BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 600012 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(CN([C@H](C)c2ccccc2F)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C61H80FN9O7/c1-36(63-10)53(72)67-51(60(4,5)6)58(77)70-34-43-21-13-12-20-42(43)31-50(70)57(76)69(38(3)45-23-16-17-25-47(45)62)33-39-27-29-41(30-28-39)55(74)65-44-32-49(56(75)66-48-26-18-22-40-19-14-15-24-46(40)48)71(35-44)59(78)52(61(7,8)9)68-54(73)37(2)64-11/h12-17,19-21,23-25,27-30,36-38,44,48-52,63-64H,18,22,26,31-35H2,1-11H3,(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t36-,37-,38+,44-,48+,49-,50-,51+,52+/m0/s1 SUVGZSPIXFUCLS-NQFXVQPCSA-N 50030268 CHEMBL3339221::US9603889, Example 1 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 60.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50030268 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50030268&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73603510 313065764 CHEMBL3339221 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600014 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(CN(CCc2ccccc2)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C61H81N9O7/c1-38(62-9)53(71)66-51(60(3,4)5)58(76)69-36-45-23-15-14-22-44(45)33-50(69)57(75)68(32-31-40-19-12-11-13-20-40)35-41-27-29-43(30-28-41)55(73)64-46-34-49(56(74)65-48-26-18-24-42-21-16-17-25-47(42)48)70(37-46)59(77)52(61(6,7)8)67-54(72)39(2)63-10/h11-17,19-23,25,27-30,38-39,46,48-52,62-63H,18,24,26,31-37H2,1-10H3,(H,64,73)(H,65,74)(H,66,71)(H,67,72)/t38-,39-,46?,48+,49-,50-,51+,52+/m0/s1 WBECJJFGDUGEEK-NPDPEGIPSA-N 312090 US9603889, Example 2 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 30.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312090&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 126725456 383539076 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600016 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(CN([C@H](C)c2cccc(OC)c2)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C62H83N9O8/c1-37(63-10)54(72)67-52(61(4,5)6)59(77)70-35-45-21-14-13-20-44(45)32-51(70)58(76)69(39(3)43-23-17-24-47(31-43)79-12)34-40-27-29-42(30-28-40)56(74)65-46-33-50(57(75)66-49-26-18-22-41-19-15-16-25-48(41)49)71(36-46)60(78)53(62(7,8)9)68-55(73)38(2)64-11/h13-17,19-21,23-25,27-31,37-39,46,49-53,63-64H,18,22,26,32-36H2,1-12H3,(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t37-,38-,39+,46?,49+,50-,51-,52+,53+/m0/s1 MCROMBFXBQBUQE-MSMLPYSUSA-N 312091 US9603889, Example 3 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 60.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312091 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312091&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106615 383539077 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600018 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(CN([C@H](C)c2ccc(F)cc2)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C61H80FN9O7/c1-36(63-10)53(72)67-51(60(4,5)6)58(77)70-34-44-19-13-12-18-43(44)31-50(70)57(76)69(38(3)40-27-29-45(62)30-28-40)33-39-23-25-42(26-24-39)55(74)65-46-32-49(56(75)66-48-22-16-20-41-17-14-15-21-47(41)48)71(35-46)59(78)52(61(7,8)9)68-54(73)37(2)64-11/h12-15,17-19,21,23-30,36-38,46,48-52,63-64H,16,20,22,31-35H2,1-11H3,(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t36-,37-,38+,46-,48+,49-,50-,51+,52+/m0/s1 VIZNQQUAZMRASA-DNDJARQFSA-N 312092 US9603889, Example 4 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 100.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312092&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73603551 383539078 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600020 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(CN([C@H](C)c2ccccc2Cl)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C61H80ClN9O7/c1-36(63-10)53(72)67-51(60(4,5)6)58(77)70-34-43-21-13-12-20-42(43)31-50(70)57(76)69(38(3)45-23-16-17-25-47(45)62)33-39-27-29-41(30-28-39)55(74)65-44-32-49(56(75)66-48-26-18-22-40-19-14-15-24-46(40)48)71(35-44)59(78)52(61(7,8)9)68-54(73)37(2)64-11/h12-17,19-21,23-25,27-30,36-38,44,48-52,63-64H,18,22,26,31-35H2,1-11H3,(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t36-,37-,38+,44-,48+,49-,50-,51+,52+/m0/s1 JUQLTUQEOXZVES-NQFXVQPCSA-N 312093 US9603889, Example 5 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 220 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312093&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73603595 383539079 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600022 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(CN([C@H](C)c2cccc(F)c2F)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C61H79F2N9O7/c1-35(64-10)53(73)68-51(60(4,5)6)58(78)71-33-42-20-13-12-19-41(42)30-49(71)57(77)70(37(3)44-23-17-24-46(62)50(44)63)32-38-26-28-40(29-27-38)55(75)66-43-31-48(56(76)67-47-25-16-21-39-18-14-15-22-45(39)47)72(34-43)59(79)52(61(7,8)9)69-54(74)36(2)65-11/h12-15,17-20,22-24,26-29,35-37,43,47-49,51-52,64-65H,16,21,25,30-34H2,1-11H3,(H,66,75)(H,67,76)(H,68,73)(H,69,74)/t35-,36-,37+,43-,47+,48-,49-,51+,52+/m0/s1 XKVHXUXRQUCUTL-ZJDZNGFLSA-N 312094 US9603889, Example 6 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 70.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312094&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73603596 383539080 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600024 CCC[C@@H](N(Cc1ccc(cc1)C(=O)N[C@H]1C[C@H](N(C1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)c1ccccc1 InChI=1S/C63H85N9O7/c1-12-21-50(43-23-14-13-15-24-43)70(59(77)52-34-45-25-16-17-26-46(45)37-71(52)60(78)53(62(4,5)6)68-55(73)39(2)64-10)36-41-30-32-44(33-31-41)57(75)66-47-35-51(58(76)67-49-29-20-27-42-22-18-19-28-48(42)49)72(38-47)61(79)54(63(7,8)9)69-56(74)40(3)65-11/h13-19,22-26,28,30-33,39-40,47,49-54,64-65H,12,20-21,27,29,34-38H2,1-11H3,(H,66,75)(H,67,76)(H,68,73)(H,69,74)/t39-,40-,47-,49+,50+,51-,52-,53+,54+/m0/s1 CXWIRGMWNKKYDO-HRRNLFNOSA-N 312095 US9603889, Example 7 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 190 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312095&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73603640 383539081 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600026 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(CN([C@@H](COC)c2ccccc2)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C62H83N9O8/c1-38(63-9)54(72)67-52(61(3,4)5)59(77)70-35-45-24-16-15-23-44(45)32-50(70)58(76)69(51(37-79-11)42-21-13-12-14-22-42)34-40-28-30-43(31-29-40)56(74)65-46-33-49(57(75)66-48-27-19-25-41-20-17-18-26-47(41)48)71(36-46)60(78)53(62(6,7)8)68-55(73)39(2)64-10/h12-18,20-24,26,28-31,38-39,46,48-53,63-64H,19,25,27,32-37H2,1-11H3,(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t38-,39-,46-,48+,49-,50-,51-,52+,53+/m0/s1 XZWQAFLMOTZHHO-DFNGJWONSA-N 50030266 CHEMBL3339223::US9603889, Example 8 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 60.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50030266 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50030266&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73603641 313065762 CHEMBL3339223 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600028 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)n1ccc2cc(CN([C@@H](COC)c3ccccc3)C(=O)[C@@H]3Cc4ccccc4CN3C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)ccc12)C(C)(C)C InChI=1S/C64H84N10O8/c1-39(65-9)56(75)69-54(63(3,4)5)60(79)73-36-46-24-16-15-23-44(46)33-52(73)59(78)72(53(38-82-11)43-21-13-12-14-22-43)35-41-28-29-50-45(32-41)30-31-71(50)62(81)67-47-34-51(58(77)68-49-27-19-25-42-20-17-18-26-48(42)49)74(37-47)61(80)55(64(6,7)8)70-57(76)40(2)66-10/h12-18,20-24,26,28-32,39-40,47,49,51-55,65-66H,19,25,27,33-38H2,1-11H3,(H,67,81)(H,68,77)(H,69,75)(H,70,76)/t39-,40-,47-,49+,51-,52-,53-,54+,55+/m0/s1 OYWRLKDYLPPCDX-DKCQCBDISA-N 312097 US9603889, Example 9 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 130 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312097 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312097&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118323245 383539083 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600030 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)N(CCc1ccccc1)C[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(C)(C)C InChI=1S/C61H81N9O7/c1-38(62-9)53(71)66-51(60(3,4)5)58(76)69-35-45-23-15-14-22-44(45)33-47(69)37-68(32-31-40-19-12-11-13-20-40)57(75)43-29-27-42(28-30-43)55(73)64-46-34-50(56(74)65-49-26-18-24-41-21-16-17-25-48(41)49)70(36-46)59(77)52(61(6,7)8)67-54(72)39(2)63-10/h11-17,19-23,25,27-30,38-39,46-47,49-52,62-63H,18,24,26,31-37H2,1-10H3,(H,64,73)(H,65,74)(H,66,71)(H,67,72)/t38-,39-,46-,47-,49+,50-,51+,52+/m0/s1 OXYMRWGLDAHNRS-PIJVGMIXSA-N 312099 US9603889, Example 10 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 60.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312099&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73603685 383539085 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600032 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN(Cc2cccc(Cl)c2Cl)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C60H77Cl2N9O7/c1-35(63-9)52(72)67-50(59(3,4)5)57(77)70-33-41-19-12-11-18-40(41)29-48(70)56(76)69(32-42-21-15-23-45(61)49(42)62)31-37-25-27-39(28-26-37)54(74)65-43-30-47(55(75)66-46-24-16-20-38-17-13-14-22-44(38)46)71(34-43)58(78)51(60(6,7)8)68-53(73)36(2)64-10/h11-15,17-19,21-23,25-28,35-36,43,46-48,50-51,63-64H,16,20,24,29-34H2,1-10H3,(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t35-,36-,43?,46?,47-,48-,50+,51+/m0/s1 UFRZPIWCZFNHSK-ASCDQIFNSA-N 312100 (S)-N-(2,3- Dichlorobenzyl)-2- ((S)-3,3-dimethyl-2- ((S)-2- (methylamino) propanamido) butanoyl)- N-(4-(((3S,5S)- 1-((S)-3,3-dimethyl- 2-((S)-2- (methylamino) propanamido) butanoyl)- 5-(((R)-1,2,3,4- tetrahydro- naphthalen- 1-yl)carbamoyl) pyrrolidin-3-yl) carbamoyl)benzyl)- 1,2,3,4-tetra- hydroisoquinoline- 3-carboxamide::US9603889, Example 11 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 70.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312100&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106617 383539086 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600034 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN(CCc2ccc3ccccc3c2)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C65H83N9O7/c1-40(66-9)57(75)70-55(64(3,4)5)62(80)73-38-49-22-14-13-21-48(49)35-54(73)61(79)72(33-32-42-26-29-44-18-11-12-20-47(44)34-42)37-43-27-30-46(31-28-43)59(77)68-50-36-53(60(78)69-52-25-17-23-45-19-15-16-24-51(45)52)74(39-50)63(81)56(65(6,7)8)71-58(76)41(2)67-10/h11-16,18-22,24,26-31,34,40-41,50,52-56,66-67H,17,23,25,32-33,35-39H2,1-10H3,(H,68,77)(H,69,78)(H,70,75)(H,71,76)/t40-,41-,50?,52?,53-,54-,55+,56+/m0/s1 WFUUBVXJSSGEKN-SZKORNPESA-N 312101 (S)-2-((S)-3,3- Dimethyl-2- ((S)-2- (methylamino) propanamido) butanoyl)-N-(4- (((3S,5S)-1-((S)- 3,3-dimethyl-2- ((S)-2-(methyl- amino) propanamido) butanoyl)- 5-(((R)-1,2,3,4- tetrahydro- naphthalen- 1-yl)carbamoyl) pyrrolidin-3-yl) carbamoyl)benzyl)- N-(2-(naphthalen- 2-yl)ethyl)-1,2,3,4- tetrahydro- isoquinoline- 3-carboxamide::US9603889, Example 12 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 90.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312101&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106618 383539087 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600036 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN(Cc2ccccc2)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)C(NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C60H79N9O7/c1-37(61-9)52(70)65-50(59(3,4)5)57(75)68-35-44-23-15-14-22-43(44)31-49(68)56(74)67(33-39-19-12-11-13-20-39)34-40-27-29-42(30-28-40)54(72)63-45-32-48(55(73)64-47-26-18-24-41-21-16-17-25-46(41)47)69(36-45)58(76)51(60(6,7)8)66-53(71)38(2)62-10/h11-17,19-23,25,27-30,37-38,45,47-51,61-62H,18,24,26,31-36H2,1-10H3,(H,63,72)(H,64,73)(H,65,70)(H,66,71)/t37-,38-,45?,47?,48-,49-,50?,51+/m0/s1 SCYPULPKNVKNQH-NJPRNJCPSA-N 312102 (S)-N-Benzyl-2- ((S)-3,3- dimethyl-2-((S)- 2-(methylamino) propanamido) butanoyl)-N-(4- (((3S,5S)-1-((S)- 3,3-dimethyl-2- ((S)- 2-(methylamino) propanamido) butanoyl)- 5-(((R)-1,2,3,4- tetrahydro- naphthalen- 1-yl)carbamoyl) pyrrolidin-3-yl) carbamoyl)benzyl)- 1,2,3,4-tetra- hydroisoquinoline- 3-carboxamide::US9603889, Example 13 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 40.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312102&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106619 383539088 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600038 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN(Cc2ccc3ccccc3c2)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C64H81N9O7/c1-39(65-9)56(74)69-54(63(3,4)5)61(79)72-37-48-22-14-13-21-47(48)33-53(72)60(78)71(36-42-28-29-43-18-11-12-20-46(43)32-42)35-41-26-30-45(31-27-41)58(76)67-49-34-52(59(77)68-51-25-17-23-44-19-15-16-24-50(44)51)73(38-49)62(80)55(64(6,7)8)70-57(75)40(2)66-10/h11-16,18-22,24,26-32,39-40,49,51-55,65-66H,17,23,25,33-38H2,1-10H3,(H,67,76)(H,68,77)(H,69,74)(H,70,75)/t39-,40-,49?,51?,52-,53-,54+,55+/m0/s1 RQSQGPVQOJIACV-APJIPKEOSA-N 312103 (S)-2-((S)- 3,3-Dimethyl- 2-((S)-2-(methyl- amino) propanamido) butanoyl)-N- (4-(((3S,5S)-1-((S)- 3,3-dimethyl-2-((S)- 2-(methylamino) propanamido) butanoyl)-5-(((R)- 1,2,3,4-tetra- hydronaphthalen-1- yl)carbamoyl) pyrrolidin-3-yl) carbamoyl)benzyl)- N-(naphthalen-2- ylmethyl)-1,2,3,4- tetrahydro- isoquinoline-3- carboxamide::US9603889, Example 14 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 40.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312103&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106620 383539089 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600040 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN([C@H](C)c2ccc3ccccc3c2)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C65H83N9O7/c1-39(66-10)57(75)70-55(64(4,5)6)62(80)73-37-49-23-15-14-22-48(49)34-54(73)61(79)72(41(3)46-32-31-43-19-12-13-21-47(43)33-46)36-42-27-29-45(30-28-42)59(77)68-50-35-53(60(78)69-52-26-18-24-44-20-16-17-25-51(44)52)74(38-50)63(81)56(65(7,8)9)71-58(76)40(2)67-11/h12-17,19-23,25,27-33,39-41,50,52-56,66-67H,18,24,26,34-38H2,1-11H3,(H,68,77)(H,69,78)(H,70,75)(H,71,76)/t39-,40-,41+,50?,52?,53-,54-,55+,56+/m0/s1 HGRBQHLSCJMBBG-ZTKZYTAPSA-N 312104 (S)-2-((S)-3,3- Dimethyl-2-((S)-2- (methylamino) propanamido) butanoyl)-N-(4- (((3S,5S)-1-((S)- 3,3-dimethyl-2-((S)- 2-(methylamino) propanamido) butanoyl)-5-(((R)- 1,2,3,4-tetra- hydronaphthalen- 1-yl)carbamoyl) pyrrolidin-3-yl) carbamoyl)benzyl)- N-((R)-1- (naphthalen- 2-yl)ethyl)-1,2,3,4- tetrahydro- isoquinoline- 3-carboxamide::US9603889, Example 15 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 90.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312104&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106621 383539090 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600042 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN(CCc2ccccc2)C(=O)[C@H]2N(CCc3ccccc23)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C61H81N9O7/c1-38(62-9)53(71)66-51(60(3,4)5)58(76)69-34-32-43-22-15-17-25-47(43)50(69)57(75)68(33-31-40-19-12-11-13-20-40)36-41-27-29-44(30-28-41)55(73)64-45-35-49(56(74)65-48-26-18-23-42-21-14-16-24-46(42)48)70(37-45)59(77)52(61(6,7)8)67-54(72)39(2)63-10/h11-17,19-22,24-25,27-30,38-39,45,48-52,62-63H,18,23,26,31-37H2,1-10H3,(H,64,73)(H,65,74)(H,66,71)(H,67,72)/t38-,39-,45?,48?,49-,50-,51+,52+/m0/s1 VPPOJCROUNMKKO-QOULSCCGSA-N 312105 (S)-2-((S)-3,3- Dimethyl- 2-((S)-2-(methyl- amino) propanamido) butanoyl)-N-(4- ((3S,5S)-1-((S)-3,3- dimethyl-2-((S)-2- (methylamino) propanamido) butanoyl)-5-(((R)- 1,2,3,4-tetra- hydronaphthalen-1- yl)carbamoyl) pyrrolidin-3-yl) carbamoyl)benzyl)- N-phenethyl- 1,2,3,4-tetrahydro- isoquinoline- 1-carboxamide::US9603889, Example 16 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 70.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312105&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106622 383539091 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600044 CN[C@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)N(C[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)[C@H](C)Cc1ccccc1F)C(C)(C)C InChI=1S/C62H82FN9O7/c1-37(31-44-21-15-17-25-49(44)63)70(36-47-32-43-20-12-13-22-45(43)34-71(47)59(78)52(61(4,5)6)68-54(73)38(2)64-10)58(77)42-29-27-41(28-30-42)56(75)66-46-33-51(57(76)67-50-26-18-23-40-19-14-16-24-48(40)50)72(35-46)60(79)53(62(7,8)9)69-55(74)39(3)65-11/h12-17,19-22,24-25,27-30,37-39,46-47,50-53,64-65H,18,23,26,31-36H2,1-11H3,(H,66,75)(H,67,76)(H,68,73)(H,69,74)/t37-,38+,39-,46+,47+,50-,51+,52-,53-/m1/s1 QCAMDWZORZRYMM-XRTXGEDASA-N 312106 N1-(((S)-2-((S)- 3,3-dimethyl- 2-((S)-2- (methylamino) propanamido) butanoyl)- 1,2,3,4-tetra- hydroisoquinolin- 3-yl)methyl)- N4-((3S,5S)-1- ((S)-3,3-dimethyl- 2-((S)-2-(methyl- amino) propanamido) butanoyl)- 5-(((R)-1,2,3,4- tetrahydro- naphthalen- 1-yl)carbamoyl) pyrrolidin-3-yl)-N1- ((R)-1-(2- fluorophenyl) propan-2-yl) terephthalamide::US9603889, Example 17 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 100.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312106&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118330703 383539092 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600046 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN(C(C)c2cccc(Cl)c2)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C61H80ClN9O7/c1-36(63-10)53(72)67-51(60(4,5)6)58(77)70-34-44-20-13-12-19-43(44)31-50(70)57(76)69(38(3)42-22-16-23-45(62)30-42)33-39-26-28-41(29-27-39)55(74)65-46-32-49(56(75)66-48-25-17-21-40-18-14-15-24-47(40)48)71(35-46)59(78)52(61(7,8)9)68-54(73)37(2)64-11/h12-16,18-20,22-24,26-30,36-38,46,48-52,63-64H,17,21,25,31-35H2,1-11H3,(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t36-,37-,38?,46?,48?,49-,50-,51+,52+/m0/s1 HQFKHRXXASCMRM-PJYHSPRCSA-N 312107 (S)-N-((S)-1-(3- Chlorophenyl) ethyl)-2-((S)- 3,3-dimethyl-2- ((S)-2- (methylamino) propanamido) butanoyl)-N-(4- (((3S,5S)-1-((S)- 3,3-dimethyl-2-((S)- 2-(methylamino) propanamido) butanoyl)- 5-(((R)-1,2,3,4- tetrahydro- naphthalen- 1-yl)carbamoyl) pyrrolidin-3-yl) carbamoyl) benzyl)-1,2,3,4- tetrahydro- isoquinoline- 3-carboxamide::US9603889, Example 18 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 120 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312107&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106623 383539093 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600048 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN([C@H](C)c2ccccc2F)C(=O)[C@H]2N(CCc3ccccc23)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C61H80FN9O7/c1-36(63-10)53(72)67-51(60(4,5)6)58(77)69-32-31-41-20-13-15-24-46(41)50(69)57(76)70(38(3)44-22-16-17-25-47(44)62)34-39-27-29-42(30-28-39)55(74)65-43-33-49(56(75)66-48-26-18-21-40-19-12-14-23-45(40)48)71(35-43)59(78)52(61(7,8)9)68-54(73)37(2)64-11/h12-17,19-20,22-25,27-30,36-38,43,48-52,63-64H,18,21,26,31-35H2,1-11H3,(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t36-,37-,38+,43?,48?,49-,50-,51+,52+/m0/s1 OJMRKFRVXDLLRT-ZODIYHDXSA-N 312108 (S)-2-((S)-3,3- Dimethyl- 2-((S)-2- (methylamino) propanamido) butanoyl)-N- (4-(((3S,5S)- 1-((S)-3,3-dimethyl- 2-((S)-2- (methylamino) propanamido) butanoyl)-5-(((R)- 1,2,3,4-tetra- hydronaphthalen- 1-yl)carbamoyl) pyrrolidin-3-yl) carbamoyl)benzyl)- N-((R)-1-(2- fluorophenyl) ethyl)-1,2,3,4- tetrahydro- isoquinoline- 1-carboxamide::US9603889, Example 19 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 290 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312108&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106624 383539094 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600050 CCC(N(Cc1ccc(cc1)C(=O)NC1C[C@H](N(C1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC1CCCc2ccccc12)C(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)c1ccccc1 InChI=1S/C62H83N9O7/c1-12-49(42-22-14-13-15-23-42)69(58(76)51-33-44-24-16-17-25-45(44)36-70(51)59(77)52(61(4,5)6)67-54(72)38(2)63-10)35-40-29-31-43(32-30-40)56(74)65-46-34-50(57(75)66-48-28-20-26-41-21-18-19-27-47(41)48)71(37-46)60(78)53(62(7,8)9)68-55(73)39(3)64-11/h13-19,21-25,27,29-32,38-39,46,48-53,63-64H,12,20,26,28,33-37H2,1-11H3,(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t38-,39-,46?,48?,49?,50-,51-,52+,53+/m0/s1 CWBSLRMZMMYANP-FSSCPAOLSA-N 312109 (S)-2-((S)-3,3- Dimethyl-2-((S)-2- (methylamino) propanamido) butanoyl)-N-(4- (((3S,5S)-1-((S)- 3,3-dimethyl-2-((S)- 2-(methylamino) propanamido) butanoyl)- 5-(((R)-1,2,3,4- tetrahydro- naphthalen-1- yl)carbamoyl) pyrrolidin- 3-yl)carbamoyl) benzyl)-N-((R)- 1-phenylpropyl)- 1,2,3,4-tetra- hydroisoquinoline- 3-carboxamide::US9603889, Example 20 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 110 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312109&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106625 383539095 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600052 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN(C(C)C(c2ccccc2)c2ccccc2)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C68H87N9O7/c1-42(69-10)60(78)73-58(67(4,5)6)65(83)76-40-51-29-19-18-28-50(51)37-56(76)64(82)75(44(3)57(47-24-14-12-15-25-47)48-26-16-13-17-27-48)39-45-33-35-49(36-34-45)62(80)71-52-38-55(63(81)72-54-32-22-30-46-23-20-21-31-53(46)54)77(41-52)66(84)59(68(7,8)9)74-61(79)43(2)70-11/h12-21,23-29,31,33-36,42-44,52,54-59,69-70H,22,30,32,37-41H2,1-11H3,(H,71,80)(H,72,81)(H,73,78)(H,74,79)/t42-,43-,44?,52?,54?,55-,56-,58+,59+/m0/s1 CYHTUCVQCYTOFX-LRGHKLHQSA-N 312110 (S)-2-((S)-3,3- Dimethyl-2-((S)- 2-(methylamino) propanamido) butanoyl)-N-(4- (((3S,5S)- 1-((S)-3,3-dimethyl- 2-((S)-2- (methylamino) propanamido) butanoyl)-5- (((R)-1,2,3,4-tetra- hydronaphthalen- 1-yl)carbamoyl) pyrrolidin- 3-yl)carbamoyl) benzyl)-N-((R)- 1,1-diphenylpropan- 2-yl)-1,2,3,4- tetrahydro- isoquinoline- 3-carboxamide::US9603889, Example 21 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 290 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312110&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106626 383539096 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600054 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN(C2CCCc3ccccc23)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C63H83N9O7/c1-38(64-9)55(73)68-53(62(3,4)5)60(78)71-36-45-22-12-11-21-44(45)33-52(71)59(77)70(50-28-18-24-42-20-14-16-26-48(42)50)35-40-29-31-43(32-30-40)57(75)66-46-34-51(58(76)67-49-27-17-23-41-19-13-15-25-47(41)49)72(37-46)61(79)54(63(6,7)8)69-56(74)39(2)65-10/h11-16,19-22,25-26,29-32,38-39,46,49-54,64-65H,17-18,23-24,27-28,33-37H2,1-10H3,(H,66,75)(H,67,76)(H,68,73)(H,69,74)/t38-,39-,46?,49?,50?,51-,52-,53+,54+/m0/s1 LDVMHSURAWAEBW-IBHSQVJQSA-N 312111 (S)-2-((S)-3,3- Dimethyl- 2-((S)-2- (methylamino) propanamido) butanoyl)-N-(4- (((3S,5S)-1-((S)- 3,3-dimethyl-2-((S)- 2-(methylamino) propanamido) butanoyl)-5-(((R)- 1,2,3,4-tetra- hydronaphthalen-1- yl)carbamoyl) pyrrolidin- 3-yl)carbamoyl) benzyl)-N-((S)- 1,2,3,4-tetrahydro- napthalen-1-yl)- 1,2,3,4- tetrahydroiso- quinoline- 3-carboxamide::US9603889, Example 22 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 110 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312111&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106627 383539097 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600056 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN(C(C)c2ccccc2)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C61H81N9O7/c1-37(62-10)53(71)66-51(60(4,5)6)58(76)69-35-45-24-16-15-23-44(45)32-50(69)57(75)68(39(3)41-20-13-12-14-21-41)34-40-28-30-43(31-29-40)55(73)64-46-33-49(56(74)65-48-27-19-25-42-22-17-18-26-47(42)48)70(36-46)59(77)52(61(7,8)9)67-54(72)38(2)63-11/h12-18,20-24,26,28-31,37-39,46,48-52,62-63H,19,25,27,32-36H2,1-11H3,(H,64,73)(H,65,74)(H,66,71)(H,67,72)/t37-,38-,39?,46?,48?,49-,50-,51+,52+/m0/s1 CLXWWRLIDSQWAQ-PBDLGBDGSA-N 312112 (S)-2-((S)-3,3- Dimethyl-2-((S)-2- (methylamino) propanamido) butanoyl)-N-(4- (((3S,5S)-1-((S)- 3,3-dimethyl-2-((S)- 2-(methylamino) propanamido) butanoyl)-5-(((R)- 1,2,3,4-tetra- hydronaphthalen-1- yl)carbamoyl) pyrrolidin-3-yl) carbamoyl) benzyl)-N- ((R)-1-phenylethyl)- 1,2,3,4-tetra- hydroisoquinoline- 3-carboxamide::US9603889, Example 23 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 120 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312112&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106628 383539098 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600058 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN(C(C)c2ccccc2OC)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C62H83N9O8/c1-37(63-10)54(72)67-52(61(4,5)6)59(77)70-35-44-22-14-13-21-43(44)32-50(70)58(76)69(39(3)46-24-17-18-27-51(46)79-12)34-40-28-30-42(31-29-40)56(74)65-45-33-49(57(75)66-48-26-19-23-41-20-15-16-25-47(41)48)71(36-45)60(78)53(62(7,8)9)68-55(73)38(2)64-11/h13-18,20-22,24-25,27-31,37-39,45,48-50,52-53,63-64H,19,23,26,32-36H2,1-12H3,(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t37-,38-,39?,45?,48?,49-,50-,52+,53+/m0/s1 NNUBYITXSVFHFX-VWJDLKNGSA-N 312113 (S)-2-((S)-3,3- Dimethyl-2-((S)-2- (methylamino) propanamido) butanoyl)-N-(4- (((3S,5S)-1-((S)-3,3- dimethyl-2-((S)-2- (methylamino) propanamido) butanoyl)- 5-(((R)-1,2,3,4- tetrahydro- naphthalen- 1-yl)carbamoyl) pyrrolidin-3-yl) carbamoyl)benzyl)- N-((R)-1-(2- methoxyphenyl) ethyl)-1,2,3,4- tetrahydro- isoquinoline- 3-carboxamide::US9603889, Example 24 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 130 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312113&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106629 383539099 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600060 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN(C(C)Cc2ccccc2F)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C62H82FN9O7/c1-37(31-44-21-15-17-25-48(44)63)70(58(77)51-32-43-20-12-13-22-45(43)35-71(51)59(78)52(61(4,5)6)68-54(73)38(2)64-10)34-40-27-29-42(30-28-40)56(75)66-46-33-50(57(76)67-49-26-18-23-41-19-14-16-24-47(41)49)72(36-46)60(79)53(62(7,8)9)69-55(74)39(3)65-11/h12-17,19-22,24-25,27-30,37-39,46,49-53,64-65H,18,23,26,31-36H2,1-11H3,(H,66,75)(H,67,76)(H,68,73)(H,69,74)/t37?,38-,39-,46?,49?,50-,51-,52+,53+/m0/s1 AZOAWRFEIPJHAZ-JAXRXAILSA-N 312114 (S)-2-((S)-3,3- Dimethyl-2-((S)- 2-(methylamino) propanamido) butanoyl)-N-(4- (((3S,5S)-1-((S)- 3,3-dimethyl-2-((S)- 2-(methylamino) propanamido) butanoyl)- 5-(((R)-1,2,3,4- tetrahydro- naphthalen- 1-yl)carbamoyl) pyrrolidin- 3-yl)carbamoyl) benzyl)-N-((R)- 1-(2-fluorophenyl) propan-2-yl)- 1,2,3,4-tetrahydro- isoquinoline- 3-carboxamide::US9603889, Example 25 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 60.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312114&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106630 383539100 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600062 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN(C(C)c2ccccc2Cl)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C61H80ClN9O7/c1-36(63-10)53(72)67-51(60(4,5)6)58(77)70-34-43-21-13-12-20-42(43)31-50(70)57(76)69(38(3)45-23-16-17-25-47(45)62)33-39-27-29-41(30-28-39)55(74)65-44-32-49(56(75)66-48-26-18-22-40-19-14-15-24-46(40)48)71(35-44)59(78)52(61(7,8)9)68-54(73)37(2)64-11/h12-17,19-21,23-25,27-30,36-38,44,48-52,63-64H,18,22,26,31-35H2,1-11H3,(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t36-,37-,38?,44?,48?,49-,50-,51+,52+/m0/s1 JUQLTUQEOXZVES-VZJDYDFESA-N 312115 (3S)-N-(1-(2- Chlorophenyl) ethyl)-2-((S)-3,3- dimethyl-2-((S)-2- (methylamino) propanamido) butanoyl)-N-(4- (((3S,5S)-1-((S)- 3,3-dimethyl- 2-((S)-2- (methylamino) propanamido) butanoyl)- 5-(((R)-1,2,3,4- tetrahydro- naphthalen- 1-yl)carbamoyl) pyrrolidin-3-yl) carbamoyl)benzyl)- 1,2,3,4-tetra- hydroisoquinoline- 3-carboxamide::US9603889, Example 26 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 190 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312115&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106631 383539101 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600064 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN([C@H](C)Cc2ccccc2F)C(=O)[C@H]2N(CCc3ccccc23)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C62H82FN9O7/c1-37(33-44-21-14-17-25-48(44)63)71(58(77)51-47-24-16-13-20-42(47)31-32-70(51)59(78)52(61(4,5)6)68-54(73)38(2)64-10)35-40-27-29-43(30-28-40)56(75)66-45-34-50(57(76)67-49-26-18-22-41-19-12-15-23-46(41)49)72(36-45)60(79)53(62(7,8)9)69-55(74)39(3)65-11/h12-17,19-21,23-25,27-30,37-39,45,49-53,64-65H,18,22,26,31-36H2,1-11H3,(H,66,75)(H,67,76)(H,68,73)(H,69,74)/t37-,38+,39+,45?,49?,50+,51+,52-,53-/m1/s1 ZUAAEZJCFHSIOK-WCHMCIFBSA-N 312116 (S)-2-((S)-3,3- Dimethyl-2-((S)-2- (methylamino) propanamido) butanoyl)- N-(4-(((3S,5S)-1- ((S)-3,3-dimethyl- 2-((S)-2- (methylamino) propanamido) butanoyl)- 5-(((R)-1,2,3,4- tetrahydro- naphthalen- 1-yl)carbamoyl) pyrrolidin-3-yl) carbamoyl) benzyl)-N-((R)-1- (2-fluorophenyl) propan-2-yl)- 1,2,3,4-tetrahydro- isoquinoline- 1-carboxamide::US9603889, Example 27 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 90.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312116&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106632 383539102 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600066 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN(C(C)c2ccccc2C)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C62H83N9O7/c1-37-20-13-17-25-47(37)40(4)69(58(76)51-32-44-22-14-15-23-45(44)35-70(51)59(77)52(61(5,6)7)67-54(72)38(2)63-11)34-41-28-30-43(31-29-41)56(74)65-46-33-50(57(75)66-49-27-19-24-42-21-16-18-26-48(42)49)71(36-46)60(78)53(62(8,9)10)68-55(73)39(3)64-12/h13-18,20-23,25-26,28-31,38-40,46,49-53,63-64H,19,24,27,32-36H2,1-12H3,(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t38-,39-,40?,46?,49?,50-,51-,52+,53+/m0/s1 LMFQEYJRLPLECC-SAHLMDJCSA-N 312117 (S)-2-((S)-3,3- Dimethyl-2-((S)-2- (methylamino) propanamido) butanoyl)- N-(4-(((3S,5S)-1- ((S)-3,3-dimethyl- 2-((S)-2- (methylamino) propanamido) butanoyl)-5-(((R)- 1,2,3,4-tetra- hydronaphthalen-1- yl)carbamoyl) pyrrolidin-3-yl) carbamoyl)benzyl)- N-((R)-1-(o-tolyl) ethyl)-1,2,3,4- tetrahydro- isoquinoline- 3-carboxamide::US9603889, Example 28 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 160 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312117&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106633 383539103 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600068 CCOc1ccccc1[C@@H](C)N(Cc1ccc(cc1)C(=O)NC1C[C@H](N(C1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC1CCCc2ccccc12)C(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C InChI=1S/C63H85N9O8/c1-13-80-52-28-19-18-25-47(52)40(4)70(59(77)51-33-44-22-14-15-23-45(44)36-71(51)60(78)53(62(5,6)7)68-55(73)38(2)64-11)35-41-29-31-43(32-30-41)57(75)66-46-34-50(58(76)67-49-27-20-24-42-21-16-17-26-48(42)49)72(37-46)61(79)54(63(8,9)10)69-56(74)39(3)65-12/h14-19,21-23,25-26,28-32,38-40,46,49-51,53-54,64-65H,13,20,24,27,33-37H2,1-12H3,(H,66,75)(H,67,76)(H,68,73)(H,69,74)/t38-,39-,40+,46?,49?,50-,51-,53+,54+/m0/s1 BZYLXAPGOBAABU-WUBRCICJSA-N 312118 (S)-2-((S)-3,3- Dimethyl-2-((S)-2- (methylamino) propanamido) butanoyl)-N-(4- (((3S,5S)-1-((S)- 3,3-dimethyl-2- ((S)-2-(methyl- amino) propanamido) butanoyl)-5-(((R)- 1,2,3,4-tetra- hydronaphthalen-1- yl)carbamoyl) pyrrolidin- 3-yl)carbamoyl) benzyl)-N-((R)- 1-(2-ethoxyphenyl) ethyl)-1,2,3,4- tetrahydro- isoquinoline- 3-carboxamide::US9603889, Example 29 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 160 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312118&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106634 383539104 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600070 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)N(C[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)[C@H](C)Cc1ccc2ccccc2c1)C(C)(C)C InChI=1S/C66H85N9O7/c1-40(33-43-27-28-44-19-12-13-21-48(44)34-43)73(39-52-35-49-22-14-15-23-50(49)37-74(52)63(81)56(65(4,5)6)71-58(76)41(2)67-10)62(80)47-31-29-46(30-32-47)60(78)69-51-36-55(61(79)70-54-26-18-24-45-20-16-17-25-53(45)54)75(38-51)64(82)57(66(7,8)9)72-59(77)42(3)68-11/h12-17,19-23,25,27-32,34,40-42,51-52,54-57,67-68H,18,24,26,33,35-39H2,1-11H3,(H,69,78)(H,70,79)(H,71,76)(H,72,77)/t40-,41+,42+,51+,52+,54-,55+,56-,57-/m1/s1 PVPQDLGMPIVRTP-KMKAQRCYSA-N 312119 N1-(((S)-2-((S)-3,3- Dimethyl-2-((S)- 2-(methylamino) propanamido) butanoyl)-1,2,3,4- tetrahydro- isoquinolin-3- yl)methyl)-N4- ((3S,5S)-1-((S)- 3,3-dimethyl-2-((S)- 2-(methylamino) propanamido) butanoyl)- 5-(((R)-1,2,3,4- tetrahydro- naphthalen- 1-yl)carbamoyl) pyrrolidin-3-yl)-N1- ((R)-1-(naphthalen- 2-yl)propan-2-yl) terephthalamide::US9603889, Example 30 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 270 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312119&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118330717 383539105 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600072 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)N(C[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)[C@H](C)c1ccc2ccccc2c1)C(C)(C)C InChI=1S/C65H83N9O7/c1-39(66-10)57(75)70-55(64(4,5)6)62(80)73-36-49-23-15-14-22-48(49)34-51(73)38-72(41(3)46-32-27-42-19-12-13-21-47(42)33-46)61(79)45-30-28-44(29-31-45)59(77)68-50-35-54(60(78)69-53-26-18-24-43-20-16-17-25-52(43)53)74(37-50)63(81)56(65(7,8)9)71-58(76)40(2)67-11/h12-17,19-23,25,27-33,39-41,50-51,53-56,66-67H,18,24,26,34-38H2,1-11H3,(H,68,77)(H,69,78)(H,70,75)(H,71,76)/t39-,40-,41+,50-,51-,53+,54-,55+,56+/m0/s1 QTSIMALYUDCMPK-KQRVCALPSA-N 312120 N1-(((S)-2-((S)-3,3- Dimethyl-2-((S)-2- (methylamino) propanamido) butanoyl)-1,2,3,4- tetrahydro- isoquinolin-3-yl) methyl)-N4- ((3S,5S)-1- ((S)-3,3-dimethyl- 2-((S)-2-(methyl- amino) propanamido) butanoyl)- 5-(((R)-1,2,3,4- tetrahydro- naphthalen- 1-yl)carbamoyl) pyrrolidin-3-yl)-N1- ((R)-1-(naphthalen- 2-yl)ethyl) terephthalamide::US9603889, Example 31 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 250 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312120&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118330676 383539106 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600074 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)N(CCc1ccc2ccccc2c1)C[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(C)(C)C InChI=1S/C65H83N9O7/c1-40(66-9)57(75)70-55(64(3,4)5)62(80)73-37-49-22-14-13-21-48(49)35-51(73)39-72(33-32-42-26-27-43-18-11-12-20-47(43)34-42)61(79)46-30-28-45(29-31-46)59(77)68-50-36-54(60(78)69-53-25-17-23-44-19-15-16-24-52(44)53)74(38-50)63(81)56(65(6,7)8)71-58(76)41(2)67-10/h11-16,18-22,24,26-31,34,40-41,50-51,53-56,66-67H,17,23,25,32-33,35-39H2,1-10H3,(H,68,77)(H,69,78)(H,70,75)(H,71,76)/t40-,41-,50-,51-,53+,54-,55+,56+/m0/s1 HJRHYWAIFLGMJQ-SWODDILSSA-N 312121 N1-(((S)-2-((S)- 3,3-Dimethyl-2- ((S)-2-(methyl- amino) propanamido) butanoyl)-1,2,3,4- tetrahydro- isoquinolin-3-yl) methyl)-N4- ((3S,5S)-1-((S)-3,3- dimethyl- 2-((S)-2- (methylamino) propanamido) butanoyl)- 5-(((R)-1,2,3,4- tetrahydro- naphthalen- 1-yl)carbamoyl) pyrrolidin-3-yl)- N1-(2-(naphthalen- 2-yl)ethyl) terephthalamide::US9603889, Example 32 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 60.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312121&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118330718 383539107 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600076 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)N(CCc1cccc2ccccc12)C[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(C)(C)C InChI=1S/C65H83N9O7/c1-40(66-9)57(75)70-55(64(3,4)5)62(80)73-37-48-22-12-11-21-47(48)35-50(73)39-72(34-33-44-24-17-23-42-19-13-15-26-51(42)44)61(79)46-31-29-45(30-32-46)59(77)68-49-36-54(60(78)69-53-28-18-25-43-20-14-16-27-52(43)53)74(38-49)63(81)56(65(6,7)8)71-58(76)41(2)67-10/h11-17,19-24,26-27,29-32,40-41,49-50,53-56,66-67H,18,25,28,33-39H2,1-10H3,(H,68,77)(H,69,78)(H,70,75)(H,71,76)/t40-,41-,49-,50-,53+,54-,55+,56+/m0/s1 UXJVAMCICAERKY-XSURLAPZSA-N 312122 N1-(((S)-2-((S)- 3,3-Dimethyl- 2-((S)-2- (methylamino) propanamido) butanoyl)-1,2,3,4- tetrahydro- isoquinolin- 3-yl)methyl)- N4-((3S,5S)- 1-((S)-3,3- dimethyl-2-((S)-2- (methylamino) propanamido) butanoyl)- 5-(((R)-1,2,3,4- tetrahydro- naphthalen- 1-yl)carbamoyl) pyrrolidin-3-yl)-N1- (2-(naphthalen-1- yl)ethyl) terephthalamide::US9603889, Example 33 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 120 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312122&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118330689 383539108 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600078 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)N(C[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)Cc1cccc2ccccc12)C(C)(C)C InChI=1S/C64H81N9O7/c1-39(65-9)56(74)69-54(63(3,4)5)61(79)72-36-46-22-12-11-21-45(46)33-49(72)38-71(35-47-25-17-23-41-19-13-15-26-50(41)47)60(78)44-31-29-43(30-32-44)58(76)67-48-34-53(59(77)68-52-28-18-24-42-20-14-16-27-51(42)52)73(37-48)62(80)55(64(6,7)8)70-57(75)40(2)66-10/h11-17,19-23,25-27,29-32,39-40,48-49,52-55,65-66H,18,24,28,33-38H2,1-10H3,(H,67,76)(H,68,77)(H,69,74)(H,70,75)/t39-,40-,48-,49-,52+,53-,54+,55+/m0/s1 CWUBQRWNMSQJRE-YDSNTJDVSA-N 312123 N1-(((S)-2-((S)- 3,3-Dimethyl- 2-((S)-2- (methylamino) propanamido) butanoyl)-1,2,3,4- tetrahydro- isoquinolin-3-yl) methyl)-N4- ((3S,5S)-1-((S)-3,3- dimethyl-2- ((S)-2- (methylamino) propanamido) butanoyl)- 5-(((R)-1,2,3,4- tetrahydro- naphthalen- 1-yl)carbamoyl) pyrrolidin-3-yl)- N1-(naphthalen-1- ylmethyl) terephthalamide::US9603889, Example 34 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 160 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312123&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118330855 383539109 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600080 CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2ccccc2C[C@H]1CN(Cc1cccc(C)c1C)C(=O)c1ccc(cc1)C(=O)Cc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C68H86N8O7/c1-41-19-17-24-51(42(41)2)37-74(40-54-35-49-21-13-14-22-52(49)38-75(54)65(82)59(67(5,6)7)72-61(78)43(3)69-11)64(81)48-31-29-47(30-32-48)58(77)34-45-27-28-50-36-57(63(80)71-56-26-18-23-46-20-15-16-25-55(46)56)76(39-53(50)33-45)66(83)60(68(8,9)10)73-62(79)44(4)70-12/h13-17,19-22,24-25,27-33,43-44,54,56-57,59-60,69-70H,18,23,26,34-40H2,1-12H3,(H,71,80)(H,72,78)(H,73,79)/t43-,44-,54-,56+,57-,59+,60+/m0/s1 DPTZSNVXBNIDSZ-RBKKZXDISA-N 312124 N1-(((S)-2-((S)- 3,3-Dimethyl- 2-((S)-2- (methylamino) propanamido) butanoyl)- 1,2,3,4-tetra- hydroisoquinolin- 3-yl)methyl)- N4-((S)-2-((S)- 3,3-dimethyl- 2-((S)-2- (methylamino) propanamido) butanoyl)- 3-(((R)-1,2,3,4- tetrahydro- naphthalen-1- yl)carbamoyl)- 1,2,3,4-tetra- hydroisoquinolin- 7-yl)-N1-(2,3- dimethylbenzyl) terephthalamide::US9603889, Example 35 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 230 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312124&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118330669 383539110 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600082 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)N(C[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)Cc1cccc(C)c1C)C(C)(C)C InChI=1S/C62H83N9O7/c1-37-19-17-24-45(38(37)2)33-69(36-48-31-44-21-13-14-22-46(44)34-70(48)59(77)52(61(5,6)7)67-54(72)39(3)63-11)58(76)43-29-27-42(28-30-43)56(74)65-47-32-51(57(75)66-50-26-18-23-41-20-15-16-25-49(41)50)71(35-47)60(78)53(62(8,9)10)68-55(73)40(4)64-12/h13-17,19-22,24-25,27-30,39-40,47-48,50-53,63-64H,18,23,26,31-36H2,1-12H3,(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t39-,40-,47-,48-,50+,51-,52+,53+/m0/s1 AECFEAWCZCFJCP-LSYVJHDCSA-N 312125 N1-(((S)-2-((S)- 3,3-Dimethyl- 2-((S)-2- (methylamino) propanamido) butanoyl)-1,2,3,4- tetrahydro- isoquinolin-3-yl) methyl)-N4- ((3S,5S)-1-((S)-3,3- dimethyl-2-((S)- 2-(methylamino) propanamido) butanoyl)- 5-(((R)-1,2,3,4- tetrahydro- naphthalen- 1-yl)carbamoyl) pyrrolidin-3-yl)-N1- (2,3-dimethyl- benzyl) terephthalamide::US9603889, Example 36 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 90.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312125&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118330705 383539111 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600084 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)N(C[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)[C@H](C)c1ccccc1F)C(C)(C)C InChI=1S/C61H80FN9O7/c1-36(63-10)53(72)67-51(60(4,5)6)58(77)70-33-43-21-13-12-20-42(43)31-45(70)35-69(38(3)46-23-16-17-25-48(46)62)57(76)41-29-27-40(28-30-41)55(74)65-44-32-50(56(75)66-49-26-18-22-39-19-14-15-24-47(39)49)71(34-44)59(78)52(61(7,8)9)68-54(73)37(2)64-11/h12-17,19-21,23-25,27-30,36-38,44-45,49-52,63-64H,18,22,26,31-35H2,1-11H3,(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t36-,37-,38+,44-,45-,49+,50-,51+,52+/m0/s1 SVZWWJONRRRSQO-LHSYOQMASA-N 312126 N1-(((S)-2- ((S)-3,3- Dimethyl-2-((S)- 2-(methylamino) propanamido) butanoyl)-1,2,3,4- tetrahydro- isoquinolin-3-yl) methyl)-N4- ((3S,5S)- 1-((S)-3,3- dimethyl-2-((S)-2- (methylamino) propanamido) butanoyl)-5-(((R)- 1,2,3,4-tetrahydro- naphthalen-1-yl) carbamoyl) pyrrolidin- 3-yl)-N1-((R)-1-(2- fluorophenyl) ethyl) terephthalamide::US9603889, Example 37 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 230 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312126&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118330708 383539112 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600086 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)C1(CN([C@@H](COC)c2ccccc2)C(=O)C2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)CC1)C(C)(C)C InChI=1S/C59H83N9O8/c1-36(60-9)50(69)64-48(57(3,4)5)54(73)66-32-41-24-16-15-23-40(41)30-46(66)53(72)68(47(34-76-11)39-21-13-12-14-22-39)35-59(28-29-59)56(75)62-42-31-45(52(71)63-44-27-19-25-38-20-17-18-26-43(38)44)67(33-42)55(74)49(58(6,7)8)65-51(70)37(2)61-10/h12-18,20-24,26,36-37,42,44-49,60-61H,19,25,27-35H2,1-11H3,(H,62,75)(H,63,71)(H,64,69)(H,65,70)/t36-,37-,42?,44?,45-,46?,47-,48+,49+/m0/s1 PIHSUMCMZMLTFD-SJEOLFCRSA-N 312127 US9603889, Example 38 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 60.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312127&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106635 383539113 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600088 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1cccc(CN([C@@H](COC)c2ccccc2)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)c1)C(C)(C)C InChI=1S/C62H83N9O8/c1-38(63-9)54(72)67-52(61(3,4)5)59(77)70-35-45-26-16-15-25-43(45)32-50(70)58(76)69(51(37-79-11)42-23-13-12-14-24-42)34-40-21-19-28-44(31-40)56(74)65-46-33-49(57(75)66-48-30-20-27-41-22-17-18-29-47(41)48)71(36-46)60(78)53(62(6,7)8)68-55(73)39(2)64-10/h12-19,21-26,28-29,31,38-39,46,48-53,63-64H,20,27,30,32-37H2,1-11H3,(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t38-,39-,46?,48?,49-,50-,51-,52+,53+/m0/s1 CVLUVKNSLZDXBF-HSBWPWBRSA-N 312128 US9603889, Example 39 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 80.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312128&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106636 383539114 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600090 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)CN([C@@H](COC)c1ccccc1)C(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(C)(C)C InChI=1S/C56H79N9O8/c1-34(57-9)49(67)61-47(55(3,4)5)53(71)63-30-39-24-16-15-23-38(39)28-44(63)52(70)65(45(33-73-11)37-21-13-12-14-22-37)32-46(66)59-40-29-43(51(69)60-42-27-19-25-36-20-17-18-26-41(36)42)64(31-40)54(72)48(56(6,7)8)62-50(68)35(2)58-10/h12-18,20-24,26,34-35,40,42-45,47-48,57-58H,19,25,27-33H2,1-11H3,(H,59,66)(H,60,69)(H,61,67)(H,62,68)/t34-,35-,40?,42?,43-,44-,45-,47+,48+/m0/s1 ANVSTNUPBVSCPB-NUGPNQOBSA-N 312129 US9603889, Example 40 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 60.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312129&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106637 383539115 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600092 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)CCCN([C@H](C)c1ccccc1F)C(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(C)(C)C InChI=1S/C57H80FN9O7/c1-34(59-10)50(69)63-48(56(4,5)6)54(73)66-32-39-22-13-12-21-38(39)30-46(66)53(72)65(36(3)41-24-16-17-26-43(41)58)29-19-28-47(68)61-40-31-45(52(71)62-44-27-18-23-37-20-14-15-25-42(37)44)67(33-40)55(74)49(57(7,8)9)64-51(70)35(2)60-11/h12-17,20-22,24-26,34-36,40,44-46,48-49,59-60H,18-19,23,27-33H2,1-11H3,(H,61,68)(H,62,71)(H,63,69)(H,64,70)/t34-,35-,36+,40?,44?,45-,46-,48+,49+/m0/s1 WXMJSBVKFBYMQY-GTMMZRPLSA-N 312130 US9603889, Example 41 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 60.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312130&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106638 383539116 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600094 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)C1CC1CN([C@H](C)c1ccccc1F)C(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(C)(C)C InChI=1S/C58H80FN9O7/c1-33(60-10)50(69)64-48(57(4,5)6)55(74)67-30-38-21-13-12-20-37(38)28-47(67)54(73)66(35(3)41-23-16-17-25-44(41)59)31-39-27-43(39)52(71)62-40-29-46(53(72)63-45-26-18-22-36-19-14-15-24-42(36)45)68(32-40)56(75)49(58(7,8)9)65-51(70)34(2)61-11/h12-17,19-21,23-25,33-35,39-40,43,45-49,60-61H,18,22,26-32H2,1-11H3,(H,62,71)(H,63,72)(H,64,69)(H,65,70)/t33-,34-,35+,39?,40?,43?,45?,46-,47-,48+,49+/m0/s1 GBSDPUWDHRVCLO-UZWRGSAHSA-N 312131 US9603889, Example 42 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 70.0 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312131&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106639 383539117 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 600096 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)C1(CN([C@H](C)c2cccc(F)c2F)C(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)CC1)C(C)(C)C InChI=1S/C58H79F2N9O7/c1-33(61-10)49(70)65-47(56(4,5)6)53(74)67-30-38-20-13-12-19-37(38)28-45(67)52(73)69(35(3)40-23-17-24-42(59)46(40)60)32-58(26-27-58)55(76)63-39-29-44(51(72)64-43-25-16-21-36-18-14-15-22-41(36)43)68(31-39)54(75)48(57(7,8)9)66-50(71)34(2)62-11/h12-15,17-20,22-24,33-35,39,43-45,47-48,61-62H,16,21,25-32H2,1-11H3,(H,63,76)(H,64,72)(H,65,70)(H,66,71)/t33-,34-,35+,39?,43?,44-,45-,47+,48+/m0/s1 GJURNFNFVYYRMJ-WQFGBWTFSA-N 312132 US9603889, Example 43 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 180 US Patent 10.7270/Q2C53NXV aid1796360 US9603889 Kim, KS; Zhang, L; Wei, DD Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312132&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106640 383539118 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603721 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@@H]2[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](Cc1ccc(OCc3cn(nn3)[C@@H]3CCN([C@@H]3C(=O)N[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@@H](Cc3ccc(OCc4cn2nn4)cc3)C(O)=O)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(O)=O)C(C)(C)C InChI=1S/C80H96N16O14/c1-45(81-9)69(97)87-67(79(3,4)5)75(103)93-33-31-63-65(93)73(101)83-59(39-49-19-25-51-15-11-13-17-53(51)35-49)71(99)85-61(77(105)106)37-47-23-29-58(30-24-47)110-44-56-42-96(92-90-56)64-32-34-94(76(104)68(80(6,7)8)88-70(98)46(2)82-10)66(64)74(102)84-60(40-50-20-26-52-16-12-14-18-54(52)36-50)72(100)86-62(78(107)108)38-48-21-27-57(28-22-48)109-43-55-41-95(63)91-89-55/h11-30,35-36,41-42,45-46,59-68,81-82H,31-34,37-40,43-44H2,1-10H3,(H,83,101)(H,84,102)(H,85,99)(H,86,100)(H,87,97)(H,88,98)(H,105,106)(H,107,108)/t45-,46-,59-,60-,61-,62-,63+,64+,65-,66-,67+,68+/m0/s1 MBKNBOLIPVRUSC-YZMHPAFASA-N 312966 US9605022, Example 1 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 4.90 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312966 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312966&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 90155550 383539915 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603723 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@H]2OCc3cn(CC[C@@H](NC(=O)[C@H](Cc4ccc5ccccc5c4)NC(=O)[C@@H]4[C@@H](CCN4C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)OCc4cn(CC[C@@H](NC(=O)[C@H](Cc5ccc6ccccc6c5)NC(=O)[C@@H]12)C(O)=O)nn4)C(O)=O)nn3)C(C)(C)C InChI=1S/C70H92N16O14/c1-39(71-9)59(87)77-57(69(3,4)5)65(93)85-29-25-53-55(85)63(91)75-51(33-41-19-21-43-15-11-13-17-45(43)31-41)61(89)73-49(67(95)96)23-28-84-36-48(80-82-84)38-100-54-26-30-86(66(94)58(70(6,7)8)78-60(88)40(2)72-10)56(54)64(92)76-52(34-42-20-22-44-16-12-14-18-46(44)32-42)62(90)74-50(68(97)98)24-27-83-35-47(37-99-53)79-81-83/h11-22,31-32,35-36,39-40,49-58,71-72H,23-30,33-34,37-38H2,1-10H3,(H,73,89)(H,74,90)(H,75,91)(H,76,92)(H,77,87)(H,78,88)(H,95,96)(H,97,98)/t39-,40-,49+,50+,51-,52-,53+,54+,55-,56-,57+,58+/m0/s1 FZGZIFOUNRXAQH-SXFVIKMQSA-N 312967 US9605022, Example 2 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 16.5 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312967 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312967&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118428895 383539916 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603725 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@H]2OCc3cn(CCC[C@@H](NC(=O)[C@H](Cc4ccc5ccccc5c4)NC(=O)[C@@H]4[C@@H](CCN4C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)OCc4cn(CCC[C@@H](NC(=O)[C@H](Cc5ccc6ccccc6c5)NC(=O)[C@@H]12)C(O)=O)nn4)C(O)=O)nn3)C(C)(C)C InChI=1S/C72H96N16O14/c1-41(73-9)61(89)79-59(71(3,4)5)67(95)87-31-27-55-57(87)65(93)77-53(35-43-23-25-45-17-11-13-19-47(45)33-43)63(91)75-51(69(97)98)21-15-30-86-38-50(82-84-86)40-102-56-28-32-88(68(96)60(72(6,7)8)80-62(90)42(2)74-10)58(56)66(94)78-54(36-44-24-26-46-18-12-14-20-48(46)34-44)64(92)76-52(70(99)100)22-16-29-85-37-49(39-101-55)81-83-85/h11-14,17-20,23-26,33-34,37-38,41-42,51-60,73-74H,15-16,21-22,27-32,35-36,39-40H2,1-10H3,(H,75,91)(H,76,92)(H,77,93)(H,78,94)(H,79,89)(H,80,90)(H,97,98)(H,99,100)/t41-,42-,51+,52+,53-,54-,55+,56+,57-,58-,59+,60+/m0/s1 UZIAKDBFVNIMHM-AHKGGJCZSA-N 312968 US9605022, Example 3 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 1.90 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312968 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312968&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118429216 383539917 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603727 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@H]2OCc3cn(nn3)[C@@H](CCNC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@@H]3[C@@H](CCN3C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)OCc3cn(nn3)[C@@H](CCNC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@@H]12)C(O)=O)C(O)=O)C(C)(C)C InChI=1S/C70H92N16O14/c1-39(71-9)59(87)77-57(69(3,4)5)65(93)83-29-25-53-55(83)63(91)75-49(33-41-19-21-43-15-11-13-17-45(43)31-41)61(89)73-27-23-52(68(97)98)86-36-48(80-82-86)38-100-54-26-30-84(66(94)58(70(6,7)8)78-60(88)40(2)72-10)56(54)64(92)76-50(34-42-20-22-44-16-12-14-18-46(44)32-42)62(90)74-28-24-51(67(95)96)85-35-47(37-99-53)79-81-85/h11-22,31-32,35-36,39-40,49-58,71-72H,23-30,33-34,37-38H2,1-10H3,(H,73,89)(H,74,90)(H,75,91)(H,76,92)(H,77,87)(H,78,88)(H,95,96)(H,97,98)/t39-,40-,49-,50-,51-,52-,53+,54+,55-,56-,57+,58+/m0/s1 SLDGGQPUIMOVMN-LUYVCQRVSA-N 312969 US9605022, Example 4 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 57.8 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312969 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312969&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118429237 383539918 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603729 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@H]2OCc3cn(nn3)[C@@H](CCCNC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@@H]3[C@@H](CCN3C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)OCc3cn(nn3)[C@@H](CCCNC(=O)[C@H](Cc3ccc4ccccc4c3)NC(=O)[C@@H]12)C(=O)NS(C)(=O)=O)C(=O)NS(C)(=O)=O)C(C)(C)C InChI=1S/C74H102N18O16S2/c1-43(75-9)63(93)81-61(73(3,4)5)71(101)89-33-29-57-59(89)69(99)79-53(37-45-25-27-47-19-13-15-21-49(47)35-45)65(95)77-31-17-23-56(68(98)86-110(12,105)106)92-40-52(84-88-92)42-108-58-30-34-90(72(102)62(74(6,7)8)82-64(94)44(2)76-10)60(58)70(100)80-54(38-46-26-28-48-20-14-16-22-50(48)36-46)66(96)78-32-18-24-55(67(97)85-109(11,103)104)91-39-51(41-107-57)83-87-91/h13-16,19-22,25-28,35-36,39-40,43-44,53-62,75-76H,17-18,23-24,29-34,37-38,41-42H2,1-12H3,(H,77,95)(H,78,96)(H,79,99)(H,80,100)(H,81,93)(H,82,94)(H,85,97)(H,86,98)/t43-,44-,53-,54-,55-,56-,57+,58+,59-,60-,61+,62+/m0/s1 FJGQHCYSBKZATB-ZSHHDKMESA-N 312970 US9605022, Example 5 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 51.0 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312970 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312970&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118429221 383539919 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603731 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@@H]2[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](Cc1ccc(OCc3cn(nn3)[C@@H]3CCN([C@@H]3C(=O)N[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@@H](Cc3ccc(OCc4cn2nn4)cc3)C(=O)OC)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(=O)NS(=O)(=O)C1CC1)C(C)(C)C InChI=1S/C84H103N17O15S/c1-48(85-9)73(102)91-71(83(3,4)5)80(109)98-36-34-67-69(98)78(107)88-63(42-52-20-26-54-16-12-14-18-56(54)38-52)75(104)87-65(77(106)95-117(112,113)62-32-33-62)40-50-22-28-60(29-23-50)115-46-58-44-101(97-93-58)68-35-37-99(81(110)72(84(6,7)8)92-74(103)49(2)86-10)70(68)79(108)89-64(43-53-21-27-55-17-13-15-19-57(55)39-53)76(105)90-66(82(111)114-11)41-51-24-30-61(31-25-51)116-47-59-45-100(67)96-94-59/h12-31,38-39,44-45,48-49,62-72,85-86H,32-37,40-43,46-47H2,1-11H3,(H,87,104)(H,88,107)(H,89,108)(H,90,105)(H,91,102)(H,92,103)(H,95,106)/t48-,49-,63-,64-,65-,66-,67+,68+,69-,70-,71+,72+/m0/s1 GUYDSOLIABCZFM-OEKHCWRBSA-N 312971 US9605022, Example 6 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 14.6 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312971 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312971&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118429189 383539920 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603733 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@@H]2[C@H]1[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](Cc1ccc(OCc3cn(nn3)[C@@H]3CCN([C@@H]3C(=O)C[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@@H](Cc3ccc(OCc4cn2nn4)cc3)C(=O)OC)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(O)=O)C(C)(C)C InChI=1S/C81H98N14O13/c1-47(82-9)72(97)86-70(80(3,4)5)76(101)92-34-32-65-68(92)62(39-52-21-27-54-17-13-15-19-56(54)37-52)75(100)84-63(78(103)104)40-49-22-28-60(29-23-49)108-46-59-44-95(91-89-59)66-33-35-93(77(102)71(81(6,7)8)87-73(98)48(2)83-10)69(66)67(96)42-57(38-51-20-26-53-16-12-14-18-55(53)36-51)74(99)85-64(79(105)106-11)41-50-24-30-61(31-25-50)107-45-58-43-94(65)90-88-58/h12-31,36-37,43-44,47-48,57,62-66,68-71,82-83H,32-35,38-42,45-46H2,1-11H3,(H,84,100)(H,85,99)(H,86,97)(H,87,98)(H,103,104)/t47-,48-,57+,62+,63-,64-,65+,66+,68+,69-,70+,71+/m0/s1 QTFUECSQPZFYEM-JQPLRMHWSA-N 312972 US9605022, Example 7 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 29.0 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312972 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312972&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106677 383539921 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603735 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@@H]2[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](Cc1ccc(OCc3cn(nn3)[C@@H]3CCN([C@@H]3C(=O)NC(=O)C[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@@H](Cc3ccc(OCc4cn2nn4)cc3)C(=O)NCc2cc(F)c(O)c(F)c2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(O)=O)C(C)(C)C InChI=1S/C89H103F2N17O15/c1-49(92-9)78(111)99-76(88(3,4)5)85(118)105-33-31-70-73(105)83(116)96-68(42-54-20-26-57-16-12-14-18-59(57)36-54)82(115)97-69(87(120)121)41-52-23-29-64(30-24-52)123-48-62-46-108(104-102-62)71-32-34-106(86(119)77(89(6,7)8)100-79(112)50(2)93-10)74(71)84(117)98-72(109)43-60(37-53-19-25-56-15-11-13-17-58(56)35-53)80(113)95-67(81(114)94-44-55-38-65(90)75(110)66(91)39-55)40-51-21-27-63(28-22-51)122-47-61-45-107(70)103-101-61/h11-30,35-36,38-39,45-46,49-50,60,67-71,73-74,76-77,92-93,110H,31-34,37,40-44,47-48H2,1-10H3,(H,94,114)(H,95,113)(H,96,116)(H,97,115)(H,99,111)(H,100,112)(H,120,121)(H,98,109,117)/t49-,50-,60+,67-,68-,69-,70+,71+,73-,74-,76+,77+/m0/s1 NOVQMSAXBZDRHD-GRFCGMDYSA-N 312973 US9605022, Example 8 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 9.10 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312973&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106678 383539922 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603737 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@@H]2[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](Cc1ccc(OCc3cn(nn3)[C@@H]3CCN([C@@H]3C(=O)NC(=O)C[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@@H](Cc3ccc(OCc4cn2nn4)cc3)C(=O)NCc2cc(F)c(O)c(F)c2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(=O)OC)C(C)(C)C InChI=1S/C90H105F2N17O15/c1-50(93-9)79(112)100-77(89(3,4)5)86(119)106-34-32-71-74(106)84(117)97-69(43-55-21-27-58-17-13-15-19-60(58)37-55)83(116)98-70(88(121)122-11)42-53-24-30-65(31-25-53)124-49-63-47-109(105-103-63)72-33-35-107(87(120)78(90(6,7)8)101-80(113)51(2)94-10)75(72)85(118)99-73(110)44-61(38-54-20-26-57-16-12-14-18-59(57)36-54)81(114)96-68(82(115)95-45-56-39-66(91)76(111)67(92)40-56)41-52-22-28-64(29-23-52)123-48-62-46-108(71)104-102-62/h12-31,36-37,39-40,46-47,50-51,61,68-72,74-75,77-78,93-94,111H,32-35,38,41-45,48-49H2,1-11H3,(H,95,115)(H,96,114)(H,97,117)(H,98,116)(H,100,112)(H,101,113)(H,99,110,118)/t50-,51-,61+,68-,69-,70-,71+,72+,74-,75-,77+,78+/m0/s1 BAODQHPEQZHMBP-ZLUOGFKFSA-N 312975 US9605022, Example 9 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 13.9 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312975 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312975&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106679 383539924 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603739 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@@H]2[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](Cc1ccc(OCc3cn(nn3)[C@@H]3CCN([C@@H]3C(=O)N[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@@H](Cc3ccc(OCc4cn2nn4)cc3)C(=O)NS(=O)(=O)c2ccccn2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(O)=O)C(C)(C)C InChI=1S/C85H100N18O15S/c1-49(86-9)74(104)93-72(84(3,4)5)81(111)100-37-34-67-70(100)79(109)90-63(43-53-22-28-55-17-11-13-19-57(55)39-53)76(106)89-65(78(108)97-119(115,116)69-21-15-16-36-88-69)41-51-24-30-61(31-25-51)117-47-59-45-103(99-95-59)68-35-38-101(82(112)73(85(6,7)8)94-75(105)50(2)87-10)71(68)80(110)91-64(44-54-23-29-56-18-12-14-20-58(56)40-54)77(107)92-66(83(113)114)42-52-26-32-62(33-27-52)118-48-60-46-102(67)98-96-60/h11-33,36,39-40,45-46,49-50,63-68,70-73,86-87H,34-35,37-38,41-44,47-48H2,1-10H3,(H,89,106)(H,90,109)(H,91,110)(H,92,107)(H,93,104)(H,94,105)(H,97,108)(H,113,114)/t49-,50-,63-,64-,65-,66-,67+,68+,70-,71-,72+,73+/m0/s1 RHIZHSHCAUUNTD-MOPRESEOSA-N 312976 US9605022, Example 10 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 63.1 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312976 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312976&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118428898 383539925 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603741 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@@H]2[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](Cc1ccc(OCc3cn(nn3)[C@@H]3CCN([C@@H]3C(=O)N[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@@H](Cc3ccc(OCc4cn2nn4)cc3)C(=O)NS(=O)(=O)C2CC2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(O)=O)C(C)(C)C InChI=1S/C83H101N17O15S/c1-47(84-9)72(101)90-70(82(3,4)5)79(108)97-35-33-66-68(97)77(106)87-62(41-51-19-25-53-15-11-13-17-55(53)37-51)74(103)86-64(76(105)94-116(112,113)61-31-32-61)39-49-21-27-59(28-22-49)114-45-57-43-100(96-92-57)67-34-36-98(80(109)71(83(6,7)8)91-73(102)48(2)85-10)69(67)78(107)88-63(42-52-20-26-54-16-12-14-18-56(54)38-52)75(104)89-65(81(110)111)40-50-23-29-60(30-24-50)115-46-58-44-99(66)95-93-58/h11-30,37-38,43-44,47-48,61-71,84-85H,31-36,39-42,45-46H2,1-10H3,(H,86,103)(H,87,106)(H,88,107)(H,89,104)(H,90,101)(H,91,102)(H,94,105)(H,110,111)/t47-,48-,62-,63-,64-,65-,66+,67+,68-,69-,70+,71+/m0/s1 QTPJJORUJRBSTP-VVJSROEGSA-N 312977 US9605022, Example 11 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 10.3 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312977 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312977&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118429191 383539926 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603743 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@@H]2[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](Cc1ccc(OCc3cn(nn3)[C@@H]3CCN([C@@H]3C(=O)N[C@H](Cc3ccc4ccccc4c3)C(=O)N[C@@H](Cc3ccc(OCc4cn2nn4)cc3)C(=O)NS(=O)(=O)C2CC2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(O)=O)C(C)(C)C InChI=1S/C83H101N17O15S/c1-47(84-9)72(101)90-70(82(3,4)5)79(108)97-35-33-66-68(97)77(106)87-62(41-51-19-25-53-15-11-13-17-55(53)37-51)74(103)86-64(76(105)94-116(112,113)61-31-32-61)39-49-21-27-59(28-22-49)114-45-57-43-100(96-92-57)67-34-36-98(80(109)71(83(6,7)8)91-73(102)48(2)85-10)69(67)78(107)88-63(42-52-20-26-54-16-12-14-18-56(54)38-52)75(104)89-65(81(110)111)40-50-23-29-60(30-24-50)115-46-58-44-99(66)95-93-58/h11-30,37-38,43-44,47-48,61-71,84-85H,31-36,39-42,45-46H2,1-10H3,(H,86,103)(H,87,106)(H,88,107)(H,89,104)(H,90,101)(H,91,102)(H,94,105)(H,110,111)/t47-,48-,62+,63-,64-,65-,66+,67+,68-,69-,70+,71+/m0/s1 QTPJJORUJRBSTP-XCZJTPFPSA-N 312978 US9605022, Example 12 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 11.0 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312978 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312978&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118428897 383539927 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603745 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@@H]2[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](Cc1ccc(OCc3cn(nn3)[C@@H]3CCN([C@@H]3C(=O)NC(=O)C[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@@H](Cc3ccc(OCc4cn2nn4)cc3)C(=O)NCC[C@@H](O)C[C@@H](O)CC(O)=O)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(O)=O)C(C)(C)C InChI=1S/C89H111N17O18/c1-50(90-9)78(112)97-76(88(3,4)5)85(119)103-35-32-70-74(103)83(117)94-68(42-55-20-26-57-16-12-14-18-59(57)38-55)82(116)95-69(87(121)122)41-53-23-29-66(30-24-53)124-49-62-47-106(102-100-62)71-33-36-104(86(120)77(89(6,7)8)98-79(113)51(2)91-10)75(71)84(118)96-72(109)43-60(39-54-19-25-56-15-11-13-17-58(56)37-54)80(114)93-67(81(115)92-34-31-63(107)44-64(108)45-73(110)111)40-52-21-27-65(28-22-52)123-48-61-46-105(70)101-99-61/h11-30,37-38,46-47,50-51,60,63-64,67-71,74-77,90-91,107-108H,31-36,39-45,48-49H2,1-10H3,(H,92,115)(H,93,114)(H,94,117)(H,95,116)(H,97,112)(H,98,113)(H,110,111)(H,121,122)(H,96,109,118)/t50-,51-,60+,63+,64+,67-,68-,69-,70+,71+,74-,75-,76+,77+/m0/s1 BOHYEMVPKFXRSG-OPNQBICOSA-N 312979 US9605022, Example 13 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 12.8 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312979 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312979&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118428899 383539928 C03834 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603747 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@@H]2[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](Cc1ccc(OCc3cn(nn3)[C@@H]3CCN([C@@H]3C(=O)NC(=O)C[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@@H](Cc3ccc(OCc4cn2nn4)cc3)C(O)=O)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)c1n[nH]c(=O)o1)C(C)(C)C 312981 US9605022, Example 14 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 8.60 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312981 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312981&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106680 383539930 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603749 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@@H]2[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](Cc1ccc(OCc3cn(nn3)[C@@H]3CCN([C@@H]3C(=O)N[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@H](C(=O)OC)c3ccc(OCc4cn2nn4)cc3)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C#N)C(C)(C)C InChI=1S/C80H95N17O12/c1-46(82-9)70(98)88-68(79(3,4)5)76(104)94-34-32-63-66(94)74(102)85-61(39-49-20-24-51-16-12-14-18-54(51)36-49)72(100)84-56(41-81)38-48-22-28-59(29-23-48)108-44-57-42-96(92-90-57)64-33-35-95(77(105)69(80(6,7)8)89-71(99)47(2)83-10)67(64)75(103)86-62(40-50-21-25-52-17-13-15-19-55(52)37-50)73(101)87-65(78(106)107-11)53-26-30-60(31-27-53)109-45-58-43-97(63)93-91-58/h12-31,36-37,42-43,46-47,56,61-69,82-83H,32-35,38-40,44-45H2,1-11H3,(H,84,100)(H,85,102)(H,86,103)(H,87,101)(H,88,98)(H,89,99)/t46-,47-,56-,61-,62-,63+,64+,65-,66?,67-,68+,69+/m0/s1 SXCAQTAHLMDLNJ-KXFHBGLFSA-N 312982 US9605022, Example 15 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 1.90 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312982 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312982&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106681 383539931 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603751 COC(=O)[C@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H]2[C@@H](CCN2C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(C)(C)C)n2cc(COc3ccc(C[C@H](NC(=O)[C@H](Cc4ccc5ccccc5c4)NC(=O)[C@@H]4[C@@H](CCN4C(=O)[C@@H](NC(=O)[C@H](C)N(C)C(=O)OC(C)(C)C)C(C)(C)C)n4cc(COc5ccc1cc5)nn4)C#N)cc3)nn2 InChI=1S/C90H111N17O16/c1-52(102(15)85(117)122-89(9,10)11)76(108)96-74(87(3,4)5)82(114)104-40-38-69-72(104)80(112)93-67(45-55-26-30-57-22-18-20-24-60(57)42-55)78(110)92-62(47-91)44-54-28-34-65(35-29-54)120-50-63-48-106(100-98-63)70-39-41-105(83(115)75(88(6,7)8)97-77(109)53(2)103(16)86(118)123-90(12,13)14)73(70)81(113)94-68(46-56-27-31-58-23-19-21-25-61(58)43-56)79(111)95-71(84(116)119-17)59-32-36-66(37-33-59)121-51-64-49-107(69)101-99-64/h18-37,42-43,48-49,52-53,62,67-75H,38-41,44-46,50-51H2,1-17H3,(H,92,110)(H,93,112)(H,94,113)(H,95,111)(H,96,108)(H,97,109)/t52-,53-,62-,67-,68-,69+,70+,71-,72?,73-,74+,75+/m0/s1 AQTZITKPGZRNPV-GBSPMIQWSA-N 312987 US9605022, Example 16 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 4.40 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312987 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312987&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118428896 383539936 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603753 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@@H]2[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@H](Cc1ccc(OCc3cn(nn3)[C@@H]3CCN([C@@H]3C(=O)N[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@@H](Cc3ccc(OCc4cn2nn4)cc3)c2nc(=S)o[nH]2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(O)=O)C(C)(C)C 312988 US9605022, Example 17 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 3.20 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312988 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312988&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106682 383539937 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603756 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@@H]2[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@H](Cc1ccc(OCc3cn(nn3)[C@@H]3CCN([C@@H]3C(=O)N[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@@H](Cc3ccc(OCc4cn2nn4)cc3)c2nc(=O)o[nH]2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(O)=O)C(C)(C)C 312990 US9605022, Example 19 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 2.00 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312990 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312990&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106684 383539939 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 603758 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@@H]2[C@H]1C(=O)N[C@@H](Cc1ccc3ccccc3c1)C(=O)N[C@@H](Cc1ccc(OCc3cn(nn3)[C@@H]3CCN([C@@H]3C(=O)N[C@@H](Cc3ccc4ccccc4c3)C(=O)N[C@@H](Cc3ccc(OCc4cn2nn4)cc3)c2nc(=O)o[nH]2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(O)=O)C(C)(C)C 312991 US9605022, Example 20 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 10.1 US Patent 10.7270/Q2959KMN aid1796415 US9605022 Borzilleri, RM; Zhang, Y; Miller, M; Fraley, A Ensemble Therapeutics Corp http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=312991 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=312991&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138106685 383539940 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681568 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C63H82N10O8/c1-36(64-9)54(74)70-52(62(3,4)5)60(80)72-34-43-31-44(30-29-42(43)32-50(72)58(78)68-48-23-15-19-38-17-11-13-21-46(38)48)66-56(76)40-25-27-41(28-26-40)57(77)67-45-33-51(59(79)69-49-24-16-20-39-18-12-14-22-47(39)49)73(35-45)61(81)53(63(6,7)8)71-55(75)37(2)65-10/h11-14,17-18,21-22,25-31,36-37,45,48-53,64-65H,15-16,19-20,23-24,32-35H2,1-10H3,(H,66,76)(H,67,77)(H,68,78)(H,69,79)(H,70,74)(H,71,75)/t36-,37-,45-,48+,49+,50-,51-,52+,53+/m0/s1 MAKVXIUNQHYAPX-UPKUDDMJSA-N 50030280 CHEMBL3339214::US9783573, Example 10 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 23.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50030280 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50030280&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73506219 103939237 CHEMBL3339214 ZINC04556609 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681570 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC(C)c1ccccc1F)C(C)(C)C InChI=1S/C61H79FN10O8/c1-34(44-19-14-15-21-46(44)62)65-56(77)48-30-40-27-28-42(29-41(40)32-71(48)58(79)50(60(4,5)6)69-52(73)35(2)63-10)66-54(75)38-23-25-39(26-24-38)55(76)67-43-31-49(57(78)68-47-22-16-18-37-17-12-13-20-45(37)47)72(33-43)59(80)51(61(7,8)9)70-53(74)36(3)64-11/h12-15,17,19-21,23-29,34-36,43,47-51,63-64H,16,18,22,30-33H2,1-11H3,(H,65,77)(H,66,75)(H,67,76)(H,68,78)(H,69,73)(H,70,74)/t34?,35-,36-,43-,47?,48-,49-,50+,51+/m0/s1 PFUPNPPJJNJCGN-BWJQVGBUSA-N 345161 N1-((S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-3- (((R)-1-(2-fluorophenyl)ethyl)carbamoyl)- 1,2,3,4-tetrahydroisoquinolin-7-yl)-N4- ((3S,5S)-1-((S)-3,3-dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-5- (((R)-1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)terephthalamide::US9783573, Example 11 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 18.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345161 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345161&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118504449 385451224 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681572 CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)c3ccc(cc3)C(=O)Nc3ccc4C[C@H](N(Cc4c3)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC(C)c3ccccc3F)ccc2C[C@H]1C(=O)NC(C)c1ccccc1F)C(C)(C)C InChI=1S/C64H78F2N10O8/c1-35(47-17-13-15-19-49(47)65)69-59(81)51-31-41-25-27-45(29-43(41)33-75(51)61(83)53(63(5,6)7)73-55(77)37(3)67-11)71-57(79)39-21-23-40(24-22-39)58(80)72-46-28-26-42-32-52(60(82)70-36(2)48-18-14-16-20-50(48)66)76(34-44(42)30-46)62(84)54(64(8,9)10)74-56(78)38(4)68-12/h13-30,35-38,51-54,67-68H,31-34H2,1-12H3,(H,69,81)(H,70,82)(H,71,79)(H,72,80)(H,73,77)(H,74,78)/t35?,36?,37-,38-,51-,52-,53+,54+/m0/s1 HCIJWALQGPLBEB-XMVXTKETSA-N 345162 N1,N4-bis((S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-3- (((R)-1-(2-fluorophenyl)ethyl)carbamoyl)- 1,2,3,4-tetrahydroisoquinolin-7- yl)terephthalamide::US9783573, Example 12 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 130 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345162 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345162&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961776 385451225 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681574 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC(COC)c1ccccc1)C(C)(C)C InChI=1S/C62H82N10O9/c1-36(63-9)53(73)69-51(61(3,4)5)59(79)71-33-43-30-44(29-28-42(43)31-49(71)57(77)68-48(35-81-11)39-19-13-12-14-20-39)65-55(75)40-24-26-41(27-25-40)56(76)66-45-32-50(58(78)67-47-23-17-21-38-18-15-16-22-46(38)47)72(34-45)60(80)52(62(6,7)8)70-54(74)37(2)64-10/h12-16,18-20,22,24-30,36-37,45,47-52,63-64H,17,21,23,31-35H2,1-11H3,(H,65,75)(H,66,76)(H,67,78)(H,68,77)(H,69,73)(H,70,74)/t36-,37-,45-,47?,48?,49-,50-,51+,52+/m0/s1 BHASZCHHIQDISV-SMLDLAEESA-N 345163 N1-((S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-3- (((R)-2-methoxy-1-phenylethyl)carbamoyl)- 1,2,3,4-tetrahydroisoquinolin-7-yl)-N4- ((3S,5S)-1-((S)-3,3-dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-5- (((R)-1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)terephthalamide::US9783573, Example 13 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 12.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345163 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345163&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118504450 385451226 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681576 CN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)c3ccc(cc3)C(=O)Nc3ccc4C[C@H](N(Cc4c3)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC(COC)c3ccccc3)ccc2C[C@H]1C(=O)NC(COC)c1ccccc1)C(C)(C)C InChI=1S/C66H84N10O10/c1-39(67-9)57(77)73-55(65(3,4)5)63(83)75-35-47-31-49(29-27-45(47)33-53(75)61(81)71-51(37-85-11)41-19-15-13-16-20-41)69-59(79)43-23-25-44(26-24-43)60(80)70-50-30-28-46-34-54(62(82)72-52(38-86-12)42-21-17-14-18-22-42)76(36-48(46)32-50)64(84)56(66(6,7)8)74-58(78)40(2)68-10/h13-32,39-40,51-56,67-68H,33-38H2,1-12H3,(H,69,79)(H,70,80)(H,71,81)(H,72,82)(H,73,77)(H,74,78)/t39-,40-,51?,52?,53-,54-,55+,56+/m0/s1 XPTXHABMKLUTIY-KBAUTRCZSA-N 345164 N1,N4-bis((S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-3- (((R)-2-methoxy-1-phenylethyl)carbamoyl)- 1,2,3,4-tetrahydroisoquinolin-7- yl)terephthalamide::US9783573, Example 14 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 130 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345164 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345164&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961777 385451227 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681578 CC[C@H](NC)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)c3ccc(cc3)C(=O)N[C@H]3C[C@H](N(C3)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC3CCCc4ccccc34)ccc2C[C@H]1C(=O)NC1CCCc2ccccc12)C(C)(C)C InChI=1S/C64H84N10O8/c1-11-48(66-10)58(78)72-54(64(6,7)8)61(81)73-35-43-32-44(31-30-42(43)33-51(73)59(79)69-49-24-16-20-38-18-12-14-22-46(38)49)67-56(76)40-26-28-41(29-27-40)57(77)68-45-34-52(60(80)70-50-25-17-21-39-19-13-15-23-47(39)50)74(36-45)62(82)53(63(3,4)5)71-55(75)37(2)65-9/h12-15,18-19,22-23,26-32,37,45,48-54,65-66H,11,16-17,20-21,24-25,33-36H2,1-10H3,(H,67,76)(H,68,77)(H,69,79)(H,70,80)(H,71,75)(H,72,78)/t37-,45-,48-,49?,50?,51-,52-,53+,54+/m0/s1 WYXHJJMQPDPGGU-HTCNLZEBSA-N 345165 N1-((S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)butanamido)butanoyl)-3-(((R)- 1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)-1,2,3,4-tetrahydroisoquinolin- 7-yl)-N4-((3S,5S)-1-((S)-3,3-dimethyl-2-((S)- 2-(methylamino)propanamido)butanoyl)-5- (((R)-1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)terephthalamide::US9783573, Example 15 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 110 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345165 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345165&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118504451 385451228 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681580 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)C(F)(F)C(F)(F)C(F)(F)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC1CCCc2ccccc12)C(C)(C)C InChI=1S/C60H78F6N10O8/c1-32(67-9)48(77)73-46(56(3,4)5)52(81)75-30-37-27-38(26-25-36(37)28-44(75)50(79)71-42-23-15-19-34-17-11-13-21-40(34)42)69-54(83)58(61,62)60(65,66)59(63,64)55(84)70-39-29-45(51(80)72-43-24-16-20-35-18-12-14-22-41(35)43)76(31-39)53(82)47(57(6,7)8)74-49(78)33(2)68-10/h11-14,17-18,21-22,25-27,32-33,39,42-47,67-68H,15-16,19-20,23-24,28-31H2,1-10H3,(H,69,83)(H,70,84)(H,71,79)(H,72,80)(H,73,77)(H,74,78)/t32-,33-,39-,42?,43?,44-,45-,46+,47+/m0/s1 QPEYDHPWFLBNLA-PQZODOBESA-N 345166 US9783573, Example 16 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 120 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345166 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345166&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961778 385451229 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681582 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)C(F)(F)C(F)(F)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC1CCCc2ccccc12)C(C)(C)C InChI=1S/C59H78F4N10O8/c1-32(64-9)48(74)70-46(56(3,4)5)52(78)72-30-37-27-38(26-25-36(37)28-44(72)50(76)68-42-23-15-19-34-17-11-13-21-40(34)42)66-54(80)58(60,61)59(62,63)55(81)67-39-29-45(51(77)69-43-24-16-20-35-18-12-14-22-41(35)43)73(31-39)53(79)47(57(6,7)8)71-49(75)33(2)65-10/h11-14,17-18,21-22,25-27,32-33,39,42-47,64-65H,15-16,19-20,23-24,28-31H2,1-10H3,(H,66,80)(H,67,81)(H,68,76)(H,69,77)(H,70,74)(H,71,75)/t32-,33-,39-,42?,43?,44-,45-,46+,47+/m0/s1 KAHNQMZNNBFFEQ-PQZODOBESA-N 345167 US9783573, Example 17 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 56.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345167 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345167&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961779 385451230 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681584 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC1CCCc2ccccc12)C(C)(C)C InChI=1S/C56H78N10O7/c1-32(57-9)48(67)63-46(55(3,4)5)52(71)65-30-37-27-38(26-25-36(37)28-44(65)50(69)61-42-23-15-19-34-17-11-13-21-40(34)42)59-54(73)60-39-29-45(51(70)62-43-24-16-20-35-18-12-14-22-41(35)43)66(31-39)53(72)47(56(6,7)8)64-49(68)33(2)58-10/h11-14,17-18,21-22,25-27,32-33,39,42-47,57-58H,15-16,19-20,23-24,28-31H2,1-10H3,(H,61,69)(H,62,70)(H,63,67)(H,64,68)(H2,59,60,73)/t32-,33-,39-,42?,43?,44-,45-,46+,47+/m0/s1 HEUQZEJFJZTMAR-PQZODOBESA-N 345168 US9783573, Example 18 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 23.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345168 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345168&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961780 385451231 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681586 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)CNc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC1CCCc2ccccc12)C(C)(C)C InChI=1S/C57H80N10O7/c1-33(58-9)50(69)64-48(56(3,4)5)54(73)66-31-38-27-39(26-25-37(38)28-45(66)52(71)62-43-23-15-19-35-17-11-13-21-41(35)43)60-30-47(68)61-40-29-46(53(72)63-44-24-16-20-36-18-12-14-22-42(36)44)67(32-40)55(74)49(57(6,7)8)65-51(70)34(2)59-10/h11-14,17-18,21-22,25-27,33-34,40,43-46,48-49,58-60H,15-16,19-20,23-24,28-32H2,1-10H3,(H,61,68)(H,62,71)(H,63,72)(H,64,69)(H,65,70)/t33-,34-,40-,43?,44?,45-,46-,48+,49+/m0/s1 GPKBDHHTTCGIAO-QSPBPXMSSA-N 345169 US9783573, Example 19 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 81.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345169 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345169&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961781 385451232 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681588 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc2sc(NC(=O)c3ccc4C[C@H](N(Cc4c3)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC3CCCc4ccccc34)nc2c1)C(C)(C)C InChI=1S/C64H81N11O8S/c1-35(65-9)54(76)71-52(63(3,4)5)60(82)74-33-42-29-40(26-25-39(42)31-49(74)58(80)68-46-23-15-19-37-17-11-13-21-44(37)46)57(79)73-62-70-48-30-41(27-28-51(48)84-62)56(78)67-43-32-50(59(81)69-47-24-16-20-38-18-12-14-22-45(38)47)75(34-43)61(83)53(64(6,7)8)72-55(77)36(2)66-10/h11-14,17-18,21-22,25-30,35-36,43,46-47,49-50,52-53,65-66H,15-16,19-20,23-24,31-34H2,1-10H3,(H,67,78)(H,68,80)(H,69,81)(H,71,76)(H,72,77)(H,70,73,79)/t35-,36-,43-,46?,47?,49-,50-,52+,53+/m0/s1 SYZOGRWMVSXFBX-FLZZYPNDSA-N 345170 US9783573, Example 20 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 37.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345170&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961782 385451233 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681590 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1cnc(NC(=O)c2ccc3C[C@H](N(Cc3c2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]2CCCc3ccccc23)s1)C(C)(C)C InChI=1S/C60H79N11O8S/c1-33(61-9)50(72)67-48(59(3,4)5)56(78)70-31-39-27-38(26-25-37(39)28-45(70)53(75)65-43-23-15-19-35-17-11-13-21-41(35)43)52(74)69-58-63-30-47(80-58)55(77)64-40-29-46(54(76)66-44-24-16-20-36-18-12-14-22-42(36)44)71(32-40)57(79)49(60(6,7)8)68-51(73)34(2)62-10/h11-14,17-18,21-22,25-27,30,33-34,40,43-46,48-49,61-62H,15-16,19-20,23-24,28-29,31-32H2,1-10H3,(H,64,77)(H,65,75)(H,66,76)(H,67,72)(H,68,73)(H,63,69,74)/t33-,34-,40-,43+,44+,45-,46-,48+,49+/m0/s1 RJXWMKIKKCMBFT-QLYDQGARSA-N 345171 (S)-2-((S)-3,3-Dimethyl-2-((S)-2-(methylamino) propanamido)butanoyl)-N7-(5-(((3S,5S)-1-((S)-3,3- dimethyl-2-((S)-2-(methylamino)propanamido) butanoyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)carbamoyl)thiazol-2-yl)- N3-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4- tetrahydroisoquinoline-3,7-dicarboxamide::US9783573, Example 21 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 17.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345171 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345171&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73507095 385451234 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681592 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1coc(NC(=O)c2ccc3C[C@H](N(Cc3c2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]2CCCc3ccccc23)n1)C(C)(C)C InChI=1S/C60H79N11O9/c1-33(61-9)50(72)67-48(59(3,4)5)56(78)70-30-39-27-38(26-25-37(39)28-46(70)54(76)64-43-23-15-19-35-17-11-13-21-41(35)43)52(74)69-58-66-45(32-80-58)53(75)63-40-29-47(55(77)65-44-24-16-20-36-18-12-14-22-42(36)44)71(31-40)57(79)49(60(6,7)8)68-51(73)34(2)62-10/h11-14,17-18,21-22,25-27,32-34,40,43-44,46-49,61-62H,15-16,19-20,23-24,28-31H2,1-10H3,(H,63,75)(H,64,76)(H,65,77)(H,67,72)(H,68,73)(H,66,69,74)/t33-,34-,40-,43+,44+,46-,47-,48+,49+/m0/s1 WZONVNDJZGEOPI-FRSYPQKNSA-N 345172 (S)-2-((S)-3,3-Dimethyl-2-((S)-2-(methylamino) propanamido)butanoyl)-N7-(4-(((3S,5S)-1-((S)-3,3- dimethyl-2-((S)-2-(methylamino)propanamido) butanoyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)carbamoyl)oxazol-2-yl)- N3-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4- tetrahydroisoquinoline-3,7-dicarboxamide::US9783573, Example 22 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 14.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345172&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73507317 385451235 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681594 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1cnc(NC(=O)c2ccc3C[C@H](N(Cc3c2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]2CCCc3ccccc23)o1)C(C)(C)C InChI=1S/C60H79N11O9/c1-33(61-9)50(72)67-48(59(3,4)5)56(78)70-31-39-27-38(26-25-37(39)28-45(70)53(75)65-43-23-15-19-35-17-11-13-21-41(35)43)52(74)69-58-63-30-47(80-58)55(77)64-40-29-46(54(76)66-44-24-16-20-36-18-12-14-22-42(36)44)71(32-40)57(79)49(60(6,7)8)68-51(73)34(2)62-10/h11-14,17-18,21-22,25-27,30,33-34,40,43-46,48-49,61-62H,15-16,19-20,23-24,28-29,31-32H2,1-10H3,(H,64,77)(H,65,75)(H,66,76)(H,67,72)(H,68,73)(H,63,69,74)/t33-,34-,40-,43+,44+,45-,46-,48+,49+/m0/s1 VYZMHQWZWYAOIA-QLYDQGARSA-N 50030270 CHEMBL3339219::US9783573, Example 23 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 10.00 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50030270 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50030270&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73507318 313065766 CHEMBL3339219 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681596 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1cc2ccc(NC(=O)c3ccc4C[C@H](N(Cc4c3)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]3CCCc4ccccc34)cc2[nH]1)C(C)(C)C InChI=1S/C65H83N11O8/c1-36(66-9)56(77)73-54(64(3,4)5)62(83)75-34-43-29-42(26-25-40(43)31-52(75)60(81)71-48-23-15-19-38-17-11-13-21-46(38)48)58(79)68-44-28-27-41-30-51(70-50(41)32-44)59(80)69-45-33-53(61(82)72-49-24-16-20-39-18-12-14-22-47(39)49)76(35-45)63(84)55(65(6,7)8)74-57(78)37(2)67-10/h11-14,17-18,21-22,25-30,32,36-37,45,48-49,52-55,66-67,70H,15-16,19-20,23-24,31,33-35H2,1-10H3,(H,68,79)(H,69,80)(H,71,81)(H,72,82)(H,73,77)(H,74,78)/t36-,37-,45-,48+,49+,52-,53-,54+,55+/m0/s1 OZBQKKNFAFJMFT-VZMWKORWSA-N 345174 (S)-2-((S)-3,3-Dimethyl-2-((S)-2-(methylamino) propanamido)butanoyl)-N7-(2-(((3S,5S)-1-((S)-3,3- dimethyl-2-((S)-2-(methylamino)propanamido) butanoyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)carbamoyl)-1H-indol-6- yl)-N3-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4- tetrahydroisoquinoline-3,7-dicarboxamide::US9783573, Example 24 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 93.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345174&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497889 385451237 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681598 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(CNC(=O)c2ccc3C[C@H](N(Cc3c2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]2CCCc3ccccc23)nc1)C(C)(C)C InChI=1S/C63H83N11O8/c1-36(64-9)54(75)71-52(62(3,4)5)60(81)73-34-43-29-41(26-25-40(43)30-50(73)58(79)69-48-23-15-19-38-17-11-13-21-46(38)48)56(77)67-33-44-28-27-42(32-66-44)57(78)68-45-31-51(59(80)70-49-24-16-20-39-18-12-14-22-47(39)49)74(35-45)61(82)53(63(6,7)8)72-55(76)37(2)65-10/h11-14,17-18,21-22,25-29,32,36-37,45,48-53,64-65H,15-16,19-20,23-24,30-31,33-35H2,1-10H3,(H,67,77)(H,68,78)(H,69,79)(H,70,80)(H,71,75)(H,72,76)/t36-,37-,45-,48+,49+,50-,51-,52+,53+/m0/s1 XZJCEISXWHYZEG-UPKUDDMJSA-N 345175 (S)-2-((S)-3,3-Dimethyl-2-((S)-2-(methylamino) propanamido)butanoyl)-N7-((5-(((3S,5S)-1-((S)-3,3- dimethyl-2-((S)-2-(methylamino)propanamido) butanoyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)carbamoyl)pyridin-2- yl)methyl)-N3-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)- 1,2,3,4-tetrahydroisoquinoline-3,7-dicarboxamide::US9783573, Example 25 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 16.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345175 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345175&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73504105 385451238 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681600 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1cn2ncnc(NC(=O)c3ccc4C[C@H](N(Cc4c3)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]3CCCc4ccccc34)c2c1C)C(C)(C)C InChI=1S/C64H83N13O8/c1-35-46(58(81)69-43-30-50(60(83)71-48-25-17-21-39-19-13-15-23-45(39)48)76(32-43)62(85)53(64(7,8)9)73-56(79)37(3)66-11)33-77-51(35)54(67-34-68-77)74-57(80)41-27-26-40-29-49(59(82)70-47-24-16-20-38-18-12-14-22-44(38)47)75(31-42(40)28-41)61(84)52(63(4,5)6)72-55(78)36(2)65-10/h12-15,18-19,22-23,26-28,33-34,36-37,43,47-50,52-53,65-66H,16-17,20-21,24-25,29-32H2,1-11H3,(H,69,81)(H,70,82)(H,71,83)(H,72,78)(H,73,79)(H,67,68,74,80)/t36-,37-,43-,47+,48+,49-,50-,52+,53+/m0/s1 LVOPBJNMNTXXAB-XROZKOHISA-N 345176 (S)-2-((S)-3,3-Dimethyl-2-((S)-2-(methylamino) propanamido)butanoyl)-N7-(6-(((3S,5S)-1-((S)-3,3- dimethyl-2-((S)-2-(methylamino)propanamido) butanoyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)carbamoyl)-5- methylpyrrolo[2,1-f][1,2,4]triazin-4-yl)-N3-((R)- 1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4- tetrahydroisoquinoline-3,7-dicarboxamide::US9783573, Example 26 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 56.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345176 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345176&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497966 385451239 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681602 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(NC(=O)c2ccc3C[C@H](N(Cc3c2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC2CCCc3ccccc23)cc1)C(C)(C)C InChI=1S/C63H82N10O8/c1-36(64-9)54(74)70-52(62(3,4)5)60(80)72-34-43-31-42(26-25-41(43)32-50(72)58(78)68-48-23-15-19-38-17-11-13-21-46(38)48)57(77)66-44-29-27-40(28-30-44)56(76)67-45-33-51(59(79)69-49-24-16-20-39-18-12-14-22-47(39)49)73(35-45)61(81)53(63(6,7)8)71-55(75)37(2)65-10/h11-14,17-18,21-22,25-31,36-37,45,48-53,64-65H,15-16,19-20,23-24,32-35H2,1-10H3,(H,66,77)(H,67,76)(H,68,78)(H,69,79)(H,70,74)(H,71,75)/t36-,37-,45?,48?,49?,50-,51-,52+,53+/m0/s1 USERKMPOWCIHLQ-WTXFRZPCSA-N 345177 US9783573, Example 27 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 73.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345177 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345177&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961783 385451240 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681604 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)C1(CC1)NC(=O)c1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C60H82N10O8/c1-34(61-9)50(71)66-48(58(3,4)5)55(76)69-32-40-29-39(26-25-38(40)30-46(69)53(74)64-44-23-15-19-36-17-11-13-21-42(36)44)52(73)68-60(27-28-60)57(78)63-41-31-47(54(75)65-45-24-16-20-37-18-12-14-22-43(37)45)70(33-41)56(77)49(59(6,7)8)67-51(72)35(2)62-10/h11-14,17-18,21-22,25-26,29,34-35,41,44-49,61-62H,15-16,19-20,23-24,27-28,30-33H2,1-10H3,(H,63,78)(H,64,74)(H,65,75)(H,66,71)(H,67,72)(H,68,73)/t34-,35-,41-,44+,45+,46-,47-,48+,49+/m0/s1 UEANYVMOHVPPNC-LPWRHJBZSA-N 345178 (S)-2-((S)-3,3-Dimethyl-2-((S)-2-(methylamino) propanamido)butanoyl)-N7-(1-(((3S,5S)-1-((S)-3,3- dimethyl-2-((S)-2-(methylamino)propanamido) butanoyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)carbamoyl)cyclopropyl)- N3((R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1,2,3,4- tetrahydroisoquinoline-3,7-dicarboxamide::US9783573, Example 28 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 98.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345178&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73504106 385451241 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681606 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)C(C)(C)NC(=O)c1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C60H84N10O8/c1-34(61-11)50(71)66-48(58(3,4)5)55(76)69-32-40-29-39(28-27-38(40)30-46(69)53(74)64-44-25-17-21-36-19-13-15-23-42(36)44)52(73)68-60(9,10)57(78)63-41-31-47(54(75)65-45-26-18-22-37-20-14-16-24-43(37)45)70(33-41)56(77)49(59(6,7)8)67-51(72)35(2)62-12/h13-16,19-20,23-24,27-29,34-35,41,44-49,61-62H,17-18,21-22,25-26,30-33H2,1-12H3,(H,63,78)(H,64,74)(H,65,75)(H,66,71)(H,67,72)(H,68,73)/t34-,35-,41-,44+,45+,46-,47-,48+,49+/m0/s1 USRMQGZFCDUGRL-LPWRHJBZSA-N 345179 (S)-2-((S)-3,3-Dimethyl-2-((S)-2-(methylamino) propanamido)butanoyl)-N7-(1-(((3S,5S)-1-((S)-3,3- dimethyl-2-((S)-2-(methylamino)propanamido) butanoyl)-5-(((R)-1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)amino)-2-methyl-1- oxopropan-2-yl)-N3-((R)-1,2,3,4-tetrahydronaphthalen- 1-yl)-1,2,3,4-tetrahydroisoquinoline-3,7-dicarboxamide::US9783573, Example 29 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 61.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345179&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497878 385451242 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681608 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CO[C@@H]2CCN([C@@H](C2)C(=O)NC2CCCc3ccccc23)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C59H83N9O8/c1-35(60-9)51(69)65-49(58(3,4)5)56(74)67-30-29-42(32-48(67)55(73)64-46-24-16-20-39-18-12-14-22-44(39)46)76-34-37-25-27-40(28-26-37)53(71)62-41-31-47(54(72)63-45-23-15-19-38-17-11-13-21-43(38)45)68(33-41)57(75)50(59(6,7)8)66-52(70)36(2)61-10/h11-14,17-18,21-22,25-28,35-36,41-42,45-50,60-61H,15-16,19-20,23-24,29-34H2,1-10H3,(H,62,71)(H,63,72)(H,64,73)(H,65,69)(H,66,70)/t35-,36-,41?,42+,45?,46?,47-,48-,49+,50+/m0/s1 CPBUAUBYAKLKOK-HAHYJMHBSA-N 345180 US9783573, Example 30 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 38.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345180&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961784 385451243 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681610 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CNc2ccc3C[C@H](N(Cc3c2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC2CCCc3ccccc23)cc1)C(C)(C)C InChI=1S/C63H84N10O7/c1-37(64-9)55(74)70-53(62(3,4)5)60(79)72-35-44-31-45(30-29-43(44)32-51(72)58(77)68-49-23-15-19-40-17-11-13-21-47(40)49)66-34-39-25-27-42(28-26-39)57(76)67-46-33-52(59(78)69-50-24-16-20-41-18-12-14-22-48(41)50)73(36-46)61(80)54(63(6,7)8)71-56(75)38(2)65-10/h11-14,17-18,21-22,25-31,37-38,46,49-54,64-66H,15-16,19-20,23-24,32-36H2,1-10H3,(H,67,76)(H,68,77)(H,69,78)(H,70,74)(H,71,75)/t37-,38-,46?,49?,50?,51-,52-,53+,54+/m0/s1 FQDRXYPGOKPIKX-GKSNKUOISA-N 345181 US9783573, Example 31 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 71.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345181 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345181&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961785 385451244 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681612 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CN(C(C)=O)c2ccc3C[C@H](N(Cc3c2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC2CCCc3ccccc23)cc1)C(C)(C)C InChI=1S/C65H86N10O8/c1-38(66-10)57(77)71-55(64(4,5)6)62(82)74-36-46-32-48(31-30-45(46)33-53(74)60(80)69-51-24-16-20-42-18-12-14-22-49(42)51)73(40(3)76)35-41-26-28-44(29-27-41)59(79)68-47-34-54(61(81)70-52-25-17-21-43-19-13-15-23-50(43)52)75(37-47)63(83)56(65(7,8)9)72-58(78)39(2)67-11/h12-15,18-19,22-23,26-32,38-39,47,51-56,66-67H,16-17,20-21,24-25,33-37H2,1-11H3,(H,68,79)(H,69,80)(H,70,81)(H,71,77)(H,72,78)/t38-,39-,47?,51?,52?,53-,54-,55+,56+/m0/s1 SUSFWURNJMTUGZ-LOKLLDKISA-N 345182 US9783573, Example 32 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 35.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345182 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345182&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961786 385451245 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681614 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(CNc2ccc3C[C@H](N(Cc3c2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC2CCCc3ccccc23)c(Cl)c1)C(C)(C)C InChI=1S/C63H83ClN10O7/c1-36(65-9)55(75)71-53(62(3,4)5)60(80)73-34-43-29-44(28-27-40(43)31-51(73)58(78)69-49-23-15-19-38-17-11-13-21-46(38)49)67-33-42-26-25-41(30-48(42)64)57(77)68-45-32-52(59(79)70-50-24-16-20-39-18-12-14-22-47(39)50)74(35-45)61(81)54(63(6,7)8)72-56(76)37(2)66-10/h11-14,17-18,21-22,25-30,36-37,45,49-54,65-67H,15-16,19-20,23-24,31-35H2,1-10H3,(H,68,77)(H,69,78)(H,70,79)(H,71,75)(H,72,76)/t36-,37-,45?,49?,50?,51-,52-,53+,54+/m0/s1 XQSIBUBOFPOXKS-MKUNCAPJSA-N 345183 US9783573, Example 33 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 66.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345183&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961787 385451246 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681616 CCN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)c3ccc(cc3)C(=O)NC3CC(N(C3)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC3CCCc4ccccc34)ccc2CC1C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C64H84N10O8/c1-11-66-38(3)56(76)72-53(63(4,5)6)61(81)73-35-44-32-45(31-30-43(44)33-51(73)59(79)69-49-24-16-20-39-18-12-14-22-47(39)49)67-57(77)41-26-28-42(29-27-41)58(78)68-46-34-52(60(80)70-50-25-17-21-40-19-13-15-23-48(40)50)74(36-46)62(82)54(64(7,8)9)71-55(75)37(2)65-10/h12-15,18-19,22-23,26-32,37-38,46,49-54,65-66H,11,16-17,20-21,24-25,33-36H2,1-10H3,(H,67,77)(H,68,78)(H,69,79)(H,70,80)(H,71,75)(H,72,76)/t37-,38-,46?,49+,50?,51?,52?,53+,54+/m0/s1 FIHIJMZKMXZYNS-GEDFJSBOSA-N 345184 N1-((3S,5S)-1-((S)-3,3-dimethyl- 2-((S)-2-(methylamino) propanamido)butanoyl)-5-(((R)- 1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)-N4- ((S)-2-((S)-2-((S)-2-(ethylamino) propanamido)-3,3- dimethylbutanoyl)-3-(((R)- 1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)-1,2,3,4- tetrahydroisoquinolin-7- yl)terephthalamide::US9783573, Example 34 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 150 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345184 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345184&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961788 385451247 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681618 CCN[C@@H](C(C)C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)c3ccc(cc3)C(=O)NC3CC(N(C3)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC3CCCc4ccccc34)ccc2CC1C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C66H88N10O8/c1-12-68-54(38(2)3)62(82)74-56(66(8,9)10)63(83)75-36-45-33-46(32-31-44(45)34-52(75)60(80)71-50-25-17-21-40-19-13-15-23-48(40)50)69-58(78)42-27-29-43(30-28-42)59(79)70-47-35-53(61(81)72-51-26-18-22-41-20-14-16-24-49(41)51)76(37-47)64(84)55(65(5,6)7)73-57(77)39(4)67-11/h13-16,19-20,23-24,27-33,38-39,47,50-56,67-68H,12,17-18,21-22,25-26,34-37H2,1-11H3,(H,69,78)(H,70,79)(H,71,80)(H,72,81)(H,73,77)(H,74,82)/t39-,47?,50+,51?,52?,53?,54-,55+,56+/m0/s1 YNRMEYBKGZVJQF-PPQBKDOFSA-N 345185 N1-(3S,5S)-1-((S)-3,3-dimethyl- 2-((S)-2-(methylamino) propanamido)butanoyl)-5-(((R)- 1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)-N4- ((S)-2-((S)-3,3-dimethyl-2-((S)-3- methyl-2-(methylamino) butanamido)butanoyl)-3-(((R)- 1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)-1,2,3,4- tetrahydroisoquinolin-7- yl)terephthalamide::US9783573, Example 35 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 200 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345185 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345185&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961789 385451248 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681620 CCN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(NC(=O)c3ccc(cc3)C(=O)NC3CC(N(C3)C(=O)[C@@H](NC(=O)[C@@H](NC)C(C)C)C(C)(C)C)C(=O)NC3CCCc4ccccc34)ccc2CC1C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C66H88N10O8/c1-12-68-39(4)57(77)73-55(65(5,6)7)63(83)75-36-45-33-46(32-31-44(45)34-52(75)60(80)71-50-25-17-21-40-19-13-15-23-48(40)50)69-58(78)42-27-29-43(30-28-42)59(79)70-47-35-53(61(81)72-51-26-18-22-41-20-14-16-24-49(41)51)76(37-47)64(84)56(66(8,9)10)74-62(82)54(67-11)38(2)3/h13-16,19-20,23-24,27-33,38-39,47,50-56,67-68H,12,17-18,21-22,25-26,34-37H2,1-11H3,(H,69,78)(H,70,79)(H,71,80)(H,72,81)(H,73,77)(H,74,82)/t39-,47?,50+,51?,52?,53?,54-,55+,56+/m0/s1 JWXXLHIYUTWEMB-PPQBKDOFSA-N 345186 N1-((S)-2-((S)-3,3-dimethyl-2- ((S)-2-(methylamino) propanamido)butanoyl)-3-(((R)- 1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)-1,2,3,4- tetrahydroisoquinolin-7-yl)-N4- ((3S,5S)-1-((S)-3,3-dimethyl-2- ((S)-3-methyl-2-(methylamino) butanamido)butanoyl)-5-(((R)- 1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3- yl)terephthalamide::US9783573, Example 36 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 190 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345186 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345186&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961790 385451249 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681622 CN[C@@H](C)C(=O)N[C@H](C(=O)[C@@H]1CC(CN1C(=O)NC1CCCc2ccccc12)NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC1CCCc2ccccc12)C(C)(C)C InChI=1S/C65H88F6N10O8/c1-36(72-9)55(83)78-53(62(3,4)5)52(82)50-33-43(35-81(50)61(89)77-49-24-16-20-39-18-12-14-22-45(39)49)75-58(86)47(28-30-65(69,70)71)46(27-29-64(66,67)68)57(85)74-42-26-25-40-32-51(59(87)76-48-23-15-19-38-17-11-13-21-44(38)48)80(34-41(40)31-42)60(88)54(63(6,7)8)79-56(84)37(2)73-10/h11-14,17-18,21-22,25-26,31,36-37,43,46-51,53-54,72-73H,15-16,19-20,23-24,27-30,32-35H2,1-10H3,(H,74,85)(H,75,86)(H,76,87)(H,77,89)(H,78,83)(H,79,84)/t36-,37-,43?,46+,47-,48?,49?,50-,51-,53+,54+/m0/s1 QBLMRKIWHODMAB-FRNOIQALSA-N 345187 (2S,3R)-N1-((3S,5S)-5-((S)-3,3- dimethyl-2-((S)-2-(methylamino) propanamido)butanoyl)-1-(((R)- 1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)-N4- ((S)-2-((S)-3,3-dimethyl-2-((S)-2- (methylamino)propanamido) butanoyl)-3-(((R)-1,2,3,4- tetrahydronaphthalen-1- yl)carbamoyl)-1,2,3,4- tetrahydroisoquinolin-7-yl)-2,3- bis(3,3,3-trifluoropropyl) succinamide::US9783573, Example 37 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 110 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345187 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345187&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961791 385451250 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681624 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(COc2ccc3C[C@H](N(Cc3c2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]2CCCc3ccccc23)cc1)C(C)(C)C InChI=1S/C63H83N9O8/c1-37(64-9)55(73)69-53(62(3,4)5)60(78)71-34-44-31-46(30-29-43(44)32-51(71)58(76)67-49-23-15-19-40-17-11-13-21-47(40)49)80-36-39-25-27-42(28-26-39)57(75)66-45-33-52(59(77)68-50-24-16-20-41-18-12-14-22-48(41)50)72(35-45)61(79)54(63(6,7)8)70-56(74)38(2)65-10/h11-14,17-18,21-22,25-31,37-38,45,49-54,64-65H,15-16,19-20,23-24,32-36H2,1-10H3,(H,66,75)(H,67,76)(H,68,77)(H,69,73)(H,70,74)/t37-,38-,45-,49+,50+,51-,52-,53+,54+/m0/s1 PXWQVOUQYPMEME-NMZKVUILSA-N 50030278 CHEMBL3339215::US9783573, Example 38 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 45.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50030278 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50030278&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 90089727 103939235 CHEMBL3339215 ZINC84462635 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681626 CCN[C@@H](C)C(=O)N[C@H](C(=O)N1Cc2cc(OCc3ccc(cc3)C(=O)NC3C[C@H](N(C3)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC3CCCc4ccccc34)ccc2C[C@H]1C(=O)NC1CCCc2ccccc12)C(C)(C)C InChI=1S/C64H85N9O8/c1-11-66-39(3)57(75)71-54(63(4,5)6)61(79)72-35-45-32-47(31-30-44(45)33-52(72)59(77)68-50-24-16-20-41-18-12-14-22-48(41)50)81-37-40-26-28-43(29-27-40)58(76)67-46-34-53(60(78)69-51-25-17-21-42-19-13-15-23-49(42)51)73(36-46)62(80)55(64(7,8)9)70-56(74)38(2)65-10/h12-15,18-19,22-23,26-32,38-39,46,50-55,65-66H,11,16-17,20-21,24-25,33-37H2,1-10H3,(H,67,76)(H,68,77)(H,69,78)(H,70,74)(H,71,75)/t38-,39-,46?,50?,51?,52-,53-,54+,55+/m0/s1 VPAMYSJLSKIUHI-HLFGYZPVSA-N 345189 ((S)-7-((4-(((3S,5S)-1-((S)-3,3- Dimethyl-2-((S)-2-(methylamino) propanamido)butanoyl)-5-(((R)- 1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3- yl)carbamoyl)benzyl)oxy)-2-((S)- 2-((S)-2-(ethylamino) propanamido)-3,3- dimethylbutanoyl)-N-((R)-1,2,3,4- tetrahydronaphthalen-1-yl)- 1,2,3,4-tetrahydroisoquinoline-3- carboxamide::US9783573, Example 39 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 89.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345189&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961792 385451252 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681628 CCN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N1Cc2cc(OCc3ccc(cc3)C(=O)NC3CC(N(C3)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC3CCCc4ccccc34)ccc2CC1C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C)C(C)(C)C InChI=1S/C70H96N10O9/c1-14-72-42(3)61(82)76-57(68(4,5)6)65(86)78-59(70(10,11)12)66(87)79-38-48-35-50(34-33-47(48)36-55(79)63(84)74-53-27-19-23-44-21-15-17-25-51(44)53)89-40-43-29-31-46(32-30-43)62(83)73-49-37-56(64(85)75-54-28-20-24-45-22-16-18-26-52(45)54)80(39-49)67(88)58(69(7,8)9)77-60(81)41(2)71-13/h15-18,21-22,25-26,29-35,41-42,49,53-59,71-72H,14,19-20,23-24,27-28,36-40H2,1-13H3,(H,73,83)(H,74,84)(H,75,85)(H,76,82)(H,77,81)(H,78,86)/t41-,42-,49?,53+,54?,55?,56?,57+,58+,59+/m0/s1 KMBWECOKLHQPRE-TUPBNSROSA-N 345190 (S)-7-((4-(((3S,5S)-1-((S)-3,3- Dimethyl-2-((S)-2-(methylamino) propanamido)butanoyl)-5-(((R)- 1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3- yl)carbamoyl)benzyl)oxy)-2-((S)- 2-((S)-2-((S)-2-(ethylamino) propanamido)-3,3- dimethylbutanamido)-3,3- dimethylbutanoyl)-N-((R)-1,2,3,4- tetrahydronaphthalen-1-yl)- 1,2,3,4-tetrahydroisoquinoline-3- carboxamide::US9783573, Example 40 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 660 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345190&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961793 385451253 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681630 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(COc2ccc3CN([C@@H](Cc3c2)C(=O)NC2CCCc3ccccc23)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C63H83N9O8/c1-37(64-9)55(73)69-53(62(3,4)5)60(78)71-34-43-29-30-46(31-44(43)32-51(71)58(76)67-49-23-15-19-40-17-11-13-21-47(40)49)80-36-39-25-27-42(28-26-39)57(75)66-45-33-52(59(77)68-50-24-16-20-41-18-12-14-22-48(41)50)72(35-45)61(79)54(63(6,7)8)70-56(74)38(2)65-10/h11-14,17-18,21-22,25-31,37-38,45,49-54,64-65H,15-16,19-20,23-24,32-36H2,1-10H3,(H,66,75)(H,67,76)(H,68,77)(H,69,73)(H,70,74)/t37-,38-,45-,49?,50?,51-,52-,53+,54+/m0/s1 MHUDJHSFECRQLB-RHNBJTJLSA-N 345191 (S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido) butanoyl)-6-((4-(((3S,5S)-1-((S)- 3,3-dimethyl-2-((S)-2- (methylamino)propanamido) butanoyl)-5-(((R)-1,2,3,4- tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3- yl)carbamoyl)benzyl)oxy)-N-((R)- 1,2,3,4-tetrahydronaphthalen-1- yl)-1,2,3,4-tetrahydroisoquinoline- 3-carboxamide::US9783573, Example 41 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 65.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345191 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345191&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961794 385451254 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681632 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(COc2ccc3CN([C@H](Cc3c2)C(=O)NC2CCCc3ccccc23)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)cc1)C(C)(C)C InChI=1S/C63H83N9O8/c1-37(64-9)55(73)69-53(62(3,4)5)60(78)71-34-43-29-30-46(31-44(43)32-51(71)58(76)67-49-23-15-19-40-17-11-13-21-47(40)49)80-36-39-25-27-42(28-26-39)57(75)66-45-33-52(59(77)68-50-24-16-20-41-18-12-14-22-48(41)50)72(35-45)61(79)54(63(6,7)8)70-56(74)38(2)65-10/h11-14,17-18,21-22,25-31,37-38,45,49-54,64-65H,15-16,19-20,23-24,32-36H2,1-10H3,(H,66,75)(H,67,76)(H,68,77)(H,69,73)(H,70,74)/t37-,38-,45-,49?,50?,51+,52-,53+,54+/m0/s1 MHUDJHSFECRQLB-CUTNUHKBSA-N 345192 (R)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido) butanoyl)-6-((4-(((3S,5S)-1-((S)- 3,3-dimethyl-2-((5)-2- (methylamino)propanamido) butanoyl)-5-(((R)-1,2,3,4- tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3- yl)carbamoyl)benzyl)oxy)-N-((R)- 1,2,3,4-tetrahydronaphthalen-1- yl)-1,2,3,4-tetrahydroisoquinoline- 3-carboxamide::US9783573, Example 42 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 240 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345192 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345192&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961795 385451255 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681634 CC[C@H](NC)C(=O)N[C@H](C(=O)N1Cc2cc(OCc3ccc(cc3)C(=O)N[C@H]3C[C@H](N(C3)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]3CCCc4ccccc34)ccc2C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C64H85N9O8/c1-11-49(66-10)58(76)71-55(64(6,7)8)61(79)72-35-44-32-46(31-30-43(44)33-52(72)59(77)68-50-24-16-20-40-18-12-14-22-47(40)50)81-37-39-26-28-42(29-27-39)57(75)67-45-34-53(60(78)69-51-25-17-21-41-19-13-15-23-48(41)51)73(36-45)62(80)54(63(3,4)5)70-56(74)38(2)65-9/h12-15,18-19,22-23,26-32,38,45,49-55,65-66H,11,16-17,20-21,24-25,33-37H2,1-10H3,(H,67,75)(H,68,77)(H,69,78)(H,70,74)(H,71,76)/t38-,45-,49-,50+,51+,52-,53-,54+,55+/m0/s1 YLQHRUUGXBXOPC-NBHXLWSESA-N 345193 S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)butanamido) butanoyl)-7-((4-(((3S,5S)-1-((S)- 3,3-dimethyl-2-((S)-2- (methylamino)propanamido) butanoyl)-5-(((R)-1,2,3,4- tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3- yl)carbamoyl)benzyl)oxy)-N-((R)- 1,2,3,4-tetrahydronaphthalen-1- yl)-1,2,3,4-tetrahydroisoquinoline- 3-carboxamide::US9783573, Example 43 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 130 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345193 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345193&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497987 385451256 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681636 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C#Cc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C64H81N9O7/c1-38(65-9)56(74)70-54(63(3,4)5)61(79)72-36-46-33-41(29-32-45(46)34-52(72)59(77)68-50-23-15-19-42-17-11-13-21-48(42)50)26-25-40-27-30-44(31-28-40)58(76)67-47-35-53(60(78)69-51-24-16-20-43-18-12-14-22-49(43)51)73(37-47)62(80)55(64(6,7)8)71-57(75)39(2)66-10/h11-14,17-18,21-22,27-33,38-39,47,50-55,65-66H,15-16,19-20,23-24,34-37H2,1-10H3,(H,67,76)(H,68,77)(H,69,78)(H,70,74)(H,71,75)/t38-,39-,47-,50+,51+,52-,53-,54+,55+/m0/s1 MZOKCLGAIIRHDG-KHFWCYFCSA-N 50030275 CHEMBL3339216::US9783573, Example 44 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 130 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50030275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50030275&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 90089572 103939232 CHEMBL3339216 ZINC04475245 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681638 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(CCc2ccc3C[C@H](N(Cc3c2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]2CCCc3ccccc23)cc1)C(C)(C)C InChI=1S/C64H85N9O7/c1-38(65-9)56(74)70-54(63(3,4)5)61(79)72-36-46-33-41(29-32-45(46)34-52(72)59(77)68-50-23-15-19-42-17-11-13-21-48(42)50)26-25-40-27-30-44(31-28-40)58(76)67-47-35-53(60(78)69-51-24-16-20-43-18-12-14-22-49(43)51)73(37-47)62(80)55(64(6,7)8)71-57(75)39(2)66-10/h11-14,17-18,21-22,27-33,38-39,47,50-55,65-66H,15-16,19-20,23-26,34-37H2,1-10H3,(H,67,76)(H,68,77)(H,69,78)(H,70,74)(H,71,75)/t38-,39-,47-,50+,51+,52-,53-,54+,55+/m0/s1 MRQUIOMXZIGPPW-KHFWCYFCSA-N 50030273 CHEMBL3339217::US9783573, Example 45 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 89.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50030273 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50030273&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 90089737 103939230 CHEMBL3339217 ZINC34932074 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681640 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Oc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C63H81N9O9/c1-36(64-9)54(73)69-52(62(3,4)5)59(78)71-34-43-31-45(30-29-42(43)32-50(71)57(76)67-48-23-15-19-38-17-11-13-21-46(38)48)81-61(80)41-27-25-40(26-28-41)56(75)66-44-33-51(58(77)68-49-24-16-20-39-18-12-14-22-47(39)49)72(35-44)60(79)53(63(6,7)8)70-55(74)37(2)65-10/h11-14,17-18,21-22,25-31,36-37,44,48-53,64-65H,15-16,19-20,23-24,32-35H2,1-10H3,(H,66,75)(H,67,76)(H,68,77)(H,69,73)(H,70,74)/t36-,37-,44-,48+,49+,50-,51-,52+,53+/m0/s1 VCQYNJLUQOHBQN-RKYLDKKZSA-N 345196 US9783573, Example 46 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 69.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345196 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345196&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497931 385451259 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681642 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)OCc1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C63H83N9O8/c1-37(64-9)55(73)69-53(62(3,4)5)60(78)71-34-44-31-45(30-29-43(44)32-51(71)58(76)67-49-23-15-19-40-17-11-13-21-47(40)49)66-57(75)42-27-25-39(26-28-42)36-80-46-33-52(59(77)68-50-24-16-20-41-18-12-14-22-48(41)50)72(35-46)61(79)54(63(6,7)8)70-56(74)38(2)65-10/h11-14,17-18,21-22,25-31,37-38,46,49-54,64-65H,15-16,19-20,23-24,32-36H2,1-10H3,(H,66,75)(H,67,76)(H,68,77)(H,69,73)(H,70,74)/t37-,38-,46-,49+,50+,51-,52-,53+,54+/m0/s1 GBSJCHIETXINLY-AZDADDNRSA-N 345197 US9783573, Example 47 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 67.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345197 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345197&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 90089585 385451260 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681644 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)OCc1ccc(cc1)C(=O)Oc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C63H82N8O9/c1-37(64-9)55(72)68-53(62(3,4)5)59(76)70-34-44-31-45(30-29-43(44)32-51(70)57(74)66-49-23-15-19-40-17-11-13-21-47(40)49)80-61(78)42-27-25-39(26-28-42)36-79-46-33-52(58(75)67-50-24-16-20-41-18-12-14-22-48(41)50)71(35-46)60(77)54(63(6,7)8)69-56(73)38(2)65-10/h11-14,17-18,21-22,25-31,37-38,46,49-54,64-65H,15-16,19-20,23-24,32-36H2,1-10H3,(H,66,74)(H,67,75)(H,68,72)(H,69,73)/t37-,38-,46-,49+,50+,51-,52-,53+,54+/m0/s1 AHHUNRGEEKTKTO-AZDADDNRSA-N 345198 US9783573, Example 48 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 92.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345198 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345198&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 90089605 385451261 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681646 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)n1ccc2cc(ccc12)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)C(NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC1CCCc2ccccc12)C(C)(C)C InChI=1S/C65H83N11O8/c1-37(66-9)56(77)72-54(64(3,4)5)61(82)75-35-44-32-45(27-25-41(44)33-52(75)59(80)70-49-23-15-19-39-17-11-13-21-47(39)49)68-58(79)43-26-28-51-42(31-43)29-30-74(51)63(84)69-46-34-53(60(81)71-50-24-16-20-40-18-12-14-22-48(40)50)76(36-46)62(83)55(65(6,7)8)73-57(78)38(2)67-10/h11-14,17-18,21-22,25-32,37-38,46,49-50,52-55,66-67H,15-16,19-20,23-24,33-36H2,1-10H3,(H,68,79)(H,69,84)(H,70,80)(H,71,81)(H,72,77)(H,73,78)/t37-,38-,46?,49?,50?,52-,53-,54?,55+/m0/s1 VBRZVKNEYITVSY-IKKLWSPUSA-N 345199 US9783573, Example 49 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 51.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345199 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345199&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118507548 385451262 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681648 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)OCc1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@H](C)c1ccccc1F)C(C)(C)C InChI=1S/C61H80FN9O8/c1-35(45-19-14-15-21-47(45)62)65-56(75)49-30-41-27-28-43(29-42(41)32-70(49)58(77)51(60(4,5)6)68-53(72)36(2)63-10)66-55(74)40-25-23-38(24-26-40)34-79-44-31-50(57(76)67-48-22-16-18-39-17-12-13-20-46(39)48)71(33-44)59(78)52(61(7,8)9)69-54(73)37(3)64-11/h12-15,17,19-21,23-29,35-37,44,48-52,63-64H,16,18,22,30-34H2,1-11H3,(H,65,75)(H,66,74)(H,67,76)(H,68,72)(H,69,73)/t35-,36+,37+,44+,48-,49+,50+,51-,52-/m1/s1 VUUPAYFAZGRMOV-REEQQHIYSA-N 345200 (S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido) butanoyl)-7-(4-((((3S,5S)-1-((S)-3,3- dimethyl-2-((S)-2-(methylamino) propanamido)butanoyl)-5-(((R)- 1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3- yl)oxy)methyl)benzamido)-N-((R)-1- (2-fluorophenyl)ethyl)-1,2,3,4- tetrahydroisoquinoline-3-carboxamide::US9783573, Example 50 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 53.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345200 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345200&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497924 385451263 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681650 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)n1ccc2c(cccc12)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@H](C)c1ccccc1F)C(C)(C)C InChI=1S/C63H80FN11O8/c1-35(43-20-14-15-23-47(43)64)67-57(79)50-31-39-26-27-41(30-40(39)33-74(50)59(81)52(62(4,5)6)71-54(76)36(2)65-10)68-56(78)46-22-17-25-49-45(46)28-29-73(49)61(83)69-42-32-51(58(80)70-48-24-16-19-38-18-12-13-21-44(38)48)75(34-42)60(82)53(63(7,8)9)72-55(77)37(3)66-11/h12-15,17-18,20-23,25-30,35-37,42,48,50-53,65-66H,16,19,24,31-34H2,1-11H3,(H,67,79)(H,68,78)(H,69,83)(H,70,80)(H,71,76)(H,72,77)/t35-,36+,37+,42+,48-,50+,51+,52-,53-/m1/s1 UPEVLUWKTPBURK-JPIKSAQKSA-N 345201 N4-((S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido) butanoyl)-3-(((R)-1-(2- fluorophenyl)ethyl)carbamoyl)- 1,2,3,4-tetrahydroisoquinolin-7-yl)- N1-(3S,5S)-1-((S)-3,3-dimethyl-2- ((S)-2-(methylamino)propanamido) butanoyl)-5-(((R)-1,2,3,4- tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)-1H- indole-1,4-dicarboxamide::US9783573, Example 51 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 54.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345201 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345201&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118507521 385451264 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681652 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)OCc1cccc(c1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C63H83N9O8/c1-37(64-9)55(73)69-53(62(3,4)5)60(78)71-34-44-31-45(29-28-42(44)32-51(71)58(76)67-49-26-16-21-40-19-11-13-24-47(40)49)66-57(75)43-23-15-18-39(30-43)36-80-46-33-52(59(77)68-50-27-17-22-41-20-12-14-25-48(41)50)72(35-46)61(79)54(63(6,7)8)70-56(74)38(2)65-10/h11-15,18-20,23-25,28-31,37-38,46,49-54,64-65H,16-17,21-22,26-27,32-36H2,1-10H3,(H,66,75)(H,67,76)(H,68,77)(H,69,73)(H,70,74)/t37-,38-,46-,49+,50+,51-,52-,53+,54+/m0/s1 DPHNGGGFYKHOKV-AZDADDNRSA-N 345202 (S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido) butanoyl)-7-(3-((((3S,5S)-1-((S)-3,3- dimethyl-2-((S)-2-(methylamino) propanamido)butanoyl)-5-(((R)- 1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3- yl)oxy)methyl)benzamido)-N-((R)- 1,2,3,4-tetrahydronaphthalen-1-yl)- 1,2,3,4-tetrahydroisoquinoline-3- carboxamide::US9783573, Example 52 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 42.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345202 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345202&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497912 385451265 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681654 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)n1ccc2ccc(cc12)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC1CCCc2ccccc12)C(C)(C)C InChI=1S/C65H83N11O8/c1-37(66-9)56(77)72-54(64(3,4)5)61(82)75-35-44-31-45(28-27-42(44)32-52(75)59(80)70-49-23-15-19-39-17-11-13-21-47(39)49)68-58(79)43-26-25-41-29-30-74(51(41)33-43)63(84)69-46-34-53(60(81)71-50-24-16-20-40-18-12-14-22-48(40)50)76(36-46)62(83)55(65(6,7)8)73-57(78)38(2)67-10/h11-14,17-18,21-22,25-31,33,37-38,46,49-50,52-55,66-67H,15-16,19-20,23-24,32,34-36H2,1-10H3,(H,68,79)(H,69,84)(H,70,80)(H,71,81)(H,72,77)(H,73,78)/t37-,38-,46?,49?,50?,52-,53-,54+,55+/m0/s1 SAOLJERBTRGSIJ-OLLRURIWSA-N 345203 N6-((3S)-2-((S)-3,3-Dimethyl-2-((S)- 2-(methylamino)propanamido) butanoyl)-3-((1,2,3,4- tetrahydronaphthalen-1- yl)carbamoyl)-1,2,3,4- tetrahydroisoquinolin-7-yl)-N1-((5S)- 1-((S)-3,3-dimethyl-2-((S)-2- (methylamino)propanamido) butanoyl)-5-((1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl) pyrrolidin-3-yl)-1H-indole-1,6- dicarboxamide::US9783573, Example 53 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 140 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345203 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345203&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497948 385451266 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681656 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)n1ccc2c(cccc12)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC1CCCc2ccccc12)C(C)(C)C InChI=1S/C65H83N11O8/c1-37(66-9)56(77)72-54(64(3,4)5)61(82)75-35-42-32-43(29-28-41(42)33-52(75)59(80)70-49-25-15-20-39-18-11-13-22-45(39)49)68-58(79)48-24-17-27-51-47(48)30-31-74(51)63(84)69-44-34-53(60(81)71-50-26-16-21-40-19-12-14-23-46(40)50)76(36-44)62(83)55(65(6,7)8)73-57(78)38(2)67-10/h11-14,17-19,22-24,27-32,37-38,44,49-50,52-55,66-67H,15-16,20-21,25-26,33-36H2,1-10H3,(H,68,79)(H,69,84)(H,70,80)(H,71,81)(H,72,77)(H,73,78)/t37-,38-,44?,49?,50?,52-,53-,54+,55+/m0/s1 PSDYJXNDCNNPNS-FAHIUXGWSA-N 345204 N4-((S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido) butanoyl)-3-(((R)-1,2,3,4- tetrahydronaphthalen-1- yl)carbamoyl)-1,2,3,4- tetrahydroisoquinolin-7-yl)-N1- ((3S,5S)-1-((S)-3,3-dimethyl-2-((S)-2- (methylamino)propanamido) butanoyl)-5-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl) pyrrolidin-3-yl)-1H-indole-1,4- dicarboxamide::US9783573, Example 54 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 76.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345204 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345204&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961796 385451267 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681658 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)SC)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C63H82N10O8S/c1-36(64-8)54(74)70-52(62(3,4)5)60(80)73-35-45(33-51(73)59(79)69-49-24-16-20-39-18-12-14-22-47(39)49)67-57(77)41-27-25-40(26-28-41)56(76)66-44-30-29-42-32-50(58(78)68-48-23-15-19-38-17-11-13-21-46(38)48)72(34-43(42)31-44)61(81)53(63(6,7)82-10)71-55(75)37(2)65-9/h11-14,17-18,21-22,25-31,36-37,45,48-53,64-65H,15-16,19-20,23-24,32-35H2,1-10H3,(H,66,76)(H,67,77)(H,68,78)(H,69,79)(H,70,74)(H,71,75)/t36-,37-,45-,48+,49?,50-,51-,52+,53+/m0/s1 YTFWSFRCHZQCCT-GWLVDWJCSA-N 345205 US9783573, Example 55 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 9.00 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345205 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345205&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118504481 385451268 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681660 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](CC1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)SCCOC=O)C(=O)NC1CCCc2ccccc12)C(C)(C)C InChI=1S/C65H84N10O10S/c1-38(66-8)56(77)72-54(64(3,4)5)62(83)75-36-47(34-53(75)61(82)71-51-23-15-19-41-17-11-13-21-49(41)51)69-59(80)43-26-24-42(25-27-43)58(79)68-46-29-28-44-33-52(60(81)70-50-22-14-18-40-16-10-12-20-48(40)50)74(35-45(44)32-46)63(84)55(73-57(78)39(2)67-9)65(6,7)86-31-30-85-37-76/h10-13,16-17,20-21,24-29,32,37-39,47,50-55,66-67H,14-15,18-19,22-23,30-31,33-36H2,1-9H3,(H,68,79)(H,69,80)(H,70,81)(H,71,82)(H,72,77)(H,73,78)/t38-,39-,47-,50?,51+,52-,53?,54+,55+/m0/s1 HCNKRWOIEAHXFI-FDXINOCVSA-N 345206 US9783573, Example 56 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 17.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345206 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345206&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961797 385451269 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681662 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2CC(N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)SC)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C63H82N10O8S/c1-36(64-8)54(74)70-52(62(3,4)5)60(80)73-35-45(33-51(73)59(79)69-49-24-16-20-39-18-12-14-22-47(39)49)67-57(77)41-27-25-40(26-28-41)56(76)66-44-30-29-42-32-50(58(78)68-48-23-15-19-38-17-11-13-21-46(38)48)72(34-43(42)31-44)61(81)53(63(6,7)82-10)71-55(75)37(2)65-9/h11-14,17-18,21-22,25-31,36-37,45,48-53,64-65H,15-16,19-20,23-24,32-35H2,1-10H3,(H,66,76)(H,67,77)(H,68,78)(H,69,79)(H,70,74)(H,71,75)/t36-,37-,45?,48+,49?,50?,51-,52+,53+/m0/s1 YTFWSFRCHZQCCT-KZJFGPMPSA-N 345207 US9783573, Example 57 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 10.00 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345207 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345207&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961798 385451270 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681664 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2CC(N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)SCC(=O)N1CCCCC1)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C69H91N11O9S/c1-41(70-8)60(82)76-58(68(3,4)5)66(88)80-39-50(37-56(80)65(87)75-54-26-18-22-44-20-12-14-24-52(44)54)73-63(85)46-29-27-45(28-30-46)62(84)72-49-32-31-47-36-55(64(86)74-53-25-17-21-43-19-11-13-23-51(43)53)79(38-48(47)35-49)67(89)59(77-61(83)42(2)71-9)69(6,7)90-40-57(81)78-33-15-10-16-34-78/h11-14,19-20,23-24,27-32,35,41-42,50,53-56,58-59,70-71H,10,15-18,21-22,25-26,33-34,36-40H2,1-9H3,(H,72,84)(H,73,85)(H,74,86)(H,75,87)(H,76,82)(H,77,83)/t41-,42-,50?,53+,54?,55?,56-,58+,59+/m0/s1 YNCBSFFLUKZFNT-NUGMDYOPSA-N 345208 US9783573, Example 58 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 27.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345208 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345208&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961799 385451271 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681666 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(CC1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)SCC(=O)N(C)CCO)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C67H89N11O10S/c1-39(68-8)58(81)74-56(66(3,4)5)64(87)78-37-48(35-54(78)63(86)73-52-24-16-20-42-18-12-14-22-50(42)52)71-61(84)44-27-25-43(26-28-44)60(83)70-47-30-29-45-34-53(62(85)72-51-23-15-19-41-17-11-13-21-49(41)51)77(36-46(45)33-47)65(88)57(75-59(82)40(2)69-9)67(6,7)89-38-55(80)76(10)31-32-79/h11-14,17-18,21-22,25-30,33,39-40,48,51-54,56-57,68-69,79H,15-16,19-20,23-24,31-32,34-38H2,1-10H3,(H,70,83)(H,71,84)(H,72,85)(H,73,86)(H,74,81)(H,75,82)/t39-,40-,48?,51+,52+,53-,54?,56+,57+/m0/s1 HOXPJVQLJUWYQE-XDKVZQBKSA-N 345209 N1-((35,5S)-1-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-5-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)-N4- ((S)-2-((R)-3-((2-((2-hydroxyethyl)(methyl)amino)-2- oxoethyl)thio)-3-methyl-2-((S)-2- (methylamino)propanamido)butanoyl)-3-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4- tetrahydroisoquinolin-7-yl)terephthalamide::US9783573, Example 59 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 11.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345209&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497991 385451272 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681668 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)SCC(=O)Nc1nccs1)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C67H84N12O9S2/c1-38(68-8)57(81)76-55(66(3,4)5)63(87)79-36-47(34-53(79)62(86)74-51-23-15-19-41-17-11-13-21-49(41)51)72-60(84)43-26-24-42(25-27-43)59(83)71-46-29-28-44-33-52(61(85)73-50-22-14-18-40-16-10-12-20-48(40)50)78(35-45(44)32-46)64(88)56(77-58(82)39(2)69-9)67(6,7)90-37-54(80)75-65-70-30-31-89-65/h10-13,16-17,20-21,24-32,38-39,47,50-53,55-56,68-69H,14-15,18-19,22-23,33-37H2,1-9H3,(H,71,83)(H,72,84)(H,73,85)(H,74,86)(H,76,81)(H,77,82)(H,70,75,80)/t38-,39-,47-,50+,51+,52-,53-,55+,56+/m0/s1 JKWASYBHAGAHGC-YKAQSNEXSA-N 345210 N1-((3S,5S)-1-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-5-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)-N4- ((S)-2-((R)-3-methyl-2-((S)-2- (methylamino)propanamido)-3-((2-oxo-2-(thiazol-2- ylamino)ethyl)thio)butanoyl)-3-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4- tetrahydroisoquinolin-7-yl)terephthalamide::US9783573, Example 60 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 42.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345210&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497873 385451273 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681670 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)SCC(=O)N1CCOCC1)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C68H89N11O10S/c1-40(69-8)59(81)75-57(67(3,4)5)65(87)79-38-49(36-55(79)64(86)74-53-23-15-19-43-17-11-13-21-51(43)53)72-62(84)45-26-24-44(25-27-45)61(83)71-48-29-28-46-35-54(63(85)73-52-22-14-18-42-16-10-12-20-50(42)52)78(37-47(46)34-48)66(88)58(76-60(82)41(2)70-9)68(6,7)90-39-56(80)77-30-32-89-33-31-77/h10-13,16-17,20-21,24-29,34,40-41,49,52-55,57-58,69-70H,14-15,18-19,22-23,30-33,35-39H2,1-9H3,(H,71,83)(H,72,84)(H,73,85)(H,74,86)(H,75,81)(H,76,82)/t40-,41-,49-,52+,53+,54-,55-,57+,58+/m0/s1 YDEZHQRMNAFGIS-QMQHYHLESA-N 345211 N1-((3S,5S)-1-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-5-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)-N4- ((S)-2-((R)-3-methyl-2-((S)-2- (methylamino)propanamido)-3-((2-morpholino-2- oxoethyl)thio)butanoyl)-3-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4- tetrahydroisoquinolin-7-yl)terephthalamide::US9783573, Example 61 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 31.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345211&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497881 385451274 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681672 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)SCC(=O)N(C)Cc1cccc(F)c1)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C72H90FN11O9S/c1-42(74-8)63(86)80-61(71(3,4)5)69(92)84-40-53(37-59(84)68(91)79-57-27-17-22-46-20-12-14-25-55(46)57)77-66(89)48-30-28-47(29-31-48)65(88)76-52-33-32-49-36-58(67(90)78-56-26-16-21-45-19-11-13-24-54(45)56)83(39-50(49)35-52)70(93)62(81-64(87)43(2)75-9)72(6,7)94-41-60(85)82(10)38-44-18-15-23-51(73)34-44/h11-15,18-20,23-25,28-35,42-43,53,56-59,61-62,74-75H,16-17,21-22,26-27,36-41H2,1-10H3,(H,76,88)(H,77,89)(H,78,90)(H,79,91)(H,80,86)(H,81,87)/t42-,43-,53-,56+,57+,58-,59-,61+,62+/m0/s1 ZMQXLXRMSMAKBR-LRSPFSTISA-N 345212 N1-((3S,5S)-1-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-5-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)-N4- ((S)-2-((R)-3-((2-((3-fluorobenzyl)(methyl)amino)-2- oxoethyl)thio)-3-methyl-2-((S)-2- (methylamino)propanamido)butanoyl)-3-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4- tetrahydroisoquinolin-7-yl)terephthalamide::US9783573, Example 62 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 73.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345212&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497890 385451275 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681674 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)SCC(=O)NCCO)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C66H87N11O10S/c1-38(67-8)57(80)74-55(65(3,4)5)63(86)77-36-47(34-53(77)62(85)73-51-23-15-19-41-17-11-13-21-49(41)51)71-60(83)43-26-24-42(25-27-43)59(82)70-46-29-28-44-33-52(61(84)72-50-22-14-18-40-16-10-12-20-48(40)50)76(35-45(44)32-46)64(87)56(75-58(81)39(2)68-9)66(6,7)88-37-54(79)69-30-31-78/h10-13,16-17,20-21,24-29,32,38-39,47,50-53,55-56,67-68,78H,14-15,18-19,22-23,30-31,33-37H2,1-9H3,(H,69,79)(H,70,82)(H,71,83)(H,72,84)(H,73,85)(H,74,80)(H,75,81)/t38-,39-,47-,50+,51+,52-,53-,55+,56+/m0/s1 ZZHZZCRXBMIUEN-YKAQSNEXSA-N 345213 N1-((3S,5S)-1-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-5-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)-N4- ((S)-2-((R)-3-((2-((2-hydroxyethyl)amino)-2- oxoethyl)thio)-3-methyl-2-((S)-2- (methylamino)propanamido)butanoyl)-3-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4- tetrahydroisoquinolin-7-yl)terephthalamide::US9783573, Example 63 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 17.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345213&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497974 385451276 C04080 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681676 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)SCC(=O)N(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C66H87N11O9S/c1-38(67-8)57(79)73-55(65(3,4)5)63(85)77-36-47(34-53(77)62(84)72-51-25-17-21-41-19-13-15-23-49(41)51)70-60(82)43-28-26-42(27-29-43)59(81)69-46-31-30-44-33-52(61(83)71-50-24-16-20-40-18-12-14-22-48(40)50)76(35-45(44)32-46)64(86)56(74-58(80)39(2)68-9)66(6,7)87-37-54(78)75(10)11/h12-15,18-19,22-23,26-32,38-39,47,50-53,55-56,67-68H,16-17,20-21,24-25,33-37H2,1-11H3,(H,69,81)(H,70,82)(H,71,83)(H,72,84)(H,73,79)(H,74,80)/t38-,39-,47-,50+,51+,52-,53-,55+,56+/m0/s1 CJRHVCMFPZPWRZ-YKAQSNEXSA-N 345214 N1-((3S,5S)-1-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-5-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)-N4- ((S)-2-((R)-3-((2-(dimethylamino)-2-oxoethyl)thio)-3- methyl-2-((S)-2-(methylamino)propanamido)butanoyl)-3- (((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)- 1,2,3,4-tetrahydroisoquinolin-7-yl)terephthalamide::US9783573, Example 64 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 14.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345214&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497951 385451277 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681678 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)SCCO)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C64H84N10O9S/c1-37(65-8)55(76)71-53(63(3,4)5)61(82)74-36-46(34-52(74)60(81)70-50-23-15-19-40-17-11-13-21-48(40)50)68-58(79)42-26-24-41(25-27-42)57(78)67-45-29-28-43-33-51(59(80)69-49-22-14-18-39-16-10-12-20-47(39)49)73(35-44(43)32-45)62(83)54(64(6,7)84-31-30-75)72-56(77)38(2)66-9/h10-13,16-17,20-21,24-29,32,37-38,46,49-54,65-66,75H,14-15,18-19,22-23,30-31,33-36H2,1-9H3,(H,67,78)(H,68,79)(H,69,80)(H,70,81)(H,71,76)(H,72,77)/t37-,38-,46-,49+,50+,51-,52-,53+,54+/m0/s1 GRLIQJGBBZIQOE-AZDADDNRSA-N 345215 N1-((3S,5S)-1-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-5-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3-yl)-N4-((S)- 2-((R)-3-((2-hydroxyethyl)thio)-3-methyl-2-((S)-2- (methylamino)propanamido)butanoyl)-3-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4- tetrahydroisoquinolin-7-yl)terephthalamide::US9783573, Example 67 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 14.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345215&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497985 385451278 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681680 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)SCc1ncc(o1)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C70H91N11O9S/c1-40(71-11)60(82)78-58(69(6,7)8)66(88)81-38-49(35-55(81)65(87)77-53-26-18-22-43-20-14-16-24-51(43)53)75-63(85)45-29-27-44(28-30-45)62(84)74-48-32-31-46-34-54(64(86)76-52-25-17-21-42-19-13-15-23-50(42)52)80(37-47(46)33-48)67(89)59(79-61(83)41(2)72-12)70(9,10)91-39-57-73-36-56(90-57)68(3,4)5/h13-16,19-20,23-24,27-33,36,40-41,49,52-55,58-59,71-72H,17-18,21-22,25-26,34-35,37-39H2,1-12H3,(H,74,84)(H,75,85)(H,76,86)(H,77,87)(H,78,82)(H,79,83)/t40-,41-,49-,52+,53+,54-,55-,58+,59+/m0/s1 TYOLHRDURCGCEM-LOPOYFHOSA-N 345216 N1-((S)-2-((R)-3-(((5-(tert-Butyl)oxazol-2-yl)methyl)thio)-3- methyl-2-((S)-2-(methylamino)propanamido)butanoyl)-3- (((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4- tetrahydroisoquinolin-7-yl)-N4-((3S,5S)-1-((S)-3,3-dimethyl-2- ((S)-2-(methylamino)propanamido)butanoyl)-5-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3- yl)terephthalamide::US9783573, Example 68 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 260 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345216&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497982 385451279 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681550 CN[C@@H](C)C(=C)N[C@H](C(=O)C1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)CCC(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)NC1CCCc2ccccc12)C(C)(C)C InChI=1S/C61H85N9O7/c1-35(62-10)36(2)64-54(60(4,5)6)53(73)46-32-43(33-47(46)57(75)67-48-24-16-20-38-18-12-14-22-44(38)48)66-52(72)29-28-51(71)65-42-27-26-40-31-50(58(76)68-49-25-17-21-39-19-13-15-23-45(39)49)70(34-41(40)30-42)59(77)55(61(7,8)9)69-56(74)37(3)63-11/h12-15,18-19,22-23,26-27,30,35,37,43,46-50,54-55,62-64H,2,16-17,20-21,24-25,28-29,31-34H2,1,3-11H3,(H,65,71)(H,66,72)(H,67,75)(H,68,76)(H,69,74)/t35-,37-,43?,46?,47+,48?,49?,50-,54+,55+/m0/s1 JDWUZMFALDSKKW-NVSALGDVSA-N 345151 US9783573, Example 1 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 61.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345151 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345151&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961774 385451214 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681552 CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC(C[C@H]1C(=O)NC1CCCc2ccccc12)NC(=O)c1ccc(cc1)C(=O)Nc1ccc2CN([C@@H](Cc2c1)C(=O)NC1CCCc2ccccc12)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(C)(C)C InChI=1S/C63H82N10O8/c1-36(64-9)54(74)70-52(62(3,4)5)60(80)72-34-42-29-30-44(31-43(42)32-50(72)58(78)68-48-23-15-19-38-17-11-13-21-46(38)48)66-56(76)40-25-27-41(28-26-40)57(77)67-45-33-51(59(79)69-49-24-16-20-39-18-12-14-22-47(39)49)73(35-45)61(81)53(63(6,7)8)71-55(75)37(2)65-10/h11-14,17-18,21-22,25-31,36-37,45,48-53,64-65H,15-16,19-20,23-24,32-35H2,1-10H3,(H,66,76)(H,67,77)(H,68,78)(H,69,79)(H,70,74)(H,71,75)/t36-,37-,45?,48?,49?,50-,51-,52+,53+/m0/s1 FYVIFHYMHJYDBM-WTXFRZPCSA-N 345152 US9783573, Example 2 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 28.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345152&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 138961775 385451215 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681554 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)CCCC(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C60H84N10O8/c1-35(61-9)53(73)67-51(59(3,4)5)57(77)69-33-40-30-41(29-28-39(40)31-47(69)55(75)65-45-24-15-20-37-18-11-13-22-43(37)45)63-49(71)26-17-27-50(72)64-42-32-48(56(76)66-46-25-16-21-38-19-12-14-23-44(38)46)70(34-42)58(78)52(60(6,7)8)68-54(74)36(2)62-10/h11-14,18-19,22-23,28-30,35-36,42,45-48,51-52,61-62H,15-17,20-21,24-27,31-34H2,1-10H3,(H,63,71)(H,64,72)(H,65,75)(H,66,76)(H,67,73)(H,68,74)/t35-,36-,42-,45+,46+,47-,48-,51+,52+/m0/s1 NQARVPNPYPHNOD-MLOMWMBNSA-N 50071850 CHEMBL3410808::US9783573, Example 3 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 58.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071850&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497874 103965560 CHEMBL3410808 ZINC26639078 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681556 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)N(C(=O)C1(CC1)C(N)=O)c1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C60H82N10O8/c1-34(62-9)50(71)66-48(58(3,4)5)54(75)68-32-39-29-40(26-25-38(39)30-46(68)52(73)64-44-23-15-19-36-17-11-13-21-42(36)44)70(57(78)60(27-28-60)56(61)77)41-31-47(53(74)65-45-24-16-20-37-18-12-14-22-43(37)45)69(33-41)55(76)49(59(6,7)8)67-51(72)35(2)63-10/h11-14,17-18,21-22,25-26,29,34-35,41,44-49,62-63H,15-16,19-20,23-24,27-28,30-33H2,1-10H3,(H2,61,77)(H,64,73)(H,65,74)(H,66,71)(H,67,72)/t34-,35-,41-,44+,45+,46-,47-,48+,49+/m0/s1 LGPGGDOPUHMXKG-LPWRHJBZSA-N 345154 N-((S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-3-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4- tetrahydroisoquinolin-7-yl)-N-((3S,5S)-1-((S)-3,3- dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)- 5-(((R)-1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)cyclopropane-1,1- dicarboxamide::US9783573, Example 4 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 53.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345154 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345154&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497957 385451217 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681558 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)N(C(=O)C1(CCC1)C(N)=O)c1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C61H84N10O8/c1-35(63-9)51(72)67-49(59(3,4)5)55(76)69-33-40-30-41(27-26-39(40)31-47(69)53(74)65-45-24-15-20-37-18-11-13-22-43(37)45)71(58(79)61(57(62)78)28-17-29-61)42-32-48(54(75)66-46-25-16-21-38-19-12-14-23-44(38)46)70(34-42)56(77)50(60(6,7)8)68-52(73)36(2)64-10/h11-14,18-19,22-23,26-27,30,35-36,42,45-50,63-64H,15-17,20-21,24-25,28-29,31-34H2,1-10H3,(H2,62,78)(H,65,74)(H,66,75)(H,67,72)(H,68,73)/t35-,36-,42-,45+,46+,47-,48-,49+,50+/m0/s1 VORKKKQKFBVOFA-PRXWBPHPSA-N 345155 N-((S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-3-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4- tetrahydroisoquinolin-7-yl)-N-((3S,5S)-1-((S)-3,3- dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)- 5-(((R)-1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)cyclobutane-1,1- dicarboxamide::US9783573, Example 5 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 69.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345155 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345155&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 118497977 385451218 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681560 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C57H78N10O8/c1-32(58-9)48(68)64-46(56(3,4)5)54(74)66-30-37-27-38(26-25-36(37)28-44(66)50(70)62-42-23-15-19-34-17-11-13-21-40(34)42)60-52(72)53(73)61-39-29-45(51(71)63-43-24-16-20-35-18-12-14-22-41(35)43)67(31-39)55(75)47(57(6,7)8)65-49(69)33(2)59-10/h11-14,17-18,21-22,25-27,32-33,39,42-47,58-59H,15-16,19-20,23-24,28-31H2,1-10H3,(H,60,72)(H,61,73)(H,62,70)(H,63,71)(H,64,68)(H,65,69)/t32-,33-,39-,42+,43+,44-,45-,46+,47+/m0/s1 NZLKULFMTUXYTR-JSNDJGPMSA-N 50071821 CHEMBL3410872::US9783573, Example 6 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 16.0 US Patent 10.7270/Q24B33FH aid1797278 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50071821 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50071821&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73505798 103965531 CHEMBL3410872 ZINC00021732 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681562 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)C1CC2(C1)CC(C2)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C64H88N10O8/c1-36(65-9)54(75)71-52(62(3,4)5)60(81)73-34-41-27-44(26-25-40(41)28-50(73)58(79)69-48-23-15-19-38-17-11-13-21-46(38)48)67-56(77)42-30-64(31-42)32-43(33-64)57(78)68-45-29-51(59(80)70-49-24-16-20-39-18-12-14-22-47(39)49)74(35-45)61(82)53(63(6,7)8)72-55(76)37(2)66-10/h11-14,17-18,21-22,25-27,36-37,42-43,45,48-53,65-66H,15-16,19-20,23-24,28-35H2,1-10H3,(H,67,77)(H,68,78)(H,69,79)(H,70,80)(H,71,75)(H,72,76)/t36-,37-,42?,43?,45-,48+,49+,50-,51-,52+,53+,64?/m0/s1 SPBAFUFNQDTHRY-QDVJPDANSA-N 345157 N2-((S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-3-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)-1,2,3,4- tetrahydroisoquinolin-7-yl)-N6-((3S,5S)-1-((S)-3,3- dimethyl-2-((S)-2-(methylamino)propanamido)butanoyl)- 5-(((R)-1,2,3,4-tetrahydronaphthalen-1- yl)carbamoyl)pyrrolidin-3-yl)spiro[3.3]heptane-2,6- dicarboxamide::US9783573, Example 7 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 83.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345157 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345157&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73506005 385451220 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681564 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)c1ccc(CCC(=O)Nc2ccc3C[C@H](N(Cc3c2)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]2CCCc3ccccc23)cc1)C(C)(C)C InChI=1S/C65H86N10O8/c1-38(66-9)57(77)72-55(64(3,4)5)62(82)74-36-45-33-46(31-30-44(45)34-52(74)60(80)70-50-23-15-19-41-17-11-13-21-48(41)50)68-54(76)32-27-40-25-28-43(29-26-40)59(79)69-47-35-53(61(81)71-51-24-16-20-42-18-12-14-22-49(42)51)75(37-47)63(83)56(65(6,7)8)73-58(78)39(2)67-10/h11-14,17-18,21-22,25-26,28-31,33,38-39,47,50-53,55-56,66-67H,15-16,19-20,23-24,27,32,34-37H2,1-10H3,(H,68,76)(H,69,79)(H,70,80)(H,71,81)(H,72,77)(H,73,78)/t38-,39-,47-,50+,51+,52-,53-,55+,56+/m0/s1 KDEVTDVUTDFKMU-YKAQSNEXSA-N 345158 (S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-7-(3-(4-(((3S,5S)- 1-((S)-3,3-dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-5-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3- yl)carbamoyl)phenyl)propanamido)-N-((R)-1,2,3,4- tetrahydronaphthalen-1-yl)-1,2,3,4- tetrahydroisoquinoline-3-carboxamide::US9783573, Example 8 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 57.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345158 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345158&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73506006 385451221 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14 681566 CN[C@@H](C)C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)N[C@@H]1CCCc2ccccc12)NC(=O)CCc1ccc(cc1)C(=O)Nc1ccc2C[C@H](N(Cc2c1)C(=O)[C@@H](NC(=O)[C@H](C)NC)C(C)(C)C)C(=O)N[C@@H]1CCCc2ccccc12)C(C)(C)C InChI=1S/C65H86N10O8/c1-38(66-9)57(77)72-55(64(3,4)5)62(82)74-36-45-33-46(31-30-44(45)34-52(74)60(80)70-50-23-15-19-41-17-11-13-21-48(41)50)69-59(79)43-28-25-40(26-29-43)27-32-54(76)68-47-35-53(61(81)71-51-24-16-20-42-18-12-14-22-49(42)51)75(37-47)63(83)56(65(6,7)8)73-58(78)39(2)67-10/h11-14,17-18,21-22,25-26,28-31,33,38-39,47,50-53,55-56,66-67H,15-16,19-20,23-24,27,32,34-37H2,1-10H3,(H,68,76)(H,69,79)(H,70,80)(H,71,81)(H,72,77)(H,73,78)/t38-,39-,47-,50+,51+,52-,53-,55+,56+/m0/s1 HBAIJECFJKLGEI-YKAQSNEXSA-N 345159 (S)-2-((S)-3,3-Dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-7-(4-(3-(((3S,5S)- 1-((S)-3,3-dimethyl-2-((S)-2- (methylamino)propanamido)butanoyl)-5-(((R)-1,2,3,4- tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-3- yl)amino)-3-oxopropyl)benzamido)-N-((R)-1,2,3,4- tetrahydronaphthalen-1-yl)-1,2,3,4- tetrahydroisoquinoline-3-carboxamide::US9783573, Example 9 Baculoviral IAP repeat-containing protein 3/E3 ubiquitin-protein ligase XIAP 65.0 US Patent 10.7270/Q24B33FH aid1797277 US9783573 Borzilleri, RM; Kim, KS; Perez, HL; Stang, EM; Williams, DK; Zhang, L Bristol-Myers Squibb Co. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=345159 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=166&target=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=345159&enzyme=Baculoviral+IAP+repeat-containing+protein+3%2FE3+ubiquitin-protein+ligase+XIAP&column=ki&startPg=0&Increment=50&submit=Search 73506218 385451222 2 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS 2UVL,3EB5,3EB6,3M0A,3M0D,6HPR,7NK0 Baculoviral IAP repeat-containing protein 3 BIRC3_HUMAN Q13489 Q16628 Q9HC27 Q9UP46 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS 1F9X,1G3F,1G73,1I4O,1NW9,1TFQ,1TFT,2JK7,2KNA,2OPY,2OPZ,2POI,2POP,2QRA,2VSL,4HY0,4IC2,4MTZ,4OXC,5O6T,6GJW,6QCI,8AZA,8GH7 E3 ubiquitin-protein ligase XIAP XIAP_HUMAN P98170 D3DTF2 Q9NQ14