BindingDB Reactant_set_id Ligand SMILES Ligand InChI Ligand InChI Key BindingDB MonomerID BindingDB Ligand Name Target Name Target Source Organism According to Curator or DataSource Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) kon (M-1-s-1) koff (s-1) pH Temp (C) Curation/DataSource Article DOI BindingDB Entry DOI PMID PubChem AID Patent Number Authors Institution Link to Ligand in BindingDB Link to Target in BindingDB Link to Ligand-Target Pair in BindingDB Ligand HET ID in PDB PDB ID(s) for Ligand-Target Complex PubChem CID PubChem SID ChEBI ID of Ligand ChEMBL ID of Ligand DrugBank ID of Ligand IUPHAR_GRAC ID of Ligand KEGG ID of Ligand ZINC ID of Ligand Number of Protein Chains in Target (>1 implies a multichain complex) BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain BindingDB Target Chain Sequence PDB ID(s) of Target Chain UniProt (SwissProt) Recommended Name of Target Chain UniProt (SwissProt) Entry Name of Target Chain UniProt (SwissProt) Primary ID of Target Chain UniProt (SwissProt) Secondary ID(s) of Target Chain UniProt (SwissProt) Alternative ID(s) of Target Chain UniProt (TrEMBL) Submitted Name of Target Chain UniProt (TrEMBL) Entry Name of Target Chain UniProt (TrEMBL) Primary ID of Target Chain UniProt (TrEMBL) Secondary ID(s) of Target Chain UniProt (TrEMBL) Alternative ID(s) of Target Chain 51077167 Nc1nc(Nc2ccc(cc2)S(=O)(=O)NCCO)nc(OCC2CCCCC2)c1[N+](=O)[N-]C#N InChI=1S/C20H26N8O5S/c21-13-23-28(30)17-18(22)26-20(27-19(17)33-12-14-4-2-1-3-5-14)25-15-6-8-16(9-7-15)34(31,32)24-10-11-29/h6-9,14,24,29H,1-5,10-12H2,(H3,22,25,26,27)/b28-23- LWXURRMEKPTBNZ-NFFVHWSESA-N 50440473 CHEMBL2425904 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1550 ChEMBL 10.1016/j.ejmech.2013.07.031 10.7270/Q2ZW1NB0 23994326 Boschi, D; Tosco, P; Chandra, N; Chaurasia, S; Fruttero, R; Griffin, R; Wang, LZ; Gasco, A Universit£ degli Studi di Torino http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440473 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440473&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 72708421 175452790 CHEMBL2425904 ZINC96284200 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51077168 CNS(=O)(=O)c1ccc(Nc2nc(N)c(c(OCC3CCCCC3)n2)[N+](=O)[N-]C#N)cc1 InChI=1S/C19H24N8O4S/c1-22-32(29,30)15-9-7-14(8-10-15)24-19-25-17(21)16(27(28)23-12-20)18(26-19)31-11-13-5-3-2-4-6-13/h7-10,13,22H,2-6,11H2,1H3,(H3,21,24,25,26)/b27-23- KRCMSHILTUKGTA-VYIQYICTSA-N 50440474 CHEMBL2425903 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1500 ChEMBL 10.1016/j.ejmech.2013.07.031 10.7270/Q2ZW1NB0 23994326 Boschi, D; Tosco, P; Chandra, N; Chaurasia, S; Fruttero, R; Griffin, R; Wang, LZ; Gasco, A Universit£ degli Studi di Torino http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50440474 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50440474&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 72708420 175452791 CHEMBL2425903 ZINC96284201 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036796 Cc1nc2CCc3cnc(Nc4cccc(O)c4)nc3-c2s1 InChI=1S/C16H14N4OS/c1-9-18-13-6-5-10-8-17-16(20-14(10)15(13)22-9)19-11-3-2-4-12(21)7-11/h2-4,7-8,21H,5-6H2,1H3,(H,17,19,20) BHDMRJQKCJHJGQ-UHFFFAOYSA-N 50423756 CHEMBL611995 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 53 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423756 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423756&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11289869 164152631 CHEMBL611995 ZINC06744724 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036797 CN(C)c1ccc(Nc2ncc3CCc4nc(C)sc4-c3n2)cc1 InChI=1S/C18H19N5S/c1-11-20-15-9-4-12-10-19-18(22-16(12)17(15)24-11)21-13-5-7-14(8-6-13)23(2)3/h5-8,10H,4,9H2,1-3H3,(H,19,21,22) LQAKEBHLLHQRTR-UHFFFAOYSA-N 50423757 CHEMBL609915 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 60 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423757 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423757&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11163528 164152632 CHEMBL609915 ZINC06744728 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036802 Nc1nc2CCc3cnc(Nc4cccc(c4)[N+]([O-])=O)nc3-c2s1 InChI=1S/C15H12N6O2S/c16-14-19-11-5-4-8-7-17-15(20-12(8)13(11)24-14)18-9-2-1-3-10(6-9)21(22)23/h1-3,6-7H,4-5H2,(H2,16,19)(H,17,18,20) YARIHEYYGBAEDE-UHFFFAOYSA-N 50423754 CHEMBL598992 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 140 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423754 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423754&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11233090 164152629 CHEMBL598992 ZINC45366264 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036806 Cc1nc2CCc3cnc(Nc4ccc(O)cc4)nc3-c2s1 InChI=1S/C16H14N4OS/c1-9-18-13-7-2-10-8-17-16(20-14(10)15(13)22-9)19-11-3-5-12(21)6-4-11/h3-6,8,21H,2,7H2,1H3,(H,17,19,20) UZIOINNWQLHWHQ-UHFFFAOYSA-N 50423762 CHEMBL605635 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 300 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423762 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423762&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11266891 164152637 CHEMBL605635 ZINC06744727 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036811 CN(C)c1ccc(Nc2ncc3CCc4nc(N)sc4-c3n2)cc1 InChI=1S/C17H18N6S/c1-23(2)12-6-4-11(5-7-12)20-17-19-9-10-3-8-13-15(14(10)22-17)24-16(18)21-13/h4-7,9H,3,8H2,1-2H3,(H2,18,21)(H,19,20,22) UURXVIAFQIYUCN-UHFFFAOYSA-N 50423759 CHEMBL598166 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 500 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423759&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 45140951 164152634 CHEMBL598166 ZINC53193347 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036818 Cc1nc2CCc3cnc(Nc4cccc(c4)[N+]([O-])=O)nc3-c2s1 InChI=1S/C16H13N5O2S/c1-9-18-13-6-5-10-8-17-16(20-14(10)15(13)24-9)19-11-3-2-4-12(7-11)21(22)23/h2-4,7-8H,5-6H2,1H3,(H,17,19,20) ZLHUAMTYKCRXDR-UHFFFAOYSA-N 50423753 CHEMBL601064 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 790 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423753 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423753&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11163580 164152628 CHEMBL601064 ZINC06744721 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036820 Cc1nc2CCc3cnc(Nc4ccc(cc4)N4CCOCC4)nc3-c2s1 InChI=1S/C20H21N5OS/c1-13-22-17-7-2-14-12-21-20(24-18(14)19(17)27-13)23-15-3-5-16(6-4-15)25-8-10-26-11-9-25/h3-6,12H,2,7-11H2,1H3,(H,21,23,24) CZKOEIIINXNUJD-UHFFFAOYSA-N 50423764 CHEMBL598993 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1000 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423764 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423764&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11199830 164152639 CHEMBL598993 ZINC06744726 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036822 COc1ccc(Nc2ncc3CCc4nc(C)sc4-c3n2)cn1 InChI=1S/C16H15N5OS/c1-9-19-12-5-3-10-7-18-16(21-14(10)15(12)23-9)20-11-4-6-13(22-2)17-8-11/h4,6-8H,3,5H2,1-2H3,(H,18,20,21) JILRFQCHFBJCKL-UHFFFAOYSA-N 50423758 CHEMBL598994 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1100 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423758 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423758&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11381775 164152633 CHEMBL598994 ZINC06744731 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036823 Nc1nc2CCc3cnc(Nc4ccccc4)nc3-c2s1 InChI=1S/C15H13N5S/c16-14-19-11-7-6-9-8-17-15(20-12(9)13(11)21-14)18-10-4-2-1-3-5-10/h1-5,8H,6-7H2,(H2,16,19)(H,17,18,20) KVWXCLSLVYUBDG-UHFFFAOYSA-N 50423760 CHEMBL599804 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1200 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423760&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11266412 164152635 CHEMBL599804 ZINC45368864 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036825 Cc1nc2CCc3cnc(Nc4ccc(Cl)nc4)nc3-c2s1 InChI=1S/C15H12ClN5S/c1-8-19-11-4-2-9-6-18-15(21-13(9)14(11)22-8)20-10-3-5-12(16)17-7-10/h3,5-7H,2,4H2,1H3,(H,18,20,21) ANWMSXOBKGKAOJ-UHFFFAOYSA-N 50423755 CHEMBL609322 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1400 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423755&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11198278 164152630 CHEMBL609322 ZINC06744730 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036827 CN(c1cccc(c1)[N+]([O-])=O)c1ncc2CCc3nc(C)sc3-c2n1 InChI=1S/C17H15N5O2S/c1-10-19-14-7-6-11-9-18-17(20-15(11)16(14)25-10)21(2)12-4-3-5-13(8-12)22(23)24/h3-5,8-9H,6-7H2,1-2H3 VWRLUJJMDMLBIF-UHFFFAOYSA-N 50423768 CHEMBL606176 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1800 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423768 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423768&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11451037 164152643 CHEMBL606176 ZINC45392226 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036829 Cc1nc2CCc3cnc(Nc4ccccc4)nc3-c2s1 InChI=1S/C16H14N4S/c1-10-18-13-8-7-11-9-17-16(20-14(11)15(13)21-10)19-12-5-3-2-4-6-12/h2-6,9H,7-8H2,1H3,(H,17,19,20) XGCZPWOZBDACQN-UHFFFAOYSA-N 50423763 CHEMBL601705 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2200 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423763 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423763&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11150562 164152638 CHEMBL601705 ZINC38304257 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036832 Cc1nc2CCc3cnc(Nc4ccc(cc4)[N+]([O-])=O)nc3-c2s1 InChI=1S/C16H13N5O2S/c1-9-18-13-7-2-10-8-17-16(20-14(10)15(13)24-9)19-11-3-5-12(6-4-11)21(22)23/h3-6,8H,2,7H2,1H3,(H,17,19,20) QSFSXNZWOUTZCW-UHFFFAOYSA-N 50423761 CHEMBL599806 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 4800 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423761 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423761&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 45140949 164152636 CHEMBL599806 ZINC45368867 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036833 COC(=O)c1ccc(Nc2ncc3CCc4nc(C)sc4-c3n2)cc1 InChI=1S/C18H16N4O2S/c1-10-20-14-8-5-12-9-19-18(22-15(12)16(14)25-10)21-13-6-3-11(4-7-13)17(23)24-2/h3-4,6-7,9H,5,8H2,1-2H3,(H,19,21,22) SXTFKTKGQZLIBF-UHFFFAOYSA-N 50423765 CHEMBL601088 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 6300 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423765 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423765&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 45140950 164152640 CHEMBL601088 ZINC45368241 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036837 Cc1nc2CCc3cnc(Nc4ccc(cc4)C(F)(F)F)nc3-c2s1 InChI=1S/C17H13F3N4S/c1-9-22-13-7-2-10-8-21-16(24-14(10)15(13)25-9)23-12-5-3-11(4-6-12)17(18,19)20/h3-6,8H,2,7H2,1H3,(H,21,23,24) BFOWMTATJFCJBB-UHFFFAOYSA-N 50423766 CHEMBL599805 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423766 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423766&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11428427 164152641 CHEMBL599805 ZINC06744723 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036839 Cc1nc2CCc3cnc(N)nc3-c2s1 InChI=1S/C10H10N4S/c1-5-13-7-3-2-6-4-12-10(11)14-8(6)9(7)15-5/h4H,2-3H2,1H3,(H2,11,12,14) ZPMLSCOIBKNXNK-UHFFFAOYSA-N 50423770 CHEMBL611074 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423770 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423770&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11287415 164152645 CHEMBL611074 ZINC45394377 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036841 CN(c1cccc(c1)[N+]([O-])=O)c1ncc2ccc3nc(C)sc3c2n1 InChI=1S/C17H13N5O2S/c1-10-19-14-7-6-11-9-18-17(20-15(11)16(14)25-10)21(2)12-4-3-5-13(8-12)22(23)24/h3-9H,1-2H3 BUBBOLABRKMKTQ-UHFFFAOYSA-N 50423769 CHEMBL597359 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423769 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423769&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11268167 164152644 CHEMBL597359 ZINC34434225 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036843 Cc1nc2ccc3cnc(Nc4ccccc4)nc3c2s1 InChI=1S/C16H12N4S/c1-10-18-13-8-7-11-9-17-16(20-14(11)15(13)21-10)19-12-5-3-2-4-6-12/h2-9H,1H3,(H,17,19,20) DZTKJPVNRWPJLO-UHFFFAOYSA-N 50423767 CHEMBL591228 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423767 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423767&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11346863 164152642 CHEMBL591228 ZINC45337705 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036846 Cc1nc2ccc3cnc(NC(=O)c4ccccc4)nc3c2s1 InChI=1S/C17H12N4OS/c1-10-19-13-8-7-12-9-18-17(20-14(12)15(13)23-10)21-16(22)11-5-3-2-4-6-11/h2-9H,1H3,(H,18,20,21,22) WFIWNOLZWKHKDY-UHFFFAOYSA-N 50423771 CHEMBL602746 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423771 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423771&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 46233557 164152646 CHEMBL602746 ZINC45369807 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51036849 Cc1nc2ccc3cnc(NCc4ccccc4)nc3c2s1 InChI=1S/C17H14N4S/c1-11-20-14-8-7-13-10-19-17(21-15(13)16(14)22-11)18-9-12-5-3-2-4-6-12/h2-8,10H,9H2,1H3,(H,18,19,21) HFSDYNSZXRTUSU-UHFFFAOYSA-N 50423772 CHEMBL596953 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/jm901660c 10.7270/Q2377B0R 20146435 McIntyre, NA; McInnes, C; Griffiths, G; Barnett, AL; Kontopidis, G; Slawin, AM; Jackson, W; Thomas, M; Zheleva, DI; Wang, S; Blake, DG; Westwood, NJ; Fischer, PM University of St. Andrews http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50423772 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50423772&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 46233558 164152647 CHEMBL596953 ZINC45356319 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51057481 CC[C@@H](Nc1nc(NCc2cc(F)ccc2O)c2ncn(C(C)C)c2n1)C(C)O InChI=1S/C20H27FN6O2/c1-5-15(12(4)28)24-20-25-18(17-19(26-20)27(10-23-17)11(2)3)22-9-13-8-14(21)6-7-16(13)29/h6-8,10-12,15,28-29H,5,9H2,1-4H3,(H2,22,24,25,26)/t12?,15-/m1/s1 IJWWOTCVYMBYJL-WPZCJLIBSA-N 50431283 CHEMBL2347577 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 180 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431283 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431283&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71579250 164160158 CHEMBL2347577 ZINC95603314 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51057482 CC[C@@H](Nc1nc(NCc2cc(Cl)ccc2O)c2ncn(C(C)C)c2n1)C(C)O InChI=1S/C20H27ClN6O2/c1-5-15(12(4)28)24-20-25-18(17-19(26-20)27(10-23-17)11(2)3)22-9-13-8-14(21)6-7-16(13)29/h6-8,10-12,15,28-29H,5,9H2,1-4H3,(H2,22,24,25,26)/t12?,15-/m1/s1 FKSQALHWIWYQJQ-WPZCJLIBSA-N 50431284 CHEMBL2347575 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 97 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431284 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431284&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71579248 164160159 CHEMBL2347575 ZINC95605588 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51057483 CC(C)n1cnc2c(NCc3cc(Cl)ccc3O)nc(NCC(C)(C)O)nc12 InChI=1S/C19H25ClN6O2/c1-11(2)26-10-23-15-16(21-8-12-7-13(20)5-6-14(12)27)24-18(25-17(15)26)22-9-19(3,4)28/h5-7,10-11,27-28H,8-9H2,1-4H3,(H2,21,22,24,25) BGOFMMCRAMGKAI-UHFFFAOYSA-N 50431293 CHEMBL2347574 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 435 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431293 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431293&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71579247 164160168 CHEMBL2347574 ZINC95601027 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51057484 CC(C)n1cnc2c(NCc3cc(Cl)ccc3O)nc(NC3CCC(N)CC3)nc12 InChI=1S/C21H28ClN7O/c1-12(2)29-11-25-18-19(24-10-13-9-14(22)3-8-17(13)30)27-21(28-20(18)29)26-16-6-4-15(23)5-7-16/h3,8-9,11-12,15-16,30H,4-7,10,23H2,1-2H3,(H2,24,26,27,28) HZNHFNRGJQRTTG-UHFFFAOYSA-N 50431286 CHEMBL2349193 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 160 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431286&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 49838820 164160161 CHEMBL2349193 ZINC95602807 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51057485 CC(C)n1cnc2c(NCc3cc(Cl)ccc3O)nc(NC3CCC(O)CC3)nc12 InChI=1S/C21H27ClN6O2/c1-12(2)28-11-24-18-19(23-10-13-9-14(22)3-8-17(13)30)26-21(27-20(18)28)25-15-4-6-16(29)7-5-15/h3,8-9,11-12,15-16,29-30H,4-7,10H2,1-2H3,(H2,23,25,26,27) CKBQQVRNWKMAPJ-UHFFFAOYSA-N 50431287 CHEMBL2349192 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 540 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431287 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431287&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71579159 164160162 CHEMBL2349192 ZINC95603478 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51057486 CC(C)[C@H](Nc1nc(NCc2ccccc2N)c2ncn(C(C)C)c2n1)C(C)(C)O InChI=1S/C22H33N7O/c1-13(2)18(22(5,6)30)26-21-27-19(24-11-15-9-7-8-10-16(15)23)17-20(28-21)29(12-25-17)14(3)4/h7-10,12-14,18,30H,11,23H2,1-6H3,(H2,24,26,27,28)/t18-/m0/s1 PKDDEKWAXOEWTM-SFHVURJKSA-N 50431290 CHEMBL2347582 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 290 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431290 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431290&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71579075 164160165 CHEMBL2347582 ZINC95603482 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51057487 CC(C)n1cnc2c(NCc3ccccc3N)nc(NCC(C)(C)O)nc12 InChI=1S/C19H27N7O/c1-12(2)26-11-23-15-16(21-9-13-7-5-6-8-14(13)20)24-18(25-17(15)26)22-10-19(3,4)27/h5-8,11-12,27H,9-10,20H2,1-4H3,(H2,21,22,24,25) DCHDOYXSTZNERE-UHFFFAOYSA-N 50431292 CHEMBL2347580 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1200 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431292 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431292&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 46926801 164160167 CHEMBL2347580 ZINC68243806 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51057488 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 793 ChEMBL 10.1016/j.ejmech.2012.06.036 10.7270/Q2QC04W7 22770608 Zatloukal, M; Jorda, R; Gucky, T; Reznickova, E; Voller, J; Pospisil, T; Malinkova, V; Adamcova, H; Krystof, V; Strnad, M Palack£ University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 13640 Cc1nc(N)sc1-c1ccnc(Nc2cccc(c2)N(=O)=O)n1 InChI=1S/C14H12N6O2S/c1-8-12(23-13(15)17-8)11-5-6-16-14(19-11)18-9-3-2-4-10(7-9)20(21)22/h2-7H,1H3,(H2,15,17)(H,16,18,19) DYTKVFHLKPDNRW-UHFFFAOYSA-N 8061 2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 32::4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-(3-nitrophenyl)pyrimidin-2-amine, 4::4-methyl-5-{2-[(3-nitrophenyl)amino]pyrimidin-4-yl}-1,3-thiazol-2-amine::CDK Inhibitor, 1::[4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl](3-nitrophenyl)amine Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 70 7.2 30.00 C Curated from the literature by BindingDB 10.1016/j.bmcl.2004.06.012 10.7270/Q2CJ8BPP 15261277 aid1796133 Wang, S; Wood, G; Meades, C; Griffiths, G; Midgley, C; McNae, I; McInnes, C; Anderson, S; Jackson, W; Mezna, M; Yuill, R; Walkinshaw, M; Fischer, PM Cyclacel Limited http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=8061 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=8061&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 1PXO,2WEV 447961 11108815 C06058 ZINC02047389 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21688 Nc1n[nH]c(N)c1\N=N\c1ccccc1[N+]([O-])=O InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-3-1-2-4-6(5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+ IXYLIAXCCAHPJQ-OUKQBFOZSA-N 12025 4-Arylazo-3,5-diamino-1H-pyrazole 26b::4-[(E)-2-(2-nitrophenyl)diazen-1-yl]-1H-pyrazole-3,5-diamine Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 77000 30.00 C Curated from the literature by BindingDB 10.1021/jm0605740 10.7270/Q2M61HHK 17064068 aid1796840 Krystof, V; Cankar, P; Frysova, I; Slouka, J; Kontopidis, G; Dzubak, P; Hajduch, M; Srovnal, J; de Azevedo, WF; Orsag, M; Paprskarova, M; Rolcik, J; Latr, A; Fischer, PM; Strnad, M Palacky University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12025 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12025&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11673204 46512532 ZINC14949079 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21689 Nc1n[nH]c(N)c1\N=N\c1cccc(c1)[N+]([O-])=O InChI=1S/C9H9N7O2/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(4-5)16(17)18/h1-4H,(H5,10,11,14,15)/b13-12+ KNSDLOIIFWEGLS-OUKQBFOZSA-N 12026 4-Arylazo-3,5-diamino-1H-pyrazole 27b::4-[(E)-2-(3-nitrophenyl)diazen-1-yl]-1H-pyrazole-3,5-diamine Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >100000 30.00 C Curated from the literature by BindingDB 10.1021/jm0605740 10.7270/Q2M61HHK 17064068 aid1796840 Krystof, V; Cankar, P; Frysova, I; Slouka, J; Kontopidis, G; Dzubak, P; Hajduch, M; Srovnal, J; de Azevedo, WF; Orsag, M; Paprskarova, M; Rolcik, J; Latr, A; Fischer, PM; Strnad, M Palacky University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12026 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12026&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10214593 46512533 ZINC14949084 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21690 Nc1n[nH]c(N)c1\N=N\c1cccc(O)c1 InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-2-1-3-6(16)4-5/h1-4,16H,(H5,10,11,14,15)/b13-12+ WELGNMVJTNYIRH-OUKQBFOZSA-N 12027 3-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]phenol::4-Arylazo-3,5-diamino-1H-pyrazole 30b Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 82000 30.00 C Curated from the literature by BindingDB 10.1021/jm0605740 10.7270/Q2M61HHK 17064068 aid1796840 Krystof, V; Cankar, P; Frysova, I; Slouka, J; Kontopidis, G; Dzubak, P; Hajduch, M; Srovnal, J; de Azevedo, WF; Orsag, M; Paprskarova, M; Rolcik, J; Latr, A; Fischer, PM; Strnad, M Palacky University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12027 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12027&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 9964499 46512534 ZINC14949086 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21691 Nc1n[nH]c(N)c1N=Nc1ccc(O)cc1 InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15) AYZRKFOEZQBUEA-UHFFFAOYSA-N 12028 4-Arylazo-3,5-diamino-1H-pyrazole 31b::4-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]phenol::CAN508 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 26000 30.00 C Curated from the literature by BindingDB 10.1021/jm0605740 10.7270/Q2M61HHK 17064068 aid1796840 Krystof, V; Cankar, P; Frysova, I; Slouka, J; Kontopidis, G; Dzubak, P; Hajduch, M; Srovnal, J; de Azevedo, WF; Orsag, M; Paprskarova, M; Rolcik, J; Latr, A; Fischer, PM; Strnad, M Palacky University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12028 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12028&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search F18 3TN8,3TNH,3TNW,2CLX 9859248 46512535 ZINC17782150 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21692 Nc1n[nH]c(N)c1\N=N\c1ccccc1CO InChI=1S/C10H12N6O/c11-9-8(10(12)16-15-9)14-13-7-4-2-1-3-6(7)5-17/h1-4,17H,5H2,(H5,11,12,15,16)/b14-13+ LOTUARPYXHNGEY-BUHFOSPRSA-N 12029 4-Arylazo-3,5-diamino-1H-pyrazole 35b::{2-[(E)-2-(3,5-diamino-1H-pyrazol-4-yl)diazen-1-yl]phenyl}methanol Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >100000 30.00 C Curated from the literature by BindingDB 10.1021/jm0605740 10.7270/Q2M61HHK 17064068 aid1796840 Krystof, V; Cankar, P; Frysova, I; Slouka, J; Kontopidis, G; Dzubak, P; Hajduch, M; Srovnal, J; de Azevedo, WF; Orsag, M; Paprskarova, M; Rolcik, J; Latr, A; Fischer, PM; Strnad, M Palacky University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12029 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12029&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10308009 46512536 ZINC14949090 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21687 Nc1n[nH]c(N)c1\N=N\c1ccccc1 InChI=1S/C9H10N6/c10-8-7(9(11)15-14-8)13-12-6-4-2-1-3-5-6/h1-5H,(H5,10,11,14,15)/b13-12+ BLXRKDXUWQFGAW-OUKQBFOZSA-N 12024 4-Arylazo-3,5-diamino-1H-pyrazole 1b::4-[(E)-2-phenyldiazen-1-yl]-1H-pyrazole-3,5-diamine Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >100000 30.00 C Curated from the literature by BindingDB 10.1021/jm0605740 10.7270/Q2M61HHK 17064068 aid1796840 Krystof, V; Cankar, P; Frysova, I; Slouka, J; Kontopidis, G; Dzubak, P; Hajduch, M; Srovnal, J; de Azevedo, WF; Orsag, M; Paprskarova, M; Rolcik, J; Latr, A; Fischer, PM; Strnad, M Palacky University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12024 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12024&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 5284904 46512531 ZINC17312777 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21861 N#Cc1ccc2c(n[nH]c2c1)-c1cc2cc(CN3CCOCC3)ccc2[nH]1 InChI=1S/C21H19N5O/c22-12-14-1-3-17-19(10-14)24-25-21(17)20-11-16-9-15(2-4-18(16)23-20)13-26-5-7-27-8-6-26/h1-4,9-11,23H,5-8,13H2,(H,24,25) QJRKDESSUVYBDT-UHFFFAOYSA-N 12116 3-(Indol-2-yl)indazole 6::3-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl]-1H-indazole-6-carbonitrile Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 11 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12116&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23645998 46512619 ZINC14949226 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21862 COC(=O)c1ccc2c(n[nH]c2c1)-c1cc2cc(CN3CCOCC3)ccc2[nH]1 InChI=1S/C22H22N4O3/c1-28-22(27)15-3-4-17-19(11-15)24-25-21(17)20-12-16-10-14(2-5-18(16)23-20)13-26-6-8-29-9-7-26/h2-5,10-12,23H,6-9,13H2,1H3,(H,24,25) WSNMWYMIZKBEKA-UHFFFAOYSA-N 12117 3-(Indol-2-yl)indazole 7::methyl 3-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl]-1H-indazole-6-carboxylate Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 6500 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12117&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23645999 46512620 ZINC14949229 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21863 NC(=O)c1ccc2c(n[nH]c2c1)-c1cc2cc(CN3CCOCC3)ccc2[nH]1 InChI=1S/C21H21N5O2/c22-21(27)14-2-3-16-18(10-14)24-25-20(16)19-11-15-9-13(1-4-17(15)23-19)12-26-5-7-28-8-6-26/h1-4,9-11,23H,5-8,12H2,(H2,22,27)(H,24,25) SVPVCRMOALGQKQ-UHFFFAOYSA-N 12118 3-(Indol-2-yl)indazole 8::3-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl]-1H-indazole-6-carboxamide Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1300 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12118&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23646000 46512621 ZINC14949232 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21864 CNC(=O)c1ccc2c(n[nH]c2c1)-c1cc2cc(CN3CCOCC3)ccc2[nH]1 InChI=1S/C22H23N5O2/c1-23-22(28)15-3-4-17-19(11-15)25-26-21(17)20-12-16-10-14(2-5-18(16)24-20)13-27-6-8-29-9-7-27/h2-5,10-12,24H,6-9,13H2,1H3,(H,23,28)(H,25,26) RXOGENJPRMPUAI-UHFFFAOYSA-N 12119 3-(Indol-2-yl)indazole 9::N-methyl-3-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl]-1H-indazole-6-carboxamide Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 4900 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12119&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23646001 46512622 ZINC14949235 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21865 CN(C)C(=O)c1ccc2c(n[nH]c2c1)-c1cc2cc(CN3CCOCC3)ccc2[nH]1 InChI=1S/C23H25N5O2/c1-27(2)23(29)16-4-5-18-20(12-16)25-26-22(18)21-13-17-11-15(3-6-19(17)24-21)14-28-7-9-30-10-8-28/h3-6,11-13,24H,7-10,14H2,1-2H3,(H,25,26) MXXHMCILDONGHI-UHFFFAOYSA-N 12120 3-(Indol-2-yl)indazole 10::N,N-dimethyl-3-[5-(morpholin-4-ylmethyl)-1H-indol-2-yl]-1H-indazole-6-carboxamide Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >100000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12120 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12120&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23646002 46512623 ZINC14949238 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21866 C(N1CCOCC1)c1ccc2[nH]c(cc2c1)-c1n[nH]c2cc(ccc12)-c1cn[nH]c1 InChI=1S/C23H22N6O/c1-4-20-17(9-15(1)14-29-5-7-30-8-6-29)11-22(26-20)23-19-3-2-16(10-21(19)27-28-23)18-12-24-25-13-18/h1-4,9-13,26H,5-8,14H2,(H,24,25)(H,27,28) SYNHRWSDSNIWGA-UHFFFAOYSA-N 12121 3-(Indol-2-yl)indazole 11::4-({2-[6-(1H-pyrazol-4-yl)-1H-indazol-3-yl]-1H-indol-5-yl}methyl)morpholine Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 25 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12121&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23646003 46512624 ZINC14949241 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21867 C(N1CCOCC1)c1ccc2[nH]c(cc2c1)-c1n[nH]c2cc(ccc12)-c1cc[nH]n1 InChI=1S/C23H22N6O/c1-4-19-17(11-15(1)14-29-7-9-30-10-8-29)13-22(25-19)23-18-3-2-16(12-21(18)27-28-23)20-5-6-24-26-20/h1-6,11-13,25H,7-10,14H2,(H,24,26)(H,27,28) YGHPDKYRIZDBRZ-UHFFFAOYSA-N 12123 3-(Indol-2-yl)indazole 13::4-({2-[6-(1H-pyrazol-5-yl)-1H-indazol-3-yl]-1H-indol-5-yl}methyl)morpholine Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 34 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12123&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23646005 46512626 ZINC14949247 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21868 C(N1CCCCC1)c1ccc2[nH]c(cc2c1)-c1n[nH]c2cc(ccc12)-c1cnsc1 InChI=1S/C24H23N5S/c1-2-8-29(9-3-1)14-16-4-7-21-18(10-16)12-23(26-21)24-20-6-5-17(11-22(20)27-28-24)19-13-25-30-15-19/h4-7,10-13,15,26H,1-3,8-9,14H2,(H,27,28) AXKZEVVSSSVTOD-UHFFFAOYSA-N 12124 3-(Indol-2-yl)indazole 14::4-{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-indazol-6-yl}-1,2-thiazole Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 18 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12124&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23646006 46512627 ZINC14949251 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21869 C(N1CCCCC1)c1ccc2[nH]c(cc2c1)-c1n[nH]c2cc(ccc12)-c1nccs1 InChI=1S/C24H23N5S/c1-2-9-29(10-3-1)15-16-4-7-20-18(12-16)14-22(26-20)23-19-6-5-17(13-21(19)27-28-23)24-25-8-11-30-24/h4-8,11-14,26H,1-3,9-10,15H2,(H,27,28) RZHGVPDZIAXVBY-UHFFFAOYSA-N 12125 2-{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-indazol-6-yl}-1,3-thiazole::3-(Indol-2-yl)indazole 15 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 4000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12125 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12125&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23646007 46512628 ZINC14949254 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21870 C(N1CCCCC1)c1ccc2[nH]c(cc2c1)-c1n[nH]c2cc(ccc12)-n1ccnn1 InChI=1S/C23H23N7/c1-2-9-29(10-3-1)15-16-4-7-20-17(12-16)13-22(25-20)23-19-6-5-18(14-21(19)26-27-23)30-11-8-24-28-30/h4-8,11-14,25H,1-3,9-10,15H2,(H,26,27) AIDWTYRIDDCANO-UHFFFAOYSA-N 12126 3-(Indol-2-yl)indazole 16::3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-6-(1H-1,2,3-triazol-1-yl)-1H-indazole Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 57 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12126 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12126&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23646008 46512629 ZINC14949257 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21871 Cc1cnnn1-c1ccc2c(n[nH]c2c1)-c1cc2cc(CN3CCCCC3)ccc2[nH]1 InChI=1S/C24H25N7/c1-16-14-25-29-31(16)19-6-7-20-22(13-19)27-28-24(20)23-12-18-11-17(5-8-21(18)26-23)15-30-9-3-2-4-10-30/h5-8,11-14,26H,2-4,9-10,15H2,1H3,(H,27,28) GVOOLHNJOQWXKE-UHFFFAOYSA-N 12127 3-(Indol-2-yl)indazole 17::6-(5-methyl-1H-1,2,3-triazol-1-yl)-3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-indazole Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 420 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12127 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12127&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23646009 46512630 ZINC14949260 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21872 C(N1CCCCC1)c1ccc2[nH]c(cc2c1)-c1n[nH]c2cc(ccc12)-n1cccn1 InChI=1S/C24H24N6/c1-2-10-29(11-3-1)16-17-5-8-21-18(13-17)14-23(26-21)24-20-7-6-19(15-22(20)27-28-24)30-12-4-9-25-30/h4-9,12-15,26H,1-3,10-11,16H2,(H,27,28) DEUPBQNMDIBCLK-UHFFFAOYSA-N 12128 3-(Indol-2-yl)indazole 18::3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-6-(1H-pyrazol-1-yl)-1H-indazole Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2300 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12128 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12128&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23646010 46512631 ZINC14949263 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21873 C(N1CCCCC1)c1ccc2[nH]c(cc2c1)-c1n[nH]c2cc(ccc12)-n1nccn1 InChI=1S/C23H23N7/c1-2-10-29(11-3-1)15-16-4-7-20-17(12-16)13-22(26-20)23-19-6-5-18(14-21(19)27-28-23)30-24-8-9-25-30/h4-9,12-14,26H,1-3,10-11,15H2,(H,27,28) NMDXBIIYGMMZCL-UHFFFAOYSA-N 12129 3-(Indol-2-yl)indazole 19::3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-6-(2H-1,2,3-triazol-2-yl)-1H-indazole Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 480 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12129 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12129&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23646011 46512632 ZINC14949266 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21874 C(N1CCCCC1)c1ccc2[nH]c(cc2c1)-c1n[nH]c2cc(ccc12)-c1ccccc1 InChI=1S/C27H26N4/c1-3-7-20(8-4-1)21-10-11-23-25(16-21)29-30-27(23)26-17-22-15-19(9-12-24(22)28-26)18-31-13-5-2-6-14-31/h1,3-4,7-12,15-17,28H,2,5-6,13-14,18H2,(H,29,30) PRNXBLOZTIGXJB-UHFFFAOYSA-N 12130 3-(Indol-2-yl)indazole 20::6-phenyl-3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-indazole Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 7000 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12130 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12130&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23646012 46512633 ZINC14949268 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21875 OCc1[nH]nnc1-c1ccc2c(n[nH]c2c1)-c1cc2cc(CN3CCCCC3)ccc2[nH]1 InChI=1S/C24H25N7O/c32-14-22-23(29-30-27-22)16-5-6-18-20(11-16)26-28-24(18)21-12-17-10-15(4-7-19(17)25-21)13-31-8-2-1-3-9-31/h4-7,10-12,25,32H,1-3,8-9,13-14H2,(H,26,28)(H,27,29,30) FNWHPLLNMLOZTL-UHFFFAOYSA-N 12131 (5-{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-indazol-6-yl}-1H-1,2,3-triazol-4-yl)methanol::3-(Indol-2-yl)indazole 21 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 56 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12131 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12131&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 2HOG 16058617 46512634 ZINC14949271 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21876 OCc1[nH]nnc1-c1ccc2c(n[nH]c2c1)-c1cc2cc(CN3CCC(F)CC3)ccc2[nH]1 InChI=1S/C24H24FN7O/c25-17-5-7-32(8-6-17)12-14-1-4-19-16(9-14)11-21(26-19)24-18-3-2-15(10-20(18)27-29-24)23-22(13-33)28-31-30-23/h1-4,9-11,17,26,33H,5-8,12-13H2,(H,27,29)(H,28,30,31) DABXYMYBOCROGP-UHFFFAOYSA-N 12132 3-(Indol-2-yl)indazole 22::[5-(3-{5-[(4-fluoropiperidin-1-yl)methyl]-1H-indol-2-yl}-1H-indazol-6-yl)-1H-1,2,3-triazol-4-yl]methanol Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 180 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12132 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12132&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23646013 46512635 ZINC14949274 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21877 NCc1[nH]nnc1-c1ccc2c(n[nH]c2c1)-c1cc2cc(CN3CCC(F)CC3)ccc2[nH]1 InChI=1S/C24H25FN8/c25-17-5-7-33(8-6-17)13-14-1-4-19-16(9-14)11-21(27-19)24-18-3-2-15(10-20(18)28-30-24)23-22(12-26)29-32-31-23/h1-4,9-11,17,27H,5-8,12-13,26H2,(H,28,30)(H,29,31,32) PTTHTNNSSNKMSD-UHFFFAOYSA-N 12133 3-(Indol-2-yl)indazole 23::[5-(3-{5-[(4-fluoropiperidin-1-yl)methyl]-1H-indol-2-yl}-1H-indazol-6-yl)-1H-1,2,3-triazol-4-yl]methanamine Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 300 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12133 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12133&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 23646014 46512636 ZINC14949277 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 21878 COc1cc(ccc1O)-c1ccc2c(n[nH]c2c1)-c1cc2cc(CN3CCCCC3)ccc2[nH]1 InChI=1S/C28H28N4O2/c1-34-27-16-20(7-10-26(27)33)19-6-8-22-24(14-19)30-31-28(22)25-15-21-13-18(5-9-23(21)29-25)17-32-11-3-2-4-12-32/h5-10,13-16,29,33H,2-4,11-12,17H2,1H3,(H,30,31) CDMSQHCJYCHHAF-UHFFFAOYSA-N 12134 2-methoxy-4-{3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-1H-indazol-6-yl}phenol::3-(Indol-2-yl)indazole 24 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 310 Curated from the literature by BindingDB 10.1016/j.bmcl.2006.08.118 10.7270/Q29P2ZVV 16978863 aid1796853 Fraley, ME; Steen, JT; Brnardic, EJ; Arrington, KL; Spencer, KL; Hanney, BA; Kim, Y; Hartman, GD; Stirdivant, SM; Drakas, BA; Rickert, K; Walsh, ES; Hamilton, K; Buser, CA; Hardwick, J; Tao, W; Beck, SC; Mao, X; Lobell, RB; Sepp-Lorenzino, L; Yan, Y; Ikuta, M; Munshi, SK; Kuo, LC; Kreatsoulas, C Merck Research Laboratories http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12134 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=12134&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11532543 46512637 ZINC14949281 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 49951 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 800 7.5 30.00 C Curated from the literature by BindingDB 10.1021/jm801340z 10.7270/Q2WQ024J 19128055 aid1798788 Popowycz, F; Fournet, G; Schneider, C; Bettayeb, K; Ferandin, Y; Lamigeon, C; Tirado, OM; Mateo-Lozano, S; Notario, V; Colas, P; Bernard, P; Meijer, L; Joseph, B Universite de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 49952 CC[C@H](CO)Nc1nc(NCc2ccccc2)n2ncc(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(12-26)22-18-23-17-16(13(2)3)11-21-25(17)19(24-18)20-10-14-8-6-5-7-9-14/h5-9,11,13,15,26H,4,10,12H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 SQUNOCMDMIQIQK-OAHLLOKOSA-N 27217 (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol::GP0210::pyrazolo[1,5-a]-1,3,5-triazine, 7a Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 500 7.5 30.00 C Curated from the literature by BindingDB 10.1021/jm801340z 10.7270/Q2WQ024J 19128055 aid1798788 Popowycz, F; Fournet, G; Schneider, C; Bettayeb, K; Ferandin, Y; Lamigeon, C; Tirado, OM; Mateo-Lozano, S; Notario, V; Colas, P; Bernard, P; Meijer, L; Joseph, B Universite de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27217&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search NNN 3DOG 25190761 57298927 DB08285 ZINC34285231 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 49953 CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)n2ncc(C(C)C)c2n1 InChI=1S/C19H25ClN6O/c1-11(2)15-9-21-26-17(15)24-18(23-16(10-27)12(3)4)25-19(26)22-14-7-5-6-13(20)8-14/h5-9,11-12,16,27H,10H2,1-4H3,(H2,22,23,24,25)/t16-/m0/s1 XCRSLBLUJPTVDN-INIZCTEOSA-N 27218 (2R)-2-({4-[(3-chlorophenyl)amino]-8-(propan-2-yl)pyrazolo[1,5-a][1,3,5]triazin-2-yl}amino)-3-methylbutan-1-ol::pyrazolo[1,5-a]-1,3,5-triazine, 7c Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >100000 7.5 30.00 C Curated from the literature by BindingDB 10.1021/jm801340z 10.7270/Q2WQ024J 19128055 aid1798788 Popowycz, F; Fournet, G; Schneider, C; Bettayeb, K; Ferandin, Y; Lamigeon, C; Tirado, OM; Mateo-Lozano, S; Notario, V; Colas, P; Bernard, P; Meijer, L; Joseph, B Universite de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27218&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 25190762 57298928 ZINC42187870 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 49954 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncc(C(C)C)n2n1 InChI=1S/C19H26N6O/c1-4-15(12-26)22-19-23-17(20-10-14-8-6-5-7-9-14)18-21-11-16(13(2)3)25(18)24-19/h5-9,11,13,15,26H,4,10,12H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 ITFLOJJAVYXCTM-OAHLLOKOSA-N 27219 (2R)-2-{[4-(benzylamino)-7-(propan-2-yl)imidazo[1,2-a][1,2,4]triazin-2-yl]amino}butan-1-ol::(2R)-2-{[4-(benzylamino)-7-(propan-2-yl)imidazo[2,1-f][1,2,4]triazin-2-yl]amino}butan-1-ol::imidazo[2,1-f]-1,2,4-triazine, 13 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 600 7.5 30.00 C Curated from the literature by BindingDB 10.1021/jm801340z 10.7270/Q2WQ024J 19128055 aid1798788 Popowycz, F; Fournet, G; Schneider, C; Bettayeb, K; Ferandin, Y; Lamigeon, C; Tirado, OM; Mateo-Lozano, S; Notario, V; Colas, P; Bernard, P; Meijer, L; Joseph, B Universite de Lyon http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27219&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 25190763 57298929 ZINC40413302 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50116469 FC(F)(F)c1cccc(NS(=O)(=O)c2cc(Cl)c(Cl)cc2Cl)c1 InChI=1S/C13H7Cl3F3NO2S/c14-9-5-11(16)12(6-10(9)15)23(21,22)20-8-3-1-2-7(4-8)13(17,18)19/h1-6,20H SIFZUZIJSUIQHX-UHFFFAOYSA-N 50321447 2,4,5-trichloro-N-(3-(trifluoromethyl)phenyl)benzenesulfonamide::CHEMBL1171969 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 200 ChEMBL 10.1016/j.bmcl.2010.05.039 10.7270/Q2F47Q3Q 20627564 Caridha, D; Kathcart, AK; Jirage, D; Waters, NC Walter Reed Army Institute of Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50321447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50321447&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 306203 104142976 CHEMBL1171969 ZINC01738108 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50116472 Cc1ccc(Cl)cc1S(=O)(=O)Nc1ccc(Cl)c(Cl)c1 InChI=1S/C13H10Cl3NO2S/c1-8-2-3-9(14)6-13(8)20(18,19)17-10-4-5-11(15)12(16)7-10/h2-7,17H,1H3 FXXZBAHVAGPHLH-UHFFFAOYSA-N 50321441 5-chloro-N-(3,4-dichlorophenyl)-2-methylbenzenesulfonamide::CHEMBL1172129 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 400 ChEMBL 10.1016/j.bmcl.2010.05.039 10.7270/Q2F47Q3Q 20627564 Caridha, D; Kathcart, AK; Jirage, D; Waters, NC Walter Reed Army Institute of Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50321441 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50321441&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 49798457 104142970 CHEMBL1172129 ZINC53296388 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50116529 Cc1ccc(cc1)S(=O)(=O)Nc1cccc(c1)C(F)(F)F InChI=1S/C14H12F3NO2S/c1-10-5-7-13(8-6-10)21(19,20)18-12-4-2-3-11(9-12)14(15,16)17/h2-9,18H,1H3 LAQWXSZWFLYJOE-UHFFFAOYSA-N 50321446 4-methyl-N-(3-(trifluoromethyl)phenyl)benzenesulfonamide::CHEMBL1170012 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 400 ChEMBL 10.1016/j.bmcl.2010.05.039 10.7270/Q2F47Q3Q 20627564 Caridha, D; Kathcart, AK; Jirage, D; Waters, NC Walter Reed Army Institute of Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50321446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50321446&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 837245 104142975 CHEMBL1170012 ZINC00364427 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50116536 Cc1ccc(NS(=O)(=O)c2cc(Cl)sc2Cl)cc1 InChI=1S/C11H9Cl2NO2S2/c1-7-2-4-8(5-3-7)14-18(15,16)9-6-10(12)17-11(9)13/h2-6,14H,1H3 OQWXAWNHXDPWGS-UHFFFAOYSA-N 50321451 2,5-dichloro-N-p-tolylthiophene-3-sulfonamide::CHEMBL1171972 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 800 ChEMBL 10.1016/j.bmcl.2010.05.039 10.7270/Q2F47Q3Q 20627564 Caridha, D; Kathcart, AK; Jirage, D; Waters, NC Walter Reed Army Institute of Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50321451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50321451&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 49798484 104142980 CHEMBL1171972 ZINC20626963 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50116539 Clc1cc(c(Cl)s1)S(=O)(=O)N(C(=O)CBr)c1ccccc1 InChI=1S/C12H8BrCl2NO3S2/c13-7-11(17)16(8-4-2-1-3-5-8)21(18,19)9-6-10(14)20-12(9)15/h1-6H,7H2 XOLGJVQMYMQCNT-UHFFFAOYSA-N 50321461 2-bromo-N-(2,5-dichlorothiophen-3-ylsulfonyl)-N-phenylacetamide::CHEMBL1171238 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 33400 ChEMBL 10.1016/j.bmcl.2010.05.039 10.7270/Q2F47Q3Q 20627564 Caridha, D; Kathcart, AK; Jirage, D; Waters, NC Walter Reed Army Institute of Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50321461 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50321461&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 49798556 104142990 CHEMBL1171238 ZINC53229868 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50116541 Cc1ccc(cc1)N(SC(Cl)(Cl)Cl)S(=O)(=O)c1cc(Cl)sc1Cl InChI=1S/C12H8Cl5NO2S3/c1-7-2-4-8(5-3-7)18(22-12(15,16)17)23(19,20)9-6-10(13)21-11(9)14/h2-6H,1H3 PKAHLRVRIDTYNC-UHFFFAOYSA-N 50321455 2,5-dichloro-N-p-tolyl-N-(trichloromethylthio)thiophene-3-sulfonamide::CHEMBL1172329 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 700 ChEMBL 10.1016/j.bmcl.2010.05.039 10.7270/Q2F47Q3Q 20627564 Caridha, D; Kathcart, AK; Jirage, D; Waters, NC Walter Reed Army Institute of Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50321455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50321455&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 49798511 104142984 CHEMBL1172329 ZINC53314063 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50115830 Cc1nc(N)sc1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1 InChI=1S/C18H20N6OS/c1-12-16(26-17(19)21-12)15-6-7-20-18(23-15)22-13-2-4-14(5-3-13)24-8-10-25-11-9-24/h2-7H,8-11H2,1H3,(H2,19,21)(H,20,22,23) GPSZYOIFQZPWEJ-UHFFFAOYSA-N 50277583 2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin-4-yl)phenyl]pyrimidin-2-amine, 5::4-Methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine::Aminopyrimidine, 9::CHEMBL482967::CYC-116 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/jm901913s 10.7270/Q2930T9D 20462263 Wang, S; Midgley, CA; Scaerou, F; Grabarek, JB; Griffiths, G; Jackson, W; Kontopidis, G; McClue, SJ; McInnes, C; Meades, C; Mezna, M; Plater, A; Stuart, I; Thomas, MP; Wood, G; Clarke, RG; Blake, DG; Zheleva, DI; Lane, DP; Jackson, RC; Glover, DM; Fischer, PM Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50277583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50277583&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 6420138 104120139 CHEMBL482967 ZINC03950132 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50115141 OCCCNc1cc(ccn1)-c1ncnc(Nc2cccc(Cl)c2)n1 InChI=1S/C17H17ClN6O/c18-13-3-1-4-14(10-13)23-17-22-11-21-16(24-17)12-5-7-20-15(9-12)19-6-2-8-25/h1,3-5,7,9-11,25H,2,6,8H2,(H,19,20)(H,21,22,23,24) AAYPLLWGPJQWCC-UHFFFAOYSA-N 50169892 3-{4-[4-(3-Chloro-phenylamino)-[1,3,5]triazin-2-yl]-pyridin-2-ylamino}-propan-1-ol::CHEMBL191336 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 126 ChEMBL 10.1021/jm040214h 10.7270/Q2833RK0 15999992 Kuo, GH; Deangelis, A; Emanuel, S; Wang, A; Zhang, Y; Connolly, PJ; Chen, X; Gruninger, RH; Rugg, C; Fuentes-Pesquera, A; Middleton, SA; Jolliffe, L; Murray, WV Johnson & Johnson Pharmaceutical Research and Development LLC http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50169892 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50169892&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 9863538 104054652 CHEMBL191336 ZINC03937622 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50174732 CC(C)c1cnn2c(NCc3ccccc3)cc(N[C@@H](CO)[C@H](O)CO)nc12 InChI=1S/C20H27N5O3/c1-13(2)15-10-22-25-19(21-9-14-6-4-3-5-7-14)8-18(24-20(15)25)23-16(11-26)17(28)12-27/h3-8,10,13,16-17,21,26-28H,9,11-12H2,1-2H3,(H,23,24)/t16-,17+/m0/s1 KRIWIRSMQRQYJG-DLBZAZTESA-N 50347388 CHEMBL1234833 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 250 ChEMBL 10.1021/jm100732t 10.7270/Q2B858GZ 21080703 Heathcote, DA; Patel, H; Kroll, SH; Hazel, P; Periyasamy, M; Alikian, M; Kanneganti, SK; Jogalekar, AS; Scheiper, B; Barbazanges, M; Blum, A; Brackow, J; Siwicka, A; Pace, RD; Fuchter, MJ; Snyder, JP; Liotta, DC; Freemont, PS; Aboagye, EO; Coombes, RC; Barrett, AG; Ali, S Imperial College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50347388 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50347388&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search NS9 3NS9 25125014 136354074 CHEMBL1234833 ZINC58655676 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50174736 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 540 ChEMBL 10.1021/jm100732t 10.7270/Q2B858GZ 21080703 Heathcote, DA; Patel, H; Kroll, SH; Hazel, P; Periyasamy, M; Alikian, M; Kanneganti, SK; Jogalekar, AS; Scheiper, B; Barbazanges, M; Blum, A; Brackow, J; Siwicka, A; Pace, RD; Fuchter, MJ; Snyder, JP; Liotta, DC; Freemont, PS; Aboagye, EO; Coombes, RC; Barrett, AG; Ali, S Imperial College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50174742 CC(C)c1cnn2c(NCc3ccccc3)cc(NCCCCCCN)nc12 InChI=1S/C22H32N6/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22(19)28)24-13-9-4-3-8-12-23/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2,1-2H3,(H,24,27) DNYBIOICMDTDAP-UHFFFAOYSA-N 50347389 CHEMBL1801932 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 21 ChEMBL 10.1021/jm100732t 10.7270/Q2B858GZ 21080703 Heathcote, DA; Patel, H; Kroll, SH; Hazel, P; Periyasamy, M; Alikian, M; Kanneganti, SK; Jogalekar, AS; Scheiper, B; Barbazanges, M; Blum, A; Brackow, J; Siwicka, A; Pace, RD; Fuchter, MJ; Snyder, JP; Liotta, DC; Freemont, PS; Aboagye, EO; Coombes, RC; Barrett, AG; Ali, S Imperial College http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50347389 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50347389&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 49867929 136354075 CHEMBL1801932 ZINC43207770 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50213270 CC(C)CC(=O)Nc1[nH]nc2c1CN(C(=O)C1CCN(C)CC1)C2(C)C InChI=1S/C19H31N5O2/c1-12(2)10-15(25)20-17-14-11-24(19(3,4)16(14)21-22-17)18(26)13-6-8-23(5)9-7-13/h12-13H,6-11H2,1-5H3,(H2,20,21,22,25) HUXYBQXJVXOMKX-UHFFFAOYSA-N 50378657 CHEMBL1230607 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 10 ChEMBL 10.1016/j.bmc.2010.01.042 10.7270/Q21R6RG5 20153204 Brasca, MG; Albanese, C; Alzani, R; Amici, R; Avanzi, N; Ballinari, D; Bischoff, J; Borghi, D; Casale, E; Croci, V; Fiorentini, F; Isacchi, A; Mercurio, C; Nesi, M; Orsini, P; Pastori, W; Pesenti, E; Pevarello, P; Roussel, P; Varasi, M; Volpi, D; Vulpetti, A; Ciomei, M Nerviano Medical Sciences srl http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50378657 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50378657&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 46191454 160857740 CHEMBL1230607 ZINC52509437 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224762 CNc1nc(C2CC2)c(s1)-c1ccnc(Nc2ccc(cc2)S(N)(=O)=O)n1 InChI=1S/C17H18N6O2S2/c1-19-17-23-14(10-2-3-10)15(26-17)13-8-9-20-16(22-13)21-11-4-6-12(7-5-11)27(18,24)25/h4-10H,2-3H2,1H3,(H,19,23)(H2,18,24,25)(H,20,21,22) GAFYDJGFHJBXQQ-UHFFFAOYSA-N 50431335 CHEMBL2348847 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 255 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431335&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562504 164160210 CHEMBL2348847 ZINC95605012 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224764 CNc1nc(C2CC2)c(s1)-c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1 InChI=1S/C17H18N6O2S2/c1-19-17-23-14(10-5-6-10)15(26-17)13-7-8-20-16(22-13)21-11-3-2-4-12(9-11)27(18,24)25/h2-4,7-10H,5-6H2,1H3,(H,19,23)(H2,18,24,25)(H,20,21,22) ASUFRYKYWHJUIO-UHFFFAOYSA-N 50431336 CHEMBL2348846 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 273 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431336&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562399 164160211 CHEMBL2348846 ZINC95601524 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224765 CNc1nc(c(s1)-c1ccnc(Nc2ccc(cc2)S(N)(=O)=O)n1)C(F)(F)F InChI=1S/C15H13F3N6O2S2/c1-20-14-24-12(15(16,17)18)11(27-14)10-6-7-21-13(23-10)22-8-2-4-9(5-3-8)28(19,25)26/h2-7H,1H3,(H,20,24)(H2,19,25,26)(H,21,22,23) FPHITTVVVWKENE-UHFFFAOYSA-N 50431339 CHEMBL2348843 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 64 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431339&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562396 164160214 CHEMBL2348843 ZINC95601088 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224766 CNc1nc(c(s1)-c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1)C(F)(F)F InChI=1S/C15H13F3N6O2S2/c1-20-14-24-12(15(16,17)18)11(27-14)10-5-6-21-13(23-10)22-8-3-2-4-9(7-8)28(19,25)26/h2-7H,1H3,(H,20,24)(H2,19,25,26)(H,21,22,23) BXMBIVXDTXURDF-UHFFFAOYSA-N 50431340 CHEMBL2348842 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 47 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431340 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431340&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562395 164160215 CHEMBL2348842 ZINC95603317 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224767 CNc1ncc(s1)-c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1 InChI=1S/C14H14N6O2S2/c1-16-14-18-8-12(23-14)11-5-6-17-13(20-11)19-9-3-2-4-10(7-9)24(15,21)22/h2-8H,1H3,(H,16,18)(H2,15,21,22)(H,17,19,20) CDKRFBBXZQUTDX-UHFFFAOYSA-N 50431337 CHEMBL2348845 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 40 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431337&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562398 164160212 CHEMBL2348845 ZINC95605502 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224768 CNc1ncc(s1)-c1ccnc(Nc2ccc(cc2)S(N)(=O)=O)n1 InChI=1S/C14H14N6O2S2/c1-16-14-18-8-12(23-14)11-6-7-17-13(20-11)19-9-2-4-10(5-3-9)24(15,21)22/h2-8H,1H3,(H,16,18)(H2,15,21,22)(H,17,19,20) BWONSNVPSAEXDY-UHFFFAOYSA-N 50431338 CHEMBL2348844 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 54 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431338 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431338&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562397 164160213 CHEMBL2348844 ZINC95603934 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224770 CNc1nc(CC(F)(F)F)c(s1)-c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1 InChI=1S/C16H15F3N6O2S2/c1-21-15-25-12(8-16(17,18)19)13(28-15)11-5-6-22-14(24-11)23-9-3-2-4-10(7-9)29(20,26)27/h2-7H,8H2,1H3,(H,21,25)(H2,20,26,27)(H,22,23,24) LTPKYPDZFVTFOH-UHFFFAOYSA-N 50431341 CHEMBL2348841 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1984 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431341 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431341&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562394 164160216 CHEMBL2348841 ZINC95602434 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224772 CNc1nc(CC(F)(F)F)c(s1)-c1ccnc(Nc2ccc(O)cc2)n1 InChI=1S/C16H14F3N5OS/c1-20-15-24-12(8-16(17,18)19)13(26-15)11-6-7-21-14(23-11)22-9-2-4-10(25)5-3-9/h2-7,25H,8H2,1H3,(H,20,24)(H,21,22,23) JDGZTYYDQGRYGF-UHFFFAOYSA-N 50431342 CHEMBL2348840 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1543 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431342&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562393 164160217 CHEMBL2348840 ZINC95605594 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224774 CNc1nc(C)c(s1)-c1ccnc(Nc2cccc(c2)[N+]([O-])=O)n1 InChI=1S/C15H14N6O2S/c1-9-13(24-15(16-2)18-9)12-6-7-17-14(20-12)19-10-4-3-5-11(8-10)21(22)23/h3-8H,1-2H3,(H,16,18)(H,17,19,20) AXAQVNRYNMCZCK-UHFFFAOYSA-N 50431363 CHEMBL46429 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 417 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431363 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431363&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 6539296 164160238 CHEMBL46429 ZINC13559874 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224856 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)[N+]([O-])=O)ncc1C#N InChI=1S/C16H13N7O2S/c1-9-14(26-16(18-2)20-9)13-10(7-17)8-19-15(22-13)21-11-4-3-5-12(6-11)23(24)25/h3-6,8H,1-2H3,(H,18,20)(H,19,21,22) OOKAYBMMWNSBPA-UHFFFAOYSA-N 50425011 CHEMBL2312182 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 260 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425011 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425011&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 44253323 164153886 CHEMBL2312182 ZINC95596415 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224860 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1C#N InChI=1S/C16H15N7O2S2/c1-9-14(26-16(19-2)21-9)13-10(7-17)8-20-15(23-13)22-11-4-3-5-12(6-11)27(18,24)25/h3-6,8H,1-2H3,(H,19,21)(H2,18,24,25)(H,20,22,23) SGOFFNQMBSXTRU-UHFFFAOYSA-N 50425010 CHEMBL2312183 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 114 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425010 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425010&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search T3E 4BCI,4BCK 44253325 164153885 CHEMBL2312183 ZINC95597472 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224862 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCCNCC2)ncc1C#N InChI=1S/C21H24N8S/c1-14-19(30-21(23-2)26-14)18-15(12-22)13-25-20(28-18)27-16-5-3-6-17(11-16)29-9-4-7-24-8-10-29/h3,5-6,11,13,24H,4,7-10H2,1-2H3,(H,23,26)(H,25,27,28) BKOYUSKBPMSUBK-UHFFFAOYSA-N 50425008 CHEMBL2312185 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 92 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425008 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425008&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search T3C 4BCP,4BCG 71300299 164153883 CHEMBL2312185 ZINC95597277 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224865 CNc1nc(CC(F)(F)F)c(s1)-c1ccnc(Nc2cccc(O)c2)n1 InChI=1S/C16H14F3N5OS/c1-20-15-24-12(8-16(17,18)19)13(26-15)11-5-6-21-14(23-11)22-9-3-2-4-10(25)7-9/h2-7,25H,8H2,1H3,(H,20,24)(H,21,22,23) JCPWXGQBEYYLTQ-UHFFFAOYSA-N 50431343 CHEMBL2348654 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 3474 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431343&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562286 164160218 CHEMBL2348654 ZINC95601131 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224866 CNc1nc(C)c(s1)-c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1 InChI=1S/C15H16N6O2S2/c1-9-13(24-15(17-2)19-9)12-6-7-18-14(21-12)20-10-4-3-5-11(8-10)25(16,22)23/h3-8H,1-2H3,(H,17,19)(H2,16,22,23)(H,18,20,21) OTPFZAVDWPCJLJ-UHFFFAOYSA-N 81430 CDK Inhibitor, 3 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1960 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81430 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81430&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11675224 131342004 ZINC38224817 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224867 CNc1nc(CC(F)(F)F)c(s1)-c1ccnc(Nc2cccc(c2)[N+]([O-])=O)n1 InChI=1S/C16H13F3N6O2S/c1-20-15-24-12(8-16(17,18)19)13(28-15)11-5-6-21-14(23-11)22-9-3-2-4-10(7-9)25(26)27/h2-7H,8H2,1H3,(H,20,24)(H,21,22,23) ZTSNAFZQMAUJCQ-UHFFFAOYSA-N 50431344 CHEMBL2348653 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431344 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431344&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562285 164160219 CHEMBL2348653 ZINC95603286 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224868 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)[N+]([O-])=O)ncc1O InChI=1S/C15H14N6O3S/c1-8-13(25-15(16-2)18-8)12-11(22)7-17-14(20-12)19-9-4-3-5-10(6-9)21(23)24/h3-7,22H,1-2H3,(H,16,18)(H,17,19,20) XGOGJKVSHQHTDQ-UHFFFAOYSA-N 50431362 CHEMBL2347594 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431362 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431362&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71561913 164160237 CHEMBL2347594 ZINC95604245 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224869 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCCNCC2)ncc1F InChI=1S/C20H24FN7S/c1-13-18(29-20(22-2)25-13)17-16(21)12-24-19(27-17)26-14-5-3-6-15(11-14)28-9-4-7-23-8-10-28/h3,5-6,11-12,23H,4,7-10H2,1-2H3,(H,22,25)(H,24,26,27) ZHXQLMCSTVATST-UHFFFAOYSA-N 50431347 CHEMBL2348650 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 111 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431347 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431347&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562168 164160222 CHEMBL2348650 ZINC95605858 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224872 CNc1nc(C)c(s1)-c1ccnc(Nc2cccc(c2)N2CCCNCC2)n1 InChI=1S/C20H25N7S/c1-14-18(28-20(21-2)24-14)17-7-9-23-19(26-17)25-15-5-3-6-16(13-15)27-11-4-8-22-10-12-27/h3,5-7,9,13,22H,4,8,10-12H2,1-2H3,(H,21,24)(H,23,25,26) BTDMLZGYAGONHW-UHFFFAOYSA-N 50431345 CHEMBL2348652 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 433 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431345&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71561659 164160220 CHEMBL2348652 ZINC95603580 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224873 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F InChI=1S/C15H15FN6O2S2/c1-8-13(25-15(18-2)20-8)12-11(16)7-19-14(22-12)21-9-4-3-5-10(6-9)26(17,23)24/h3-7H,1-2H3,(H,18,20)(H2,17,23,24)(H,19,21,22) GAIOPWBQKZMUNO-UHFFFAOYSA-N 50431360 CHEMBL2347597 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 91 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431360 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431360&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71561915 164160235 CHEMBL2347597 ZINC95605236 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224875 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCCN(CC2)C(C)=O)ncc1C#N InChI=1S/C23H26N8OS/c1-15-21(33-23(25-3)27-15)20-17(13-24)14-26-22(29-20)28-18-6-4-7-19(12-18)31-9-5-8-30(10-11-31)16(2)32/h4,6-7,12,14H,5,8-11H2,1-3H3,(H,25,27)(H,26,28,29) DZHBFQMOLIUZMP-UHFFFAOYSA-N 50431346 CHEMBL2348651 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 210 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431346 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431346&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search T6Q 4BCF,4BCO 70680234 164160221 CHEMBL2348651 ZINC95603671 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224876 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1O InChI=1S/C15H16N6O3S2/c1-8-13(25-15(17-2)19-8)12-11(22)7-18-14(21-12)20-9-4-3-5-10(6-9)26(16,23)24/h3-7,22H,1-2H3,(H,17,19)(H2,16,23,24)(H,18,20,21) HVCCBYPTQRNASA-UHFFFAOYSA-N 50431361 CHEMBL2347596 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431361 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431361&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71561914 164160236 CHEMBL2347596 ZINC95602872 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224880 CNc1nc(c(s1)-c1ccnc(Nc2cccc(c2)[N+]([O-])=O)n1)-c1ccccc1 InChI=1S/C20H16N6O2S/c1-21-20-25-17(13-6-3-2-4-7-13)18(29-20)16-10-11-22-19(24-16)23-14-8-5-9-15(12-14)26(27)28/h2-12H,1H3,(H,21,25)(H,22,23,24) CSSKMDOTUWJHLE-UHFFFAOYSA-N 50424999 CHEMBL2312193 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50424999 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50424999&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562284 164153874 CHEMBL2312193 ZINC95593895 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224892 CCc1cnc(Nc2cccc(c2)S(N)(=O)=O)nc1-c1sc(NC)nc1C InChI=1S/C17H20N6O2S2/c1-4-11-9-20-16(22-12-6-5-7-13(8-12)27(18,24)25)23-14(11)15-10(2)21-17(19-3)26-15/h5-9H,4H2,1-3H3,(H,19,21)(H2,18,24,25)(H,20,22,23) IMJBYEMGFQYCFQ-UHFFFAOYSA-N 50431357 CHEMBL2348639 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1285 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431357 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431357&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71561918 164160232 CHEMBL2348639 ZINC95604147 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224894 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1C InChI=1S/C16H18N6O2S2/c1-9-8-19-15(21-11-5-4-6-12(7-11)26(17,23)24)22-13(9)14-10(2)20-16(18-3)25-14/h4-8H,1-3H3,(H,18,20)(H2,17,23,24)(H,19,21,22) LVJZZDNNQXAXPX-UHFFFAOYSA-N 50431358 CHEMBL2348638 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1176 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431358 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431358&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71561917 164160233 CHEMBL2348638 ZINC95601753 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224896 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1Cl InChI=1S/C15H15ClN6O2S2/c1-8-13(25-15(18-2)20-8)12-11(16)7-19-14(22-12)21-9-4-3-5-10(6-9)26(17,23)24/h3-7H,1-2H3,(H,18,20)(H2,17,23,24)(H,19,21,22) ZOLPUEOXQAILTM-UHFFFAOYSA-N 50431359 CHEMBL2348637 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 685 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431359 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431359&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71561916 164160234 CHEMBL2348637 ZINC95605850 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224913 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCNCC2)ncc1F InChI=1S/C19H22FN7S/c1-12-17(28-19(21-2)24-12)16-15(20)11-23-18(26-16)25-13-4-3-5-14(10-13)27-8-6-22-7-9-27/h3-5,10-11,22H,6-9H2,1-2H3,(H,21,24)(H,23,25,26) CKIFWVSQRJHDKI-UHFFFAOYSA-N 50431350 CHEMBL2348647 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 193 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431350 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431350&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562165 164160225 CHEMBL2348647 ZINC95602927 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224915 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCN(CC2)C(C)=O)ncc1F InChI=1S/C21H24FN7OS/c1-13-19(31-21(23-3)25-13)18-17(22)12-24-20(27-18)26-15-5-4-6-16(11-15)29-9-7-28(8-10-29)14(2)30/h4-6,11-12H,7-10H2,1-3H3,(H,23,25)(H,24,26,27) MCFCYLCLAYXQIZ-UHFFFAOYSA-N 50431351 CHEMBL2348646 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 302 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431351 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431351&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562046 164160226 CHEMBL2348646 ZINC95604947 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224916 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCNCC2)ncc1Cl InChI=1S/C19H22ClN7S/c1-12-17(28-19(21-2)24-12)16-15(20)11-23-18(26-16)25-13-4-3-5-14(10-13)27-8-6-22-7-9-27/h3-5,10-11,22H,6-9H2,1-2H3,(H,21,24)(H,23,25,26) YZRRSIPTHDIILM-UHFFFAOYSA-N 50431348 CHEMBL2348649 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 155 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431348 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431348&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562167 164160223 CHEMBL2348649 ZINC95602151 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224917 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCOCC2)ncc1F InChI=1S/C19H21FN6OS/c1-12-17(28-19(21-2)23-12)16-15(20)11-22-18(25-16)24-13-4-3-5-14(10-13)26-6-8-27-9-7-26/h3-5,10-11H,6-9H2,1-2H3,(H,21,23)(H,22,24,25) HXZXJLLRGFULES-UHFFFAOYSA-N 50431349 CHEMBL2348648 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 473 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431349 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431349&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562166 164160224 CHEMBL2348648 ZINC95602450 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224919 CNc1nc(C)c(s1)-c1nc(Nc2ccc(cc2)N2CCN(CC2)C(C)=O)ncc1C#N InChI=1S/C22H24N8OS/c1-14-20(32-22(24-3)26-14)19-16(12-23)13-25-21(28-19)27-17-4-6-18(7-5-17)30-10-8-29(9-11-30)15(2)31/h4-7,13H,8-11H2,1-3H3,(H,24,26)(H,25,27,28) CLHJUHZESGJESB-UHFFFAOYSA-N 50431354 CHEMBL2348643 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 316 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431354&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562043 164160229 CHEMBL2348643 ZINC95603258 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224920 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCNCC2)ncc1C#N InChI=1S/C20H22N8S/c1-13-18(29-20(22-2)25-13)17-14(11-21)12-24-19(27-17)26-15-4-3-5-16(10-15)28-8-6-23-7-9-28/h3-5,10,12,23H,6-9H2,1-2H3,(H,22,25)(H,24,26,27) HMCJMBDXHYZRRL-UHFFFAOYSA-N 50431355 CHEMBL2348642 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 68 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431355 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431355&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562042 164160230 CHEMBL2348642 ZINC95602636 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224921 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCCCC2)ncc1C#N InChI=1S/C21H23N7S/c1-14-19(29-21(23-2)25-14)18-15(12-22)13-24-20(27-18)26-16-7-6-8-17(11-16)28-9-4-3-5-10-28/h6-8,11,13H,3-5,9-10H2,1-2H3,(H,23,25)(H,24,26,27) BCKLVLDQAAHMQR-UHFFFAOYSA-N 50431352 CHEMBL2348645 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 286 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431352 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431352&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562045 164160227 CHEMBL2348645 ZINC95605230 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224923 CNc1nc(C)c(s1)-c1nc(Nc2ccc(cc2)N2CCNCC2)ncc1C#N InChI=1S/C20H22N8S/c1-13-18(29-20(22-2)25-13)17-14(11-21)12-24-19(27-17)26-15-3-5-16(6-4-15)28-9-7-23-8-10-28/h3-6,12,23H,7-10H2,1-2H3,(H,22,25)(H,24,26,27) WMMICHSZLWUPOT-UHFFFAOYSA-N 50431353 CHEMBL2348644 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 71 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431353 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431353&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562044 164160228 CHEMBL2348644 ZINC95602425 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224925 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCN(CC2)C(C)=O)ncc1C#N InChI=1S/C22H24N8OS/c1-14-20(32-22(24-3)26-14)19-16(12-23)13-25-21(28-19)27-17-5-4-6-18(11-17)30-9-7-29(8-10-30)15(2)31/h4-6,11,13H,7-10H2,1-3H3,(H,24,26)(H,25,27,28) BGPUFSMDGGQOIE-UHFFFAOYSA-N 50431356 CHEMBL2348641 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 92 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431356 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431356&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562041 164160231 CHEMBL2348641 ZINC95603985 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224954 CNc1nc(C2CC2)c(s1)-c1ccnc(Nc2cccc(c2)N2CCCNCC2)n1 InChI=1S/C22H27N7S/c1-23-22-28-19(15-6-7-15)20(30-22)18-8-10-25-21(27-18)26-16-4-2-5-17(14-16)29-12-3-9-24-11-13-29/h2,4-5,8,10,14-15,24H,3,6-7,9,11-13H2,1H3,(H,23,28)(H,25,26,27) PHDVEAVKGNZPQH-UHFFFAOYSA-N 50431334 CHEMBL2348848 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 464 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50431334 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50431334&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 71562505 164160209 CHEMBL2348848 ZINC95605024 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50224958 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 500 ChEMBL 10.1021/jm301475f 10.7270/Q26D5VBB 23301767 Shao, H; Shi, S; Huang, S; Hole, AJ; Abbas, AY; Baumli, S; Liu, X; Lam, F; Foley, DW; Fischer, PM; Noble, M; Endicott, JA; Pepper, C; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50447171 Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(c1=O)S(=O)(=O)c1ccc(F)cc1F InChI=1S/C22H15F2N5O3S/c1-29-20-13(9-19(21(29)30)33(31,32)18-5-2-14(23)10-16(18)24)11-26-22(28-20)27-15-3-4-17-12(8-15)6-7-25-17/h2-11,25H,1H3,(H,26,27,28) ZEHBZHZMQSHZFI-UHFFFAOYSA-N 50135286 CHEMBL3745885 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.bmc.2015.11.045 10.7270/Q24Q7WT8 26762835 Reddy, MV; Akula, B; Jatiani, S; Vasquez-Del Carpio, R; Billa, VK; Mallireddigari, MR; Cosenza, SC; Venkata Subbaiah, DR; Bharathi, EV; Pallela, VR; Ramkumar, P; Jain, R; Aggarwal, AK; Reddy, EP Icahn School of Medicine at Mount Sinai http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50135286 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50135286&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 67240318 336951802 CHEMBL3745885 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50594472 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 360 ChEMBL 10.1158/0008-5472.CAN-05-0233 10.7270/Q2125SWP 15958589 MacCallum, DE; Melville, J; Frame, S; Watt, K; Anderson, S; Gianella-Borradori, A; Lane, DP; Green, SR Cyclacel Ltd http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50635140 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2n[nH]c(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-14(11-26)21-19-22-16-15(12(2)3)24-25-17(16)18(23-19)20-10-13-8-6-5-7-9-13/h5-9,12,14,26H,4,10-11H2,1-3H3,(H,24,25)(H2,20,21,22,23)/t14-/m1/s1 AOPRHEOJTUWSAR-CQSZACIVSA-N 50341878 (2R)-2-{[7-(benzylamino)-3-(propan-2-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]amino}butan-1-ol::7-Benzylamino-5(R)-[2-(hydroxymethyl)propyl]amino-3-isopropyl-1(2)H-pyrazolo[4,3-d]pyrimidine::CHEMBL1738742 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 160 ChEMBL 10.1021/jm200064p 10.7270/Q20K28XN 21417417 Jorda, R; Havlicek, L; McNae, IW; Walkinshaw, MD; Voller, J; Sturc, A; Navratilova, J; Kuzma, M; Mistrik, M; Bartek, J; Strnad, M; Krystof, V Palacky£? University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50341878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50341878&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 51000420 131344814 CHEMBL1738742 ZINC66166057 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50635144 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 480 ChEMBL 10.1021/jm200064p 10.7270/Q20K28XN 21417417 Jorda, R; Havlicek, L; McNae, IW; Walkinshaw, MD; Voller, J; Sturc, A; Navratilova, J; Kuzma, M; Mistrik, M; Bartek, J; Strnad, M; Krystof, V Palacky£? University and Institute of Experimental Botany ASCR http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703972 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 520 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703973 CC[C@H](CO)Nc1nc(NCc2ccccn2)c2ncn(C(C)C)c2n1 InChI=1S/C18H25N7O/c1-4-13(10-26)22-18-23-16(20-9-14-7-5-6-8-19-14)15-17(24-18)25(11-21-15)12(2)3/h5-8,11-13,26H,4,9-10H2,1-3H3,(H2,20,22,23,24)/t13-/m1/s1 LAJPWWATQVPFEQ-CYBMUJFWSA-N 50358214 CHEMBL454617 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 40 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358214&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10021108 136962238 CHEMBL454617 ZINC01491370 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703974 CC[C@@H](Nc1nc(NCc2ccccn2)c2ncn(C(C)C)c2n1)C(C)O InChI=1S/C19H27N7O/c1-5-15(13(4)27)23-19-24-17(21-10-14-8-6-7-9-20-14)16-18(25-19)26(11-22-16)12(2)3/h6-9,11-13,15,27H,5,10H2,1-4H3,(H2,21,23,24,25)/t13?,15-/m1/s1 KBBUFDNIKCQBPT-AWKYBWMHSA-N 50358215 CHEMBL1922114 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 550 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358215&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 57393383 136962239 CHEMBL1922114 ZINC38932994 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703975 CCC(O)[C@@H](CC)Nc1nc(NCc2ccccn2)c2ncn(C(C)C)c2n1 InChI=1S/C20H29N7O/c1-5-15(16(28)6-2)24-20-25-18(22-11-14-9-7-8-10-21-14)17-19(26-20)27(12-23-17)13(3)4/h7-10,12-13,15-16,28H,5-6,11H2,1-4H3,(H2,22,24,25,26)/t15-,16?/m1/s1 DXWFIHMYKMOOAL-AAFJCEBUSA-N 50358216 CHEMBL1922115 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1200 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358216&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10339936 136962240 CHEMBL1922115 ZINC13975710 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703976 CC[C@@H](Nc1nc(NCc2ccccn2)c2ncn(C(C)C)c2n1)C(O)C(C)C InChI=1S/C21H31N7O/c1-6-16(18(29)13(2)3)25-21-26-19(23-11-15-9-7-8-10-22-15)17-20(27-21)28(12-24-17)14(4)5/h7-10,12-14,16,18,29H,6,11H2,1-5H3,(H2,23,25,26,27)/t16-,18?/m1/s1 XSIHMBADMZSOSO-PYUWXLGESA-N 50358217 CHEMBL1922116 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 3900 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358217&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10000883 136962241 CHEMBL1922116 ZINC13975712 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703977 CC[C@@H](Nc1nc(NCc2ccccn2)c2ncn(C(C)C)c2n1)C(O)C(C)(C)C InChI=1S/C22H33N7O/c1-7-16(18(30)22(4,5)6)26-21-27-19(24-12-15-10-8-9-11-23-15)17-20(28-21)29(13-25-17)14(2)3/h8-11,13-14,16,18,30H,7,12H2,1-6H3,(H2,24,26,27,28)/t16-,18?/m1/s1 PGZQBZCWIHOLGU-PYUWXLGESA-N 50358218 CHEMBL1922117 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2400 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358218&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10001666 136962242 CHEMBL1922117 ZINC13975714 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703978 CC[C@@H](Nc1nc(NCc2ccccn2)c2ncn(C(C)C)c2n1)C(C)(C)O InChI=1S/C20H29N7O/c1-6-15(20(4,5)28)24-19-25-17(22-11-14-9-7-8-10-21-14)16-18(26-19)27(12-23-16)13(2)3/h7-10,12-13,15,28H,6,11H2,1-5H3,(H2,22,24,25,26)/t15-/m1/s1 OPOKLUOSXLQAIT-OAHLLOKOSA-N 50358219 CHEMBL1922118 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 4200 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358219 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358219&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10339935 136962243 CHEMBL1922118 ZINC03939646 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703979 CC[C@H](CO)Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1 InChI=1S/C18H25N7O/c1-4-14(10-26)22-18-23-16(20-9-13-6-5-7-19-8-13)15-17(24-18)25(11-21-15)12(2)3/h5-8,11-12,14,26H,4,9-10H2,1-3H3,(H2,20,22,23,24)/t14-/m1/s1 ITWHOUBMQIJNKR-CQSZACIVSA-N 50358220 CHEMBL455389 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 180 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358220 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358220&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10247627 136962244 CHEMBL455389 ZINC38422778 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703980 CC[C@@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)[C@H](C)O InChI=1S/C19H27N7O/c1-5-15(13(4)27)23-19-24-17(21-10-14-7-6-8-20-9-14)16-18(25-19)26(11-22-16)12(2)3/h6-9,11-13,15,27H,5,10H2,1-4H3,(H2,21,23,24,25)/t13-,15+/m0/s1 SCACHXWSWJBIHG-DZGCQCFKSA-N 50358212 CHEMBL1922218::US8846696, (2S3R)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-pentan-2-ol Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 500 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358212&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 12111408 136962236 CHEMBL1922218 ZINC03939648 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703981 CCC(O)[C@@H](CC)Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1 InChI=1S/C20H29N7O/c1-5-15(16(28)6-2)24-20-25-18(22-11-14-8-7-9-21-10-14)17-19(26-20)27(12-23-17)13(3)4/h7-10,12-13,15-16,28H,5-6,11H2,1-4H3,(H2,22,24,25,26)/t15-,16?/m1/s1 VFEDEOUBYBLDKN-AAFJCEBUSA-N 50358221 CHEMBL1922120::US8846696, (3RS,4R)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-hexan-3-ol Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1100 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358221 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358221&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 12111409 136962245 CHEMBL1922120 ZINC13975716 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703982 CC[C@@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)C(O)C(C)C InChI=1S/C21H31N7O/c1-6-16(18(29)13(2)3)25-21-26-19(23-11-15-8-7-9-22-10-15)17-20(27-21)28(12-24-17)14(4)5/h7-10,12-14,16,18,29H,6,11H2,1-5H3,(H2,23,25,26,27)/t16-,18?/m1/s1 AGGGWZCOULSEER-PYUWXLGESA-N 50358222 CHEMBL1922121::US8846696, (3RS,4R)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-hexan-3-ol Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2200 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358222 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358222&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 12111411 136962246 CHEMBL1922121 ZINC73166188 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703983 CC[C@@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)C(O)C(C)(C)C InChI=1S/C22H33N7O/c1-7-16(18(30)22(4,5)6)26-21-27-19(24-12-15-9-8-10-23-11-15)17-20(28-21)29(13-25-17)14(2)3/h8-11,13-14,16,18,30H,7,12H2,1-6H3,(H2,24,26,27,28)/t16-,18?/m1/s1 XHPNYYOUZWOWNT-PYUWXLGESA-N 50358223 CHEMBL1922122::US8846696, (3RS,4R)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2,2-dimethyl-hexan-3-ol Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1600 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358223 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358223&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 12111413 136962247 CHEMBL1922122 ZINC73168664 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703984 CC[C@@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)C(C)(C)O InChI=1S/C20H29N7O/c1-6-15(20(4,5)28)24-19-25-17(22-11-14-8-7-9-21-10-14)16-18(26-19)27(12-23-16)13(2)3/h7-10,12-13,15,28H,6,11H2,1-5H3,(H2,22,24,25,26)/t15-/m1/s1 SQUNXPPTEPGMQR-OAHLLOKOSA-N 50358210 CHEMBL1922123::US8846696, (3R)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-ol Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 3100 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358210&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11574520 136962234 CHEMBL1922123 ZINC03939653 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703985 CC[C@H](CO)Nc1nc(NCc2ccncc2)c2ncn(C(C)C)c2n1 InChI=1S/C18H25N7O/c1-4-14(10-26)22-18-23-16(20-9-13-5-7-19-8-6-13)15-17(24-18)25(11-21-15)12(2)3/h5-8,11-12,14,26H,4,9-10H2,1-3H3,(H2,20,22,23,24)/t14-/m1/s1 BJDIQUJXLIZDRH-CQSZACIVSA-N 50358224 CHEMBL455641 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 740 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358224 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358224&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 24782039 136962248 CHEMBL455641 ZINC01491371 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703986 CC[C@@H](Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1)C(C)O InChI=1S/C20H28N6O/c1-5-16(14(4)27)23-20-24-18(21-11-15-9-7-6-8-10-15)17-19(25-20)26(12-22-17)13(2)3/h6-10,12-14,16,27H,5,11H2,1-4H3,(H2,21,23,24,25)/t14?,16-/m1/s1 CVIBDXQYFNZNMA-BZSJEYESSA-N 50358225 CHEMBL1922199 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 390 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358225 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358225&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 24782040 136962249 CHEMBL1922199 ZINC01491372 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703987 CCC(O)[C@@H](CC)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C21H30N6O/c1-5-16(17(28)6-2)24-21-25-19(22-12-15-10-8-7-9-11-15)18-20(26-21)27(13-23-18)14(3)4/h7-11,13-14,16-17,28H,5-6,12H2,1-4H3,(H2,22,24,25,26)/t16-,17?/m1/s1 DCBVAYFYFOLMIC-TZHYSIJRSA-N 50358226 CHEMBL1922200 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1200 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358226 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358226&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10177964 136962250 CHEMBL1922200 ZINC13974086 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703988 CC[C@@H](Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1)C(O)C(C)C InChI=1S/C22H32N6O/c1-6-17(19(29)14(2)3)25-22-26-20(23-12-16-10-8-7-9-11-16)18-21(27-22)28(13-24-18)15(4)5/h7-11,13-15,17,19,29H,6,12H2,1-5H3,(H2,23,25,26,27)/t17-,19?/m1/s1 CCMLBTWPLDKEBS-DUSLRRAJSA-N 50358227 CHEMBL1922201 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 4400 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358227&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10272087 136962251 CHEMBL1922201 ZINC13974088 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703989 CC[C@@H](Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1)C(O)C(C)(C)C InChI=1S/C23H34N6O/c1-7-17(19(30)23(4,5)6)26-22-27-20(24-13-16-11-9-8-10-12-16)18-21(28-22)29(14-25-18)15(2)3/h8-12,14-15,17,19,30H,7,13H2,1-6H3,(H2,24,26,27,28)/t17-,19?/m1/s1 JNYINEBNIROMEU-DUSLRRAJSA-N 50358228 CHEMBL1922202 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 3700 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358228 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358228&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10136280 136962252 CHEMBL1922202 ZINC13974090 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703990 CC[C@@H](Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1)C(C)(C)O InChI=1S/C21H30N6O/c1-6-16(21(4,5)28)24-20-25-18(22-12-15-10-8-7-9-11-15)17-19(26-20)27(13-23-17)14(2)3/h7-11,13-14,16,28H,6,12H2,1-5H3,(H2,22,24,25,26)/t16-/m1/s1 JBFPVHXMCIWHJX-MRXNPFEDSA-N 50358229 CHEMBL1922203 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 3700 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358229 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358229&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10199925 136962253 CHEMBL1922203 ZINC01491379 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703991 CC[C@H](Nc1nc(NCc2ccccn2)c2ncn(C(C)C)c2n1)C(C)O InChI=1S/C19H27N7O/c1-5-15(13(4)27)23-19-24-17(21-10-14-8-6-7-9-20-14)16-18(25-19)26(11-22-16)12(2)3/h6-9,11-13,15,27H,5,10H2,1-4H3,(H2,21,23,24,25)/t13?,15-/m0/s1 KBBUFDNIKCQBPT-WUJWULDRSA-N 50358230 CHEMBL1922204 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2600 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358230 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358230&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 57402042 136962254 CHEMBL1922204 ZINC34136930 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703992 CCC(O)[C@H](CC)Nc1nc(NCc2ccccn2)c2ncn(C(C)C)c2n1 InChI=1S/C20H29N7O/c1-5-15(16(28)6-2)24-20-25-18(22-11-14-9-7-8-10-21-14)17-19(26-20)27(12-23-17)13(3)4/h7-10,12-13,15-16,28H,5-6,11H2,1-4H3,(H2,22,24,25,26)/t15-,16?/m0/s1 DXWFIHMYKMOOAL-VYRBHSGPSA-N 50358231 CHEMBL1922205 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2600 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358231 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358231&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10407625 136962255 CHEMBL1922205 ZINC13975711 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703993 CC[C@H](Nc1nc(NCc2ccccn2)c2ncn(C(C)C)c2n1)C(O)C(C)C InChI=1S/C21H31N7O/c1-6-16(18(29)13(2)3)25-21-26-19(23-11-15-9-7-8-10-22-15)17-20(27-21)28(12-24-17)14(4)5/h7-10,12-14,16,18,29H,6,11H2,1-5H3,(H2,23,25,26,27)/t16-,18?/m0/s1 XSIHMBADMZSOSO-ATNAJCNCSA-N 50358232 CHEMBL1922206 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 3300 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358232 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358232&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10475938 136962256 CHEMBL1922206 ZINC13975713 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703994 CC[C@H](Nc1nc(NCc2ccccn2)c2ncn(C(C)C)c2n1)C(O)C(C)(C)C InChI=1S/C22H33N7O/c1-7-16(18(30)22(4,5)6)26-21-27-19(24-12-15-10-8-9-11-23-15)17-20(28-21)29(13-25-17)14(2)3/h8-11,13-14,16,18,30H,7,12H2,1-6H3,(H2,24,26,27,28)/t16-,18?/m0/s1 PGZQBZCWIHOLGU-ATNAJCNCSA-N 50358233 CHEMBL1922207 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 5800 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358233 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358233&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10001665 136962257 CHEMBL1922207 ZINC13975715 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703995 CC[C@H](Nc1nc(NCc2ccccn2)c2ncn(C(C)C)c2n1)C(C)(C)O InChI=1S/C20H29N7O/c1-6-15(20(4,5)28)24-19-25-17(22-11-14-9-7-8-10-21-14)16-18(26-19)27(12-23-16)13(2)3/h7-10,12-13,15,28H,6,11H2,1-5H3,(H2,22,24,25,26)/t15-/m0/s1 OPOKLUOSXLQAIT-HNNXBMFYSA-N 50358234 CHEMBL1921805 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 4300 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358234 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358234&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10317812 136962258 CHEMBL1921805 ZINC03939647 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703996 CC[C@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)[C@@H](C)O InChI=1S/C19H27N7O/c1-5-15(13(4)27)23-19-24-17(21-10-14-7-6-8-20-9-14)16-18(25-19)26(11-22-16)12(2)3/h6-9,11-13,15,27H,5,10H2,1-4H3,(H2,21,23,24,25)/t13-,15+/m1/s1 SCACHXWSWJBIHG-HIFRSBDPSA-N 50358213 CHEMBL1922219::US8846696, (2R3S)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-pentan-2-ol Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1300 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358213&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 8QT 5MHQ 9842276 136962237 CHEMBL1922219 ZINC03939649 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703997 CCC(O)[C@H](CC)Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1 InChI=1S/C20H29N7O/c1-5-15(16(28)6-2)24-20-25-18(22-11-14-8-7-9-21-10-14)17-19(26-20)27(12-23-17)13(3)4/h7-10,12-13,15-16,28H,5-6,11H2,1-4H3,(H2,22,24,25,26)/t15-,16?/m0/s1 VFEDEOUBYBLDKN-VYRBHSGPSA-N 50358235 CHEMBL1922209::US8846696, (3RS,4S)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-hexan-3-ol Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1500 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358235 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358235&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 12111410 136962259 CHEMBL1922209 ZINC13975717 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703998 CC[C@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)C(O)C(C)C InChI=1S/C21H31N7O/c1-6-16(18(29)13(2)3)25-21-26-19(23-11-15-8-7-9-22-10-15)17-20(27-21)28(12-24-17)14(4)5/h7-10,12-14,16,18,29H,6,11H2,1-5H3,(H2,23,25,26,27)/t16-,18?/m0/s1 AGGGWZCOULSEER-ATNAJCNCSA-N 50358236 CHEMBL1922210::US8846696, (3RS,4S)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-hexan-3-ol Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 3500 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358236 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358236&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 12111412 136962260 CHEMBL1922210 ZINC73160288 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50703999 CC[C@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)C(O)C(C)(C)C InChI=1S/C22H33N7O/c1-7-16(18(30)22(4,5)6)26-21-27-19(24-12-15-9-8-10-23-11-15)17-20(28-21)29(13-25-17)14(2)3/h8-11,13-14,16,18,30H,7,12H2,1-6H3,(H2,24,26,27,28)/t16-,18?/m0/s1 XHPNYYOUZWOWNT-ATNAJCNCSA-N 50358237 CHEMBL1922211::US8846696, (3RS,4S)-4-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2,2-dimethyl-hexan-3-ol Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 3500 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358237 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358237&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 12111414 136962261 CHEMBL1922211 ZINC14020367 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50704000 CC[C@H](Nc1nc(NCc2cccnc2)c2ncn(C(C)C)c2n1)C(C)(C)O InChI=1S/C20H29N7O/c1-6-15(20(4,5)28)24-19-25-17(22-11-14-8-7-9-21-10-14)16-18(26-19)27(12-23-16)13(2)3/h7-10,12-13,15,28H,6,11H2,1-5H3,(H2,22,24,25,26)/t15-/m0/s1 SQUNXPPTEPGMQR-HNNXBMFYSA-N 50358211 CHEMBL1922212::US8846696, (3S)-3-{9-Isopropyl-6-[(pyridin-3-ylmethyl)-amino]-9H-purin-2-ylamino}-2-methyl-pentan-2-ol Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2500 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358211&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11581762 136962235 CHEMBL1922212 ZINC03939654 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50704001 CC[C@H](Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1)C(C)O InChI=1S/C20H28N6O/c1-5-16(14(4)27)23-20-24-18(21-11-15-9-7-6-8-10-15)17-19(25-20)26(12-22-17)13(2)3/h6-10,12-14,16,27H,5,11H2,1-4H3,(H2,21,23,24,25)/t14?,16-/m0/s1 CVIBDXQYFNZNMA-WMCAAGNKSA-N 50358238 CHEMBL1922213 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 690 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358238 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358238&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10155901 136962262 CHEMBL1922213 ZINC34337850 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50704002 CCC(O)[C@H](CC)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C21H30N6O/c1-5-16(17(28)6-2)24-21-25-19(22-12-15-10-8-7-9-11-15)18-20(26-21)27(13-23-18)14(3)4/h7-11,13-14,16-17,28H,5-6,12H2,1-4H3,(H2,22,24,25,26)/t16-,17?/m0/s1 DCBVAYFYFOLMIC-BHWOMJMDSA-N 50358239 CHEMBL1922214 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1100 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358239 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358239&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10293288 136962263 CHEMBL1922214 ZINC13974087 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50704003 CC[C@H](Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1)C(O)C(C)C InChI=1S/C22H32N6O/c1-6-17(19(29)14(2)3)25-22-26-20(23-12-16-10-8-7-9-11-16)18-21(27-22)28(13-24-18)15(4)5/h7-11,13-15,17,19,29H,6,12H2,1-5H3,(H2,23,25,26,27)/t17-,19?/m0/s1 CCMLBTWPLDKEBS-KKFHFHRHSA-N 50358240 CHEMBL1922215 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 3000 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358240 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358240&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10178895 136962264 CHEMBL1922215 ZINC13974089 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50704004 CC[C@H](Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1)C(O)C(C)(C)C InChI=1S/C23H34N6O/c1-7-17(19(30)23(4,5)6)26-22-27-20(24-13-16-11-9-8-10-12-16)18-21(28-22)29(14-25-18)15(2)3/h8-12,14-15,17,19,30H,7,13H2,1-6H3,(H2,24,26,27,28)/t17-,19?/m0/s1 JNYINEBNIROMEU-KKFHFHRHSA-N 50358241 CHEMBL1922216 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 4300 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358241 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358241&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10273006 136962265 CHEMBL1922216 ZINC13974085 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50704005 CC[C@H](Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1)C(C)(C)O InChI=1S/C21H30N6O/c1-6-16(21(4,5)28)24-20-25-18(22-12-15-10-8-7-9-11-15)17-19(26-20)27(13-23-17)14(2)3/h7-11,13-14,16,28H,6,12H2,1-5H3,(H2,22,24,25,26)/t16-/m0/s1 JBFPVHXMCIWHJX-INIZCTEOSA-N 50358242 CHEMBL1922217 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2000 ChEMBL 10.1016/j.bmc.2011.08.051 10.7270/Q2NP24V1 21982796 Wilson, SC; Atrash, B; Barlow, C; Eccles, S; Fischer, PM; Hayes, A; Kelland, L; Jackson, W; Jarman, M; Mirza, A; Moreno, J; Nutley, BP; Raynaud, FI; Sheldrake, P; Walton, M; Westwood, R; Whittaker, S; Workman, P; McDonald, E The Institute of Cancer Research http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50358242 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50358242&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10156756 136962266 CHEMBL1922217 ZINC01491380 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50865091 Cc1nc(N)sc1-c1ccnc(Nc2cccc(c2)[N+]([O-])=O)n1 InChI=1S/C14H12N6O2S/c1-8-12(23-13(15)17-8)11-5-6-16-14(19-11)18-9-3-2-4-10(7-9)20(21)22/h2-7H,1H3,(H2,15,17)(H,16,18,19) DYTKVFHLKPDNRW-UHFFFAOYSA-N 50229973 (4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(3-nitrophenyl)amine::4-methyl-5-(2-(3-nitrophenylamino)pyrimidin-4-yl)thiazol-2-amine::CHEMBL298445::[4-(2-AMINO-4-METHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-(3-NITRO-PHENYL)-AMINE Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 70 ChEMBL 10.1073/pnas.0708800104 10.7270/Q2DB82RH 18077363 Fedorov, O; Marsden, B; Pogacic, V; Rellos, P; Muller, S; Bullock, AN; Schwaller, J; Sundstrom, M; Knapp, S University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50229973 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50229973&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search CK7 2WEV,1PXO,4B9D 447961 104098225 CHEMBL298445 DB02833 ZINC02047389 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50864948 CC(C)c1nn(-c2c(Cl)cccc2Cl)c2nc(Cc3ccc(OCCO)cc3)[nH]c(=O)c12 InChI=1S/C23H22Cl2N4O3/c1-13(2)20-19-22(29(28-20)21-16(24)4-3-5-17(21)25)26-18(27-23(19)31)12-14-6-8-15(9-7-14)32-11-10-30/h3-9,13,30H,10-12H2,1-2H3,(H,26,27,31) RSQPNXBTPUXMQN-UHFFFAOYSA-N 59227 Pyrazolopyrimidone analog, RGB-286147 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 71 ChEMBL 10.1073/pnas.0708800104 10.7270/Q2DB82RH 18077363 Fedorov, O; Marsden, B; Pogacic, V; Rellos, P; Muller, S; Bullock, AN; Schwaller, J; Sundstrom, M; Knapp, S University of Oxford http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=59227 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=59227&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 9549301 125082193 5943 ZINC29056064 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50953156 Cn1nc(-c2ccnc(Nc3ccc(cc3)S(N)(=O)=O)n2)c2ccccc12 InChI=1S/C18H16N6O2S/c1-24-16-5-3-2-4-14(16)17(23-24)15-10-11-20-18(22-15)21-12-6-8-13(9-7-12)27(19,25)26/h2-11H,1H3,(H2,19,25,26)(H,20,21,22) ZFEYLWUPVGFOSD-UHFFFAOYSA-N 50391211 CHEMBL2088826 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391211 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391211&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 70682821 160870294 CHEMBL2088826 ZINC84690007 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50953157 Cn1nc(-c2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c2ccccc12 InChI=1S/C18H16N6O2S/c1-24-16-8-3-2-7-14(16)17(23-24)15-9-10-20-18(22-15)21-12-5-4-6-13(11-12)27(19,25)26/h2-11H,1H3,(H2,19,25,26)(H,20,21,22) ZGYYSZDEERINCY-UHFFFAOYSA-N 50391212 CHEMBL2088827 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391212 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391212&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 70691236 160870295 CHEMBL2088827 ZINC84739777 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50953158 CCn1nc(-c2ccnc(Nc3ccc(cc3)S(N)(=O)=O)n2)c2ccccc12 InChI=1S/C19H18N6O2S/c1-2-25-17-6-4-3-5-15(17)18(24-25)16-11-12-21-19(23-16)22-13-7-9-14(10-8-13)28(20,26)27/h3-12H,2H2,1H3,(H2,20,26,27)(H,21,22,23) KUGVZTUWNUHAHF-UHFFFAOYSA-N 50391213 CHEMBL2088828 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391213 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391213&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 70689145 160870296 CHEMBL2088828 ZINC84739783 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50953159 CCn1nc(-c2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c2ccccc12 InChI=1S/C19H18N6O2S/c1-2-25-17-9-4-3-8-15(17)18(24-25)16-10-11-21-19(23-16)22-13-6-5-7-14(12-13)28(20,26)27/h3-12H,2H2,1H3,(H2,20,26,27)(H,21,22,23) XLVAOYFVEAWDSR-UHFFFAOYSA-N 50391214 CHEMBL2088829 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391214 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391214&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 70684896 160870297 CHEMBL2088829 ZINC84739787 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50953160 CCCn1nc(-c2ccnc(Nc3ccc(cc3)S(N)(=O)=O)n2)c2ccccc12 InChI=1S/C20H20N6O2S/c1-2-13-26-18-6-4-3-5-16(18)19(25-26)17-11-12-22-20(24-17)23-14-7-9-15(10-8-14)29(21,27)28/h3-12H,2,13H2,1H3,(H2,21,27,28)(H,22,23,24) VRHNNRWRKNFLEX-UHFFFAOYSA-N 50391215 CHEMBL2088835 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391215 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391215&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 70684897 160870298 CHEMBL2088835 ZINC84739215 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50953161 CCCn1nc(-c2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c2ccccc12 InChI=1S/C20H20N6O2S/c1-2-12-26-18-9-4-3-8-16(18)19(25-26)17-10-11-22-20(24-17)23-14-6-5-7-15(13-14)29(21,27)28/h3-11,13H,2,12H2,1H3,(H2,21,27,28)(H,22,23,24) CRAMQTAMSPUOSC-UHFFFAOYSA-N 50391216 CHEMBL2088836 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391216 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391216&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 70687054 160870299 CHEMBL2088836 ZINC84688281 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50953162 NS(=O)(=O)c1ccc(Nc2nccc(n2)-c2nn(Cc3cccnc3)c3ccccc23)cc1 InChI=1S/C23H19N7O2S/c24-33(31,32)18-9-7-17(8-10-18)27-23-26-13-11-20(28-23)22-19-5-1-2-6-21(19)30(29-22)15-16-4-3-12-25-14-16/h1-14H,15H2,(H2,24,31,32)(H,26,27,28) NXXCZSSBACNPLO-UHFFFAOYSA-N 50391217 CHEMBL2088837 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391217&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 70695451 160870300 CHEMBL2088837 ZINC84733060 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50953163 NS(=O)(=O)c1cccc(Nc2nccc(n2)-c2nn(Cc3cccnc3)c3ccccc23)c1 InChI=1S/C23H19N7O2S/c24-33(31,32)18-7-3-6-17(13-18)27-23-26-12-10-20(28-23)22-19-8-1-2-9-21(19)30(29-22)15-16-5-4-11-25-14-16/h1-14H,15H2,(H2,24,31,32)(H,26,27,28) LDBOYZUPWICGFP-UHFFFAOYSA-N 50391218 CHEMBL2088838 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391218 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391218&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 70684898 160870301 CHEMBL2088838 ZINC84725380 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50953164 NS(=O)(=O)c1ccc(Nc2nccc(n2)-n2ncc3ccccc23)cc1 InChI=1S/C17H14N6O2S/c18-26(24,25)14-7-5-13(6-8-14)21-17-19-10-9-16(22-17)23-15-4-2-1-3-12(15)11-20-23/h1-11H,(H2,18,24,25)(H,19,21,22) MGYDUQVCVWCQMO-UHFFFAOYSA-N 50391209 CHEMBL2088839 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 328 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391209 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391209&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 70691237 160870292 CHEMBL2088839 ZINC84733065 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50953165 NS(=O)(=O)c1cccc(Nc2nccc(n2)-n2ncc3ccccc23)c1 InChI=1S/C17H14N6O2S/c18-26(24,25)14-6-3-5-13(10-14)21-17-19-9-8-16(22-17)23-15-7-2-1-4-12(15)11-20-23/h1-11H,(H2,18,24,25)(H,19,21,22) VLROOZRSNWRFKW-UHFFFAOYSA-N 50391210 CHEMBL2088840 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1016/j.ejmech.2012.09.034 10.7270/Q2GX4CNV 23085105 Lukasik, PM; Elabar, S; Lam, F; Shao, H; Liu, X; Abbas, AY; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50391210 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50391210&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 24959532 160870293 CHEMBL2088840 ZINC84733068 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50972131 O=C1NC(Nc2ccccc2)=NC1=Cc1ccc2OCOc2c1 InChI=1S/C17H13N3O3/c21-16-13(8-11-6-7-14-15(9-11)23-10-22-14)19-17(20-16)18-12-4-2-1-3-5-12/h1-9H,10H2,(H2,18,19,20,21) PGPHHJBZEGSUNE-UHFFFAOYSA-N 50347750 CHEMBL1802358 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/jm301034u 10.7270/Q2571D55 22998443 Tahtouh, T; Elkins, JM; Filippakopoulos, P; Soundararajan, M; Burgy, G; Durieu, E; Cochet, C; Schmid, RS; Lo, DC; Delhommel, F; Oberholzer, AE; Pearl, LH; Carreaux, F; Bazureau, JP; Knapp, S; Meijer, L CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50347750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50347750&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 25230621 136354436 CHEMBL1802358 ZINC59182036 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50972150 CN1C(N)=NC(=Cc2ccc3OCOc3c2)C1=O InChI=1S/C12H11N3O3/c1-15-11(16)8(14-12(15)13)4-7-2-3-9-10(5-7)18-6-17-9/h2-5H,6H2,1H3,(H2,13,14) PKEDBIGNILOTHW-UHFFFAOYSA-N 50292406 CHEMBL485053::leucettamine B Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/jm301034u 10.7270/Q2571D55 22998443 Tahtouh, T; Elkins, JM; Filippakopoulos, P; Soundararajan, M; Burgy, G; Durieu, E; Cochet, C; Schmid, RS; Lo, DC; Delhommel, F; Oberholzer, AE; Pearl, LH; Carreaux, F; Bazureau, JP; Knapp, S; Meijer, L CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50292406 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50292406&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 10037501 104133957 CHEMBL485053 ZINC34118117 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50972169 COc1ccc2c(c1)[nH]c1c(C)nccc21 InChI=1S/C13H12N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-7,15H,1-2H3 BXNJHAXVSOCGBA-UHFFFAOYSA-N 100152 7-methoxy-1-methyl-9H-beta-carboline;hydrochloride::7-methoxy-1-methyl-9H-pyrido[3,4-b]indole;hydrochloride::HARMINE::Harmine hydrochloride::MLS002153910::SMR001233259::cid_5359389 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1021/jm301034u 10.7270/Q2571D55 22998443 Tahtouh, T; Elkins, JM; Filippakopoulos, P; Soundararajan, M; Burgy, G; Durieu, E; Cochet, C; Schmid, RS; Lo, DC; Delhommel, F; Oberholzer, AE; Pearl, LH; Carreaux, F; Bazureau, JP; Knapp, S; Meijer, L CNRS http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=100152 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=100152&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search HRM 7X9D,5Y86,2Z5X,3ANR,2Z5Y 5280953 252663240 28121 DB07919 C06538 ZINC18847046 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083835 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)C(=O)NC2CCN(C)CC2)ncc1C#N InChI=1S/C23H26N8OS/c1-14-20(33-23(25-2)27-14)19-16(12-24)13-26-22(30-19)29-18-6-4-5-15(11-18)21(32)28-17-7-9-31(3)10-8-17/h4-6,11,13,17H,7-10H2,1-3H3,(H,25,27)(H,28,32)(H,26,29,30) HAOOVLDCSQZODX-UHFFFAOYSA-N 50443456 CHEMBL3087432 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 163 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443456 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443456&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 76328016 194941352 CHEMBL3087432 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083836 CNc1nc(C)c(s1)-c1nc(Nc2ccc(cc2)C(=O)NC2CCN(C)CC2)ncc1C#N InChI=1S/C23H26N8OS/c1-14-20(33-23(25-2)27-14)19-16(12-24)13-26-22(30-19)29-17-6-4-15(5-7-17)21(32)28-18-8-10-31(3)11-9-18/h4-7,13,18H,8-11H2,1-3H3,(H,25,27)(H,28,32)(H,26,29,30) ANZDEYYSOIFTCU-UHFFFAOYSA-N 50443457 CHEMBL3087433 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 304 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443457 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443457&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 76313579 194941353 CHEMBL3087433 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083837 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)C(=O)NC2CCN(C)CC2)ncc1F InChI=1S/C22H26FN7OS/c1-13-19(32-22(24-2)26-13)18-17(23)12-25-21(29-18)28-16-6-4-5-14(11-16)20(31)27-15-7-9-30(3)10-8-15/h4-6,11-12,15H,7-10H2,1-3H3,(H,24,26)(H,27,31)(H,25,28,29) AFCWHBYSCXCKFL-UHFFFAOYSA-N 50443458 CHEMBL3087434 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 542 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443458 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443458&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 76309866 194941354 CHEMBL3087434 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083838 CNc1nc(C)c(s1)-c1nc(Nc2cc(ccc2Cl)C(=O)N2CCN(C)CC2)ncc1C#N InChI=1S/C22H23ClN8OS/c1-13-19(33-22(25-2)27-13)18-15(11-24)12-26-21(29-18)28-17-10-14(4-5-16(17)23)20(32)31-8-6-30(3)7-9-31/h4-5,10,12H,6-9H2,1-3H3,(H,25,27)(H,26,28,29) NGIUJEJHSLLBCD-UHFFFAOYSA-N 50443459 CHEMBL3087435 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443459 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443459&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 76313580 194941355 CHEMBL3087435 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51092103 CCC(CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24) BTIHMVBBUGXLCJ-UHFFFAOYSA-N 7585 (R,S)-Roscovitine::2,6,9-Trisubstituted purine deriv. 27::2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::CHEMBL52387::US10294218, Example Roscovitine::US9617225, Roscovitine Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 490 ChEMBL 10.1021/jm401073p 10.7270/Q28W3FSW 24417566 Reddy, MV; Akula, B; Cosenza, SC; Athuluridivakar, S; Mallireddigari, MR; Pallela, VR; Billa, VK; Subbaiah, DR; Bharathi, EV; Vasquez-Del Carpio, R; Padgaonkar, A; Baker, SJ; Reddy, EP Icahn School of Medicine at Mount Sinai http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7585 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7585&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 5097 11108369 CHEMBL52387 ZINC01649340 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083840 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)C(=O)N2CCN(CC2)C(C)=O)ncc1C#N InChI=1S/C23H24N8O2S/c1-14-20(34-23(25-3)27-14)19-17(12-24)13-26-22(29-19)28-18-6-4-5-16(11-18)21(33)31-9-7-30(8-10-31)15(2)32/h4-6,11,13H,7-10H2,1-3H3,(H,25,27)(H,26,28,29) APNXOACTQOYOLQ-UHFFFAOYSA-N 50443444 CHEMBL3087437 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 552 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443444 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443444&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 44253321 194941340 CHEMBL3087437 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083841 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)C(=O)N2CCOCC2)ncc1C#N InChI=1S/C21H21N7O2S/c1-13-18(31-21(23-2)25-13)17-15(11-22)12-24-20(27-17)26-16-5-3-4-14(10-16)19(29)28-6-8-30-9-7-28/h3-5,10,12H,6-9H2,1-2H3,(H,23,25)(H,24,26,27) UFUGKBGESCNADR-UHFFFAOYSA-N 50425002 CHEMBL2312191 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1870 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50425002 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50425002&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search TJF 4BCQ 44253188 164153877 CHEMBL2312191 ZINC95593936 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083842 CNc1nc(C)c(s1)-c1ccnc(Nc2cccc(c2)C(=O)N2CCOCC2)n1 InChI=1S/C20H22N6O2S/c1-13-17(29-20(21-2)23-13)16-6-7-22-19(25-16)24-15-5-3-4-14(12-15)18(27)26-8-10-28-11-9-26/h3-7,12H,8-11H2,1-2H3,(H,21,23)(H,22,24,25) BVPOKPFALSNQSI-UHFFFAOYSA-N 50443445 CHEMBL3087438 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 393 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443445 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443445&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 76331677 194941341 CHEMBL3087438 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083843 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(=O)(=O)N2CCN(C)CC2)ncc1C#N InChI=1S/C21H24N8O2S2/c1-14-19(32-21(23-2)25-14)18-15(12-22)13-24-20(27-18)26-16-5-4-6-17(11-16)33(30,31)29-9-7-28(3)8-10-29/h4-6,11,13H,7-10H2,1-3H3,(H,23,25)(H,24,26,27) YKBWHMMFNLYZNJ-UHFFFAOYSA-N 50443446 CHEMBL3087439 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 24 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443446 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443446&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 76317084 194941342 CHEMBL3087439 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083844 CNc1nc(C)c(s1)-c1nc(Nc2ccc(C)c(c2)S(=O)(=O)N2CCOCC2)ncc1F InChI=1S/C20H23FN6O3S2/c1-12-4-5-14(10-16(12)32(28,29)27-6-8-30-9-7-27)25-19-23-11-15(21)17(26-19)18-13(2)24-20(22-3)31-18/h4-5,10-11H,6-9H2,1-3H3,(H,22,24)(H,23,25,26) JADZIABDRVBRMR-UHFFFAOYSA-N 50443447 CHEMBL3087440 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 133 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443447 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443447&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 76309867 194941343 CHEMBL3087440 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083845 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(=O)(=O)N2CCOCC2)ncc1C#N InChI=1S/C20H21N7O3S2/c1-13-18(31-20(22-2)24-13)17-14(11-21)12-23-19(26-17)25-15-4-3-5-16(10-15)32(28,29)27-6-8-30-9-7-27/h3-5,10,12H,6-9H2,1-2H3,(H,22,24)(H,23,25,26) AFYLTDZJAWPVBM-UHFFFAOYSA-N 50443448 CHEMBL3087441 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 893 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443448&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 44253464 194941344 CHEMBL3087441 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083846 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(=O)(=O)NCCOC)ncc1F InChI=1S/C18H21FN6O3S2/c1-11-16(29-18(20-2)23-11)15-14(19)10-21-17(25-15)24-12-5-4-6-13(9-12)30(26,27)22-7-8-28-3/h4-6,9-10,22H,7-8H2,1-3H3,(H,20,23)(H,21,24,25) CGBFAYLLULJFBW-UHFFFAOYSA-N 50443449 CHEMBL3087442 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 30 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443449 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443449&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 76313581 194941345 CHEMBL3087442 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083847 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(=O)(=O)NCCOC)ncc1C#N InChI=1S/C19H21N7O3S2/c1-12-17(30-19(21-2)24-12)16-13(10-20)11-22-18(26-16)25-14-5-4-6-15(9-14)31(27,28)23-7-8-29-3/h4-6,9,11,23H,7-8H2,1-3H3,(H,21,24)(H,22,25,26) AZPRRIBSKMOFDL-UHFFFAOYSA-N 50443450 CHEMBL3087443 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 180 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443450 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443450&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 76313582 194941346 CHEMBL3087443 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083848 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)S(C)(=O)=O)ncc1C#N InChI=1S/C17H16N6O2S2/c1-10-15(26-17(19-2)21-10)14-11(8-18)9-20-16(23-14)22-12-5-4-6-13(7-12)27(3,24)25/h4-7,9H,1-3H3,(H,19,21)(H,20,22,23) WVRPZYQKQWOMIH-UHFFFAOYSA-N 50443451 CHEMBL3087444 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 110 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443451 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443451&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 44253466 194941347 CHEMBL3087444 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083849 CN1CCN(CC1)c1cccc(Nc2ncc(F)c(n2)-c2sc(N)nc2C)c1 InChI=1S/C19H22FN7S/c1-12-17(28-18(21)23-12)16-15(20)11-22-19(25-16)24-13-4-3-5-14(10-13)27-8-6-26(2)7-9-27/h3-5,10-11H,6-9H2,1-2H3,(H2,21,23)(H,22,24,25) LRPFDZCHJQTXPT-UHFFFAOYSA-N 50443452 CHEMBL3087445 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 476 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443452 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443452&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 76317085 194941348 CHEMBL3087445 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083850 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCN(C)CC2)ncc1F InChI=1S/C20H24FN7S/c1-13-18(29-20(22-2)24-13)17-16(21)12-23-19(26-17)25-14-5-4-6-15(11-14)28-9-7-27(3)8-10-28/h4-6,11-12H,7-10H2,1-3H3,(H,22,24)(H,23,25,26) PJIPYWGIYRUKIG-UHFFFAOYSA-N 50443453 CHEMBL3087447 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 541 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443453 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443453&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 76317086 194941349 CHEMBL3087447 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083851 CC(=O)N1CCN(CC1)c1cccc(Nc2ncc(F)c(n2)-c2sc(N)nc2C)c1 InChI=1S/C20H22FN7OS/c1-12-18(30-19(22)24-12)17-16(21)11-23-20(26-17)25-14-4-3-5-15(10-14)28-8-6-27(7-9-28)13(2)29/h3-5,10-11H,6-9H2,1-2H3,(H2,22,24)(H,23,25,26) DLENXRXJIRCJJB-UHFFFAOYSA-N 50443454 CHEMBL3087446 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1457 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443454 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443454&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 76335286 194941350 CHEMBL3087446 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083852 Cc1nc(N)sc1-c1nc(Nc2cccc(c2)S(N)(=O)=O)ncc1F InChI=1S/C14H13FN6O2S2/c1-7-12(24-13(16)19-7)11-10(15)6-18-14(21-11)20-8-3-2-4-9(5-8)25(17,22)23/h2-6H,1H3,(H2,16,19)(H2,17,22,23)(H,18,20,21) BQLLLVDIZXOQJD-UHFFFAOYSA-N 50443455 CHEMBL3087448 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 252 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443455 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443455&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 72204789 194941351 CHEMBL3087448 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083874 CNc1nc(C)c(s1)-c1ccnc(Nc2ccc(C)c(c2)S(=O)(=O)N2CCOCC2)n1 InChI=1S/C20H24N6O3S2/c1-13-4-5-15(12-17(13)31(27,28)26-8-10-29-11-9-26)24-19-22-7-6-16(25-19)18-14(2)23-20(21-3)30-18/h4-7,12H,8-11H2,1-3H3,(H,21,23)(H,22,24,25) NNMRZPOMVQNXMS-UHFFFAOYSA-N 81436 CDK Inhibitor, 9 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 150 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=81436 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=81436&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11510921 131342010 ZINC43101526 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51083839 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)C(=O)N2CCN(C)CC2)ncc1C#N InChI=1S/C22H24N8OS/c1-14-19(32-22(24-2)26-14)18-16(12-23)13-25-21(28-18)27-17-6-4-5-15(11-17)20(31)30-9-7-29(3)8-10-30/h4-6,11,13H,7-10H2,1-3H3,(H,24,26)(H,25,27,28) ROGLCZFAMZYZJO-UHFFFAOYSA-N 50443443 CHEMBL3087436 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 840 ChEMBL 10.1016/j.ejmech.2013.08.052 10.7270/Q24J0GKS 24185375 Shao, H; Shi, S; Foley, DW; Lam, F; Abbas, AY; Liu, X; Huang, S; Jiang, X; Baharin, N; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50443443 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50443443&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74222731 194941339 CHEMBL3087436 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50519870 COCCN1CCN(Cc2ccc(cc2)-c2n[nH]c3-c4cccc(NC(=O)NN5CCOCC5)c4C(=O)c23)CC1 InChI=1S/C29H35N7O4/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36/h2-8H,9-19H2,1H3,(H,31,32)(H2,30,33,38) XLSYZSRXVVCHLS-UHFFFAOYSA-N 50193093 RGB-286638 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2.0 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50193093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50193093&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 11285002 375076103 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50519920 CC[C@H](Nc1nc(NCc2cnc(C)cc2C)c2ncn(C(C)C)c2n1)[C@@H](C)O InChI=1S/C21H31N7O/c1-7-17(15(6)29)25-21-26-19(18-20(27-21)28(11-24-18)12(2)3)23-10-16-9-22-14(5)8-13(16)4/h8-9,11-12,15,17,29H,7,10H2,1-6H3,(H2,23,25,26,27)/t15-,17+/m1/s1 DLPIYBKBHMZCJI-WBVHZDCISA-N 106950 US8592581, 1 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 193 ChEMBL 10.1021/acs.jmedchem.6b00150 10.7270/Q2G73GP8 27171036 Sonawane, YA; Taylor, MA; Napoleon, JV; Rana, S; Contreras, JI; Natarajan, A University of Nebraska Medical Center http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=106950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=106950&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 24983461 174009261 ZINC96177788 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51062260 CN[C@@H]1CC2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1 HKSZLNNOFSGOKW-ZGQXJOJZSA-N 50059889 (staurosporine)3-methoxy-2-methyl-4-methylamino-(2S,3S,4S,6S)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::12-[3-methoxy-2,6-dimethyl-4-methylamino-(2S,3R,4R,6S)-tetrahydro-2H-2-pyranyl]-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one::12-[3-methoxy-6-methyl-4-methylamino-(2S,3R,4R,6S)-tetrahydro-2H-2-pyranyl]-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one::15,16-dimethoxy-15-methyl-17-methylamino-(15S)-4,14,20-triazaheptacyclo[12.12.2.02,6.07,28.08,13.020,27.021,26]octacosa-1(27),2(6),7(28),8(13),9,11,21(26),22,24-nonaen-3-one::2-Amino-4-(2-amino-2-phenyl-ethyl)-6-(2-hydroxy-phenyl)-nicotinonitrile::3-methoxy-2-methyl-4-methylamino-(2R,3S,4S)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14,19,21(26),22,24,27-nonaen-16-one::3-methoxy-2-methyl-4-methylamino-(2R,3S,4S)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::3-methoxy-2-methyl-4-methylamino-(2R,3S,4S,6S)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::3-methoxy-2-methyl-4-methylamino-(2R,3S,4S,6S)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one(Staurosporine)::3-methoxy-2-methyl-4-methylamino-(2R,3S,4S,6S)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14(28),15(19),20(27),21,23,25-nonaen-16-one::3-methoxy-2-methyl-4-methylamino-(2R,3S,4S,6S)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14,19,21(26),22,24,27-nonaen-16-one::3-methoxy-2-methyl-4-methylamino-(2R,3S,4S,6S)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::3-methoxy-2-methyl-4-methylamino-(2S,3R,4R)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::3-methoxy-2-methyl-4-methylamino-(2S,3R,4R)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14,19,21(26),22,24,27-nonaen-16-one::3-methoxy-2-methyl-4-methylamino-(2S,3R,4R,6R)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::3-methoxy-2-methyl-4-methylamino-(2S,3R,4R,6R)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::3-methoxy-2-methyl-4-methylamino-(2S,3S,4S,6R)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14(28),15(19),20(27),21,23,25-nonaen-16-one::3-methoxy-2-methyl-4-methylamino-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::3-methoxy-2-methyl-4-methylamino-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14,19,21(26),22,24,27-nonaen-16-one::3-methoxy-4-methylamino-(2R,3S,4S,6S)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::3-methoxy-4-methylamino-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one::8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one,2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-::AM-2282::CHEMBL162::Indolocarbazole nitrogen derivative::Isoindolinone Urea derivative::staurosporin Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 910 ChEMBL 10.1021/jm301234k 10.7270/Q25T3MV7 23600925 Schonbrunn, E; Betzi, S; Alam, R; Martin, MP; Becker, A; Han, H; Francis, R; Chakrasali, R; Jakkaraj, S; Kazi, A; Sebti, SM; Cubitt, CL; Gebhard, AW; Hazlehurst, LA; Tash, JS; Georg, GI H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50059889 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50059889&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 44299148 103955664 CHEMBL162 C02079 ZINC03814434 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51062261 Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)sc1C(=O)c1ccccc1[N+]([O-])=O InChI=1S/C16H13N5O5S2/c17-15-14(13(22)11-3-1-2-4-12(11)21(23)24)27-16(20-15)19-9-5-7-10(8-6-9)28(18,25)26/h1-8H,17H2,(H,19,20)(H2,18,25,26) JXJHPQHLHQTQQI-UHFFFAOYSA-N 50433369 CHEMBL2377825 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000 ChEMBL 10.1021/jm301234k 10.7270/Q25T3MV7 23600925 Schonbrunn, E; Betzi, S; Alam, R; Martin, MP; Becker, A; Han, H; Francis, R; Chakrasali, R; Jakkaraj, S; Kazi, A; Sebti, SM; Cubitt, CL; Gebhard, AW; Hazlehurst, LA; Tash, JS; Georg, GI H. Lee Moffitt Cancer Center and Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50433369 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50433369&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search X64 4GCJ,3QXP 66553053 175445686 CHEMBL2377825 ZINC95920805 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50724371 NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3nc[nH]c3n2)cc1 InChI=1S/C18H22N6O3S/c19-28(25,26)14-8-6-13(7-9-14)22-18-23-16-15(20-11-21-16)17(24-18)27-10-12-4-2-1-3-5-12/h6-9,11-12H,1-5,10H2,(H2,19,25,26)(H2,20,21,22,23,24) OWXORKPNCHJYOF-UHFFFAOYSA-N 50235342 CHEMBL319467::NU-6102 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 4400 ChEMBL 10.1021/acs.jmedchem.6b01254 10.7270/Q2833V86 28005359 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235342&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 4SP 5M57,6BSS,2C6O,4EOK,4EOR,1H1S,5LQF,2IW8,2IW9 4566 384991216 CHEMBL319467 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50724374 NS(=O)(=O)c1ccc(Nc2ncc3nc[nH]c3n2)cc1 InChI=1S/C11H10N6O2S/c12-20(18,19)8-3-1-7(2-4-8)16-11-13-5-9-10(17-11)15-6-14-9/h1-6H,(H2,12,18,19)(H2,13,14,15,16,17) ZVHABBMEQZWREZ-UHFFFAOYSA-N 50235339 CHEMBL4073211 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 75000 ChEMBL 10.1021/acs.jmedchem.6b01254 10.7270/Q2833V86 28005359 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235339 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235339&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137640533 384991213 CHEMBL4073211 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50724375 NS(=O)(=O)c1ccc(Nc2nc(-c3ccccc3)c3nc[nH]c3n2)cc1 InChI=1S/C17H14N6O2S/c18-26(24,25)13-8-6-12(7-9-13)21-17-22-14(11-4-2-1-3-5-11)15-16(23-17)20-10-19-15/h1-10H,(H2,18,24,25)(H2,19,20,21,22,23) GETVVUWUPLHXBE-UHFFFAOYSA-N 50235345 CHEMBL4105278 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 6800 ChEMBL 10.1021/acs.jmedchem.6b01254 10.7270/Q2833V86 28005359 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235345 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235345&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137656537 384991219 CHEMBL4105278 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50724383 NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3cn[nH]c3n2)cc1 InChI=1S/C18H22N6O3S/c19-28(25,26)14-8-6-13(7-9-14)21-18-22-16-15(10-20-24-16)17(23-18)27-11-12-4-2-1-3-5-12/h6-10,12H,1-5,11H2,(H2,19,25,26)(H2,20,21,22,23,24) MWINFFOPTSOXJI-UHFFFAOYSA-N 50235336 CHEMBL4085238 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 7000 ChEMBL 10.1021/acs.jmedchem.6b01254 10.7270/Q2833V86 28005359 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235336 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235336&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 24800068 384991210 CHEMBL4085238 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50724385 NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3nn[nH]c3n2)cc1 InChI=1S/C17H21N7O3S/c18-28(25,26)13-8-6-12(7-9-13)19-17-20-15-14(22-24-23-15)16(21-17)27-10-11-4-2-1-3-5-11/h6-9,11H,1-5,10H2,(H2,18,25,26)(H2,19,20,21,22,23,24) HQGOXGMCHYWWCV-UHFFFAOYSA-N 50235335 CHEMBL4092981 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 6800 ChEMBL 10.1021/acs.jmedchem.6b01254 10.7270/Q2833V86 28005359 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235335 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235335&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137654694 384991209 CHEMBL4092981 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50724401 NS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3cc[nH]c3n2)cc1 InChI=1S/C19H23N5O3S/c20-28(25,26)15-8-6-14(7-9-15)22-19-23-17-16(10-11-21-17)18(24-19)27-12-13-4-2-1-3-5-13/h6-11,13H,1-5,12H2,(H2,20,25,26)(H2,21,22,23,24) NJZMZGLYZQNCHS-UHFFFAOYSA-N 50235337 CHEMBL4062554 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 4100 ChEMBL 10.1021/acs.jmedchem.6b01254 10.7270/Q2833V86 28005359 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235337 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235337&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137634367 384991211 CHEMBL4062554 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50724419 CCC(C)Oc1nc(Nc2ccc(cc2)S(N)(=O)=O)nc2[nH]cnc12 InChI=1S/C15H18N6O3S/c1-3-9(2)24-14-12-13(18-8-17-12)20-15(21-14)19-10-4-6-11(7-5-10)25(16,22)23/h4-9H,3H2,1-2H3,(H2,16,22,23)(H2,17,18,19,20,21) LSJIMMQWBYSNTG-UHFFFAOYSA-N 50235343 CHEMBL4103249 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2800 ChEMBL 10.1021/acs.jmedchem.6b01254 10.7270/Q2833V86 28005359 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Newcastle University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50235343 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50235343&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137658097 384991217 CHEMBL4103249 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 50860782 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(\C=C\c1c(Cl)cccc1Cl)cc2=O InChI=1S/C23H21Cl2NO5/c1-26-8-7-14(20(30)11-26)21-18(28)10-19(29)22-17(27)9-12(31-23(21)22)5-6-13-15(24)3-2-4-16(13)25/h2-6,9-10,14,20,28-30H,7-8,11H2,1H3/b6-5+/t14-,20+/m0/s1 NFTJDXGFOUFNKG-UGBNQVSOSA-N 50263013 CHEMBL4079206 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 711 ChEMBL 10.1021/acs.jmedchem.7b01765 10.7270/Q2DV1NC4 29370702 Bharate, SB; Kumar, V; Jain, SK; Mintoo, MJ; Guru, SK; Nuthakki, VK; Sharma, M; Bharate, SS; Gandhi, SG; Mondhe, DM; Bhushan, S; Vishwakarma, RA CSIR-Indian Institute of Integrative Medicine http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50263013 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50263013&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 137628639 404341348 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51142829 CC[C@H](CO)Nc1nc(NCc2ccccc2)n2ncc(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(12-26)22-18-23-17-16(13(2)3)11-21-25(17)19(24-18)20-10-14-8-6-5-7-9-14/h5-9,11,13,15,26H,4,10,12H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 SQUNOCMDMIQIQK-OAHLLOKOSA-N 27217 (2R)-2-{[4-(benzylamino)-8-(propan-2-yl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol::GP0210::pyrazolo[1,5-a]-1,3,5-triazine, 7a Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 43 ChEMBL 10.1016/j.ejmech.2017.09.035 10.7270/Q2HH6NRF 29046238 Cascioferro, S; Parrino, B; Spanò, V; Carbone, A; Montalbano, A; Barraja, P; Diana, P; Cirrincione, G Universit£ degli Studi di Palermo http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27217 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=27217&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search NNN 3DOG 25190761 57298927 DB08285 ZINC34285231 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220689 Cc1nc(NC2CCCC2)sc1-c1nc(Nc2ccc(cn2)N2CCNCC2)ncc1F InChI=1S/C22H27FN8S/c1-14-20(32-22(27-14)28-15-4-2-3-5-15)19-17(23)13-26-21(30-19)29-18-7-6-16(12-25-18)31-10-8-24-9-11-31/h6-7,12-13,15,24H,2-5,8-11H2,1H3,(H,27,28)(H,25,26,29,30) AMPDZRFNHCTPTF-UHFFFAOYSA-N 50501579 CHEMBL4089056 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 790 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501579 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501579&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126534479 433913480 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220690 Cc1nc(NC2CCCC2)sc1-c1nc(Nc2ccc(cn2)N2CCCNCC2)ncc1F InChI=1S/C23H29FN8S/c1-15-21(33-23(28-15)29-16-5-2-3-6-16)20-18(24)14-27-22(31-20)30-19-8-7-17(13-26-19)32-11-4-9-25-10-12-32/h7-8,13-14,16,25H,2-6,9-12H2,1H3,(H,28,29)(H,26,27,30,31) IMDAAVXNKFRYNY-UHFFFAOYSA-N 50501580 CHEMBL4067844 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 815 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501580 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501580&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135286381 433913481 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220691 CN1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2sc(NC3CCCC3)nc2C)nc1 InChI=1S/C23H29FN8S/c1-15-21(33-23(27-15)28-16-5-3-4-6-16)20-18(24)14-26-22(30-20)29-19-8-7-17(13-25-19)32-11-9-31(2)10-12-32/h7-8,13-14,16H,3-6,9-12H2,1-2H3,(H,27,28)(H,25,26,29,30) ZFNZZKVYLDBWRD-UHFFFAOYSA-N 50501581 CHEMBL4072255 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2020 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501581 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501581&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135296339 433913482 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220692 CCN1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2sc(NC3CCCC3)nc2C)nc1 InChI=1S/C24H31FN8S/c1-3-32-10-12-33(13-11-32)18-8-9-20(26-14-18)30-23-27-15-19(25)21(31-23)22-16(2)28-24(34-22)29-17-6-4-5-7-17/h8-9,14-15,17H,3-7,10-13H2,1-2H3,(H,28,29)(H,26,27,30,31) UVEBMCRIHHZDFG-UHFFFAOYSA-N 50501582 CHEMBL4098475 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 685 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501582 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501582&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126559601 433913483 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220693 CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2sc(NC3CCCC3)nc2C)nc1 InChI=1S/C24H29FN8OS/c1-15-22(35-24(28-15)29-17-5-3-4-6-17)21-19(25)14-27-23(31-21)30-20-8-7-18(13-26-20)33-11-9-32(10-12-33)16(2)34/h7-8,13-14,17H,3-6,9-12H2,1-2H3,(H,28,29)(H,26,27,30,31) FQOMMDNBEIZMGZ-UHFFFAOYSA-N 50501583 CHEMBL4087343 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501583 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501583&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135286391 433913484 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220694 Cc1nc(NC2CCCC2)sc1-c1nc(Nc2ccc(cn2)N2CCOCC2)ncc1F InChI=1S/C22H26FN7OS/c1-14-20(32-22(26-14)27-15-4-2-3-5-15)19-17(23)13-25-21(29-19)28-18-7-6-16(12-24-18)30-8-10-31-11-9-30/h6-7,12-13,15H,2-5,8-11H2,1H3,(H,26,27)(H,24,25,28,29) ULIMVSSEPMLVHV-UHFFFAOYSA-N 50501584 CHEMBL4102865 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501584 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501584&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135296341 433913485 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220769 Cc1nc(NC2CCCC2)sc1-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1 InChI=1S/C22H28N8S/c1-15-20(31-22(26-15)27-16-4-2-3-5-16)18-8-9-24-21(28-18)29-19-7-6-17(14-25-19)30-12-10-23-11-13-30/h6-9,14,16,23H,2-5,10-13H2,1H3,(H,26,27)(H,24,25,28,29) JTZWTKLEXMYEMU-UHFFFAOYSA-N 50501577 CHEMBL4071812 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1108 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501577 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501577&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126534285 433913478 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220785 Cc1nc(NC2CCCC2)sc1-c1ccnc(Nc2ccc(cn2)N2CCCNCC2)n1 InChI=1S/C23H30N8S/c1-16-21(32-23(27-16)28-17-5-2-3-6-17)19-9-11-25-22(29-19)30-20-8-7-18(15-26-20)31-13-4-10-24-12-14-31/h7-9,11,15,17,24H,2-6,10,12-14H2,1H3,(H,27,28)(H,25,26,29,30) LICJOAWXMPKZSX-UHFFFAOYSA-N 50501578 CHEMBL4098811 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 282 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501578 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501578&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135286395 433913479 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220786 CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2sc(NC3CCCC3)nc2C)nc1 InChI=1S/C23H30N8S/c1-16-21(32-23(26-16)27-17-5-3-4-6-17)19-9-10-24-22(28-19)29-20-8-7-18(15-25-20)31-13-11-30(2)12-14-31/h7-10,15,17H,3-6,11-14H2,1-2H3,(H,26,27)(H,24,25,28,29) OIQCBGFNCAFMQX-UHFFFAOYSA-N 50501612 CHEMBL4091780 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 865 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501612 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501612&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126559600 433913513 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220787 CCN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2sc(NC3CCCC3)nc2C)nc1 InChI=1S/C24H32N8S/c1-3-31-12-14-32(15-13-31)19-8-9-21(26-16-19)30-23-25-11-10-20(29-23)22-17(2)27-24(33-22)28-18-6-4-5-7-18/h8-11,16,18H,3-7,12-15H2,1-2H3,(H,27,28)(H,25,26,29,30) QLTMJJAAHXGJMD-UHFFFAOYSA-N 50501611 CHEMBL4070914 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 780 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501611 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501611&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135286342 433913512 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220788 CC(=O)N1CCN(CC1)c1ccc(Nc2nccc(n2)-c2sc(NC3CCCC3)nc2C)nc1 InChI=1S/C24H30N8OS/c1-16-22(34-24(27-16)28-18-5-3-4-6-18)20-9-10-25-23(29-20)30-21-8-7-19(15-26-21)32-13-11-31(12-14-32)17(2)33/h7-10,15,18H,3-6,11-14H2,1-2H3,(H,27,28)(H,25,26,29,30) ONRJNVZFOSHIQI-UHFFFAOYSA-N 50501610 CHEMBL4099517 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 3453 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501610 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501610&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135286306 433913511 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220789 Cc1nc(NC2CCCC2)sc1-c1ccnc(Nc2ccc(cn2)N2CCC(N)CC2)n1 InChI=1S/C23H30N8S/c1-15-21(32-23(27-15)28-17-4-2-3-5-17)19-8-11-25-22(29-19)30-20-7-6-18(14-26-20)31-12-9-16(24)10-13-31/h6-8,11,14,16-17H,2-5,9-10,12-13,24H2,1H3,(H,27,28)(H,25,26,29,30) SHEPFXMPLORKLW-UHFFFAOYSA-N 50501608 CHEMBL4061223 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1187 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501608 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501608&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126559606 433913509 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220801 Cc1nc(NC2CCCC2)sc1-c1ccnc(Nc2ccc(cn2)N2CCN(CC2)S(C)(=O)=O)n1 InChI=1S/C23H30N8O2S2/c1-16-21(34-23(26-16)27-17-5-3-4-6-17)19-9-10-24-22(28-19)29-20-8-7-18(15-25-20)30-11-13-31(14-12-30)35(2,32)33/h7-10,15,17H,3-6,11-14H2,1-2H3,(H,26,27)(H,24,25,28,29) ZIWFXQFVSGOWAZ-UHFFFAOYSA-N 50501606 CHEMBL4069886 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2640 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501606 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501606&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135296342 433913507 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220802 CN(C1CCCC1)c1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1 InChI=1S/C23H30N8S/c1-16-21(32-23(27-16)30(2)17-5-3-4-6-17)19-9-10-25-22(28-19)29-20-8-7-18(15-26-20)31-13-11-24-12-14-31/h7-10,15,17,24H,3-6,11-14H2,1-2H3,(H,25,26,28,29) VSTBDMYJXAWENH-UHFFFAOYSA-N 50501605 CHEMBL4102935 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 3200 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501605 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501605&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126535129 433913506 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220814 CN(C1CCCC1)c1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1 InChI=1S/C24H32N8S/c1-17-22(33-24(27-17)31(3)18-6-4-5-7-18)20-10-11-25-23(28-20)29-21-9-8-19(16-26-21)32-14-12-30(2)13-15-32/h8-11,16,18H,4-7,12-15H2,1-3H3,(H,25,26,28,29) OHNWSWSUMDWFSA-UHFFFAOYSA-N 50501604 CHEMBL4084985 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501604 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501604&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135286434 433913505 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220815 Cc1nc(sc1-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1)N(C1CCCC1)C1CCCC1 InChI=1S/C27H36N8S/c1-19-25(36-27(31-19)35(20-6-2-3-7-20)21-8-4-5-9-21)23-12-13-29-26(32-23)33-24-11-10-22(18-30-24)34-16-14-28-15-17-34/h10-13,18,20-21,28H,2-9,14-17H2,1H3,(H,29,30,32,33) DEUZACBXMBZZRF-UHFFFAOYSA-N 50501602 CHEMBL4065844 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501602 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501602&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135286356 433913503 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220816 Cc1nc(Nc2ccccc2)sc1-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1 InChI=1S/C23H24N8S/c1-16-21(32-23(27-16)28-17-5-3-2-4-6-17)19-9-10-25-22(29-19)30-20-8-7-18(15-26-20)31-13-11-24-12-14-31/h2-10,15,24H,11-14H2,1H3,(H,27,28)(H,25,26,29,30) UNVBFURIHRAGGO-UHFFFAOYSA-N 50501601 CHEMBL4085708 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1660 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501601 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501601&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126535189 433913502 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220817 CN(c1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1)c1ccccc1 InChI=1S/C25H28N8S/c1-18-23(34-25(28-18)32(3)19-7-5-4-6-8-19)21-11-12-26-24(29-21)30-22-10-9-20(17-27-22)33-15-13-31(2)14-16-33/h4-12,17H,13-16H2,1-3H3,(H,26,27,29,30) HCDMSNJPLKSFOG-UHFFFAOYSA-N 50501594 CHEMBL4077857 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501594 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501594&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135286350 433913495 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220818 CC(C)Nc1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1 InChI=1S/C20H26N8S/c1-13(2)24-20-25-14(3)18(29-20)16-6-7-22-19(26-16)27-17-5-4-15(12-23-17)28-10-8-21-9-11-28/h4-7,12-13,21H,8-11H2,1-3H3,(H,24,25)(H,22,23,26,27) QRNHMYCAPGHBKI-UHFFFAOYSA-N 50501593 CHEMBL4095884 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 775 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501593 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501593&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135286354 433913494 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220819 CC(C)Nc1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCCNCC2)n1 InChI=1S/C21H28N8S/c1-14(2)25-21-26-15(3)19(30-21)17-7-9-23-20(27-17)28-18-6-5-16(13-24-18)29-11-4-8-22-10-12-29/h5-7,9,13-14,22H,4,8,10-12H2,1-3H3,(H,25,26)(H,23,24,27,28) HBUAOMASWHOWJB-UHFFFAOYSA-N 50501592 CHEMBL4066878 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1160 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501592 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501592&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135286352 433913493 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220838 CC(C)Nc1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCN(C)CC2)n1 InChI=1S/C21H28N8S/c1-14(2)24-21-25-15(3)19(30-21)17-7-8-22-20(26-17)27-18-6-5-16(13-23-18)29-11-9-28(4)10-12-29/h5-8,13-14H,9-12H2,1-4H3,(H,24,25)(H,22,23,26,27) USXJKWQIDCWKGZ-UHFFFAOYSA-N 50501591 CHEMBL4088160 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 760 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501591 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501591&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126535619 433913492 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220839 CC(C)Nc1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCN(CC2)C(C)=O)n1 InChI=1S/C22H28N8OS/c1-14(2)25-22-26-15(3)20(32-22)18-7-8-23-21(27-18)28-19-6-5-17(13-24-19)30-11-9-29(10-12-30)16(4)31/h5-8,13-14H,9-12H2,1-4H3,(H,25,26)(H,23,24,27,28) PTKMSTJCOJHQGV-UHFFFAOYSA-N 50501590 CHEMBL4082236 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 4385 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501590 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501590&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126535633 433913491 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220840 CC(C)Nc1nc(C)c(s1)-c1ccnc(Nc2ccc(cn2)N2CCOCC2)n1 InChI=1S/C20H25N7OS/c1-13(2)23-20-24-14(3)18(29-20)16-6-7-21-19(25-16)26-17-5-4-15(12-22-17)27-8-10-28-11-9-27/h4-7,12-13H,8-11H2,1-3H3,(H,23,24)(H,21,22,25,26) MIFCTDCDIAKSQG-UHFFFAOYSA-N 50501589 CHEMBL4100252 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501589 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501589&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126534280 433913490 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220841 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220842 FC(F)(F)c1nc(NC2CCCC2)sc1-c1ccnc(Nc2ccc(cn2)N2CCNCC2)n1 InChI=1S/C22H25F3N8S/c23-22(24,25)19-18(34-21(32-19)29-14-3-1-2-4-14)16-7-8-27-20(30-16)31-17-6-5-15(13-28-17)33-11-9-26-10-12-33/h5-8,13-14,26H,1-4,9-12H2,(H,29,32)(H,27,28,30,31) XZQBJKPCLITHDB-UHFFFAOYSA-N 50501588 CHEMBL4102076 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 194 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501588 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501588&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126535147 433913489 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220843 CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2sc(NC3CCCC3)nc2C(F)(F)F)nc1 InChI=1S/C23H27F3N8S/c1-33-10-12-34(13-11-33)16-6-7-18(28-14-16)31-21-27-9-8-17(30-21)19-20(23(24,25)26)32-22(35-19)29-15-4-2-3-5-15/h6-9,14-15H,2-5,10-13H2,1H3,(H,29,32)(H,27,28,30,31) LUHGNQLUGTWNCL-UHFFFAOYSA-N 50501587 CHEMBL4066828 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 189 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501587 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501587&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126535157 433913488 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220844 CC(=O)N1CCN(CC1)c1ccc(Nc2nccc(n2)-c2sc(NC3CCCC3)nc2C(F)(F)F)nc1 InChI=1S/C24H27F3N8OS/c1-15(36)34-10-12-35(13-11-34)17-6-7-19(29-14-17)32-22-28-9-8-18(31-22)20-21(24(25,26)27)33-23(37-20)30-16-4-2-3-5-16/h6-9,14,16H,2-5,10-13H2,1H3,(H,30,33)(H,28,29,31,32) BXSSOAIGLMVYQR-UHFFFAOYSA-N 50501586 CHEMBL4079469 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2615 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501586 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501586&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135286368 433913487 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220845 FC(F)(F)c1nc(NC2CCCC2)sc1-c1ccnc(Nc2ccc(cn2)N2CCN(CC2)C=O)n1 InChI=1S/C23H25F3N8OS/c24-23(25,26)20-19(36-22(32-20)29-15-3-1-2-4-15)17-7-8-27-21(30-17)31-18-6-5-16(13-28-18)34-11-9-33(14-35)10-12-34/h5-8,13-15H,1-4,9-12H2,(H,29,32)(H,27,28,30,31) XLZANAXESDHDPY-UHFFFAOYSA-N 50501599 CHEMBL4072388 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1900 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501599 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501599&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126535576 433913500 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220846 CCN1CCN(Cc2ccc(Nc3nccc(n3)-c3sc(NC4CCCC4)nc3C)nc2)CC1 InChI=1S/C25H34N8S/c1-3-32-12-14-33(15-13-32)17-19-8-9-22(27-16-19)31-24-26-11-10-21(30-24)23-18(2)28-25(34-23)29-20-6-4-5-7-20/h8-11,16,20H,3-7,12-15,17H2,1-2H3,(H,28,29)(H,26,27,30,31) VJFMIBISXQANRG-UHFFFAOYSA-N 50501598 CHEMBL4103372 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 211 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501598 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501598&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135286343 433913499 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51220847 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3sc(NC4CCCC4)nc3C)nc2)CC1 InChI=1S/C25H33FN8S/c1-3-33-10-12-34(13-11-33)16-18-8-9-21(27-14-18)31-24-28-15-20(26)22(32-24)23-17(2)29-25(35-23)30-19-6-4-5-7-19/h8-9,14-15,19H,3-7,10-13,16H2,1-2H3,(H,29,30)(H,27,28,31,32) POFVJRKJJBFPII-UHFFFAOYSA-N 50501597 CHEMBL4067549 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 630 ChEMBL 10.1021/acs.jmedchem.6b01670 10.7270/Q29Z97XG 28156111 Tadesse, S; Yu, M; Mekonnen, LB; Lam, F; Islam, S; Tomusange, K; Rahaman, MH; Noll, B; Basnet, SK; Teo, T; Albrecht, H; Milne, R; Wang, S University of South Australia http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50501597 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50501597&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126535127 433913498 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51212014 Nc1n[nH]c(N)c1\N=N\c1ccncc1 InChI=1S/C8H9N7/c9-7-6(8(10)15-14-7)13-12-5-1-3-11-4-2-5/h1-4H,(H5,9,10,14,15)/b13-12+ RZLCSJZALMLKCU-OUKQBFOZSA-N 123786 AAP1742 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 14880 ChEMBL 10.1016/j.bmc.2015.03.025 10.7270/Q21V5HZ6 25835357 Jorda, R; Schütznerová, E; CankaÅ™, P; Brychtová, V; Navrátilová, J; KryÅ¡tof, V Palack� University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=123786 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=123786&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 21955055 225150195 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51212018 Nc1n[nH]c(N)c1\N=N\c1ccc(O)cc1 InChI=1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15)/b13-12+ AYZRKFOEZQBUEA-OUKQBFOZSA-N 50455463 CHEMBL215205 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 26000 ChEMBL 10.1016/j.bmc.2015.03.025 10.7270/Q21V5HZ6 25835357 Jorda, R; Schütznerová, E; CankaÅ™, P; Brychtová, V; Navrátilová, J; KryÅ¡tof, V Palack� University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50455463 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50455463&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135398514 433923556 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51212022 Cn1nc(N)c(\N=N\c2ccncc2)c1N InChI=1S/C9H11N7/c1-16-9(11)7(8(10)15-16)14-13-6-2-4-12-5-3-6/h2-5H,11H2,1H3,(H2,10,15)/b14-13+ HUHDSOITAVSODF-BUHFOSPRSA-N 50498121 CHEMBL3402060 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >50000 ChEMBL 10.1016/j.bmc.2015.03.025 10.7270/Q21V5HZ6 25835357 Jorda, R; Schütznerová, E; CankaÅ™, P; Brychtová, V; Navrátilová, J; KryÅ¡tof, V Palack� University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50498121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50498121&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 136961394 433965386 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51251867 CNC(=O)c1nn(C)c-2c1C(C)(C)Cc1cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc-21 InChI=1S/C25H32N8O/c1-25(2)14-16-15-27-24(29-20(16)22-19(25)21(23(34)26-3)30-32(22)5)28-17-6-8-18(9-7-17)33-12-10-31(4)11-13-33/h6-9,15H,10-14H2,1-5H3,(H,26,34)(H,27,28,29) RXZMYLDMFYNEIM-UHFFFAOYSA-N 31545 Milciclib::pyrazolo[4,3-h]quinazoline-3-carboxamide, 28 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 150 ChEMBL 10.1021/acs.jmedchem.8b01469 10.7270/Q26Q21J2 30543440 Tadesse, S; Caldon, EC; Tilley, W; Wang, S University of South Australia Cancer Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31545 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=31545&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search P48 2WIH,5VD1,5VC6 16718576 172097446 ZINC53119602 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51251921 Nc1nc(Nc2ccc(cc2)S(=O)(=O)NCCO)nc(OCC2CCCCC2)c1N=O InChI=1S/C19H26N6O5S/c20-17-16(25-27)18(30-12-13-4-2-1-3-5-13)24-19(23-17)22-14-6-8-15(9-7-14)31(28,29)21-10-11-26/h6-9,13,21,26H,1-5,10-12H2,(H3,20,22,23,24) BOCJDTQHHGUTIM-UHFFFAOYSA-N 50511934 CHEMBL4590821 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 4800 ChEMBL 10.1021/acs.jmedchem.8b01469 10.7270/Q26Q21J2 30543440 Tadesse, S; Caldon, EC; Tilley, W; Wang, S University of South Australia Cancer Research Institute http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511934&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 16719774 440720516 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51240732 CN1CCC(CC1)Nc1ccc(cc1)C(=O)Nc1cc(n[nH]1)-c1cc(cs1)C#N InChI=1S/C21H22N6OS/c1-27-8-6-17(7-9-27)23-16-4-2-15(3-5-16)21(28)24-20-11-18(25-26-20)19-10-14(12-22)13-29-19/h2-5,10-11,13,17,23H,6-9H2,1H3,(H2,24,25,26,28) HGLWPJISHDLCTE-UHFFFAOYSA-N 50507645 CHEMBL4473820 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 7914 ChEMBL 10.1016/j.ejmech.2018.11.063 10.7270/Q2S185R2 30508668 Heng, H; Zhi, Y; Yuan, H; Wang, Z; Li, H; Wang, S; Tian, J; Liu, H; Chen, Y; Lu, T; Ran, T; Lu, S China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50507645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50507645&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155536820 440716230 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51240747 CN1CCC(CC1)Nc1ccc(cc1)C(=O)Nc1cc(n[nH]1)-c1cc(cs1)C#N InChI=1S/C21H22N6OS/c1-27-8-6-17(7-9-27)23-16-4-2-15(3-5-16)21(28)24-20-11-18(25-26-20)19-10-14(12-22)13-29-19/h2-5,10-11,13,17,23H,6-9H2,1H3,(H2,24,25,26,28) HGLWPJISHDLCTE-UHFFFAOYSA-N 50507645 CHEMBL4473820 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 7943 ChEMBL 10.1016/j.ejmech.2018.11.063 10.7270/Q2S185R2 30508668 Heng, H; Zhi, Y; Yuan, H; Wang, Z; Li, H; Wang, S; Tian, J; Liu, H; Chen, Y; Lu, T; Ran, T; Lu, S China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50507645 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50507645&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155536820 440716230 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51267929 CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1 BIIVYFLTOXDAOV-YVEFUNNKSA-N 5655 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one::CHEMBL428690::Flavopiridol::US10294218, Example Flavopiridol::US9617225, Flavopiridol Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 110 ChEMBL 10.1016/j.bmc.2019.01.027 10.7270/Q2CF9TG4 30733087 Zhao, L; Yuan, X; Wang, J; Feng, Y; Ji, F; Li, Z; Bian, J China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5655&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search CPB 1C8K,1E1Y,3BLR,3EBP,4O71 5287969 8035270 CHEMBL428690 DB03496 5680 ZINC21288966 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51297406 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 520 ChEMBL 10.1016/j.bmcl.2019.126637 10.7270/Q23F4T3T 31477350 Sánchez-Martínez, C; Lallena, MJ; Sanfeliciano, SG; de Dios, A Eli Lilly and Company http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958842 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+ OBJNFLYHUXWUPF-IZZDOVSWSA-N 50110178 CHEMBL3603847::US10787436, Compound I-23 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 11.3 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110178&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 73602827 319493132 CHEMBL3603847 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958843 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6-11-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-13-4-3-12-24(25)27/h3-14,16-19,33H,15H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b14-7+ FONRCZUZCHXWBD-VGOFMYFVSA-N 50526794 CHEMBL4303287::US10787436, Compound I-18 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 13.9 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526794&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 78357763 440735376 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958844 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(Cl)c(Nc2ncc(C)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C32H30ClN7O2/c1-20-18-35-32(39-30(20)25-19-34-27-8-5-4-7-24(25)27)38-28-17-23(14-15-26(28)33)37-31(42)21-10-12-22(13-11-21)36-29(41)9-6-16-40(2)3/h4-15,17-19,34H,16H2,1-3H3,(H,36,41)(H,37,42)(H,35,38,39)/b9-6+ JWSOGQQJKIDIMQ-RMKNXTFCSA-N 464083 US10787436, Compound I-19 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 15.7 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464083&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155921943 441573895 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958845 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cc(Nc2ncc(C)c(n2)-c2c[nH]c3ccccc23)c(Cl)cc1C InChI=1S/C33H32ClN7O2/c1-20-16-26(34)29(39-33-36-18-21(2)31(40-33)25-19-35-27-9-6-5-8-24(25)27)17-28(20)38-32(43)22-11-13-23(14-12-22)37-30(42)10-7-15-41(3)4/h5-14,16-19,35H,15H2,1-4H3,(H,37,42)(H,38,43)(H,36,39,40)/b10-7+ HXQFRKQZYGMLTR-JXMROGBWSA-N 464084 US10787436, Compound I-20 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 20.9 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464084&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155921944 441573896 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958846 CCc1cnc(Nc2cccc(NC(=O)c3ccc(NC(=O)\C=C\CN(C)C)cc3)c2)nc1-c1c[nH]c2ccccc12 InChI=1S/C33H33N7O2/c1-4-22-20-35-33(39-31(22)28-21-34-29-12-6-5-11-27(28)29)38-26-10-7-9-25(19-26)37-32(42)23-14-16-24(17-15-23)36-30(41)13-8-18-40(2)3/h5-17,19-21,34H,4,18H2,1-3H3,(H,36,41)(H,37,42)(H,35,38,39)/b13-8+ NGJZZNXZCNMUCG-MDWZMJQESA-N 464085 US10787436, Compound I-21 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 22.7 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464085&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74221540 441573897 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958847 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C32H30ClN7O2/c1-20-10-13-23(37-31(42)21-11-14-22(15-12-21)36-29(41)9-6-16-40(2)3)17-28(20)38-32-35-19-26(33)30(39-32)25-18-34-27-8-5-4-7-24(25)27/h4-15,17-19,34H,16H2,1-3H3,(H,36,41)(H,37,42)(H,35,38,39)/b9-6+ CXEVHNQTHRJLAT-RMKNXTFCSA-N 464086 US10787436, Compound I-22 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 32.6 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464086&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74221541 441573898 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958848 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+ OBJNFLYHUXWUPF-IZZDOVSWSA-N 50110178 CHEMBL3603847::US10787436, Compound I-23 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 33.5 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110178&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 73602827 319493132 CHEMBL3603847 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958849 Cc1ccc(NC(=O)c2ccc(NC(=O)C=C)cc2)cc1Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C29H23ClN6O2/c1-3-26(37)33-19-12-9-18(10-13-19)28(38)34-20-11-8-17(2)25(14-20)35-29-32-16-23(30)27(36-29)22-15-31-24-7-5-4-6-21(22)24/h3-16,31H,1H2,2H3,(H,33,37)(H,34,38)(H,32,35,36) OHOSYPVIDYXWQF-UHFFFAOYSA-N 464088 US10787436, Compound I-24 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 40.0 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464088&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155921946 441573900 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958850 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(Cl)c(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H27Cl2N7O2/c1-40(2)15-5-8-28(41)36-20-11-9-19(10-12-20)30(42)37-21-13-14-24(32)27(16-21)38-31-35-18-25(33)29(39-31)23-17-34-26-7-4-3-6-22(23)26/h3-14,16-18,34H,15H2,1-2H3,(H,36,41)(H,37,42)(H,35,38,39)/b8-5+ BWRIYUPYJGGSDC-VMPITWQZSA-N 464089 US10787436, Compound I-25 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 87.8 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464089&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220554 441573901 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958851 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(C3CC3)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C34H33N7O2/c1-41(2)18-6-11-31(42)37-24-16-14-23(15-17-24)33(43)38-25-7-5-8-26(19-25)39-34-36-20-28(22-12-13-22)32(40-34)29-21-35-30-10-4-3-9-27(29)30/h3-11,14-17,19-22,35H,12-13,18H2,1-2H3,(H,37,42)(H,38,43)(H,36,39,40)/b11-6+ ZXZIDMZAUJDORD-IZZDOVSWSA-N 464090 US10787436, Compound I-26 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 184 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464090 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464090&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220555 441573902 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958852 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+ OBJNFLYHUXWUPF-IZZDOVSWSA-N 50110178 CHEMBL3603847::US10787436, Compound I-23 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 201 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110178&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 73602827 319493132 CHEMBL3603847 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958853 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2cn(C)c3ccccc23)c1 InChI=1S/C32H30ClN7O2/c1-39(2)17-7-12-29(41)35-22-15-13-21(14-16-22)31(42)36-23-8-6-9-24(18-23)37-32-34-19-27(33)30(38-32)26-20-40(3)28-11-5-4-10-25(26)28/h4-16,18-20H,17H2,1-3H3,(H,35,41)(H,36,42)(H,34,37,38)/b12-7+ ZHQRVBKMSQSDNB-KPKJPENVSA-N 464092 US10787436, Compound I-28 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 238 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464092&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220557 441573904 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958854 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2cnc3[nH]ccc3c2)c1 InChI=1S/C30H27ClN8O2/c1-39(2)14-4-7-26(40)35-22-10-8-19(9-11-22)29(41)36-23-5-3-6-24(16-23)37-30-34-18-25(31)27(38-30)21-15-20-12-13-32-28(20)33-17-21/h3-13,15-18H,14H2,1-2H3,(H,32,33)(H,35,40)(H,36,41)(H,34,37,38)/b7-4+ QOPLZGZOVVLAOF-QPJJXVBHSA-N 464093 US10787436, Compound I-29 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 288 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464093 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464093&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220558 441573905 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958855 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2cccc3[nH]ccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)17-5-10-28(40)35-21-13-11-20(12-14-21)30(41)36-22-6-3-7-23(18-22)37-31-34-19-26(32)29(38-31)25-8-4-9-27-24(25)15-16-33-27/h3-16,18-19,33H,17H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b10-5+ TZRKZDKAUKKAPI-BJMVGYQFSA-N 464094 US10787436, Compound I-30 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 347 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464094 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464094&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220622 441573906 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958856 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2nc(-c3c[nH]c4ccccc34)c3ccccc3n2)c1 InChI=1S/C35H31N7O2/c1-42(2)20-8-15-32(43)37-24-18-16-23(17-19-24)34(44)38-25-9-7-10-26(21-25)39-35-40-31-14-6-4-12-28(31)33(41-35)29-22-36-30-13-5-3-11-27(29)30/h3-19,21-22,36H,20H2,1-2H3,(H,37,43)(H,38,44)(H,39,40,41)/b15-8+ HTIMMKYGXURPFM-OVCLIPMQSA-N 464095 US10787436, Compound I-31::US10787436, Compound I-33 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 416 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464095&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220625 441573907 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958857 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2ccc3cc[nH]c3c2)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-4-7-28(40)35-23-12-10-21(11-13-23)30(41)36-24-5-3-6-25(18-24)37-31-34-19-26(32)29(38-31)22-9-8-20-14-15-33-27(20)17-22/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b7-4+ SFVIQNNFGWEJKU-QPJJXVBHSA-N 464096 US10787436, Compound I-32 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1180 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464096 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464096&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220624 441573908 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958858 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2nc(-c3c[nH]c4ccccc34)c3ccccc3n2)c1 InChI=1S/C35H31N7O2/c1-42(2)20-8-15-32(43)37-24-18-16-23(17-19-24)34(44)38-25-9-7-10-26(21-25)39-35-40-31-14-6-4-12-28(31)33(41-35)29-22-36-30-13-5-3-11-27(29)30/h3-19,21-22,36H,20H2,1-2H3,(H,37,43)(H,38,44)(H,39,40,41)/b15-8+ HTIMMKYGXURPFM-OVCLIPMQSA-N 464095 US10787436, Compound I-31::US10787436, Compound I-33 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1420 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464095&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220625 441573907 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958859 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2cc3ccccc3[nH]2)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)34-22-14-12-20(13-15-22)30(41)35-23-8-5-9-24(18-23)36-31-33-19-25(32)29(38-31)27-17-21-7-3-4-10-26(21)37-27/h3-15,17-19,37H,16H2,1-2H3,(H,34,40)(H,35,41)(H,33,36,38)/b11-6+ RNPURZRGYPFGQQ-IZZDOVSWSA-N 464098 US10787436, Compound I-34 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 4750 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464098 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464098&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220626 441573909 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958860 CCSNC(=O)CCNc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C30H28ClN7O2S/c1-2-41-38-27(39)14-15-32-20-12-10-19(11-13-20)29(40)35-21-6-5-7-22(16-21)36-30-34-18-25(31)28(37-30)24-17-33-26-9-4-3-8-23(24)26/h3-13,16-18,32-33H,2,14-15H2,1H3,(H,35,40)(H,38,39)(H,34,36,37) YDAALMVESRFPLH-UHFFFAOYSA-N 464099 US10787436, Compound I-37 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 557 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464099&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155921948 441573910 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958861 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c(nn3ccccc23)-c2ccccc2)c1 InChI=1S/C36H31ClN8O2/c1-44(2)20-9-15-31(46)39-26-18-16-25(17-19-26)35(47)40-27-12-8-13-28(22-27)41-36-38-23-29(37)34(42-36)32-30-14-6-7-21-45(30)43-33(32)24-10-4-3-5-11-24/h3-19,21-23H,20H2,1-2H3,(H,39,46)(H,40,47)(H,38,41,42)/b15-9+ FZHSJFYSFOKBJX-OQLLNIDSSA-N 464100 US10787436, Compound I-38 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 3010 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464100&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220694 441573911 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958862 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2nc(C)c(C)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C33H33N7O2/c1-21-22(2)35-33(39-31(21)28-20-34-29-12-6-5-11-27(28)29)38-26-10-7-9-25(19-26)37-32(42)23-14-16-24(17-15-23)36-30(41)13-8-18-40(3)4/h5-17,19-20,34H,18H2,1-4H3,(H,36,41)(H,37,42)(H,35,38,39)/b13-8+ AFDUXWRPPMNYMV-MDWZMJQESA-N 464101 US10787436, Compound I-39 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1350 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464101&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220695 441573912 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958863 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2nccc(n2)-c2c[nH]c3cccc(C)c23)c1 InChI=1S/C32H31N7O2/c1-21-7-4-10-28-30(21)26(20-34-28)27-16-17-33-32(38-27)37-25-9-5-8-24(19-25)36-31(41)22-12-14-23(15-13-22)35-29(40)11-6-18-39(2)3/h4-17,19-20,34H,18H2,1-3H3,(H,35,40)(H,36,41)(H,33,37,38)/b11-6+ SEEVXFIEBQXBPA-IZZDOVSWSA-N 464102 US10787436, Compound I-40 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 3470 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464102 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464102&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220756 441573913 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958864 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(C)c(n2)-c2c[nH]c3cccc(C)c23)c1 InChI=1S/C33H33N7O2/c1-21-8-5-11-28-30(21)27(20-34-28)31-22(2)19-35-33(39-31)38-26-10-6-9-25(18-26)37-32(42)23-13-15-24(16-14-23)36-29(41)12-7-17-40(3)4/h5-16,18-20,34H,17H2,1-4H3,(H,36,41)(H,37,42)(H,35,38,39)/b12-7+ MYJSVLNSLBZAAZ-KPKJPENVSA-N 464103 US10787436, Compound I-41 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 809 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464103 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464103&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220757 441573914 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958865 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(c(n2)-c2c[nH]c3ccccc23)C(F)(F)F)c1 InChI=1S/C32H28F3N7O2/c1-42(2)16-6-11-28(43)38-21-14-12-20(13-15-21)30(44)39-22-7-5-8-23(17-22)40-31-37-19-26(32(33,34)35)29(41-31)25-18-36-27-10-4-3-9-24(25)27/h3-15,17-19,36H,16H2,1-2H3,(H,38,43)(H,39,44)(H,37,40,41)/b11-6+ CUBLXHMKEYHDBZ-IZZDOVSWSA-N 464104 US10787436, Compound I-42 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 35.7 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464104&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220758 441573915 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958866 CN(C)C\C=C\C(=O)NCc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C32H30ClN7O2/c1-40(2)16-6-11-29(41)35-18-21-12-14-22(15-13-21)31(42)37-23-7-5-8-24(17-23)38-32-36-20-27(33)30(39-32)26-19-34-28-10-4-3-9-25(26)28/h3-15,17,19-20,34H,16,18H2,1-2H3,(H,35,41)(H,37,42)(H,36,38,39)/b11-6+ VHEPZOYVQIFCJY-IZZDOVSWSA-N 464105 US10787436, Compound I-43 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 36.2 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464105&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220759 441573916 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958867 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2nccc(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H29N7O2/c1-38(2)18-6-11-29(39)34-22-14-12-21(13-15-22)30(40)35-23-7-5-8-24(19-23)36-31-32-17-16-28(37-31)26-20-33-27-10-4-3-9-25(26)27/h3-17,19-20,33H,18H2,1-2H3,(H,34,39)(H,35,40)(H,32,36,37)/b11-6+ YXZRQBQVHOCFEU-IZZDOVSWSA-N 464106 US10787436, Compound I-44 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 391 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464106&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220760 441573917 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958868 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2sc(C)nc2C)c1 InChI=1S/C28H28ClN7O2S/c1-17-26(39-18(2)31-17)25-23(29)16-30-28(35-25)34-22-8-5-7-21(15-22)33-27(38)19-10-12-20(13-11-19)32-24(37)9-6-14-36(3)4/h5-13,15-16H,14H2,1-4H3,(H,32,37)(H,33,38)(H,30,34,35)/b9-6+ SWAMHZPWHCCEDV-RMKNXTFCSA-N 464107 US10787436, Compound I-50 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 92.3 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464107&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 124134327 441573918 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958869 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+ OBJNFLYHUXWUPF-IZZDOVSWSA-N 50110178 CHEMBL3603847::US10787436, Compound I-23 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110178&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 73602827 319493132 CHEMBL3603847 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958870 CN(C)C\C=C\C(=O)Nc1cccc(c1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6-11-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-13-4-3-12-24(25)27/h3-14,16-19,33H,15H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b14-7+ FONRCZUZCHXWBD-VGOFMYFVSA-N 50526794 CHEMBL4303287::US10787436, Compound I-18 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526794 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526794&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 78357763 440735376 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958871 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(Cl)c(Nc2ncc(C)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C32H30ClN7O2/c1-20-18-35-32(39-30(20)25-19-34-27-8-5-4-7-24(25)27)38-28-17-23(14-15-26(28)33)37-31(42)21-10-12-22(13-11-21)36-29(41)9-6-16-40(2)3/h4-15,17-19,34H,16H2,1-3H3,(H,36,41)(H,37,42)(H,35,38,39)/b9-6+ JWSOGQQJKIDIMQ-RMKNXTFCSA-N 464083 US10787436, Compound I-19 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464083 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464083&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155921943 441573895 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958872 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cc(Nc2ncc(C)c(n2)-c2c[nH]c3ccccc23)c(Cl)cc1C InChI=1S/C33H32ClN7O2/c1-20-16-26(34)29(39-33-36-18-21(2)31(40-33)25-19-35-27-9-6-5-8-24(25)27)17-28(20)38-32(43)22-11-13-23(14-12-22)37-30(42)10-7-15-41(3)4/h5-14,16-19,35H,15H2,1-4H3,(H,37,42)(H,38,43)(H,36,39,40)/b10-7+ HXQFRKQZYGMLTR-JXMROGBWSA-N 464084 US10787436, Compound I-20 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464084 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464084&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155921944 441573896 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958873 CCc1cnc(Nc2cccc(NC(=O)c3ccc(NC(=O)\C=C\CN(C)C)cc3)c2)nc1-c1c[nH]c2ccccc12 InChI=1S/C33H33N7O2/c1-4-22-20-35-33(39-31(22)28-21-34-29-12-6-5-11-27(28)29)38-26-10-7-9-25(19-26)37-32(42)23-14-16-24(17-15-23)36-30(41)13-8-18-40(2)3/h5-17,19-21,34H,4,18H2,1-3H3,(H,36,41)(H,37,42)(H,35,38,39)/b13-8+ NGJZZNXZCNMUCG-MDWZMJQESA-N 464085 US10787436, Compound I-21 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464085 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464085&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74221540 441573897 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958874 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C32H30ClN7O2/c1-20-10-13-23(37-31(42)21-11-14-22(15-12-21)36-29(41)9-6-16-40(2)3)17-28(20)38-32-35-19-26(33)30(39-32)25-18-34-27-8-5-4-7-24(25)27/h4-15,17-19,34H,16H2,1-3H3,(H,36,41)(H,37,42)(H,35,38,39)/b9-6+ CXEVHNQTHRJLAT-RMKNXTFCSA-N 464086 US10787436, Compound I-22 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464086 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464086&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74221541 441573898 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958875 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+ OBJNFLYHUXWUPF-IZZDOVSWSA-N 50110178 CHEMBL3603847::US10787436, Compound I-23 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110178&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 73602827 319493132 CHEMBL3603847 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958876 Cc1ccc(NC(=O)c2ccc(NC(=O)C=C)cc2)cc1Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C29H23ClN6O2/c1-3-26(37)33-19-12-9-18(10-13-19)28(38)34-20-11-8-17(2)25(14-20)35-29-32-16-23(30)27(36-29)22-15-31-24-7-5-4-6-21(22)24/h3-16,31H,1H2,2H3,(H,33,37)(H,34,38)(H,32,35,36) OHOSYPVIDYXWQF-UHFFFAOYSA-N 464088 US10787436, Compound I-24 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464088 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464088&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155921946 441573900 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958877 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(Cl)c(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H27Cl2N7O2/c1-40(2)15-5-8-28(41)36-20-11-9-19(10-12-20)30(42)37-21-13-14-24(32)27(16-21)38-31-35-18-25(33)29(39-31)23-17-34-26-7-4-3-6-22(23)26/h3-14,16-18,34H,15H2,1-2H3,(H,36,41)(H,37,42)(H,35,38,39)/b8-5+ BWRIYUPYJGGSDC-VMPITWQZSA-N 464089 US10787436, Compound I-25 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464089 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464089&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220554 441573901 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958878 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6+ OBJNFLYHUXWUPF-IZZDOVSWSA-N 50110178 CHEMBL3603847::US10787436, Compound I-23 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110178 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110178&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 73602827 319493132 CHEMBL3603847 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958879 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2cn(C)c3ccccc23)c1 InChI=1S/C32H30ClN7O2/c1-39(2)17-7-12-29(41)35-22-15-13-21(14-16-22)31(42)36-23-8-6-9-24(18-23)37-32-34-19-27(33)30(38-32)26-20-40(3)28-11-5-4-10-25(26)28/h4-16,18-20H,17H2,1-3H3,(H,35,41)(H,36,42)(H,34,37,38)/b12-7+ ZHQRVBKMSQSDNB-KPKJPENVSA-N 464092 US10787436, Compound I-28 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464092 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464092&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220557 441573904 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958880 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2nc(-c3c[nH]c4ccccc34)c3ccccc3n2)c1 InChI=1S/C35H31N7O2/c1-42(2)20-8-15-32(43)37-24-18-16-23(17-19-24)34(44)38-25-9-7-10-26(21-25)39-35-40-31-14-6-4-12-28(31)33(41-35)29-22-36-30-13-5-3-11-27(29)30/h3-19,21-22,36H,20H2,1-2H3,(H,37,43)(H,38,44)(H,39,40,41)/b15-8+ HTIMMKYGXURPFM-OVCLIPMQSA-N 464095 US10787436, Compound I-31::US10787436, Compound I-33 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464095 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464095&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220625 441573907 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958881 CCSNC(=O)CCNc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C30H28ClN7O2S/c1-2-41-38-27(39)14-15-32-20-12-10-19(11-13-20)29(40)35-21-6-5-7-22(16-21)36-30-34-18-25(31)28(37-30)24-17-33-26-9-4-3-8-23(24)26/h3-13,16-18,32-33H,2,14-15H2,1H3,(H,35,40)(H,38,39)(H,34,36,37) YDAALMVESRFPLH-UHFFFAOYSA-N 464099 US10787436, Compound I-37 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464099 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464099&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155921948 441573910 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958882 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c(nn3ccccc23)-c2ccccc2)c1 InChI=1S/C36H31ClN8O2/c1-44(2)20-9-15-31(46)39-26-18-16-25(17-19-26)35(47)40-27-12-8-13-28(22-27)41-36-38-23-29(37)34(42-36)32-30-14-6-7-21-45(30)43-33(32)24-10-4-3-5-11-24/h3-19,21-23H,20H2,1-2H3,(H,39,46)(H,40,47)(H,38,41,42)/b15-9+ FZHSJFYSFOKBJX-OQLLNIDSSA-N 464100 US10787436, Compound I-38 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464100 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464100&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220694 441573911 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958883 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2nc(C)c(C)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C33H33N7O2/c1-21-22(2)35-33(39-31(21)28-20-34-29-12-6-5-11-27(28)29)38-26-10-7-9-25(19-26)37-32(42)23-14-16-24(17-15-23)36-30(41)13-8-18-40(3)4/h5-17,19-20,34H,18H2,1-4H3,(H,36,41)(H,37,42)(H,35,38,39)/b13-8+ AFDUXWRPPMNYMV-MDWZMJQESA-N 464101 US10787436, Compound I-39 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464101 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464101&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220695 441573912 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958884 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(c(n2)-c2c[nH]c3ccccc23)C(F)(F)F)c1 InChI=1S/C32H28F3N7O2/c1-42(2)16-6-11-28(43)38-21-14-12-20(13-15-21)30(44)39-22-7-5-8-23(17-22)40-31-37-19-26(32(33,34)35)29(41-31)25-18-36-27-10-4-3-9-24(25)27/h3-15,17-19,36H,16H2,1-2H3,(H,38,43)(H,39,44)(H,37,40,41)/b11-6+ CUBLXHMKEYHDBZ-IZZDOVSWSA-N 464104 US10787436, Compound I-42 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464104 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464104&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220758 441573915 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958885 CN(C)C\C=C\C(=O)NCc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C32H30ClN7O2/c1-40(2)16-6-11-29(41)35-18-21-12-14-22(15-13-21)31(42)37-23-7-5-8-24(17-23)38-32-36-20-27(33)30(39-32)26-19-34-28-10-4-3-9-25(26)28/h3-15,17,19-20,34H,16,18H2,1-2H3,(H,35,41)(H,37,42)(H,36,38,39)/b11-6+ VHEPZOYVQIFCJY-IZZDOVSWSA-N 464105 US10787436, Compound I-43 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464105 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464105&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220759 441573916 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958886 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2nccc(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H29N7O2/c1-38(2)18-6-11-29(39)34-22-14-12-21(13-15-22)30(40)35-23-7-5-8-24(19-23)36-31-32-17-16-28(37-31)26-20-33-27-10-4-3-9-25(26)27/h3-17,19-20,33H,18H2,1-2H3,(H,34,39)(H,35,40)(H,32,36,37)/b11-6+ YXZRQBQVHOCFEU-IZZDOVSWSA-N 464106 US10787436, Compound I-44 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464106 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464106&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 74220760 441573917 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958887 CN(CCCNC(=O)NCCOCCOCCOCCNC(=O)CCCCC1SCC2NC(=O)NC12)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 464108 US10787436, Compound I-49 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464108 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464108&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155921949 441573919 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958888 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2sc(C)nc2C)c1 InChI=1S/C28H28ClN7O2S/c1-17-26(39-18(2)31-17)25-23(29)16-30-28(35-25)34-22-8-5-7-21(15-22)33-27(38)19-10-12-20(13-11-19)32-24(37)9-6-14-36(3)4/h5-13,15-16H,14H2,1-4H3,(H,32,37)(H,33,38)(H,30,34,35)/b9-6+ SWAMHZPWHCCEDV-RMKNXTFCSA-N 464107 US10787436, Compound I-50 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464107 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464107&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 124134327 441573918 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958889 CN(C)C\C=C\C(=O)Nc1ccc(cc1)S(=O)(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C30H28ClN7O3S/c1-38(2)16-6-11-28(39)34-20-12-14-23(15-13-20)42(40,41)37-22-8-5-7-21(17-22)35-30-33-19-26(31)29(36-30)25-18-32-27-10-4-3-9-24(25)27/h3-15,17-19,32,37H,16H2,1-2H3,(H,34,39)(H,33,35,36)/b11-6+ YBVSJBLXFZBKSU-IZZDOVSWSA-N 464109 US10787436, Compound I-52::US10787436, Compound I-65 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464109&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 90102417 441573920 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958890 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(C#N)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C32H28N8O2/c1-40(2)16-6-11-29(41)36-23-14-12-21(13-15-23)31(42)37-24-7-5-8-25(17-24)38-32-35-19-22(18-33)30(39-32)27-20-34-28-10-4-3-9-26(27)28/h3-15,17,19-20,34H,16H2,1-2H3,(H,36,41)(H,37,42)(H,35,38,39)/b11-6+ LZXYKKBAENJHCB-IZZDOVSWSA-N 464110 US10787436, Compound I-53 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464110 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464110&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121302693 441573921 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958891 CN(C)C\C=C\C(=O)Nc1ccc(cc1)S(=O)(=O)Nc1cccc(Nc2ncc(C#N)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C31H28N8O3S/c1-39(2)16-6-11-29(40)35-22-12-14-25(15-13-22)43(41,42)38-24-8-5-7-23(17-24)36-31-34-19-21(18-32)30(37-31)27-20-33-28-10-4-3-9-26(27)28/h3-15,17,19-20,33,38H,16H2,1-2H3,(H,35,40)(H,34,36,37)/b11-6+ BVHFTJVSCXCBTK-IZZDOVSWSA-N 464111 US10787436, Compound I-55 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464111 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464111&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121302691 441573922 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958892 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cc(Nc2ncc(C#N)c(n2)-c2c[nH]c3ccccc23)ccc1C InChI=1S/C33H30N8O2/c1-21-10-13-25(38-33-36-19-23(18-34)31(40-33)27-20-35-28-8-5-4-7-26(27)28)17-29(21)39-32(43)22-11-14-24(15-12-22)37-30(42)9-6-16-41(2)3/h4-15,17,19-20,35H,16H2,1-3H3,(H,37,42)(H,39,43)(H,36,38,40)/b9-6+ QBKKIHULSIJEIO-RMKNXTFCSA-N 464112 US10787436, Compound I-56 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464112 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464112&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121302694 441573923 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958893 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N(C)c1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C32H30ClN7O2/c1-39(2)17-7-12-29(41)36-22-15-13-21(14-16-22)31(42)40(3)24-9-6-8-23(18-24)37-32-35-20-27(33)30(38-32)26-19-34-28-11-5-4-10-25(26)28/h4-16,18-20,34H,17H2,1-3H3,(H,36,41)(H,35,37,38)/b12-7+ WCEPKSPQLQRWAD-KPKJPENVSA-N 464113 US10787436, Compound I-57 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464113 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464113&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121302690 441573924 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958894 CC(C)c1cnc(Nc2cccc(NC(=O)c3ccc(NC(=O)\C=C\CN(C)C)cc3)c2)nc1-c1c[nH]c2ccccc12 InChI=1S/C34H35N7O2/c1-22(2)28-20-36-34(40-32(28)29-21-35-30-12-6-5-11-27(29)30)39-26-10-7-9-25(19-26)38-33(43)23-14-16-24(17-15-23)37-31(42)13-8-18-41(3)4/h5-17,19-22,35H,18H2,1-4H3,(H,37,42)(H,38,43)(H,36,39,40)/b13-8+ TWFMMYCBZCJWPK-MDWZMJQESA-N 464114 US10787436, Compound I-59 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464114 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464114&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121312277 441573925 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958895 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2cccc3n(C)ccc23)c1 InChI=1S/C32H30ClN7O2/c1-39(2)17-6-11-29(41)35-22-14-12-21(13-15-22)31(42)36-23-7-4-8-24(19-23)37-32-34-20-27(33)30(38-32)26-9-5-10-28-25(26)16-18-40(28)3/h4-16,18-20H,17H2,1-3H3,(H,35,41)(H,36,42)(H,34,37,38)/b11-6+ QIHAGXYTEOJIHP-IZZDOVSWSA-N 464115 US10787436, Compound I-60 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464115 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464115&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121312276 441573926 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958896 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2ccc3n(C)ccc3c2)c1 InChI=1S/C32H30ClN7O2/c1-39(2)16-5-8-29(41)35-24-12-9-21(10-13-24)31(42)36-25-6-4-7-26(19-25)37-32-34-20-27(33)30(38-32)23-11-14-28-22(18-23)15-17-40(28)3/h4-15,17-20H,16H2,1-3H3,(H,35,41)(H,36,42)(H,34,37,38)/b8-5+ QYFYSDHOBJHFRT-VMPITWQZSA-N 464116 US10787436, Compound I-61 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464116 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464116&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121312280 441573927 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958897 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2ccc3ccn(C)c3c2)c1 InChI=1S/C32H30ClN7O2/c1-39(2)16-5-8-29(41)35-24-13-11-22(12-14-24)31(42)36-25-6-4-7-26(19-25)37-32-34-20-27(33)30(38-32)23-10-9-21-15-17-40(3)28(21)18-23/h4-15,17-20H,16H2,1-3H3,(H,35,41)(H,36,42)(H,34,37,38)/b8-5+ RHXBDQFYXIAUKF-VMPITWQZSA-N 464117 US10787436, Compound I-62 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464117 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464117&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121312281 441573928 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958898 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2cc3ccccc3n2C)c1 InChI=1S/C32H30ClN7O2/c1-39(2)17-7-12-29(41)35-23-15-13-21(14-16-23)31(42)36-24-9-6-10-25(19-24)37-32-34-20-26(33)30(38-32)28-18-22-8-4-5-11-27(22)40(28)3/h4-16,18-20H,17H2,1-3H3,(H,35,41)(H,36,42)(H,34,37,38)/b12-7+ ANZXJFLLIHLZIC-KPKJPENVSA-N 464118 US10787436, Compound I-63 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464118 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464118&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121312278 441573929 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958899 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2ccc3ccn(C)c3n2)c1 InChI=1S/C31H29ClN8O2/c1-39(2)16-5-8-27(41)34-22-12-9-21(10-13-22)30(42)35-23-6-4-7-24(18-23)36-31-33-19-25(32)28(38-31)26-14-11-20-15-17-40(3)29(20)37-26/h4-15,17-19H,16H2,1-3H3,(H,34,41)(H,35,42)(H,33,36,38)/b8-5+ KWRZXFVKKDOYHF-VMPITWQZSA-N 464119 US10787436, Compound I-64 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464119&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121312279 441573930 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958900 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2ccc3ccn(C)c3n2)c1 InChI=1S/C31H29ClN8O2/c1-39(2)16-5-8-27(41)34-22-12-9-21(10-13-22)30(42)35-23-6-4-7-24(18-23)36-31-33-19-25(32)28(38-31)26-14-11-20-15-17-40(3)29(20)37-26/h4-15,17-19H,16H2,1-3H3,(H,34,41)(H,35,42)(H,33,36,38)/b8-5+ KWRZXFVKKDOYHF-VMPITWQZSA-N 464119 US10787436, Compound I-64 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464119 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464119&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 121312279 441573930 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958901 CN(C)C\C=C\C(=O)Nc1ccc(cc1)S(=O)(=O)Nc1cccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c1 InChI=1S/C30H28ClN7O3S/c1-38(2)16-6-11-28(39)34-20-12-14-23(15-13-20)42(40,41)37-22-8-5-7-21(17-22)35-30-33-19-26(31)29(36-30)25-18-32-27-10-4-3-9-24(25)27/h3-15,17-19,32,37H,16H2,1-2H3,(H,34,39)(H,33,35,36)/b11-6+ YBVSJBLXFZBKSU-IZZDOVSWSA-N 464109 US10787436, Compound I-52::US10787436, Compound I-65 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464109 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464109&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 90102417 441573920 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958902 CN(C)C\C=C/C(=O)Nc1ccc(NC(=O)c2cccc(Nc3ncc(Cl)c(n3)-c3c[nH]c4ccccc34)c2)cc1 InChI=1S/C31H28ClN7O2/c1-39(2)16-6-11-28(40)35-21-12-14-22(15-13-21)36-30(41)20-7-5-8-23(17-20)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-15,17-19,33H,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b11-6- PVQGKFOUZXHLJB-WDZFZDKYSA-N 464121 US10787436, Compound I-68 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464121 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464121&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155921950 441573931 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958903 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)cc1 InChI=1S/C31H28ClN7O2/c1-39(2)17-5-8-28(40)35-21-11-9-20(10-12-21)30(41)36-22-13-15-23(16-14-22)37-31-34-19-26(32)29(38-31)25-18-33-27-7-4-3-6-24(25)27/h3-16,18-19,33H,17H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b8-5+ AFQZBMLTFSUGTN-VMPITWQZSA-N 464122 US10787436, Compound I-69 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464122 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464122&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 124134227 441573932 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958904 CN1CCN(CC1)c1cc(ccn1)-c1nc(Nc2cccc(NC(=O)c3ccc(NC(=O)C=C)cc3)c2)ncc1Cl InChI=1S/C30H29ClN8O2/c1-3-27(40)34-22-9-7-20(8-10-22)29(41)35-23-5-4-6-24(18-23)36-30-33-19-25(31)28(37-30)21-11-12-32-26(17-21)39-15-13-38(2)14-16-39/h3-12,17-19H,1,13-16H2,2H3,(H,34,40)(H,35,41)(H,33,36,37) WAXFETFFIWFJFJ-UHFFFAOYSA-N 464123 US10787436, Compound I-70 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens <100 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464123 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464123&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 123847495 441573933 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 958905 Clc1cnc(Nc2cccc(NC(=O)c3ccc(NC(=O)C=C)cc3)c2)nc1-c1ccnc(c1)N1CCNCC1 InChI=1S/C29H27ClN8O2/c1-2-26(39)34-21-8-6-19(7-9-21)28(40)35-22-4-3-5-23(17-22)36-29-33-18-24(30)27(37-29)20-10-11-32-25(16-20)38-14-12-31-13-15-38/h2-11,16-18,31H,1,12-15H2,(H,34,39)(H,35,40)(H,33,36,37) MTXOSFKTSDSINE-UHFFFAOYSA-N 464124 US10787436, Compound I-71 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 550 US Patent 10.7270/Q20G3P6J aid1804831 US10787436 Gray, N; Zhang, T; Kwiatkowski, NP Dana-Farber Cancer Institute, Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=464124 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=464124&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 123849314 441573934 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1083677 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2071 US Patent 10.7270/Q2959MRV aid1805875 US11053238 Wang, Y; Wang, J; Ding, L BETTA PHARMACEUTICALS CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1083678 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc5CCCC(C)n5c4c3)nc2)CC1 InChI=1S/C28H32F2N8/c1-3-36-9-11-37(12-10-36)17-19-7-8-24(31-15-19)33-28-32-16-22(30)26(35-28)20-13-21(29)27-23(14-20)38-18(2)5-4-6-25(38)34-27/h7-8,13-16,18H,3-6,9-12,17H2,1-2H3,(H,31,32,33,35) XOJPAVACYRFOBK-UHFFFAOYSA-N 515905 N-(5-((4-ethylpiperazin- 1-yl)methyl) pyridin-2-yl)-5- fluoro-4-(6- fluoro-1-methyl- 1,2,3,4-tetrahydrobenzo [4,5]imidazo[l,2- a]pyridin- 8-yl)pyrimidin-2-amine::US11053238, Example 2 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1050 US Patent 10.7270/Q2959MRV aid1805875 US11053238 Wang, Y; Wang, J; Ding, L BETTA PHARMACEUTICALS CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=515905 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=515905&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135181567 461601990 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1083679 CN1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCCCn4c3c2)nc1 InChI=1S/C25H26F2N8/c1-33-8-10-34(11-9-33)17-5-6-21(28-14-17)30-25-29-15-19(27)23(32-25)16-12-18(26)24-20(13-16)35-7-3-2-4-22(35)31-24/h5-6,12-15H,2-4,7-11H2,1H3,(H,28,29,30,32) DIFUHKJZJNRRMN-UHFFFAOYSA-N 516039 US11053238, Compound 2a::US11053238, Compound 2b Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2370 US Patent 10.7270/Q2959MRV aid1805875 US11053238 Wang, Y; Wang, J; Ding, L BETTA PHARMACEUTICALS CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516039&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135181734 461602122 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1083680 CN1CCN(CC1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCCCn4c3c2)nc1 InChI=1S/C25H26F2N8/c1-33-8-10-34(11-9-33)17-5-6-21(28-14-17)30-25-29-15-19(27)23(32-25)16-12-18(26)24-20(13-16)35-7-3-2-4-22(35)31-24/h5-6,12-15H,2-4,7-11H2,1H3,(H,28,29,30,32) DIFUHKJZJNRRMN-UHFFFAOYSA-N 516039 US11053238, Compound 2a::US11053238, Compound 2b Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 664 US Patent 10.7270/Q2959MRV aid1805875 US11053238 Wang, Y; Wang, J; Ding, L BETTA PHARMACEUTICALS CO., LTD. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=516039 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=516039&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 135181734 461602122 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51394362 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 490 ChEMBL 10.1016/j.ejmech.2021.113281 10.7270/Q2TX3K3W 33611192 Lin, T; Li, J; Liu, L; Li, Y; Jiang, H; Chen, K; Xu, P; Luo, C; Zhou, B ShanghaiTech University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51363726 Nc1ccccc1NC(=O)c1ccc(CNC(=O)c2n[nH]cc2NC(=O)c2c(Cl)cccc2Cl)cc1 InChI=1S/C25H20Cl2N6O3/c26-16-4-3-5-17(27)21(16)24(35)32-20-13-30-33-22(20)25(36)29-12-14-8-10-15(11-9-14)23(34)31-19-7-2-1-6-18(19)28/h1-11,13H,12,28H2,(H,29,36)(H,30,33)(H,31,34)(H,32,35) ZBKTZKKFSWSOOE-UHFFFAOYSA-N 50551189 CHEMBL4761880 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2020.112073 10.7270/Q21V5JKP 31991336 Cheng, C; Yun, F; Ullah, S; Yuan, Q Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551189 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551189&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162659451 461681529 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51363727 Nc1ccccc1NC(=O)Cc1ccc(NC(=O)c2n[nH]cc2NC(=O)c2c(Cl)cccc2Cl)cc1 InChI=1S/C25H20Cl2N6O3/c26-16-4-3-5-17(27)22(16)24(35)32-20-13-29-33-23(20)25(36)30-15-10-8-14(9-11-15)12-21(34)31-19-7-2-1-6-18(19)28/h1-11,13H,12,28H2,(H,29,33)(H,30,36)(H,31,34)(H,32,35) DYZDPPLEIVDWAH-UHFFFAOYSA-N 50551190 CHEMBL4745240 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2020.112073 10.7270/Q21V5JKP 31991336 Cheng, C; Yun, F; Ullah, S; Yuan, Q Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50551190 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50551190&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162648845 461681530 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51363728 Fc1ccc(NC(=O)c2n[nH]cc2NC(=O)c2c(F)cccc2F)cc1 InChI=1S/C17H11F3N4O2/c18-9-4-6-10(7-5-9)22-17(26)15-13(8-21-24-15)23-16(25)14-11(19)2-1-3-12(14)20/h1-8H,(H,21,24)(H,22,26)(H,23,25) BDRDBXXWQDFXEC-UHFFFAOYSA-N 50113342 CHEMBL518383 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000000 ChEMBL 10.1016/j.ejmech.2020.112073 10.7270/Q21V5JKP 31991336 Cheng, C; Yun, F; Ullah, S; Yuan, Q Key Laboratory of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50113342 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50113342&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search LZ9 5HQ0,4Y72,2VTP 24864079 104007691 CHEMBL518383 DB08138 ZINC13473878 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1111268 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(C3CCN(C)CC3)c(F)c2)ncc1F InChI=1S/C27H30F3N5O/c1-16(2)35-10-11-36-26-22(29)12-18(13-24(26)35)25-23(30)15-31-27(33-25)32-19-4-5-20(21(28)14-19)17-6-8-34(3)9-7-17/h4-5,12-17H,6-11H2,1-3H3,(H,31,32,33) DZKMAWNYSJECKX-UHFFFAOYSA-N 525729 US11174252, Compound 24 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 96.0 US Patent 10.7270/Q27D2Z99 aid1806111 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525729 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525729&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139390111 463789376 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1111277 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(N3CCC(CC3)N(C)C)c(F)c2)ncc1F InChI=1S/C28H33F3N6O/c1-17(2)37-11-12-38-27-22(30)13-18(14-25(27)37)26-23(31)16-32-28(34-26)33-19-5-6-24(21(29)15-19)36-9-7-20(8-10-36)35(3)4/h5-6,13-17,20H,7-12H2,1-4H3,(H,32,33,34) LSBJWBSFOYFELK-UHFFFAOYSA-N 525730 US11174252, Compound 25 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 145 US Patent 10.7270/Q27D2Z99 aid1806111 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525730 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525730&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139390154 463789377 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1111307 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(nc2)C2CCN(C)CC2)ncc1F InChI=1S/C26H30F2N6O/c1-16(2)34-10-11-35-25-20(27)12-18(13-23(25)34)24-21(28)15-30-26(32-24)31-19-4-5-22(29-14-19)17-6-8-33(3)9-7-17/h4-5,12-17H,6-11H2,1-3H3,(H,30,31,32) BRBJCJHJBAMBPR-UHFFFAOYSA-N 525738 US11174252, Compound 33 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 54.0 US Patent 10.7270/Q27D2Z99 aid1806111 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525738 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525738&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139390102 463789385 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1111327 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(nc2)N2CCC(CC2)N(C)C)ncc1F InChI=1S/C27H33F2N7O/c1-17(2)36-11-12-37-26-21(28)13-18(14-23(26)36)25-22(29)16-31-27(33-25)32-19-5-6-24(30-15-19)35-9-7-20(8-10-35)34(3)4/h5-6,13-17,20H,7-12H2,1-4H3,(H,31,32,33) YGZQAQIWZFMADC-UHFFFAOYSA-N 525743 US11174252, Compound 38 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 163 US Patent 10.7270/Q27D2Z99 aid1806111 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525743 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525743&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139390224 463789390 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1111350 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCC(CC2)N(C)C)ncc1F InChI=1S/C27H33F2N7O/c1-17(2)36-11-12-37-26-21(28)13-18(14-23(26)36)25-22(29)16-31-27(33-25)32-24-6-5-20(15-30-24)35-9-7-19(8-10-35)34(3)4/h5-6,13-17,19H,7-12H2,1-4H3,(H,30,31,32,33) HCEVZIBGQRWFCG-UHFFFAOYSA-N 525749 US11174252, Compound 436 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2360 US Patent 10.7270/Q27D2Z99 aid1806111 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525749 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525749&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139390214 463789396 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1111358 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccn(C3CCNCC3)c(=O)c2)ncc1F InChI=1S/C25H28F2N6O2/c1-15(2)32-9-10-35-24-19(26)11-16(12-21(24)32)23-20(27)14-29-25(31-23)30-17-5-8-33(22(34)13-17)18-3-6-28-7-4-18/h5,8,11-15,18,28H,3-4,6-7,9-10H2,1-2H3,(H,29,30,31) UPQKBKLECVIXJR-UHFFFAOYSA-N 525750 US11174252, Compound 437 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 85.0 US Patent 10.7270/Q27D2Z99 aid1806111 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525750 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525750&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139390031 463789397 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1111380 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)C2CCN(C)CC2)ncc1F InChI=1S/C26H30F2N6O/c1-16(2)34-10-11-35-25-20(27)12-19(13-22(25)34)24-21(28)15-30-26(32-24)31-23-5-4-18(14-29-23)17-6-8-33(3)9-7-17/h4-5,12-17H,6-11H2,1-3H3,(H,29,30,31,32) YZSCPLGKKMSBMV-UHFFFAOYSA-N 525755 US11174252, Compound 442 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1160 US Patent 10.7270/Q27D2Z99 aid1806111 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525755 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525755&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139390026 463789402 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1111400 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCOCC2)ncc1F InChI=1S/C24H26F2N6O2/c1-15(2)32-7-10-34-23-18(25)11-16(12-20(23)32)22-19(26)14-28-24(30-22)29-21-4-3-17(13-27-21)31-5-8-33-9-6-31/h3-4,11-15H,5-10H2,1-2H3,(H,27,28,29,30) MDSUHMLXNPZZHO-UHFFFAOYSA-N 525759 US11174252, Compound 446 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >10000 US Patent 10.7270/Q27D2Z99 aid1806111 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525759 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525759&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139390009 463789406 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1111408 CC(C)N1CCOc2c(F)cc(cc12)-c1nc(Nc2ccc(cn2)N2CCC(O)CC2)ncc1F InChI=1S/C25H28F2N6O2/c1-15(2)33-9-10-35-24-19(26)11-16(12-21(24)33)23-20(27)14-29-25(31-23)30-22-4-3-17(13-28-22)32-7-5-18(34)6-8-32/h3-4,11-15,18,34H,5-10H2,1-2H3,(H,28,29,30,31) XSAQISWEGTUJBT-UHFFFAOYSA-N 525760 US11174252, Compound 447 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >10000 US Patent 10.7270/Q27D2Z99 aid1806111 US11174252 Pham, SM; Chakravarty, S; Kankanala, J; Pujala, B; Shete, A; Bhatt, B; Agarwal, AK; Soni, S; Chen, J NUVATION BIO INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=525760 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=525760&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139390011 463789407 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51396977 CC(C)c1cn2c(n1)c(C(C)=O)c(C)c1cnc(Nc3ccc(cc3)N3CCNCC3)nc21 InChI=1S/C25H29N7O/c1-15(2)21-14-32-23-20(16(3)22(17(4)33)24(32)29-21)13-27-25(30-23)28-18-5-7-19(8-6-18)31-11-9-26-10-12-31/h5-8,13-15,26H,9-12H2,1-4H3,(H,27,28,30) DEVYXOKAXWLJRC-UHFFFAOYSA-N 50564275 CHEMBL4778367 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 95 ChEMBL 10.1016/j.ejmech.2020.112239 10.7270/Q27S7SHM 32200202 Shi, C; Wang, Q; Liao, X; Ge, H; Huo, G; Zhang, L; Chen, N; Zhai, X; Hong, Y; Wang, L; Wang, Z; Shi, W; Mao, Y; Yu, J; Ke, Y; Xia, G Shanghai Pharmaceuticals Holding Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564275 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564275&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 156024485 461684613 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51396978 CC(=O)c1c(C)c2cnc(Nc3ccc(cc3)N3CCNCC3)nc2n2cc(nc12)C(C)(C)C InChI=1S/C26H31N7O/c1-16-20-14-28-25(29-18-6-8-19(9-7-18)32-12-10-27-11-13-32)31-23(20)33-15-21(26(3,4)5)30-24(33)22(16)17(2)34/h6-9,14-15,27H,10-13H2,1-5H3,(H,28,29,31) QCXLRAYMDUWMRT-UHFFFAOYSA-N 50564276 CHEMBL4776781 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 204 ChEMBL 10.1016/j.ejmech.2020.112239 10.7270/Q27S7SHM 32200202 Shi, C; Wang, Q; Liao, X; Ge, H; Huo, G; Zhang, L; Chen, N; Zhai, X; Hong, Y; Wang, L; Wang, Z; Shi, W; Mao, Y; Yu, J; Ke, Y; Xia, G Shanghai Pharmaceuticals Holding Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564276 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564276&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162643767 461684614 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51396979 CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29) AHJRHEGDXFFMBM-UHFFFAOYSA-N 6309 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one Hydrochloride::8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H,8H-pyrido[2,3-d]pyrimidin-7-one::Ibrance::PD 0332991::Palbociclib::Pyrido-[2,3-d]-pyrimidin-7-one 43::US10189849, PD0332991::US10464927, Compound Palbociclib::US10696682, Compound PD0332991::US10927120, PD0332991::US9464092, PD0332991::US9957276, PD0332991 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >3333 ChEMBL 10.1016/j.ejmech.2020.112239 10.7270/Q27S7SHM 32200202 Shi, C; Wang, Q; Liao, X; Ge, H; Huo, G; Zhang, L; Chen, N; Zhai, X; Hong, Y; Wang, L; Wang, Z; Shi, W; Mao, Y; Yu, J; Ke, Y; Xia, G Shanghai Pharmaceuticals Holding Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=6309 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=6309&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search LQQ 2EUF,5L2I,7N7O 5330286 8035907 DB09073 ZINC03938686 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51396980 CCN1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)nc2)CC1 InChI=1S/C27H32F2N8/c1-5-35-8-10-36(11-9-35)16-19-6-7-24(30-14-19)33-27-31-15-22(29)25(34-27)20-12-21(28)26-23(13-20)37(17(2)3)18(4)32-26/h6-7,12-15,17H,5,8-11,16H2,1-4H3,(H,30,31,33,34) UZWDCWONPYILKI-UHFFFAOYSA-N 50110183 Abemaciclib::LY-2835219::US10662186, Compound LY2835219::US10696678, Example LY2835219::US10988476, Compound LY2835219::US11053238, LY2835219::US11091476, Example LY2835219::US11351170, Example Abemaciclib Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1596 ChEMBL 10.1016/j.ejmech.2020.112239 10.7270/Q27S7SHM 32200202 Shi, C; Wang, Q; Liao, X; Ge, H; Huo, G; Zhang, L; Chen, N; Zhai, X; Hong, Y; Wang, L; Wang, Z; Shi, W; Mao, Y; Yu, J; Ke, Y; Xia, G Shanghai Pharmaceuticals Holding Co., Ltd. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50110183 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50110183&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 6ZV 7O7K,7O7J,5L2S,7SJ3 46220502 319493137 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51398008 CC(=O)c1c(C)c2ccc(Nc3nccc(n3)-c3cccnc3)cc2oc1=O InChI=1S/C21H16N4O3/c1-12-16-6-5-15(10-18(16)28-20(27)19(12)13(2)26)24-21-23-9-7-17(25-21)14-4-3-8-22-11-14/h3-11H,1-2H3,(H,23,24,25) QNFBTXLSIOCFSM-UHFFFAOYSA-N 50564790 CHEMBL4781627 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >27000 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564790&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155677550 461685128 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51398009 COc1cc(F)ccc1-c1nc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)ncc1F InChI=1S/C26H22F2N4O5/c1-14(33)22-24(32-7-9-36-10-8-32)18-6-4-16(12-21(18)37-25(22)34)30-26-29-13-19(28)23(31-26)17-5-3-15(27)11-20(17)35-2/h3-6,11-13H,7-10H2,1-2H3,(H,29,30,31) RDOKVGWGKMHBMG-UHFFFAOYSA-N 50564816 CHEMBL4788347 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 16600 ChEMBL 10.1016/j.ejmech.2020.112424 10.7270/Q2H70KJW 32447197 Xu, J; Li, H; Wang, X; Huang, J; Li, S; Liu, C; Dong, R; Zhu, G; Duan, C; Jiang, F; Zhang, Y; Zhu, Y; Zhang, T; Chen, Y; Tang, W; Lu, T China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50564816 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50564816&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155677629 461685154 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51405076 COc1ccc(cc1)C(=O)C=CNc1cc(nn1-c1ccccc1)-c1ccccc1 InChI=1S/C25H21N3O2/c1-30-22-14-12-20(13-15-22)24(29)16-17-26-25-18-23(19-8-4-2-5-9-19)27-28(25)21-10-6-3-7-11-21/h2-18,26H,1H3/b17-16- CUVLPOCXZYLQBD-MSUUIHNZSA-N 50567652 CHEMBL4878693 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 326 ChEMBL 10.1016/j.ejmech.2021.113389 10.7270/Q26W9FVF 33784602 Hassan, GS; Georgey, HH; Mohammed, EZ; George, RF; Mahmoud, WR; Omar, FA Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50567652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50567652&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164628079 471057797 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51405077 COc1ccc(cc1)C(=O)C=CNc1cc(nn1-c1ccccc1)-c1ccccc1 InChI=1S/C25H21N3O2/c1-30-22-14-12-20(13-15-22)24(29)16-17-26-25-18-23(19-8-4-2-5-9-19)27-28(25)21-10-6-3-7-11-21/h2-18,26H,1H3/b17-16- CUVLPOCXZYLQBD-MSUUIHNZSA-N 50567652 CHEMBL4878693 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 208 ChEMBL 10.1016/j.ejmech.2021.113389 10.7270/Q26W9FVF 33784602 Hassan, GS; Georgey, HH; Mohammed, EZ; George, RF; Mahmoud, WR; Omar, FA Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50567652 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50567652&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164628079 471057797 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51405078 Fc1ccc(cc1)-c1ccnc2n(nc(-c3ccccc3)c12)-c1ccccc1 InChI=1S/C24H16FN3/c25-19-13-11-17(12-14-19)21-15-16-26-24-22(21)23(18-7-3-1-4-8-18)27-28(24)20-9-5-2-6-10-20/h1-16H YUJQCKBKJPDNIA-UHFFFAOYSA-N 50567655 CHEMBL4873710 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1991 ChEMBL 10.1016/j.ejmech.2021.113389 10.7270/Q26W9FVF 33784602 Hassan, GS; Georgey, HH; Mohammed, EZ; George, RF; Mahmoud, WR; Omar, FA Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50567655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50567655&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164621204 471057800 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51405079 Fc1ccc(cc1)-c1ccnc2n(nc(-c3ccccc3)c12)-c1ccccc1 InChI=1S/C24H16FN3/c25-19-13-11-17(12-14-19)21-15-16-26-24-22(21)23(18-7-3-1-4-8-18)27-28(24)20-9-5-2-6-10-20/h1-16H YUJQCKBKJPDNIA-UHFFFAOYSA-N 50567655 CHEMBL4873710 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1272 ChEMBL 10.1016/j.ejmech.2021.113389 10.7270/Q26W9FVF 33784602 Hassan, GS; Georgey, HH; Mohammed, EZ; George, RF; Mahmoud, WR; Omar, FA Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50567655 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50567655&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164621204 471057800 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51405080 COc1ccc(cc1)-c1nc2n(nc(-c3ccccc3)c2c(-c2ccc(cc2)N2CCOCC2)c1C#N)-c1ccccc1 InChI=1S/C36H29N5O2/c1-42-30-18-14-27(15-19-30)34-31(24-37)32(25-12-16-28(17-13-25)40-20-22-43-23-21-40)33-35(26-8-4-2-5-9-26)39-41(36(33)38-34)29-10-6-3-7-11-29/h2-19H,20-23H2,1H3 IIBAZCJTYALPIR-UHFFFAOYSA-N 50567665 CHEMBL4855877 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 318 ChEMBL 10.1016/j.ejmech.2021.113389 10.7270/Q26W9FVF 33784602 Hassan, GS; Georgey, HH; Mohammed, EZ; George, RF; Mahmoud, WR; Omar, FA Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50567665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50567665&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164610236 471057810 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51405081 COc1ccc(cc1)-c1nc2n(nc(-c3ccccc3)c2c(-c2ccc(cc2)N2CCOCC2)c1C#N)-c1ccccc1 InChI=1S/C36H29N5O2/c1-42-30-18-14-27(15-19-30)34-31(24-37)32(25-12-16-28(17-13-25)40-20-22-43-23-21-40)33-35(26-8-4-2-5-9-26)39-41(36(33)38-34)29-10-6-3-7-11-29/h2-19H,20-23H2,1H3 IIBAZCJTYALPIR-UHFFFAOYSA-N 50567665 CHEMBL4855877 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 203 ChEMBL 10.1016/j.ejmech.2021.113389 10.7270/Q26W9FVF 33784602 Hassan, GS; Georgey, HH; Mohammed, EZ; George, RF; Mahmoud, WR; Omar, FA Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50567665 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50567665&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164610236 471057810 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51405082 COc1ccc(cc1)-c1nc2n(nc(-c3ccccc3)c2c(-c2ccc(cc2)N2CCN(C)CC2)c1C#N)-c1ccccc1 InChI=1S/C37H32N6O/c1-41-21-23-42(24-22-41)29-17-13-26(14-18-29)33-32(25-38)35(28-15-19-31(44-2)20-16-28)39-37-34(33)36(27-9-5-3-6-10-27)40-43(37)30-11-7-4-8-12-30/h3-20H,21-24H2,1-2H3 MMYWILWEDPWJHZ-UHFFFAOYSA-N 50567666 CHEMBL4850615 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 225 ChEMBL 10.1016/j.ejmech.2021.113389 10.7270/Q26W9FVF 33784602 Hassan, GS; Georgey, HH; Mohammed, EZ; George, RF; Mahmoud, WR; Omar, FA Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50567666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50567666&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164617299 471057811 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51405083 COc1ccc(cc1)-c1nc2n(nc(-c3ccccc3)c2c(-c2ccc(cc2)N2CCN(C)CC2)c1C#N)-c1ccccc1 InChI=1S/C37H32N6O/c1-41-21-23-42(24-22-41)29-17-13-26(14-18-29)33-32(25-38)35(28-15-19-31(44-2)20-16-28)39-37-34(33)36(27-9-5-3-6-10-27)40-43(37)30-11-7-4-8-12-30/h3-20H,21-24H2,1-2H3 MMYWILWEDPWJHZ-UHFFFAOYSA-N 50567666 CHEMBL4850615 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 144 ChEMBL 10.1016/j.ejmech.2021.113389 10.7270/Q26W9FVF 33784602 Hassan, GS; Georgey, HH; Mohammed, EZ; George, RF; Mahmoud, WR; Omar, FA Cairo University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50567666 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50567666&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164617299 471057811 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419827 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 InChI=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7-22(19-38)35-30-33-18-25(31)28(36-30)24-17-32-26-9-4-3-8-23(24)26/h3-4,6,8-14,17-18,22,32H,5,7,15-16,19H2,1-2H3,(H,34,39)(H,33,35,36)/b10-6+/t22-/m1/s1 RUBYHLPRZRMTJO-MOVYNIQHSA-N 50528813 CHEMBL4163879 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 452 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50528813 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50528813&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025540 440737395 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419828 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(Br)c(n1)-c1c[nH]c2ccccc12 50573503 CHEMBL4862603 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 115 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573503 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573503&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164623114 471063648 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419829 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(C2CC2)c(n1)-c1c[nH]c2ccccc12 50573504 CHEMBL4848336 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 625 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573504 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573504&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164611038 471063649 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419830 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(c(n1)-c1c[nH]c2ccccc12)C(F)(F)F 50573505 CHEMBL4854583 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >10000 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573505 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573505&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164615138 471063650 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419831 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573506 CHEMBL4861833 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 633 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573506 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573506&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 118025416 471063651 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419832 CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573507 CHEMBL4870659 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 388 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573507 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573507&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164625238 471063652 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419833 CN(C)C\C=C\C(=O)Nc1ccc(nc1)C(=O)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573508 CHEMBL4787545 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 402 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573508 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573508&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 134560546 471063653 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419834 Clc1cnc(N[C@@H]2CCCN(C2)C(=O)c2ccc(NC(=O)C=C)cn2)nc1-c1c[nH]c2ccccc12 50573509 CHEMBL4758566 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 919 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573509 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573509&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 134560346 471063654 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419835 CN(C)C\C=C\C(=O)Nc1ccc(cc1)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573510 CHEMBL4866812 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 70 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573510 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573510&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 134543415 471063655 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419836 C\C=C\C(=O)Nc1ccc(cc1)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573511 CHEMBL4864697 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 162 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573511 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573511&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164621718 471063656 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419837 CN(C)C\C=C\C(=O)Nc1ccc(nc1)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573512 CHEMBL4748005 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 74 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573512 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573512&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 134543949 471063657 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419838 C\C=C\C(=O)Nc1ccc(nc1)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573513 CHEMBL4866757 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 433 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573513 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573513&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164620575 471063658 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419839 C\C=C\C(=O)Nc1ccc(cc1C)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573514 CHEMBL4860981 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 197 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573514 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573514&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164612563 471063659 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419840 C\C=C\C(=O)Nc1ccc(N2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c(F)c1 50573515 CHEMBL4853887 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 318 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573515 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573515&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164612914 471063660 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419841 C\C=C\C(=O)Nc1cc(F)c(cc1C)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573516 CHEMBL4853964 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 118 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573516 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573516&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164615728 471063661 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419842 COc1cc(NC(=O)\C=C\C)c(C)cc1N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12 50573517 CHEMBL4872216 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 403 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573517 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573517&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164619029 471063662 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419843 CN(C)C\C=C\C(=O)Nc1ccc(O[C@@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)cc1 50573518 CHEMBL4754873 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 187 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573518 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573518&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search UUB 7NXK 134560325 471063663 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419844 C\C=C\C(=O)Nc1ccc(O[C@@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)cc1 50573519 CHEMBL4862643 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 587 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573519 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573519&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164623631 471063664 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419845 CN(C)C\C=C\C(=O)Nc1ccc(O[C@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)cc1 50573520 CHEMBL4862284 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 112 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573520 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573520&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 134560314 471063665 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51419846 CN(C)C\C=C\C(=O)Nc1ccc(O[C@@H]2CCC[C@H](C2)Nc2ncc(Cl)c(n2)-c2c[nH]c3ccccc23)c(F)c1 50573521 CHEMBL4753819 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 269 ChEMBL 10.1016/j.ejmech.2021.113481 10.7270/Q22B92TP 33945934 Jiang, B; Jiang, J; Kaltheuner, IH; Iniguez, AB; Anand, K; Ferguson, FM; Ficarro, SB; Seong, BKA; Greifenberg, AK; Dust, S; Kwiatkowski, NP; Marto, JA; Stegmaier, K; Zhang, T; Geyer, M; Gray, NS Harvard Medical School http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573521 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573521&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 134560316 471063666 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51411593 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCNCC2)ncc1C InChI=1S/C20H25N7S/c1-13-12-23-19(26-17(13)18-14(2)24-20(21-3)28-18)25-15-5-4-6-16(11-15)27-9-7-22-8-10-27/h4-6,11-12,22H,7-10H2,1-3H3,(H,21,24)(H,23,25,26) GZDFPDSMIHMTRU-UHFFFAOYSA-N 50570299 CHEMBL4879020 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 472 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570299 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570299&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164629222 471060444 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51411594 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCCNCC2)ncc1C InChI=1S/C21H27N7S/c1-14-13-24-20(27-18(14)19-15(2)25-21(22-3)29-19)26-16-6-4-7-17(12-16)28-10-5-8-23-9-11-28/h4,6-7,12-13,23H,5,8-11H2,1-3H3,(H,22,25)(H,24,26,27) DIHQGMJAKVBZHN-UHFFFAOYSA-N 50570302 CHEMBL4853628 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 89 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570302 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570302&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164612906 471060447 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51411595 CNc1nc(C)c(s1)-c1nc(Nc2cccc(c2)N2CCN3CCC2CC3)ncc1C InChI=1S/C23H29N7S/c1-15-14-25-22(28-20(15)21-16(2)26-23(24-3)31-21)27-17-5-4-6-19(13-17)30-12-11-29-9-7-18(30)8-10-29/h4-6,13-14,18H,7-12H2,1-3H3,(H,24,26)(H,25,27,28) RSTOVEUALSXORR-UHFFFAOYSA-N 50570304 CHEMBL4860925 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 546 ChEMBL 10.1016/j.ejmech.2021.113244 10.7270/Q2RX9GV5 33581551 Shao, H; Foley, DW; Huang, S; Abbas, AY; Lam, F; Gershkovich, P; Bradshaw, TD; Pepper, C; Fischer, PM; Wang, S University of Nottingham http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50570304 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50570304&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164612545 471060449 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51429289 COc1ccccc1C1=C(Nc2cccc(c2)C#N)C(=O)NC1=O InChI=1S/C18H13N3O3/c1-24-14-8-3-2-7-13(14)15-16(18(23)21-17(15)22)20-12-6-4-5-11(9-12)10-19/h2-9H,1H3,(H2,20,21,22,23) CRZIGHVWJFDSFR-UHFFFAOYSA-N 50577328 CHEMBL4875188 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >50000 ChEMBL 10.1021/acs.jmedchem.0c01579 10.7270/Q2ST7TPK 34463505 Serafim, RAM; Sorrell, FJ; Berger, BT; Collins, RJ; Vasconcelos, SNS; Massirer, KB; Knapp, S; Bennett, J; Fedorov, O; Patel, H; Zuercher, WJ; Elkins, JM University of Campinas (UNICAMP) http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50577328 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50577328&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164626135 471053451 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51420880 CC(C)c1n(C)nc2ccc(cc12)-c1ccnc(Nc2ccc3c(N4CCOCC4)c(C(C)=O)c(=O)oc3c2)n1 InChI=1S/C30H30N6O4/c1-17(2)27-22-15-19(5-8-24(22)34-35(27)4)23-9-10-31-30(33-23)32-20-6-7-21-25(16-20)40-29(38)26(18(3)37)28(21)36-11-13-39-14-12-36/h5-10,15-17H,11-14H2,1-4H3,(H,31,32,33) RVKNONNXSNALJV-UHFFFAOYSA-N 50573929 CHEMBL4848734 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 78 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573929&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162515863 471064074 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51420881 CC(C)c1n(C)nc2ccc(cc12)-c1ccnc(Nc2ccc3c(ccnc3c2)N2CCN(C)CC2)n1 InChI=1S/C29H32N8/c1-19(2)28-23-17-20(5-8-25(23)34-36(28)4)24-9-11-31-29(33-24)32-21-6-7-22-26(18-21)30-12-10-27(22)37-15-13-35(3)14-16-37/h5-12,17-19H,13-16H2,1-4H3,(H,31,32,33) NBSJZWFDNFWQDN-UHFFFAOYSA-N 50573930 CHEMBL4856177 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 96 ChEMBL 10.1021/acs.jmedchem.1c00271 10.7270/Q2ZG6X2G 34415148 Huang, J; Wang, X; Dong, R; Liu, X; Li, H; Zhang, T; Xu, J; Liu, C; Zhang, Y; Hou, S; Tang, W; Lu, T; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50573930 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50573930&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164610267 471064075 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51449535 CC(C)N1CCN(Cc2ccc(Nc3ncc(F)c(n3)-c3cn(C(C)C)c4ncccc34)nc2)CC1 InChI=1S/C27H33FN8/c1-18(2)35-12-10-34(11-13-35)16-20-7-8-24(30-14-20)32-27-31-15-23(28)25(33-27)22-17-36(19(3)4)26-21(22)6-5-9-29-26/h5-9,14-15,17-19H,10-13,16H2,1-4H3,(H,30,31,32,33) BKMZBHQCZLDPLV-UHFFFAOYSA-N 50585354 CHEMBL5084067 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >5000 ChEMBL 10.1016/j.ejmech.2021.114024 10.7270/Q2ZC86SX 34875521 Yuan, K; Kuang, W; Chen, W; Ji, M; Min, W; Zhu, Y; Hou, Y; Wang, X; Li, J; Wang, L; Yang, P China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50585354 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50585354&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 166627766 476021441 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51445085 Clc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 InChI=1S/C17H18ClN5/c18-14-10-21-17(22-11-4-3-7-19-8-11)23-16(14)13-9-20-15-6-2-1-5-12(13)15/h1-2,5-6,9-11,19-20H,3-4,7-8H2,(H,21,22,23)/t11-/m0/s1 XWKQZYOSWGEGIH-NSHDSACASA-N 50526790 CHEMBL4555799 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.330000 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50526790 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50526790&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 155557337 440735372 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51445086 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 50583916 CHEMBL4786320 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.150000 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583916 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583916&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162667027 476020003 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51445087 CCc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2ccccc12 50583917 CHEMBL4800180 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.400000 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583917 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583917&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 150511766 476020004 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51445088 CS(=O)(=O)c1cccc2c(c[nH]c12)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 50583918 CHEMBL4791134 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.070000 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583918 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583918&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 3I3 7RA5 156631275 476020005 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51445089 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(ccc12)C#N 50583919 CHEMBL5083688 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.090000 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583919 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583919&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 166630093 476020006 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51445090 CC1(C)CC[C@@H](CN1)Nc1ncc(c(n1)-c1c[nH]c2ccccc12)C(F)(F)F 50583920 CHEMBL4786843 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.340000 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583920 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583920&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 154940270 476020007 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51445091 CS(=O)(=O)c1ccc2c(c[nH]c2c1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 50583921 CHEMBL4779443 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.100000 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583921 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583921&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145444157 476020008 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51445092 CC1(C)CNC[C@H](C1)Nc1ncc(c(n1)-c1c[nH]c2ccccc12)C(F)(F)F 50583922 CHEMBL4786555 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.210000 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583922 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583922&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 142751812 476020009 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51445093 CP(C)(=O)c1cccc2c(c[nH]c12)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 50583923 CHEMBL4786592 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.080000 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583923 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583923&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 142751836 476020010 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51445094 Cc1noc(C)c1-c1ccc2c(c[nH]c2c1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 50583924 CHEMBL4790490 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.100000 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583924 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583924&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 139339317 476020011 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51445095 CS(=O)(=O)c1c(ccc2c(c[nH]c12)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F)C#N 50583925 CHEMBL4782954 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.080000 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583925 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583925&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145444136 476020012 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51445096 CCc1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2c(c(ccc12)C#N)S(C)(=O)=O 50583926 CHEMBL4798916 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.150000 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583926&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145444094 476020013 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51445097 Cl.Cc1noc(C)c1-c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 50583927 CHEMBL5088381 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.030000 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583927 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583927&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 166632650 476020014 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51445098 CC1(C)CNC[C@H](C1)Nc1ncc(c(n1)-c1c[nH]c2c(c(ccc12)C#N)P(C)(C)=O)C(F)(F)F 50583928 CHEMBL5080711 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.060000 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583928 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583928&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 146662734 476020015 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51445099 CC1(C)CC[C@@H](CN1)Nc1ncc(c(n1)-c1c[nH]c2c(c(ccc12)C#N)P(C)(C)=O)C(F)(F)F 50583929 SY-5609::SY5609::Sy 5609::Sy-5609 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.070000 ChEMBL 10.1021/acs.jmedchem.1c01171 10.7270/Q2736VSR 34726887 Marineau, JJ; Hamman, KB; Hu, S; Alnemy, S; Mihalich, J; Kabro, A; Whitmore, KM; Winter, DK; Roy, S; Ciblat, S; Ke, N; Savinainen, A; Wilsily, A; Malojcic, G; Zahler, R; Schmidt, D; Bradley, MJ; Waters, NJ; Chuaqui, C Syros Pharmaceuticals Inc. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50583929 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50583929&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 146662729 476020016 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1236714 Clc1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1 InChI=1S/C17H18ClN5/c18-12-4-5-17-20-10-15(23(17)11-12)14-2-1-3-16(22-14)21-13-6-8-19-9-7-13/h1-5,10-11,13,19H,6-9H2,(H,21,22) TWWKXZDIDHDHRF-UHFFFAOYSA-N 50377170 CHEMBL256570::US11254667, Compound I-2::US11542261, Compound I-2 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.996 US Patent 10.7270/Q2154MW8 US11542261 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377170&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 44449050 160856253 CHEMBL256570 ZINC29045252 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1236715 Cn1cc(cn1)-c1cn2c(cnc2cc1CO)-c1cccc(NC2CCNC2)n1 InChI=1S/C21H23N7O/c1-27-11-15(8-24-27)17-12-28-19(10-23-21(28)7-14(17)13-29)18-3-2-4-20(26-18)25-16-5-6-22-9-16/h2-4,7-8,10-12,16,22,29H,5-6,9,13H2,1H3,(H,25,26) HTJGFHHVVPNDMR-UHFFFAOYSA-N 538621 NCGC 00371481::US11254667, Compound I-24::US11542261, Compound I-24 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 174 US Patent 10.7270/Q2154MW8 US11542261 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=538621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=538621&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 153515746 464923733 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1236716 COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cccnc1 InChI=1S/C22H22N6O/c1-29-20-10-22-25-13-19(28(22)14-17(20)15-4-3-8-23-11-15)18-5-2-6-21(27-18)26-16-7-9-24-12-16/h2-6,8,10-11,13-14,16,24H,7,9,12H2,1H3,(H,26,27) ZQKNIPQNEVNCDY-UHFFFAOYSA-N 538619 NCGC 00371479::US11254667, Compound I-22::US11542261, Compound I-22 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 177 US Patent 10.7270/Q2154MW8 US11542261 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=538619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=538619&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 134284346 464923731 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1236717 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.623 US Patent 10.7270/Q2154MW8 US11542261 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1236824 Clc1ccc2ncc(-c3cccc(NC4CCCNC4)n3)n2c1 InChI=1S/C17H18ClN5/c18-12-6-7-17-20-10-15(23(17)11-12)14-4-1-5-16(22-14)21-13-3-2-8-19-9-13/h1,4-7,10-11,13,19H,2-3,8-9H2,(H,21,22) SZFYZDIPRMLBDC-UHFFFAOYSA-N 538658 NCGC 00249373::US11254667, Compound I-17::US11542261, Compound I-17 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 588 US Patent 10.7270/Q2154MW8 US11542261 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=538658 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=538658&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 25169384 464923767 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1236825 COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cn[nH]c1 538618 NCGC 00262327::US11254667, Compound I-20::US11542261, Compound I-20 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 116 US Patent 10.7270/Q2154MW8 US11542261 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=538618 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=538618&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 134284282 464923730 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1236826 COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cccnc1 InChI=1S/C22H22N6O/c1-29-20-10-22-25-13-19(28(22)14-17(20)15-4-3-8-23-11-15)18-5-2-6-21(27-18)26-16-7-9-24-12-16/h2-6,8,10-11,13-14,16,24H,7,9,12H2,1H3,(H,26,27) ZQKNIPQNEVNCDY-UHFFFAOYSA-N 538619 NCGC 00371479::US11254667, Compound I-22::US11542261, Compound I-22 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 177 US Patent 10.7270/Q2154MW8 US11542261 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=538619 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=538619&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 134284346 464923731 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1236827 Cn1cc(cn1)-c1cn2c(cnc2cc1CO)-c1cccc(NC2CCNC2)n1 InChI=1S/C21H23N7O/c1-27-11-15(8-24-27)17-12-28-19(10-23-21(28)7-14(17)13-29)18-3-2-4-20(26-18)25-16-5-6-22-9-16/h2-4,7-8,10-12,16,22,29H,5-6,9,13H2,1H3,(H,25,26) HTJGFHHVVPNDMR-UHFFFAOYSA-N 538621 NCGC 00371481::US11254667, Compound I-24::US11542261, Compound I-24 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 174 US Patent 10.7270/Q2154MW8 US11542261 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=538621 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=538621&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 153515746 464923733 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1236828 CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1 YISMQBFJYDFMAL-AESIHLKFSA-N 139540 US10189849, staurosporine::US10307427, Staurosporine::US10329300, Staurosporine::US11091485, Compound Staurosporine::US11542261, Compound staurosporine::US8889696, Staurosporine::US9051313, Staurosporine::US9586965, Control Staurosporine Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 174 US Patent 10.7270/Q2154MW8 US11542261 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139540&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 91669270 249871008 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1236875 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.623 US Patent 10.7270/Q2154MW8 US11542261 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1236876 CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1 YISMQBFJYDFMAL-AESIHLKFSA-N 139540 US10189849, staurosporine::US10307427, Staurosporine::US10329300, Staurosporine::US11091485, Compound Staurosporine::US11542261, Compound staurosporine::US8889696, Staurosporine::US9051313, Staurosporine::US9586965, Control Staurosporine Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.623 US Patent 10.7270/Q2154MW8 US11542261 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139540&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 91669270 249871008 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1236883 CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36) CVWXJKQAOSCOAB-UHFFFAOYSA-N 50300690 1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morpholin-4-Yl)ethoxy]imidazo[2,1-B][1,3]benzothiazol-2-Yl}phenyl)urea::AC 010220::AC 220::AC-220::AC010220::AC220::ASP-2689::CHEMBL576982::N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea::Quizartinib::Quizartinib (AC220)::US10266535, Compound AC220::US11542261, Compound quizartinib::US9216997, Quizartinib (positive compound) Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.623 US Patent 10.7270/Q2154MW8 US11542261 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50300690 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50300690&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search P30 4XUF,4RT7 24889392 104155051 CHEMBL576982 5658 ZINC43204002 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1236884 Clc1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1 InChI=1S/C17H18ClN5/c18-12-4-5-17-20-10-15(23(17)11-12)14-2-1-3-16(22-14)21-13-6-8-19-9-7-13/h1-5,10-11,13,19H,6-9H2,(H,21,22) TWWKXZDIDHDHRF-UHFFFAOYSA-N 50377170 CHEMBL256570::US11254667, Compound I-2::US11542261, Compound I-2 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.996 US Patent 10.7270/Q2154MW8 US11542261 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50377170 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50377170&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 44449050 160856253 CHEMBL256570 ZINC29045252 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1236885 CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1 YISMQBFJYDFMAL-AESIHLKFSA-N 139540 US10189849, staurosporine::US10307427, Staurosporine::US10329300, Staurosporine::US11091485, Compound Staurosporine::US11542261, Compound staurosporine::US8889696, Staurosporine::US9051313, Staurosporine::US9586965, Control Staurosporine Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.996 US Patent 10.7270/Q2154MW8 US11542261 Starczynowski, DT; Thomas, CJ; Rhyasen, G; Melgar, K; Walker, MM; Jiang, J CHILDREN''S HOSPITAL MEDICAL CENTER; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=139540 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=139540&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 91669270 249871008 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51471918 CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1 InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 7533 (2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]amino]butan-1-ol::(2R)-2-[[6-(benzylamino)-9-propan-2-ylpurin-2-yl]amino]butan-1-ol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-2-purinyl]amino]-1-butanol::(2R)-2-[[6-[(phenylmethyl)amino]-9-propan-2-yl-purin-2-yl]amino]butan-1-ol::(2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}butan-1-ol::(R)-Roscovitine::2,6,9-Trisubstituted purine deriv. 28::CHEMBL14762::CYC-202::Roscovitine::cid_160355 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 0.460000 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=7533 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=7533&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search RRC 3DDQ,1YGK,2A4L,1UNL 160355 11108321 CHEMBL14762 6035 ZINC01649340 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51471919 C[C@H](CO)Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)ncc1Br InChI=1S/C13H16BrN5O3S/c1-8(7-20)17-12-11(14)6-16-13(19-12)18-9-2-4-10(5-3-9)23(15,21)22/h2-6,8,20H,7H2,1H3,(H2,15,21,22)(H2,16,17,18,19)/t8-/m1/s1 MJIALGDLOLWBRQ-MRVPVSSYSA-N 50553480 CHEMBL4741442 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 85 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553480 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553480&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 3I6 4BGH 58890996 461692248 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51471920 C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(cc2)S(=N)(=O)C2CC2)ncc1C(F)(F)F InChI=1S/C18H21F3N4O3S/c1-10(26)11(2)28-16-15(18(19,20)21)9-23-17(25-16)24-12-3-5-13(6-4-12)29(22,27)14-7-8-14/h3-6,9-11,14,22,26H,7-8H2,1-2H3,(H,23,24,25)/t10-,11-,29?/m1/s1 UELYDGOOJPRWGF-MFOHZAOFSA-N 50511926 CHEMBL4442620 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 25 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50511926 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50511926&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search R0N 5IEV 45380979 440720508 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51471921 Cn1ncc(c1CC1CC1)-c1nc(N[C@H]2CC[C@H](N)CC2)ncc1Cl InChI=1S/C18H25ClN6/c1-25-16(8-11-2-3-11)14(9-22-25)17-15(19)10-21-18(24-17)23-13-6-4-12(20)5-7-13/h9-13H,2-8,20H2,1H3,(H,21,23,24)/t12-,13- RVZJFCNYSSUDCU-JOCQHMNTSA-N 50553499 CHEMBL4754493 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 1.3 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50553499 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50553499&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 126558497 461692267 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51471922 CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1 InChI=1S/C17H24N4O2S2/c1-17(2,3)12-8-19-13(23-12)10-24-14-9-20-16(25-14)21-15(22)11-4-6-18-7-5-11/h8-9,11,18H,4-7,10H2,1-3H3,(H,20,21,22) OUSFTKFNBAZUKL-UHFFFAOYSA-N 5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 62 ChEMBL 10.7270/Q2SB49QV 35485642 Shi, Z; Tian, L; Qiang, T; Li, J; Xing, Y; Ren, X; Liu, C; Liang, C The People's Hospital of Xinjiang Uyghur Autonomous Region http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=5931 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=5931&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 56H 5D1J 3025986 8035540 CHEMBL296468 5670 ZINC03816409 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51484277 CCN1C(=O)COc2c(CN3CCN(CC3)C(C)=O)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12 InChI=1S/C28H30F2N6O4/c1-4-36-23-13-20(32-28-31-14-22(30)26(33-28)21-6-5-19(29)12-24(21)39-3)11-18(27(23)40-16-25(36)38)15-34-7-9-35(10-8-34)17(2)37/h5-6,11-14H,4,7-10,15-16H2,1-3H3,(H,31,32,33) YKSDGHNGKNMUGI-UHFFFAOYSA-N 50598078 CHEMBL5207141 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 58 ChEMBL 10.7270/Q2154N2X 35605362 Wang, X; Liu, X; Huang, J; Liu, C; Li, H; Wang, C; Hong, Q; Lei, Y; Xia, J; Yu, Z; Dong, R; Xu, J; Tu, Z; Duan, C; Li, S; Lu, T; Tang, W; Chen, Y China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50598078 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50598078&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 168296796 482608930 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1325868 Cc1cc2cnc(NC3CCN(CC3)S(C)(=O)=O)nc2c(N[C@@H]2CCC[C@@]2(C)O)n1 InChI=1S/C20H30N6O3S/c1-13-11-14-12-21-19(23-15-6-9-26(10-7-15)30(3,28)29)25-17(14)18(22-13)24-16-5-4-8-20(16,2)27/h11-12,15-16,27H,4-10H2,1-3H3,(H,22,24)(H,21,23,25)/t16-,20-/m1/s1 AAVOJGZMGDAVNM-OXQOHEQNSA-N 621172 US20230303564, Compound 6::US20230303564, Compound 8 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 41.0 US Patent 10.7270/Q2KP869B US20230303564 XU, Z; JIANG, W; HU, L; DING, CZ; HU, G; LI, J; CHEN, S; CHEN, P; YAN, X; LIU, Y MEDSHINE DISCOVERY INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621172 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621172&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 169076003 485228329 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P6V,8P6Y Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1325875 CS(=O)(=O)N1CCC(CC1)Sc1ncc2ccnc(C3CCCC3O)c2n1 InChI=1S/C18H24N4O3S2/c1-27(24,25)22-9-6-13(7-10-22)26-18-20-11-12-5-8-19-17(16(12)21-18)14-3-2-4-15(14)23/h5,8,11,13-15,23H,2-4,6-7,9-10H2,1H3 GAASHZGNZTYOCB-UHFFFAOYSA-N 621174 US20230303564, Compound 11 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 227 US Patent 10.7270/Q2KP869B US20230303564 XU, Z; JIANG, W; HU, L; DING, CZ; HU, G; LI, J; CHEN, S; CHEN, P; YAN, X; LIU, Y MEDSHINE DISCOVERY INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621174 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621174&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 169429064 485228330 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P6V,8P6Y Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1325896 CS(=O)(=O)N1CCC(CC1)Nc1ncc2cc(nc(N[C@H]3CCCC3(F)F)c2n1)C(F)F InChI=1S/C19H24F4N6O2S/c1-32(30,31)29-7-4-12(5-8-29)25-18-24-10-11-9-13(16(20)21)26-17(15(11)28-18)27-14-3-2-6-19(14,22)23/h9-10,12,14,16H,2-8H2,1H3,(H,26,27)(H,24,25,28)/t14-/m0/s1 DJXMWMFZMCZDNH-AWEZNQCLSA-N 621179 US20230303564, Compound 21 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 32.9 US Patent 10.7270/Q2KP869B US20230303564 XU, Z; JIANG, W; HU, L; DING, CZ; HU, G; LI, J; CHEN, S; CHEN, P; YAN, X; LIU, Y MEDSHINE DISCOVERY INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621179 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621179&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 169076011 485228335 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P6V,8P6Y Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1325902 CS(=O)(=O)N1CCC(CC1)Nc1ncc2cc(nc(N[C@@H]3CCCC3(F)F)c2n1)C(F)F InChI=1S/C19H24F4N6O2S/c1-32(30,31)29-7-4-12(5-8-29)25-18-24-10-11-9-13(16(20)21)26-17(15(11)28-18)27-14-3-2-6-19(14,22)23/h9-10,12,14,16H,2-8H2,1H3,(H,26,27)(H,24,25,28)/t14-/m1/s1 DJXMWMFZMCZDNH-CQSZACIVSA-N 621180 US20230303564, Compound 22 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 80.5 US Patent 10.7270/Q2KP869B US20230303564 XU, Z; JIANG, W; HU, L; DING, CZ; HU, G; LI, J; CHEN, S; CHEN, P; YAN, X; LIU, Y MEDSHINE DISCOVERY INC. http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=621180 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=621180&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 169075948 485228336 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P6V,8P6Y Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8ORM,8P4Z,8P6V,8P6Y Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 51502609 CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2nccc(Sc3cnc(cn3)N3CCC4(CO[C@@H](C)[C@H]4N)CC3)c2Cl)ncc1F InChI=1S/C33H35ClF2N10OS/c1-17(2)46-19(4)42-29-21(35)11-20(12-23(29)46)28-22(36)13-41-32(43-28)44-31-27(34)24(5-8-38-31)48-26-15-39-25(14-40-26)45-9-6-33(7-10-45)16-47-18(3)30(33)37/h5,8,11-15,17-18,30H,6-7,9-10,16,37H2,1-4H3,(H,38,41,43,44)/t18-,30+/m0/s1 ZDEBEWQYXJZQRS-YVGXBJCXSA-N 50605448 CHEMBL5179617 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 968 ChEMBL 10.7270/Q2NG4VR2 35447031 Chen, X; Shu, C; Li, W; Hou, Q; Luo, G; Yang, K; Wu, X China Pharmaceutical University http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50605448 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50605448&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164887497 482616299 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 1KXU,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 1UA2,6O9L,6XBZ,6XD3,7B5O,7B5Q,7EGB,7EGC,7ENA,7ENC,7LBM,7NVR,8BVW,8BYQ,8P4Z Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412135 O=C(N1CCOCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H27N7O3/c32-21(30-10-12-34-13-11-30)16-4-6-18(7-5-16)26-23-25-15-17-14-19-28-29-22(33)24(8-2-1-3-9-24)31(19)20(17)27-23/h4-7,14-15,28H,1-3,8-13H2,(H,29,33)(H,25,26,27) CEIJSVLEARLWRF-UHFFFAOYSA-N 601961 7'-((4-(morpholine-4- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 74::US20240150369, Compound 74 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601961 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601961&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360194 482093043 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412028 NS(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O4S/c21-31(29,30)14-6-4-13(5-7-14)23-19-22-11-12-10-15-17(27)25-18(28)20(8-2-1-3-9-20)26(15)16(12)24-19/h4-7,10-11,17,27H,1-3,8-9H2,(H,25,28)(H2,21,29,30)(H,22,23,24) DQBASRYERZQRJJ-UHFFFAOYSA-N 601933 4-((6'-hydroxy-8'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]- 2'-yl)amino)benzenesulfonamide::US11643416, Compound 1::US20240150369, Compound 1 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 560 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601933 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601933&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360122 482093015 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412033 NS(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H22N6O3S/c21-30(28,29)15-6-4-14(5-7-15)23-19-22-12-13-10-16-24-17(27)11-20(8-2-1-3-9-20)26(16)18(13)25-19/h4-7,10,12H,1-3,8-9,11H2,(H,24,27)(H2,21,28,29)(H,22,23,25) IAPISFUJUUDVNW-UHFFFAOYSA-N 601934 4-((7'-oxo-7',8'-dihydro-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5-a:2,3- d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 2::US20240150369, Compound 2 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 200 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601934 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601934&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 165172635 482093016 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412038 NS(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O3S/c20-30(28,29)14-6-4-13(5-7-14)22-18-21-11-12-10-15-24-25-17(27)19(8-2-1-3-9-19)26(15)16(12)23-18/h4-7,10-11,24H,1-3,8-9H2,(H,25,27)(H2,20,28,29)(H,21,22,23) KGJVKYSVVOQPDL-UHFFFAOYSA-N 601935 4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 3::US20240150369, Compound 3 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601935 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601935&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360412 482093017 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412042 NS(=O)(=O)c1ccc(Nc2ncc3cc4NN=CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C19H21N7O2S/c20-29(27,28)15-6-4-14(5-7-15)23-18-21-11-13-10-16-25-22-12-19(8-2-1-3-9-19)26(16)17(13)24-18/h4-7,10-12,25H,1-3,8-9H2,(H2,20,27,28)(H,21,23,24) YLWSVZLNZZVTSM-UHFFFAOYSA-N 601936 4-((1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 4::US20240150369, Compound 4 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 230 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601936 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601936&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360213 482093018 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412047 CN1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O3S/c1-26-16-11-13-12-22-19(23-14-5-7-15(8-6-14)31(21,29)30)24-17(13)27(16)20(18(28)25-26)9-3-2-4-10-20/h5-8,11-12H,2-4,9-10H2,1H3,(H,25,28)(H2,21,29,30)(H,22,23,24) YQOZFMRCEONJEU-UHFFFAOYSA-N 601937 4-((1'-methyl-3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 12::US20240150369, Compound 12 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601937 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601937&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360058 482093019 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412052 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27)/t16-/m0/s1 FKAJEPVSQITQLJ-INIZCTEOSA-N 601938 (R)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 18::US20240150369, Compound 18 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 840 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601938 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601938&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360080 482093020 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412057 C[C@@H]1NC(=O)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C21H24N6O3S/c1-13-17-11-14-12-23-20(25-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(19(28)24-13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,24,28)(H2,22,29,30)(H,23,25,26)/t13-/m0/s1 ZJKDYTFNXUBLEQ-ZDUSSCGKSA-N 601939 (S)-4-((6'-methyl-8'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane- 1,9'-pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 19::US20240150369, Compound 19 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 800 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601939 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601939&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360280 482093021 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412061 CN1N=CC2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C20H23N7O2S/c1-26-17-11-14-12-22-19(24-15-5-7-16(8-6-15)30(21,28)29)25-18(14)27(17)20(13-23-26)9-3-2-4-10-20/h5-8,11-13H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,24,25) PHZDWQYTFQOSSZ-UHFFFAOYSA-N 601940 4-((1'-methyl-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 5::US20240150369, Compound 5 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 875 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601940 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601940&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360258 482093022 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412065 NS(=O)(=O)c1ccc(Nc2ncc3cc4[C@@H](CF)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23FN6O3S/c22-11-16-17-10-13-12-24-20(25-14-4-6-15(7-5-14)32(23,30)31)27-18(13)28(17)21(19(29)26-16)8-2-1-3-9-21/h4-7,10,12,16H,1-3,8-9,11H2,(H,26,29)(H2,23,30,31)(H,24,25,27)/t16-/m1/s1 FKAJEPVSQITQLJ-MRXNPFEDSA-N 601941 (S)-4-((6'-(fluoromethyl)-8'-oxo- 7',8'-dihydro-6'H- spiro[cyclohexane-1,9'- pyrazino[1'2':1,5]pyrrolo[2,3- d]pyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 23::US20240150369, Compound 23 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 682 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601941 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601941&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360272 482093023 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412069 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C21H24N6O3S/c1-13-19(28)25-17-11-14-12-23-20(24-15-5-7-16(8-6-15)31(22,29)30)26-18(14)27(17)21(13)9-3-2-4-10-21/h5-8,11-13H,2-4,9-10H2,1H3,(H,25,28)(H2,22,29,30)(H,23,24,26) KJHOORCYJSBANN-UHFFFAOYSA-N 601942 4-((8'-methyl-7'-oxo-7',8'-dihydro- 6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 42::US20240150369, Compound 42 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 83.0 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601942 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601942&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360186 482093024 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412073 CC1C(=O)N(C)c2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C22H26N6O3S/c1-14-20(29)27(2)18-12-15-13-24-21(25-16-6-8-17(9-7-16)32(23,30)31)26-19(15)28(18)22(14)10-4-3-5-11-22/h6-9,12-14H,3-5,10-11H2,1-2H3,(H2,23,30,31)(H,24,25,26) FLIVKVQMXOAQAK-UHFFFAOYSA-N 601944 4-((6',8'-dimethyl-7'-oxo-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrrolo[1,5-a:2,3-d']dipyrimidin]-2'- yl)amino)benzenesulfonamide::US11643416, Compound 43::US20240150369, Compound 43 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 250 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601944 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601944&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360168 482093026 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412077 CC1=NNc2cc3cnc(Nc4ccc(cc4)S(N)(=O)=O)nc3n2C11CCCCC1 InChI=1S/C20H23N7O2S/c1-13-20(9-3-2-4-10-20)27-17(26-25-13)11-14-12-22-19(24-18(14)27)23-15-5-7-16(8-6-15)30(21,28)29/h5-8,11-12,26H,2-4,9-10H2,1H3,(H2,21,28,29)(H,22,23,24) SMWJYKRUKGMKJV-UHFFFAOYSA-N 601945 4-((3'-methyl-1'H-spiro[cyclohexane- 1,4'-pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 45::US20240150369, Compound 45 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601945 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601945&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360356 482093027 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412081 CN1N=C(C)C2(CCCCC2)n2c1cc1cnc(Nc3ccc(cc3)S(N)(=O)=O)nc21 InChI=1S/C21H25N7O2S/c1-14-21(10-4-3-5-11-21)28-18(27(2)26-14)12-15-13-23-20(25-19(15)28)24-16-6-8-17(9-7-16)31(22,29)30/h6-9,12-13H,3-5,10-11H2,1-2H3,(H2,22,29,30)(H,23,24,25) RWSCYFXGWJPUQX-UHFFFAOYSA-N 601946 4-((1',3'-dimethyl-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzenesulfonamide::US11643416, Compound 46::US20240150369, Compound 46 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 723 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601946 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601946&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360359 482093028 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412085 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H30N8O3S/c1-30-11-13-31(14-12-30)36(34,35)19-7-5-18(6-8-19)26-23-25-16-17-15-20-28-29-22(33)24(9-3-2-4-10-24)32(20)21(17)27-23/h5-8,15-16,28H,2-4,9-14H2,1H3,(H,29,33)(H,25,26,27) ZLNVBIGZYRPQKY-UHFFFAOYSA-N 601947 7'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 49::US20240150369, Compound 49 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 242 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601947 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601947&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360274 482093029 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412089 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O4S/c1-30-11-13-31(14-12-30)37(35,36)19-7-5-18(6-8-19)27-24-26-16-17-15-20-22(33)29-23(34)25(9-3-2-4-10-25)32(20)21(17)28-24/h5-8,15-16,22,33H,2-4,9-14H2,1H3,(H,29,34)(H,26,27,28) CXMKIWPGGSLHRE-UHFFFAOYSA-N 601948 6'-hydroxy-2'-((4-((4- methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US11643416, Compound 50::US20240150369, Compound 50 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 118 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601948 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601948&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360335 482093030 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412093 CN1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H31N7O3S/c1-30-11-13-31(14-12-30)36(34,35)20-7-5-19(6-8-20)27-24-26-17-18-15-21-28-22(33)16-25(9-3-2-4-10-25)32(21)23(18)29-24/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,28,33)(H,26,27,29) TYSWNLQZLBRNSE-UHFFFAOYSA-N 601949 2'-((4-((4-methylpiperazin-1- yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US11643416, Compound 51::US20240150369, Compound 51 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 66.0 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601949 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601949&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360110 482093031 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412097 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H30N8O2/c1-31-11-13-32(14-12-31)22(34)17-5-7-19(8-6-17)27-24-26-16-18-15-20-29-30-23(35)25(9-3-2-4-10-25)33(20)21(18)28-24/h5-8,15-16,29H,2-4,9-14H2,1H3,(H,30,35)(H,26,27,28) ZPHBEDTYTQWLFC-UHFFFAOYSA-N 601950 7'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 52::US20240150369, Compound 52 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601950 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601950&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360421 482093032 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412101 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4C(O)NC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O3/c1-31-11-13-32(14-12-31)23(35)17-5-7-19(8-6-17)28-25-27-16-18-15-20-22(34)30-24(36)26(9-3-2-4-10-26)33(20)21(18)29-25/h5-8,15-16,22,34H,2-4,9-14H2,1H3,(H,30,36)(H,27,28,29) VASFNXBXECJRSY-UHFFFAOYSA-N 601951 6'-hydroxy-2'-((4-(4- methylpiperazine-1- carbonyl)phenyl)amino)-6',7'- dihydro-8'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-8'-one::US11643416, Compound 53::US20240150369, Compound 53 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 615 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601951 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601951&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360096 482093033 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412105 CN1CCN(CC1)C(=O)c1ccc(Nc2ncc3cc4NC(=O)CC5(CCCCC5)n4c3n2)cc1 InChI=1S/C26H31N7O2/c1-31-11-13-32(14-12-31)24(35)18-5-7-20(8-6-18)28-25-27-17-19-15-21-29-22(34)16-26(9-3-2-4-10-26)33(21)23(19)30-25/h5-8,15,17H,2-4,9-14,16H2,1H3,(H,29,34)(H,27,28,30) YZVFJIYEYQIHIP-UHFFFAOYSA-N 601952 2'-((4-(4-methylpiperazine-1- carbonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US11643416, Compound 54::US20240150369, Compound 54 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 144 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601952 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601952&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360319 482093034 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412109 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4C(=O)NCC5(CCCCC5)n4c3n2)cc1 InChI=1S/C25H29N7O2/c33-22-20-14-18-15-27-24(30-21(18)32(20)25(16-28-22)8-2-1-3-9-25)29-19-6-4-17(5-7-19)23(34)31-12-10-26-11-13-31/h4-7,14-15,26H,1-3,8-13,16H2,(H,28,33)(H,27,29,30) BKCOGSHTNWTZNI-UHFFFAOYSA-N 601953 2'-((4-(piperazine-1- carbonyl)phenyl)amino)-7',8'- dihydro-6'H-spiro[cyclohexane-1,9'- pyrazino[1',2':1,5]pyrrolo[2,3- d]pyrimidin]-6'-one::US11643416, Compound 55::US20240150369, Compound 55 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 27.0 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601953 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601953&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360217 482093035 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412113 CC1C(=O)Nc2cc3cnc(Nc4ccc(cc4)S(=O)(=O)N4CCN(C)CC4)nc3n2C11CCCCC1 InChI=1S/C26H33N7O3S/c1-18-24(34)29-22-16-19-17-27-25(30-23(19)33(22)26(18)10-4-3-5-11-26)28-20-6-8-21(9-7-20)37(35,36)32-14-12-31(2)13-15-32/h6-9,16-18H,3-5,10-15H2,1-2H3,(H,29,34)(H,27,28,30) CELCCCWTAADGDV-UHFFFAOYSA-N 601954 8'-methyl-2'-((4-((4-methylpiperazin- 1-yl)sulfonyl)phenyl)amino)-6'H- spiro[cyclohexane-1,9'-pyrrolo[1,5- a:2,3-d']dipyrimidin]-7'(8'H)-one::US11643416, Compound 59::US20240150369, Compound 59 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 16.0 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601954 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601954&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162359990 482093036 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412117 O=C(N1CCNCC1)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C24H28N8O2/c33-21(31-12-10-25-11-13-31)16-4-6-18(7-5-16)27-23-26-15-17-14-19-29-30-22(34)24(8-2-1-3-9-24)32(19)20(17)28-23/h4-7,14-15,25,29H,1-3,8-13H2,(H,30,34)(H,26,27,28) NKSJUACUARPPLH-UHFFFAOYSA-N 601955 7'-((4-(piperazine-1- carbonyl)phenyl)amino)-1',2'- dihydro-3'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-3'-one::US11643416, Compound 61::US20240150369, Compound 61 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601955 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601955&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360337 482093037 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412121 CN(C)C(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C22H25N7O2/c1-28(2)19(30)14-6-8-16(9-7-14)24-21-23-13-15-12-17-26-27-20(31)22(10-4-3-5-11-22)29(17)18(15)25-21/h6-9,12-13,26H,3-5,10-11H2,1-2H3,(H,27,31)(H,23,24,25) FCLBVILBAPMKST-UHFFFAOYSA-N 601956 N,N-dimethyl-4-((3'-oxo-2',3'- dihydro-1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US11643416, Compound 62::US20240150369, Compound 62 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601956 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601956&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360175 482093038 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412125 NC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C20H21N7O2/c21-16(28)12-4-6-14(7-5-12)23-19-22-11-13-10-15-25-26-18(29)20(8-2-1-3-9-20)27(15)17(13)24-19/h4-7,10-11,25H,1-3,8-9H2,(H2,21,28)(H,26,29)(H,22,23,24) YPSCKJWJIXZMSC-UHFFFAOYSA-N 601957 4-((3'-oxo-2',3'-dihydro-1'H- spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US11643416, Compound 63::US20240150369, Compound 63 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 579 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601957 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601957&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360187 482093039 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1412129 CNC(=O)c1ccc(Nc2ncc3cc4NNC(=O)C5(CCCCC5)n4c3n2)cc1 InChI=1S/C21H23N7O2/c1-22-18(29)13-5-7-15(8-6-13)24-20-23-12-14-11-16-26-27-19(30)21(9-3-2-4-10-21)28(16)17(14)25-20/h5-8,11-12,26H,2-4,9-10H2,1H3,(H,22,29)(H,27,30)(H,23,24,25) NUBBIJVOSXWZTF-UHFFFAOYSA-N 601958 N-methyl-4-((3'-oxo-2',3'-dihydro- 1'H-spiro[cyclohexane-1,4'- pyrimido[5',4':4,5]pyrrolo[2,1- c][1,2,4]triazin]-7'- yl)amino)benzamide::US11643416, Compound 64::US20240150369, Compound 64 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens >1000 US Patent 10.7270/Q2862MR7 US20240150369 n/a n/a http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=601958 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=601958&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 162360349 482093040 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406616 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCOCC1 669827 (S)-4-(6-morpholinyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 1 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 13.4 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669827 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669827&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544551 497613784 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406620 C[C@@H]1CN([C@H](C)CO1)c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669828 4-(6-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N—((S)-piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 2 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 10.4 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669828 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669828&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171902384 497613785 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406624 OC1CCN(CC1)c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669829 US20240132489, Compound 3::amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidin-4-ol Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 17.4 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669829 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669829&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544521 497613786 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406628 OCC1CCN(CC1)c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669830 US20240132489, Compound 4::amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidin-4-yl)methanol Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 17.4 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669830 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669830&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544558 497613787 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406632 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CC2COCC2C1 669831 N—((S)-piperidin-3-yl)-4-(6-(tetrahydro-1H-furan[3,4-c]pyrrol-5(3H)-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 5 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 12.1 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669831 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669831&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544541 497613788 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406636 CC1(O)CCN(C1)c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669832 3-methyl-1-(3-(2-(((S)-piperidin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)pyrrolidin-3-ol ::US20240132489, Compound 6 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 10.4 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669832 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669832&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167142654 497613789 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406640 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCCC2(CCOC2)C1 669833 4-(6-(2-oxa-7-azaspiro[4.5]decan-7-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N—((S)-piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 7 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 24.3 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669833 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669833&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167142628 497613790 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406644 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCC2(COC2)C1 669834 (S)-4-(6-(2-oxa-6-azaspiro[3.4]octan-6-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 8 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 40.3 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669834 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669834&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544528 497613791 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406648 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCC2(CCOC2)CC1 669835 (S)-4-(6-(2-oxa-8-azaspiro[4.5]decan-8-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 9 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 28.7 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669835 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669835&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544538 497613792 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406652 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCCC2(CCOCC2)C1 669836 (S)-4-(6-(9-oxa-2-azaspiro[5.5]undecan-2-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 10 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 27.0 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669836 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669836&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544519 497613793 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406708 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCN(CC1)C1COC1 669850 (S)-4-(6-(4-(oxetan-3-yl)piperazin-1-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 24 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 17.4 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669850 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669850&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544556 497613807 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406712 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCS(=O)(=O)CC1 669851 (S)-4-(3-(2-(piperidine-3-amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)thiomorpholine-1,1-dioxide ::US20240132489, Compound 25 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 6.50 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669851 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669851&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141931 497613808 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406716 C[C@H]1COCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCC(C)(C)NC2)ncc1C(F)(F)F 669852 N—((S)-6,6-dimethylpiperidin-3-yl)-4-(6-((S)-3-methylmorpholinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 26 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 9.50 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669852 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669852&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544562 497613809 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406720 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1=CCOCC1 669853 (S)-4-(6-(3,6-dihydro-2H-pyran-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 27 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2.17 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669853 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669853&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544525 497613810 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406724 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1CCOCC1 669854 US20240132489, Compound 28::formate Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 6.96 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669854 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669854&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544548 497613811 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406728 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1CCOC1 669855 US20240132489, Compound 107::US20240132489, Compound 108::US20240132489, Compound 29::formate Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 7.08 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669855&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141946 497613812 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406732 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1CCCCO1 InChI=1S/C22H25F3N6O/c23-22(24,25)16-12-28-21(29-13-4-3-8-26-10-13)31-19(16)15-11-27-20-14(15)6-7-17(30-20)18-5-1-2-9-32-18/h6-7,11-13,18,26H,1-5,8-10H2,(H,27,30)(H,28,29,31)/t13-,18?/m0/s1 NFSYJPOVLYTWLS-FVRDMJKUSA-N 669856 US20240132489, Compound 30 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 10.5 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669856 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669856&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544514 497613813 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406736 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C12CC1COCC2 669857 US20240132489, Compound 31::formate Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 8.13 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669857 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669857&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141927 497613814 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406740 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CC2CCC1CO2 669858 4-(6-(2-oxo-5-azabicyclo[2.2.2]octan-5-yl)-1H-pyrrol[2,3-b]pyridin-3-yl)-N—((S)-piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 32 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 19.9 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669858 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669858&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167142464 497613815 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406744 FC(F)(F)[C@H]1COCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669859 N—((S)-piperidin-3-yl)-5-(trifluoromethyl)-4-(6-((R)-3-(trifluoromethyl)morpholinyl)-1H-pyrrol[2,3-b]pyridin-3-yl)pyrimidine-2-amine ::US20240132489, Compound 33 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 46.8 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669859 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669859&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544512 497613816 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406748 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CC2CC(C1)O2 669860 4-(6-(6-oxo-3-azabicyclo[3.1.1]heptan-3-yl)-1H-pyrrol[2,3-b]pyridin-3-yl)-N—((S)-piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 34 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 40.2 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669860 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669860&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141967 497613817 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406752 FC(F)(F)c1cnc(N[C@@H]2[C@@H]3CC[C@H]2NC3)nc1-c1c[nH]c2nc(ccc12)N1CCOCC1 669861 US20240132489, Compound 43::formate Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 82.8 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669861 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669861&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171902385 497613818 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406756 FC(F)(F)c1cnc(N[C@@H]2CN3CCC2CC3)nc1-c1c[nH]c2nc(ccc12)N1CCOCC1 669862 US20240132489, Compound 44::formate Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 131 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669862 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669862&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141937 497613819 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406656 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CC2(C1)CCOC2 669837 (S)-4-(6-(6-oxa-2-azaspiro[3.4]octan-2-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 11 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 27.8 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669837 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669837&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544559 497613794 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406660 C[C@@H]1OCC2(CCN(CC2)c2ccc3c(c[nH]c3n2)-c2nc(N[C@H]3CCCNC3)ncc2C(F)(F)F)[C@@H]1N 669838 (3S,4S)-3-methyl-8-(3-(2-(((S)-piperidin-3-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrol[2,3-b]pyridin-6-yl)-2-oxa-8-azaspiro[4.5]decan-4-amine ::US20240132489, Compound 12 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 17.4 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669838 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669838&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544552 497613795 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406664 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1C[C@@H]2C[C@H]1CO2 669839 4-(6-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N—((S)-piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 13 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 7.05 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669839 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669839&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167142493 497613796 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406668 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CC2(COC2)C1 669840 (S)-4-(6-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 14 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 7.11 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669840 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669840&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544522 497613797 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406672 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCC2(COC2)CC1 669841 (S)-4-(6-(2-oxa-7-azaspiro[3.5]nonan-7-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 15 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 16.5 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669841 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669841&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544549 497613798 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406676 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCC2(CCO2)CC1 669842 (S)-4-(6-(1-oxa-7-azaspiro[3.5]nonan-7-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 16 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 10.8 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669842 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669842&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544530 497613799 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406680 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CC2(C1)CCCOC2 669843 (S)-4-(6-(6-oxa-2-azaspiro[3.5]nonan-2-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 17 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 20.0 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669843 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669843&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544542 497613800 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406684 C[C@H]1COCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669844 4-(6-((S)-3-methylmorpholinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N—((S)-piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 18 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 9.47 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669844 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669844&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141934 497613801 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406688 C[C@@H]1COCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669845 4-(6-((R)-3-methylmorpholinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N—((S)-piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 19 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 159 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669845 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669845&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141929 497613802 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406692 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCC(CC1)C#N 669846 (S)-1-(3-(2-(piperidine-3-amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidine-4-nitrile ::US20240132489, Compound 20 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 8.43 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669846 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669846&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141952 497613803 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406696 CC1(CN(C1)c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F)C#N 669847 (S)-3-methyl-1-(3-(2-(piperidine-3-amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)azetidine-3-formonitrile ::US20240132489, Compound 21 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 8.81 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669847 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669847&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141953 497613804 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406700 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1CCCOCC1 669848 (S)-4-(6-(1,4-oxazepan-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 22 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 7.05 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669848 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669848&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141945 497613805 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406704 CC1(O)CCN(CC1)c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669849 (S)-4-methyl-1-(3-(2-(piperidine-3-amino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)piperidin-4-ol ::US20240132489, Compound 23 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 13.1 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669849 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669849&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141954 497613806 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406812 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1CCOC1 669855 US20240132489, Compound 107::US20240132489, Compound 108::US20240132489, Compound 29::formate Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 4.36 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669855&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141946 497613812 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406816 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1=CCCCO1 669877 (S)-4-(6-(3,4-dihydropyran-6-yl)-1H-pyrrol[2,3-b]pyridin-3-yl)-N-(piperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 109 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 5.62 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669877 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669877&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544561 497613832 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406820 CC1COCCC1c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669878 US20240132489, Compound 110::formate Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 3.48 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669878 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669878&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141985 497613833 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406824 FC(F)(F)c1cnc(N[C@@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1CCCCO1 669879 Monomer ::US20240132489, Compound 112 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 5.82 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669879 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669879&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171441850 497613834 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406825 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1CCCCO1 669880 Monomer ::US20240132489, Compound 113 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 4.76 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669880 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669880&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544514 497613835 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406826 CP(C)(=O)c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669881 US20240132489, Compound 114::formate Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 6.73 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669881 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669881&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141955 497613836 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406830 C[C@@H]1CNC[C@H](C1)Nc1ncc(c(n1)-c1c[nH]c2nc(ccc12)N1CCOC[C@@H]1C)C(F)(F)F 669882 4-(6-((S)-3-methylmorpholinyl)-1H-pyrrol[2,3-b]pyridin-3-yl)-N-((3S,5S)-5-methylpiperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 115 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 9.52 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669882 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669882&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141989 497613837 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406834 CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1 InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 50326053 CHEMBL608533::PKC-412::US20240132489, Compound Staurosporine Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 797 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50326053 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=50326053&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 2K2 4NCT 9829523 123105168 63452 CHEMBL608533 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406760 CC1(C)CC[C@@H](CN1)Nc1ncc(c(n1)-c1c[nH]c2nc(ccc12)N1CCOCC1)C(F)(F)F 669863 (S)—N-(6,6-dimethylpiperidin-3-yl)-4-(6-morpholinyl-1H-pyrrol[2,3-b]pyridin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 60 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 8.79 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669863 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669863&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 164544526 497613820 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406764 C[C@H]1CC[C@@H](CN1)Nc1ncc(c(n1)-c1c[nH]c2nc(ccc12)N1CCCOC[C@@H]1C)C(F)(F)F 669864 4-(6-((S)-3-methylmorpholine)-1H-pyrrol[2,3-b]pyridin-3-yl)-N-((3S,6S)-6-methylpiperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 69 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 28.4 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669864 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669864&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171902386 497613821 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406768 C[C@H]1COCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCC3(CC3)NC2)ncc1C(F)(F)F 669865 US20240132489, Compound 70::formate Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 41.2 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669865 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669865&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171902387 497613822 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406772 C[C@H]1COCCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@@H]2CNCC(F)(F)C2)ncc1C(F)(F)F 669866 N—((S)-5,5-difluoropiperidin-3-yl)-4-(6-((S)-3-methylmorpholinyl)-1H-pyrrol[2,3-b]pyridin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 71 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 31.7 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669866 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669866&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171902388 497613823 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406776 C[C@H]1CNC[C@H](C1)Nc1ncc(c(n1)-c1c[nH]c2nc(ccc12)N1CCCOC[C@@H]1C)C(F)(F)F 669867 4-(6-((S)-3-methylmorpholinyl)-1H-pyrrol[2,3-b]pyridin-3-yl)-N-((3S,5R)-5-methylpiperidin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 72 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 17.6 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669867 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669867&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171902389 497613824 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406780 C[C@H]1COCCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@@H]2CNC[C@@H](F)C2)ncc1C(F)(F)F 669868 N-((3S,5S)-5-fluoropyridin-3-yl)-4-(6-((S)-3-methylmorpholinyl)-1H-pyrrol[2,3-b]pyridin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 73 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 11.5 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669868 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669868&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171902390 497613825 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406784 C[C@H]1COCCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@@H]2CNC[C@H](F)C2)ncc1C(F)(F)F 669869 N-((3S,5R)-5-fluoropyridin-3-yl)-4-(6-((S)-3-methylmorpholinyl)-1H-pyrrol[2,3-b]pyridin-3-yl)-5-(trifluoromethyl)pyrimidine-2-amine ::US20240132489, Compound 74 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 10.2 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669869 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669869&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171902391 497613826 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406788 C[C@H]1COCCCN1c1nc2[nH]cc(-c3nc(N[C@H]4CCCNC4)ncc3C(F)(F)F)c2cc1F 669870 US20240132489, Compound 75::formate Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 8.50 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669870 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669870&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 171902392 497613827 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406792 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2cc(ccc12)N1CCCC1 InChI=1S/C22H25F3N6/c23-22(24,25)18-13-28-21(29-14-4-3-7-26-11-14)30-20(18)17-12-27-19-10-15(5-6-16(17)19)31-8-1-2-9-31/h5-6,10,12-14,26-27H,1-4,7-9,11H2,(H,28,29,30)/t14-/m0/s1 WVOMSZCXYDTSHK-AWEZNQCLSA-N 669871 US20240132489, Compound 101 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 28.5 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669871 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669871&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 145444159 497613828 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406796 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)N1C2CC1COC2 669872 US20240132489, Compound 103::formate Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 7.26 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669872 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669872&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167142494 497613829 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406800 CC[C@H]1COCCN1c1ccc2c(c[nH]c2n1)-c1nc(N[C@H]2CCCNC2)ncc1C(F)(F)F 669873 US20240132489, Compound 104::formate Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 5.85 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669873 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669873&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167142489 497613830 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406804 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1=CCOC1 669874 US20240132489, Compound Mixture 105 and 106 Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 2.70 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669874 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669874&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141994 497613831 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19 1406808 FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c2nc(ccc12)C1CCOC1 669855 US20240132489, Compound 107::US20240132489, Compound 108::US20240132489, Compound 29::formate Cyclin-H/Cyclin-dependent kinase 7 Homo sapiens 6.40 US Patent 10.7270/Q2JW8K5V US20240132489 GU, X; BAI, H; BARBEAU, OR; BESNARD, J Gt Apeiron Therapeutics http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=669855 http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=com&complexid=112&target=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search http://www.bindingdb.org/jsp/dbsearch/PrimarySearch_ki.jsp?energyterm=kJ/mole&tag=r21&monomerid=669855&enzyme=Cyclin-H%2FCyclin-dependent+kinase+7&column=ki&startPg=0&Increment=50&submit=Search 167141946 497613812 2 MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL 8PYR,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,8GXS,8GXQ,7B5Q,7B5O,6XD3,6XBZ,1KXU Cyclin-H CCNH_HUMAN P51946 Q53X72 Q8TBL9 MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF 8P7L,8PLZ,8P79,8P78,8P77,8P76,8P75,8P74,8P73,8P72,8P71,8P70,8P6Z,8P6Y,8P6X,8P6W,8P6V,8ORM,6XD3,8PYR,1UA2,7B5Q,7B5O,6XBZ,8R9U,8R9S,8R9O,8R9A,8R99 Cyclin-dependent kinase 7 CDK7_HUMAN P50613 Q9BS60 Q9UE19