32(37)33(38)39)13-9-19-41-28-14-8-11-21-10-4-5-12-22(21)28/h4-5,8,10-12,14-16H,3,6-7,9,13,17-20H2,1-2H3,(H,38,39) COJURVSFEDLRNW-UHFFFAOYSA-N 572166 (rac)-4-chloro-3-ethyl-2-methyl-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 19::US11447504, Example 20::US11447504, Example 21::US11447504, Example 25::US11478451, Example 21 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.30 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572166&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591254 473133232 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218000 CCc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H34ClN3O4/c1-3-27-30-26(35-36(27)2)20-40-18-7-6-17-37-31-24(15-16-25(34)29(30)31)23(32(37)33(38)39)13-9-19-41-28-14-8-11-21-10-4-5-12-22(21)28/h4-5,8,10-12,14-16H,3,6-7,9,13,17-20H2,1-2H3,(H,38,39) COJURVSFEDLRNW-UHFFFAOYSA-N 572166 (rac)-4-chloro-3-ethyl-2-methyl-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 19::US11447504, Example 20::US11447504, Example 21::US11447504, Example 25::US11478451, Example 21 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 8.90 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572166&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591254 473133232 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218003 CCc1c-2c(CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H37ClN4O3/c1-4-28-31-27(36-38(28)3)21-37(2)18-7-8-19-39-32-25(16-17-26(35)30(31)32)24(33(39)34(40)41)14-10-20-42-29-15-9-12-22-11-5-6-13-23(22)29/h5-6,9,11-13,15-17H,4,7-8,10,14,18-21H2,1-3H3,(H,40,41) SMIRFHPIIHOGEQ-UHFFFAOYSA-N 572169 (rac)-4-chloro-3-ethyl-2,14-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 22::US11447504, Example 23::US11447504, Example 24::US11478451, Example 24 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.50 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572169&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591133 473133233 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218008 CCc1c-2c(CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H37ClN4O3/c1-4-28-31-27(36-38(28)3)21-37(2)18-7-8-19-39-32-25(16-17-26(35)30(31)32)24(33(39)34(40)41)14-10-20-42-29-15-9-12-22-11-5-6-13-23(22)29/h5-6,9,11-13,15-17H,4,7-8,10,14,18-21H2,1-3H3,(H,40,41) SMIRFHPIIHOGEQ-UHFFFAOYSA-N 572169 (rac)-4-chloro-3-ethyl-2,14-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 22::US11447504, Example 23::US11447504, Example 24::US11478451, Example 24 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 15.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572169&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591133 473133233 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218011 Cc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H32ClN3O4/c1-20-28-26(34-35(20)2)19-39-17-6-5-16-36-30-24(14-15-25(33)29(28)30)23(31(36)32(37)38)12-8-18-40-27-13-7-10-21-9-3-4-11-22(21)27/h3-4,7,9-11,13-15H,5-6,8,12,16-19H2,1-2H3,(H,37,38) YJACXUAPNWODLN-UHFFFAOYSA-N 577624 (rac)-4-chloro-2,3-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid::US11478451, Example 25 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.20 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577624 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577624&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591216 474499800 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218016 Cc1[nH]nc2COCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C31H30ClN3O4/c1-19-27-25(34-33-19)18-38-16-5-4-15-35-29-23(13-14-24(32)28(27)29)22(30(35)31(36)37)11-7-17-39-26-12-6-9-20-8-2-3-10-21(20)26/h2-3,6,8-10,12-14H,4-5,7,11,15-18H2,1H3,(H,33,34)(H,36,37) STPZDEATQDDZCR-UHFFFAOYSA-N 572173 4-chloro-2,3-dimethyl-7-[3-(naphthalen-1-yloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo-[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid-N-ethylethanamine Salt (Enantiomer 1)::US11447504, Example 26::US11447504, Example 27::US11478451, Example 27 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 18.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572173 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572173&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591331 473133234 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218019 Cc1c-2c(CNCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C31H31ClN4O3/c1-19-27-25(34-35(19)2)18-33-15-7-16-36-29-23(13-14-24(32)28(27)29)22(30(36)31(37)38)11-6-17-39-26-12-5-9-20-8-3-4-10-21(20)26/h3-5,8-10,12-14,33H,6-7,11,15-18H2,1-2H3,(H,37,38) UQDUQFWHFLOCHG-UHFFFAOYSA-N 572175 (rac)-12-chloro-10,11-dimethyl-1-[3-(naphthalen-1-yloxy)propyl]-4,5,6,7,8,10-hexahydropyrazolo[3′,4′:7,8][1,5]diazecino[9,10,1-hi]indole-2-carboxylic Acid-Formic Acid Salt::US11447504, Example 28::US11478451, Example 28 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.30 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572175&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 155123531 473133235 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218022 CN1CCCn2c(C(O)=O)c(CCCOc3cccc4ccccc34)c3ccc(Cl)c(-c4c(C)n(C)nc4C1)c23 InChI=1S/C32H33ClN4O3/c1-20-28-26(34-36(20)3)19-35(2)16-8-17-37-30-24(14-15-25(33)29(28)30)23(31(37)32(38)39)12-7-18-40-27-13-6-10-21-9-4-5-11-22(21)27/h4-6,9-11,13-15H,7-8,12,16-19H2,1-3H3,(H,38,39) AZNRUVYELMSHOT-UHFFFAOYSA-N 572176 (rac)-12-chloro-7,10,11-trimethyl-1-[3-(naphthalen-1-yloxy)propyl]-4,5,6,7,8,10-hexahydropyrazolo[3′,4′:7,8][1,5]diazecino[9,10,1-hi]indole-2-carboxylic Acid::US11447504, Example 29::US11478451, Example 29 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.50 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572176&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591196 473133236 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218029 CN1CCCCn2c(C(O)=O)c(CCCOc3cccc4cc(F)ccc34)c3ccc(Cl)c(-c4c(C)[nH]nc4C1)c23 InChI=1S/C32H32ClFN4O3/c1-19-28-26(36-35-19)18-37(2)14-3-4-15-38-30-24(12-13-25(33)29(28)30)23(31(38)32(39)40)8-6-16-41-27-9-5-7-20-17-21(34)10-11-22(20)27/h5,7,9-13,17H,3-4,6,8,14-16,18H2,1-2H3,(H,35,36)(H,39,40) MCNVWPUURUOIIZ-UHFFFAOYSA-N 572178 (+)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3,14-trimethyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid-N-ethylethanamine Salt (Enantiomer 1)::US11447504, Example 31::US11478451, Example 32 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 26.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572178&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591090 473133238 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218032 CCc1nn(C)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C33H33ClFN3O4/c1-3-26-30-27(37(2)36-26)19-41-16-5-4-15-38-31-24(13-14-25(34)29(30)31)23(32(38)33(39)40)9-7-17-42-28-10-6-8-20-18-21(35)11-12-22(20)28/h6,8,10-14,18H,3-5,7,9,15-17,19H2,1-2H3,(H,39,40) VDWYPXRLOOMXTJ-UHFFFAOYSA-N 572180 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-1-methyl-1,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 33::US11478451, Example 35 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.70 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572180&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591268 473133240 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218037 CCc1nn(C)c2COCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C33H33ClFN3O4/c1-3-26-30-27(37(2)36-26)19-41-16-5-4-15-38-31-24(13-14-25(34)29(30)31)23(32(38)33(39)40)9-7-17-42-28-10-6-8-20-18-21(35)11-12-22(20)28/h6,8,10-14,18H,3-5,7,9,15-17,19H2,1-2H3,(H,39,40) VDWYPXRLOOMXTJ-UHFFFAOYSA-N 572180 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-1-methyl-1,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 33::US11478451, Example 35 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 22.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572180&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591268 473133240 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218044 CCc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H33ClFN3O4/c1-3-27-30-26(36-37(27)2)19-41-16-5-4-15-38-31-24(13-14-25(34)29(30)31)23(32(38)33(39)40)9-7-17-42-28-10-6-8-20-18-21(35)11-12-22(20)28/h6,8,10-14,18H,3-5,7,9,15-17,19H2,1-2H3,(H,39,40) DSRUJIWLAZNHGL-UHFFFAOYSA-N 572183 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 36::US11478451, Example 069 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 16.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572183&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591175 473133243 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218051 CCc1nn(C)c2CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C34H36ClFN4O3/c1-4-27-31-28(39(3)37-27)20-38(2)16-5-6-17-40-32-25(14-15-26(35)30(31)32)24(33(40)34(41)42)10-8-18-43-29-11-7-9-21-19-22(36)12-13-23(21)29/h7,9,11-15,19H,4-6,8,10,16-18,20H2,1-3H3,(H,41,42) LFUKYUNPOGFDAD-UHFFFAOYSA-N 572186 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-1,14-dimethyl-10,11,12,13,14,15-hexahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 39::US11447504, Example 40::US11447504, Example 41::US11478451, Example 41 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.30 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572186&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591100 473133246 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218054 CCc1nn(CCN2CCOCC2)c2CN(C)C\C=C/Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C39H44ClN5O4/c1-3-32-36-33(45(41-32)20-19-43-21-24-48-25-22-43)26-42(2)17-6-7-18-44-37-30(15-16-31(40)35(36)37)29(38(44)39(46)47)13-9-23-49-34-14-8-11-27-10-4-5-12-28(27)34/h4-8,10-12,14-16H,3,9,13,17-26H2,1-2H3,(H,46,47)/b7-6- SJXJNUGYXIGETG-SREVYHEPSA-N 572189 (rac)-(11Z)-4-chloro-3-ethyl-14-methyl-1-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]-propyl}-10,13,14,15-tetrahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 42::US11447504, Example 43::US11447504, Example 44::US11478451, Example 44 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 12.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572189&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591324 473133247 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218057 CCc1nn(CCN2CCOCC2)c2CN(C)C\C=C/Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C39H44ClN5O4/c1-3-32-36-33(45(41-32)20-19-43-21-24-48-25-22-43)26-42(2)17-6-7-18-44-37-30(15-16-31(40)35(36)37)29(38(44)39(46)47)13-9-23-49-34-14-8-11-27-10-4-5-12-28(27)34/h4-8,10-12,14-16H,3,9,13,17-26H2,1-2H3,(H,46,47)/b7-6- SJXJNUGYXIGETG-SREVYHEPSA-N 572189 (rac)-(11Z)-4-chloro-3-ethyl-14-methyl-1-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]-propyl}-10,13,14,15-tetrahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 42::US11447504, Example 43::US11447504, Example 44::US11478451, Example 44 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 4.00 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572189&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591324 473133247 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218060 CCc1nn(CCN2CCOCC2)c2CN(C)C\C=C/Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C39H44ClN5O4/c1-3-32-36-33(45(41-32)20-19-43-21-24-48-25-22-43)26-42(2)17-6-7-18-44-37-30(15-16-31(40)35(36)37)29(38(44)39(46)47)13-9-23-49-34-14-8-11-27-10-4-5-12-28(27)34/h4-8,10-12,14-16H,3,9,13,17-26H2,1-2H3,(H,46,47)/b7-6- SJXJNUGYXIGETG-SREVYHEPSA-N 572189 (rac)-(11Z)-4-chloro-3-ethyl-14-methyl-1-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]-propyl}-10,13,14,15-tetrahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 42::US11447504, Example 43::US11447504, Example 44::US11478451, Example 44 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.40 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572189&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591324 473133247 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218063 CCc1nn(CCN2CCOCC2)c2CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C39H46ClN5O4/c1-3-32-36-33(45(41-32)20-19-43-21-24-48-25-22-43)26-42(2)17-6-7-18-44-37-30(15-16-31(40)35(36)37)29(38(44)39(46)47)13-9-23-49-34-14-8-11-27-10-4-5-12-28(27)34/h4-5,8,10-12,14-16H,3,6-7,9,13,17-26H2,1-2H3,(H,46,47) GHFRJMORTHPRRF-UHFFFAOYSA-N 572192 (rac)-4-chloro-3-ethyl-14-methyl-1-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 45::US11447504, Example 46::US11447504, Example 47::US11478451, Example 47 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 41.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572192&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591276 473133248 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218066 CCc1nn(CCN2CCOCC2)c2CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C39H46ClN5O4/c1-3-32-36-33(45(41-32)20-19-43-21-24-48-25-22-43)26-42(2)17-6-7-18-44-37-30(15-16-31(40)35(36)37)29(38(44)39(46)47)13-9-23-49-34-14-8-11-27-10-4-5-12-28(27)34/h4-5,8,10-12,14-16H,3,6-7,9,13,17-26H2,1-2H3,(H,46,47) GHFRJMORTHPRRF-UHFFFAOYSA-N 572192 (rac)-4-chloro-3-ethyl-14-methyl-1-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 45::US11447504, Example 46::US11447504, Example 47::US11478451, Example 47 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.30 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572192&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591276 473133248 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218069 CCc1nn(CCN2CCOCC2)c2CN(C)CCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c(-c12)c34 InChI=1S/C39H46ClN5O4/c1-3-32-36-33(45(41-32)20-19-43-21-24-48-25-22-43)26-42(2)17-6-7-18-44-37-30(15-16-31(40)35(36)37)29(38(44)39(46)47)13-9-23-49-34-14-8-11-27-10-4-5-12-28(27)34/h4-5,8,10-12,14-16H,3,6-7,9,13,17-26H2,1-2H3,(H,46,47) GHFRJMORTHPRRF-UHFFFAOYSA-N 572192 (rac)-4-chloro-3-ethyl-14-methyl-1-[2-(morpholin-4-yl)ethyl]-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-1H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 45::US11447504, Example 46::US11447504, Example 47::US11478451, Example 47 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 44.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572192&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591276 473133248 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218074 CN1CCN(CCCn2nc3COCCCCn4c(C(O)=O)c(CCCOc5cccc6ccccc56)c5ccc(Cl)c(-c3c2C)c45)CC1 InChI=1S/C39H46ClN5O4/c1-27-35-33(41-45(27)19-9-17-43-22-20-42(2)21-23-43)26-48-24-6-5-18-44-37-31(15-16-32(40)36(35)37)30(38(44)39(46)47)13-8-25-49-34-14-7-11-28-10-3-4-12-29(28)34/h3-4,7,10-12,14-16H,5-6,8-9,13,17-26H2,1-2H3,(H,46,47) DQGMLLGNPCATLY-UHFFFAOYSA-N 572195 (rac)-4-chloro-3-methyl-2-[3-(4-methylpiperazin-1-yl)propyl]-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 48::US11478451, Example 50 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.70 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572195 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572195&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591098 473133249 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218079 CCc1c-2c(CCCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H36ClN3O3/c1-3-28-31-27(36-37(28)2)16-6-4-5-9-20-38-32-25(18-19-26(35)30(31)32)24(33(38)34(39)40)15-11-21-41-29-17-10-13-22-12-7-8-14-23(22)29/h7-8,10,12-14,17-19H,3-6,9,11,15-16,20-21H2,1-2H3,(H,39,40) SSTSSUXFOIWKBG-UHFFFAOYSA-N 572198 (rac)-4-chloro-3-ethyl-2-methyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5]azacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 51::US11478451, Example 52 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 15.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572198&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591134 473133252 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218082 CCc1c-2c(CCCCCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H36ClN3O3/c1-3-28-31-27(36-37(28)2)16-6-4-5-9-20-38-32-25(18-19-26(35)30(31)32)24(33(38)34(39)40)15-11-21-41-29-17-10-13-22-12-7-8-14-23(22)29/h7-8,10,12-14,17-19H,3-6,9,11,15-16,20-21H2,1-2H3,(H,39,40) SSTSSUXFOIWKBG-UHFFFAOYSA-N 572198 (rac)-4-chloro-3-ethyl-2-methyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5]azacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 51::US11478451, Example 52 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 3.30 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572198&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591134 473133252 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218085 CCc1c-2c(CCCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H35ClFN3O3/c1-3-28-31-27(37-38(28)2)12-6-4-5-7-18-39-32-25(16-17-26(35)30(31)32)24(33(39)34(40)41)11-9-19-42-29-13-8-10-21-20-22(36)14-15-23(21)29/h8,10,13-17,20H,3-7,9,11-12,18-19H2,1-2H3,(H,40,41) OHARMQWZWCLEAS-UHFFFAOYSA-N 572201 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5]azacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 54::US11478451, Example 071 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 21.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572201&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591153 473133255 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218088 Cc1c-2c(COCC(F)(F)CCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H30ClF2N3O4/c1-19-27-25(36-37(19)2)17-41-18-32(34,35)14-15-38-29-23(12-13-24(33)28(27)29)22(30(38)31(39)40)10-6-16-42-26-11-5-8-20-7-3-4-9-21(20)26/h3-5,7-9,11-13H,6,10,14-18H2,1-2H3,(H,39,40) BGHOHGRGKVVKET-UHFFFAOYSA-N 572203 4-chloro-12,12-difluoro-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid-N-ethylethanamine Salt—Enantiomer 1::US11447504, Example 56::US11447504, Example 57::US11478451, Example 57 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.30 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572203&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591179 473133257 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218091 Cc1c-2c(COCC(F)(F)CCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H30ClF2N3O4/c1-19-27-25(36-37(19)2)17-41-18-32(34,35)14-15-38-29-23(12-13-24(33)28(27)29)22(30(38)31(39)40)10-6-16-42-26-11-5-8-20-7-3-4-9-21(20)26/h3-5,7-9,11-13H,6,10,14-18H2,1-2H3,(H,39,40) BGHOHGRGKVVKET-UHFFFAOYSA-N 572203 4-chloro-12,12-difluoro-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid-N-ethylethanamine Salt—Enantiomer 1::US11447504, Example 56::US11447504, Example 57::US11478451, Example 57 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 7.20 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572203&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591179 473133257 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218094 Cc1c-2c(CN(CC(F)(F)F)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H33ClF4N4O3/c1-20-29-27(40-41(20)2)18-42(19-34(37,38)39)14-3-4-15-43-31-25(12-13-26(35)30(29)31)24(32(43)33(44)45)8-6-16-46-28-9-5-7-21-17-22(36)10-11-23(21)28/h5,7,9-13,17H,3-4,6,8,14-16,18-19H2,1-2H3,(H,44,45) RFZZMGINSPWQEQ-UHFFFAOYSA-N 572205 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-14-(2,2,2-trifluoroethyl)-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 58::US11447504, Example 59::US11447504, Example 60::US11478451, Example 60 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.30 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572205&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591124 473133258 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218099 Cc1c-2c(CN(CC(F)(F)F)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H33ClF4N4O3/c1-20-29-27(40-41(20)2)18-42(19-34(37,38)39)14-3-4-15-43-31-25(12-13-26(35)30(29)31)24(32(43)33(44)45)8-6-16-46-28-9-5-7-21-17-22(36)10-11-23(21)28/h5,7,9-13,17H,3-4,6,8,14-16,18-19H2,1-2H3,(H,44,45) RFZZMGINSPWQEQ-UHFFFAOYSA-N 572205 (rac)-4-chloro-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2,3-dimethyl-14-(2,2,2-trifluoroethyl)-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 58::US11447504, Example 59::US11447504, Example 60::US11478451, Example 60 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 23.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572205&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591124 473133258 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218102 CCc1c-2c(CN(CC(F)(F)F)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C35H35ClF4N4O3/c1-3-28-31-27(41-42(28)2)19-43(20-35(38,39)40)15-4-5-16-44-32-25(13-14-26(36)30(31)32)24(33(44)34(45)46)9-7-17-47-29-10-6-8-21-18-22(37)11-12-23(21)29/h6,8,10-14,18H,3-5,7,9,15-17,19-20H2,1-2H3,(H,45,46) SOQSAVNRWHIOGH-UHFFFAOYSA-N 572208 (rac) 4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-14-(2,2,2-trifluoroethyl)-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic Acid::US11447504, Example 61::US11447504, Example 62::US11478451, Example 61 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.50 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572208&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591302 473133259 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218105 CCc1c-2c(CN(CC(F)F)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C35H36ClF3N4O3/c1-3-28-32-27(40-41(28)2)19-42(20-30(38)39)15-4-5-16-43-33-25(13-14-26(36)31(32)33)24(34(43)35(44)45)9-7-17-46-29-10-6-8-21-18-22(37)11-12-23(21)29/h6,8,10-14,18,30H,3-5,7,9,15-17,19-20H2,1-2H3,(H,44,45) SKCPFJJDOFGWGO-UHFFFAOYSA-N 577659 (rac)-4-chloro-14-(2,2-difluoroethyl)-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 075::US11478451, Example 076::US11478451, Example 62 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.50 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577659&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591242 474499835 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218108 Cc1c-2c(COCC3CCC3Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H34ClN3O4/c1-20-30-28(36-37(20)2)19-41-18-23-13-12-22(23)17-38-32-26(14-15-27(35)31(30)32)25(33(38)34(39)40)10-6-16-42-29-11-5-8-21-7-3-4-9-24(21)29/h3-5,7-9,11,14-15,22-23H,6,10,12-13,16-19H2,1-2H3,(H,39,40) UXSFIMYRQOIGPQ-UHFFFAOYSA-N 572210 (9aS,11 aR)-3-chloro-4,5-dimethyl-15-{3-[(naphthalen-1-yl)oxy]propyl}-5,7,9,9a, 10,11,11a, 12-octahydrocyclobuta[3,4]pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-14-carboxylic Acid—Stereoisomer 1::US11447504, Example 63::US11447504, Example 64::US11478451, Example 081 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 50.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572210&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591248 473133260 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218111 Cc1c-2c(COCC3CCC3Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H34ClN3O4/c1-20-30-28(36-37(20)2)19-41-18-23-13-12-22(23)17-38-32-26(14-15-27(35)31(30)32)25(33(38)34(39)40)10-6-16-42-29-11-5-8-21-7-3-4-9-24(21)29/h3-5,7-9,11,14-15,22-23H,6,10,12-13,16-19H2,1-2H3,(H,39,40) UXSFIMYRQOIGPQ-UHFFFAOYSA-N 572210 (9aS,11 aR)-3-chloro-4,5-dimethyl-15-{3-[(naphthalen-1-yl)oxy]propyl}-5,7,9,9a, 10,11,11a, 12-octahydrocyclobuta[3,4]pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-14-carboxylic Acid—Stereoisomer 1::US11447504, Example 63::US11447504, Example 64::US11478451, Example 081 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.40 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572210&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591248 473133260 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218114 Cc1c-2c(COCC3CC3Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H32ClN3O4/c1-19-29-27(35-36(19)2)18-40-17-22-15-21(22)16-37-31-25(12-13-26(34)30(29)31)24(32(37)33(38)39)10-6-14-41-28-11-5-8-20-7-3-4-9-23(20)28/h3-5,7-9,11-13,21-22H,6,10,14-18H2,1-2H3,(H,38,39) NAMHEZLSLWIGJK-UHFFFAOYSA-N 572212 (9aS,10aR or 9aR, 10aS)-3-chloro-4,5-dimethyl-14-{3-[(naphthalen-1-yl)oxy]propyl}-5,7,9a, 10,10a, 11-hexahydro-9H-cyclopropa[3,4]pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino-[8,7,6-hi]indole-13-carboxylic Acid—Stereoisomer 1::US11447504, Example 65::US11447504, Example 66::US11478451, Example 083 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 2.70 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572212&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591299 473133261 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218117 Cc1c-2c(COCC(F)(F)C(F)(F)Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H28ClF4N3O4/c1-18-26-24(38-39(18)2)15-43-17-32(36,37)31(34,35)16-40-28-22(12-13-23(33)27(26)28)21(29(40)30(41)42)10-6-14-44-25-11-5-8-19-7-3-4-9-20(19)25/h3-5,7-9,11-13H,6,10,14-17H2,1-2H3,(H,41,42) NCBOLFGZINPIFJ-UHFFFAOYSA-N 577663 (rac)-4-chloro-11,11,12,12-tetrafluoro-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid::US11478451, Example 67 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 22.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577663 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577663&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591337 474499839 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218120 Cc1c-2c(COCCC(F)(F)Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H30ClF2N3O4/c1-19-27-25(36-37(19)2)17-41-16-14-32(34,35)18-38-29-23(12-13-24(33)28(27)29)22(30(38)31(39)40)10-6-15-42-26-11-5-8-20-7-3-4-9-21(20)26/h3-5,7-9,11-13H,6,10,14-18H2,1-2H3,(H,39,40) OUQRKUSSDUUFLP-UHFFFAOYSA-N 577664 (rac)-4-chloro-11,11-difluoro-2,3-dimethyl-7-[3-(1-naphthyloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid::US11478451, Example 094::US11478451, Example 095::US11478451, Example 68 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.50 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577664&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591271 474499840 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218123 CCc1c-2c(COCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H33ClFN3O4/c1-3-27-30-26(36-37(27)2)19-41-16-5-4-15-38-31-24(13-14-25(34)29(30)31)23(32(38)33(39)40)9-7-17-42-28-10-6-8-20-18-21(35)11-12-22(20)28/h6,8,10-14,18H,3-5,7,9,15-17,19H2,1-2H3,(H,39,40) DSRUJIWLAZNHGL-UHFFFAOYSA-N 572183 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 36::US11478451, Example 069 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 4.90 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572183&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591175 473133243 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218128 CCc1c-2c(CCCCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H35ClFN3O3/c1-3-28-31-27(37-38(28)2)12-6-4-5-7-18-39-32-25(16-17-26(35)30(31)32)24(33(39)34(40)41)11-9-19-42-29-13-8-10-21-20-22(36)14-15-23(21)29/h8,10,13-17,20H,3-7,9,11-12,18-19H2,1-2H3,(H,40,41) OHARMQWZWCLEAS-UHFFFAOYSA-N 572201 (rac)-4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[4′,3′:4,5]azacycloundecino[3,2,1-hi]indole-8-carboxylic Acid::US11447504, Example 54::US11478451, Example 071 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 25.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572201&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591153 473133255 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218131 CCc1c-2c(COCC3(CC3)CCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C35H36ClN3O4/c1-3-28-31-27(37-38(28)2)20-42-21-35(15-16-35)17-18-39-32-25(13-14-26(36)30(31)32)24(33(39)34(40)41)11-7-19-43-29-12-6-9-22-8-4-5-10-23(22)29/h4-6,8-10,12-14H,3,7,11,15-21H2,1-2H3,(H,40,41) LIPRSTXCRRUMBL-UHFFFAOYSA-N 577668 US11478451, Example 072::US11478451, Example 073::US11478451, Example 074 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.80 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577668&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591323 474499844 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218134 CCc1c-2c(COCC3(CC3)CCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C35H36ClN3O4/c1-3-28-31-27(37-38(28)2)20-42-21-35(15-16-35)17-18-39-32-25(13-14-26(36)30(31)32)24(33(39)34(40)41)11-7-19-43-29-12-6-9-22-8-4-5-10-23(22)29/h4-6,8-10,12-14H,3,7,11,15-21H2,1-2H3,(H,40,41) LIPRSTXCRRUMBL-UHFFFAOYSA-N 577668 US11478451, Example 072::US11478451, Example 073::US11478451, Example 074 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 110 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577668 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577668&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591323 474499844 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218139 CCc1c-2c(CN(CC(F)F)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C35H36ClF3N4O3/c1-3-28-32-27(40-41(28)2)19-42(20-30(38)39)15-4-5-16-43-33-25(13-14-26(36)31(32)33)24(34(43)35(44)45)9-7-17-46-29-10-6-8-21-18-22(37)11-12-23(21)29/h6,8,10-14,18,30H,3-5,7,9,15-17,19-20H2,1-2H3,(H,44,45) SKCPFJJDOFGWGO-UHFFFAOYSA-N 577659 (rac)-4-chloro-14-(2,2-difluoroethyl)-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2-methyl-10,11,12,13,14,15-hexahydro-2H-pyrazolo[3′,4′:8,9][1,6]diazacycloundecino[10,11,1-hi]indole-8-carboxylic acid::US11478451, Example 075::US11478451, Example 076::US11478451, Example 62 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.70 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577659 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577659&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591242 474499835 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218144 Cc1c-2c(CN(CC(F)F)CCCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H34ClF3N4O3/c1-20-30-27(39-40(20)2)18-41(19-29(37)38)14-3-4-15-42-32-25(12-13-26(35)31(30)32)24(33(42)34(43)44)8-6-16-45-28-9-5-7-21-17-22(36)10-11-23(21)28/h5,7,9-13,17,29H,3-4,6,8,14-16,18-19H2,1-2H3,(H,43,44) KZNKRINHHKLXHL-UHFFFAOYSA-N 577673 US11478451, Example 077 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 13.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577673 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577673&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591218 474499845 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218147 Cc1c-2c(COCC3CCC3Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H34ClN3O4/c1-20-30-28(36-37(20)2)19-41-18-23-13-12-22(23)17-38-32-26(14-15-27(35)31(30)32)25(33(38)34(39)40)10-6-16-42-29-11-5-8-21-7-3-4-9-24(21)29/h3-5,7-9,11,14-15,22-23H,6,10,12-13,16-19H2,1-2H3,(H,39,40) UXSFIMYRQOIGPQ-UHFFFAOYSA-N 572210 (9aS,11 aR)-3-chloro-4,5-dimethyl-15-{3-[(naphthalen-1-yl)oxy]propyl}-5,7,9,9a, 10,11,11a, 12-octahydrocyclobuta[3,4]pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-14-carboxylic Acid—Stereoisomer 1::US11447504, Example 63::US11447504, Example 64::US11478451, Example 081 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.30 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572210&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591248 473133260 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218150 Cc1c-2c(COCC3CCC3Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H34ClN3O4/c1-20-30-28(36-37(20)2)19-41-18-23-13-12-22(23)17-38-32-26(14-15-27(35)31(30)32)25(33(38)34(39)40)10-6-16-42-29-11-5-8-21-7-3-4-9-24(21)29/h3-5,7-9,11,14-15,22-23H,6,10,12-13,16-19H2,1-2H3,(H,39,40) UXSFIMYRQOIGPQ-UHFFFAOYSA-N 572210 (9aS,11 aR)-3-chloro-4,5-dimethyl-15-{3-[(naphthalen-1-yl)oxy]propyl}-5,7,9,9a, 10,11,11a, 12-octahydrocyclobuta[3,4]pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-14-carboxylic Acid—Stereoisomer 1::US11447504, Example 63::US11447504, Example 64::US11478451, Example 081 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.60 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572210&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591248 473133260 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218153 Cc1c-2c(COCC3CCC3Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H34ClN3O4/c1-20-30-28(36-37(20)2)19-41-18-23-13-12-22(23)17-38-32-26(14-15-27(35)31(30)32)25(33(38)34(39)40)10-6-16-42-29-11-5-8-21-7-3-4-9-24(21)29/h3-5,7-9,11,14-15,22-23H,6,10,12-13,16-19H2,1-2H3,(H,39,40) UXSFIMYRQOIGPQ-UHFFFAOYSA-N 572210 (9aS,11 aR)-3-chloro-4,5-dimethyl-15-{3-[(naphthalen-1-yl)oxy]propyl}-5,7,9,9a, 10,11,11a, 12-octahydrocyclobuta[3,4]pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-14-carboxylic Acid—Stereoisomer 1::US11447504, Example 63::US11447504, Example 64::US11478451, Example 081 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572210&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591248 473133260 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218156 Cc1c-2c(COCC3CCC3Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H34ClN3O4/c1-20-30-28(36-37(20)2)19-41-18-23-13-12-22(23)17-38-32-26(14-15-27(35)31(30)32)25(33(38)34(39)40)10-6-16-42-29-11-5-8-21-7-3-4-9-24(21)29/h3-5,7-9,11,14-15,22-23H,6,10,12-13,16-19H2,1-2H3,(H,39,40) UXSFIMYRQOIGPQ-UHFFFAOYSA-N 572210 (9aS,11 aR)-3-chloro-4,5-dimethyl-15-{3-[(naphthalen-1-yl)oxy]propyl}-5,7,9,9a, 10,11,11a, 12-octahydrocyclobuta[3,4]pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-14-carboxylic Acid—Stereoisomer 1::US11447504, Example 63::US11447504, Example 64::US11478451, Example 081 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 64.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572210&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591248 473133260 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218159 Cc1c-2c(COCC3CC3Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H32ClN3O4/c1-19-29-27(35-36(19)2)18-40-17-22-15-21(22)16-37-31-25(12-13-26(34)30(29)31)24(32(37)33(38)39)10-6-14-41-28-11-5-8-20-7-3-4-9-23(20)28/h3-5,7-9,11-13,21-22H,6,10,14-18H2,1-2H3,(H,38,39) NAMHEZLSLWIGJK-UHFFFAOYSA-N 572212 (9aS,10aR or 9aR, 10aS)-3-chloro-4,5-dimethyl-14-{3-[(naphthalen-1-yl)oxy]propyl}-5,7,9a, 10,10a, 11-hexahydro-9H-cyclopropa[3,4]pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino-[8,7,6-hi]indole-13-carboxylic Acid—Stereoisomer 1::US11447504, Example 65::US11447504, Example 66::US11478451, Example 083 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.60 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572212&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591299 473133261 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218164 CCc1c-2c(COCC(F)(F)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H31ClF3N3O4/c1-3-26-29-25(38-39(26)2)17-43-18-33(36,37)13-14-40-30-23(11-12-24(34)28(29)30)22(31(40)32(41)42)7-5-15-44-27-8-4-6-19-16-20(35)9-10-21(19)27/h4,6,8-12,16H,3,5,7,13-15,17-18H2,1-2H3,(H,41,42) RVPQOBYZHGHWNE-UHFFFAOYSA-N 572202 (rac)-4-chloro-12,12-difluoro-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 55::US11478451, Example 086 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 52.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572202&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591253 473133256 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218166 CCc1c-2c(COCC(F)(F)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H31ClF3N3O4/c1-3-26-29-25(38-39(26)2)17-43-18-33(36,37)13-14-40-30-23(11-12-24(34)28(29)30)22(31(40)32(41)42)7-5-15-44-27-8-4-6-19-16-20(35)9-10-21(19)27/h4,6,8-12,16H,3,5,7,13-15,17-18H2,1-2H3,(H,41,42) RVPQOBYZHGHWNE-UHFFFAOYSA-N 572202 (rac)-4-chloro-12,12-difluoro-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 55::US11478451, Example 086 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572202&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591253 473133256 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218169 CCc1c-2c(COCC(F)(F)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H31ClF3N3O4/c1-3-26-29-25(38-39(26)2)17-43-18-33(36,37)13-14-40-30-23(11-12-24(34)28(29)30)22(31(40)32(41)42)7-5-15-44-27-8-4-6-19-16-20(35)9-10-21(19)27/h4,6,8-12,16H,3,5,7,13-15,17-18H2,1-2H3,(H,41,42) RVPQOBYZHGHWNE-UHFFFAOYSA-N 572202 (rac)-4-chloro-12,12-difluoro-2,3-dimethyl-7-{3-[(naphthalen-1-yl)oxy]propyl}-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic Acid::US11447504, Example 55::US11478451, Example 086 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.00 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=572202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=572202&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591253 473133256 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218174 Cc1c-2c(COCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C30H28ClN3O4/c1-18-26-24(32-33(18)2)17-37-16-14-34-28-22(12-13-23(31)27(26)28)21(29(34)30(35)36)10-6-15-38-25-11-5-8-19-7-3-4-9-20(19)25/h3-5,7-9,11-13H,6,10,14-17H2,1-2H3,(H,35,36) FQNIYAGBZSSXJR-UHFFFAOYSA-N 577683 US11478451, Example 087::US11478451, Example 088::US11478451, Example 089 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 13.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577683&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591313 474499854 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218177 Cc1c-2c(COCCn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C30H28ClN3O4/c1-18-26-24(32-33(18)2)17-37-16-14-34-28-22(12-13-23(31)27(26)28)21(29(34)30(35)36)10-6-15-38-25-11-5-8-19-7-3-4-9-20(19)25/h3-5,7-9,11-13H,6,10,14-17H2,1-2H3,(H,35,36) FQNIYAGBZSSXJR-UHFFFAOYSA-N 577683 US11478451, Example 087::US11478451, Example 088::US11478451, Example 089 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 10.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577683 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577683&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591313 474499854 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218180 Cc1c-2c(COCC(F)(F)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H29ClF3N3O4/c1-18-27-25(37-38(18)2)16-42-17-32(35,36)12-13-39-29-23(10-11-24(33)28(27)29)22(30(39)31(40)41)6-4-14-43-26-7-3-5-19-15-20(34)8-9-21(19)26/h3,5,7-11,15H,4,6,12-14,16-17H2,1-2H3,(H,40,41) YREPGHIIHZAQNE-UHFFFAOYSA-N 577686 US11478451, Example 090::US11478451, Example 091::US11478451, Example 092 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 3.50 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577686&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591107 474499855 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218183 Cc1c-2c(COCC(F)(F)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H29ClF3N3O4/c1-18-27-25(37-38(18)2)16-42-17-32(35,36)12-13-39-29-23(10-11-24(33)28(27)29)22(30(39)31(40)41)6-4-14-43-26-7-3-5-19-15-20(34)8-9-21(19)26/h3,5,7-11,15H,4,6,12-14,16-17H2,1-2H3,(H,40,41) YREPGHIIHZAQNE-UHFFFAOYSA-N 577686 US11478451, Example 090::US11478451, Example 091::US11478451, Example 092 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 24.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577686&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591107 474499855 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218186 Cc1c-2c(COCC(F)(F)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H29ClF3N3O4/c1-18-27-25(37-38(18)2)16-42-17-32(35,36)12-13-39-29-23(10-11-24(33)28(27)29)22(30(39)31(40)41)6-4-14-43-26-7-3-5-19-15-20(34)8-9-21(19)26/h3,5,7-11,15H,4,6,12-14,16-17H2,1-2H3,(H,40,41) YREPGHIIHZAQNE-UHFFFAOYSA-N 577686 US11478451, Example 090::US11478451, Example 091::US11478451, Example 092 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.10 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577686 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577686&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591107 474499855 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218191 Cc1c-2c(COCCC(F)(F)Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H30ClF2N3O4/c1-19-27-25(36-37(19)2)17-41-16-14-32(34,35)18-38-29-23(12-13-24(33)28(27)29)22(30(38)31(39)40)10-6-15-42-26-11-5-8-20-7-3-4-9-21(20)26/h3-5,7-9,11-13H,6,10,14-18H2,1-2H3,(H,39,40) OUQRKUSSDUUFLP-UHFFFAOYSA-N 577664 (rac)-4-chloro-11,11-difluoro-2,3-dimethyl-7-[3-(1-naphthyloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid::US11478451, Example 094::US11478451, Example 095::US11478451, Example 68 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 11.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577664&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591271 474499840 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218194 Cc1c-2c(COCCC(F)(F)Cn3c(C(O)=O)c(CCCOc4cccc5ccccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C32H30ClF2N3O4/c1-19-27-25(36-37(19)2)17-41-16-14-32(34,35)18-38-29-23(12-13-24(33)28(27)29)22(30(38)31(39)40)10-6-15-42-26-11-5-8-20-7-3-4-9-21(20)26/h3-5,7-9,11-13H,6,10,14-18H2,1-2H3,(H,39,40) OUQRKUSSDUUFLP-UHFFFAOYSA-N 577664 (rac)-4-chloro-11,11-difluoro-2,3-dimethyl-7-[3-(1-naphthyloxy)propyl]-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid::US11478451, Example 094::US11478451, Example 095::US11478451, Example 68 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.20 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577664 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577664&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591271 474499840 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218197 CCc1c-2c(COCCC(F)(F)Cn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H31ClF3N3O4/c1-3-26-29-25(38-39(26)2)17-43-15-13-33(36,37)18-40-30-23(11-12-24(34)28(29)30)22(31(40)32(41)42)7-5-14-44-27-8-4-6-19-16-20(35)9-10-21(19)27/h4,6,8-12,16H,3,5,7,13-15,17-18H2,1-2H3,(H,41,42) HRVSPZYJJJPUPB-UHFFFAOYSA-N 577692 US11478451, Example 096::US11478451, Example 097::US11478451, Example 098 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.30 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577692&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591096 474499857 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218201 CCc1c-2c(COCCC(F)(F)Cn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H31ClF3N3O4/c1-3-26-29-25(38-39(26)2)17-43-15-13-33(36,37)18-40-30-23(11-12-24(34)28(29)30)22(31(40)32(41)42)7-5-14-44-27-8-4-6-19-16-20(35)9-10-21(19)27/h4,6,8-12,16H,3,5,7,13-15,17-18H2,1-2H3,(H,41,42) HRVSPZYJJJPUPB-UHFFFAOYSA-N 577692 US11478451, Example 096::US11478451, Example 097::US11478451, Example 098 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 20.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577692 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577692&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591096 474499857 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218206 CCc1c-2c(COCC(O)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H33ClFN3O5/c1-3-27-30-26(36-37(27)2)18-42-17-21(39)13-14-38-31-24(11-12-25(34)29(30)31)23(32(38)33(40)41)7-5-15-43-28-8-4-6-19-16-20(35)9-10-22(19)28/h4,6,8-12,16,21,39H,3,5,7,13-15,17-18H2,1-2H3,(H,40,41) PKDNZESWIQFBSN-UHFFFAOYSA-N 577695 4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-12-hydroxy-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid-N-ethylethanamine salt (Stereoisomer 1)::US11478451, Example 101::US11478451, Example 102::US11478451, Example 99 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 6.90 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577695&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591259 474499858 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218209 CCc1c-2c(COCC(O)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H33ClFN3O5/c1-3-27-30-26(36-37(27)2)18-42-17-21(39)13-14-38-31-24(11-12-25(34)29(30)31)23(32(38)33(40)41)7-5-15-43-28-8-4-6-19-16-20(35)9-10-22(19)28/h4,6,8-12,16,21,39H,3,5,7,13-15,17-18H2,1-2H3,(H,40,41) PKDNZESWIQFBSN-UHFFFAOYSA-N 577695 4-chloro-3-ethyl-7-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-12-hydroxy-2-methyl-2,10,11,12,13,15-hexahydropyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-8-carboxylic acid-N-ethylethanamine salt (Stereoisomer 1)::US11478451, Example 101::US11478451, Example 102::US11478451, Example 99 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 11.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577695 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577695&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591259 474499858 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218214 CCc1c-2c(COCC3CC3Cn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H33ClFN3O4/c1-3-28-31-27(37-38(28)2)18-42-17-21-14-20(21)16-39-32-25(11-12-26(35)30(31)32)24(33(39)34(40)41)7-5-13-43-29-8-4-6-19-15-22(36)9-10-23(19)29/h4,6,8-12,15,20-21H,3,5,7,13-14,16-18H2,1-2H3,(H,40,41) NNIZSKXUZBQRNK-UHFFFAOYSA-N 577699 (+)-3-chloro-4-ethyl-14-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-5-methyl-5,7,9a,10,10a,11-hexahydro-9H-cyclopropa[3,4]pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-13-carboxylic acid N-ethylethanamine salt (Enantiomer 1)::US11478451, Example 104 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.40 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577699 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577699&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591257 474499860 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218219 CCc1c-2c(COCC3CC3Cn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H33ClFN3O4/c1-3-28-31-27(37-38(28)2)18-42-17-21-14-20(21)16-39-32-25(11-12-26(35)30(31)32)24(33(39)34(40)41)7-5-13-43-29-8-4-6-19-15-22(36)9-10-23(19)29/h4,6,8-12,15,20-21H,3,5,7,13-14,16-18H2,1-2H3,(H,40,41) NNIZSKXUZBQRNK-UHFFFAOYSA-N 577701 (rac)-3-chloro-4-ethyl-14-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-5-methyl-5,7,9a,10,10a,11-hexahydro-9H-cyclopropa[3,4]pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-13-carboxylic acid (Racemate 2)::US11478451, Example 106 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 5.60 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577701 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577701&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591257 474499862 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218224 CCc1c-2c(COCC3CC3Cn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C34H33ClFN3O4/c1-3-28-31-27(37-38(28)2)18-42-17-21-14-20(21)16-39-32-25(11-12-26(35)30(31)32)24(33(39)34(40)41)7-5-13-43-29-8-4-6-19-15-22(36)9-10-23(19)29/h4,6,8-12,15,20-21H,3,5,7,13-14,16-18H2,1-2H3,(H,40,41) NNIZSKXUZBQRNK-UHFFFAOYSA-N 577703 (−)-3-chloro-4-ethyl-14-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-5-methyl-5,7,9a,10,10a,11-hexahydro-9H-cyclopropa[3,4]pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole-13-carboxylic acid (Enantiomer 4)::US11478451, Example 108 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 7.60 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577703 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577703&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591257 474499864 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218227 CCc1c-2c(COCC3(CC3)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C35H35ClFN3O4/c1-3-28-31-27(38-39(28)2)19-43-20-35(13-14-35)15-16-40-32-25(11-12-26(36)30(31)32)24(33(40)34(41)42)7-5-17-44-29-8-4-6-21-18-22(37)9-10-23(21)29/h4,6,8-12,18H,3,5,7,13-17,19-20H2,1-2H3,(H,41,42) KVOJNOZDXGZAIE-UHFFFAOYSA-N 577704 (rac)-4′-chloro-3′-ethyl-7′-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2′-methyl-2′,10′,11′,15′-tetrahydro-13′H-spiro[cyclopropane-1,12′-pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole]-8′-carboxylic acid::US11478451, Example 109 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.20 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577704 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577704&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591314 474499865 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218232 CCc1c-2c(COCC3(CC3)CCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C35H35ClFN3O4/c1-3-28-31-27(38-39(28)2)19-43-20-35(13-14-35)15-16-40-32-25(11-12-26(36)30(31)32)24(33(40)34(41)42)7-5-17-44-29-8-4-6-21-18-22(37)9-10-23(21)29/h4,6,8-12,18H,3,5,7,13-17,19-20H2,1-2H3,(H,41,42) KVOJNOZDXGZAIE-UHFFFAOYSA-N 577706 (+)-4′-chloro-3′-ethyl-7′-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-2′-methyl-2′,10′,11′,15′-tetrahydro-13′H-spiro[cyclopropane-1,12′-pyrazolo[4′,3′:9,10][1,6]oxazacycloundecino[8,7,6-hi]indole]-8′-carboxylic acid-N-ethylethanamine salt (Enantiomer 2)::US11478451, Example 111 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 19.0 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577706 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577706&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591314 474499867 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589 1218235 CCc1c-2c(CN(C)CCCn3c(C(O)=O)c(CCCOc4cccc5cc(F)ccc45)c4ccc(Cl)c-2c34)nn1C InChI=1S/C33H34ClFN4O3/c1-4-27-30-26(36-38(27)3)19-37(2)15-7-16-39-31-24(13-14-25(34)29(30)31)23(32(39)33(40)41)9-6-17-42-28-10-5-8-20-18-21(35)11-12-22(20)28/h5,8,10-14,18H,4,6-7,9,15-17,19H2,1-3H3,(H,40,41) SBCOOYGIYRFUJP-UHFFFAOYSA-N 577707 (rac)-12-chloro-11-ethyl-1-{3-[(6-fluoronaphthalen-1-yl)oxy]propyl}-7,10-dimethyl-4,5,6,7,8,10-hexahydropyrazolo[3′,4′:7,8][1,5]diazecino[9,10,1-hi]indole-2-carboxylic acid::US11478451, Example 112 Induced myeloid leukemia cell differentiation protein Mcl-1 [173-321]/Noxa BH3 Peptide 1.20 US Patent 10.7270/Q2NG4TXW aid1806933 US11478451 Thede, K; Mengel, A; Christ, C; Kuhnke, J; Johannes, SA; Buchgraber, P; Klar, U; Rauh, U; Kaulfuss, S; Fernandez-Montalvan, AE; Werbeck, N; Moenning, U; Nowak-Reppel, K; Lemke, C; Serrano-Wu, MH; McKinney, D; Fitzgerald, M; Nasveschuk, C; Lazarski, K; Ferrara, SJ; Furst, L; Wei, G; McCarren, PR; Harvey, RA; Payne, D; Pesnot, T; Wilson, C Bayer Aktiengesellschaft; Bayer Pharma Aktiengesellschaft; The Broad Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=577707 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=197&target=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=577707&enzyme=Induced+myeloid+leukemia+cell+differentiation+protein+Mcl-1+%5B173-321%5D%2FNoxa+BH3+Peptide&column=ki&startPg=0&Increment=50&submit=Search 142591135 474499868 3 ELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV 7XGE,8H7B,8IQM Induced myeloid leukemia cell differentiation protein Mcl-1 MCL1_HUMAN Q07820 B2R6B2 D3DV03 D3DV04 Q9HD91 Q9NRQ3 Q9NRQ4 Q9UHR7 Q9UHR8 Q9UHR9 Q9UNJ1 MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV 1Q12,1Q1B,1Q1E,2AWN,2AWO,3FH6,3PUV,3PUW,3PUX,3PUY,3PUZ,3PV0,3RLF,4JBW,4KHZ,4KI0 Maltose/maltodextrin import ATP-binding protein MalK MALK_ECOLI P68187 P02914 Q2M6R9 Q47348 PAELEVEVATQLRRFGDKLNFRQKLL Phorbol-12-myristate-13-acetate-induced protein 1 APR_HUMAN Q13794 B2R4T7 Q8N589