Compile Data Set for Download or QSAR
Report error Found 143 Enz. Inhib. hit(s) with Target = 'RAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase'
LigandChemical structure of BindingDB Monomer ID 431867BDBM431867(US10550114, Compound 1a)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of AKT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50633609BDBM50633609(CHEMBL5426352)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50633610BDBM50633610(CHEMBL5414256)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50633614BDBM50633614(CHEMBL5406950)
Affinity DataIC50: 1nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 182517BDBM182517(US9145392, 218)
Affinity DataIC50: 1nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50633615BDBM50633615(CHEMBL5402470)
Affinity DataIC50: 1nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50550738BDBM50550738(CHEMBL4792262)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human AKT assessed as inhibition of substrate phosphorylation using AKTide-2T as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50572156BDBM50572156(CHEMBL4853207)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50633618BDBM50633618(CHEMBL5437679)
Affinity DataIC50: 2nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50550740BDBM50550740(CHEMBL4780030)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human AKT assessed as inhibition of substrate phosphorylation using AKTide-2T as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182373BDBM182373(US9145392, 74)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50633606BDBM50633606(CHEMBL5423227)
Affinity DataIC50: 3nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50637405BDBM50637405(Capivasertib | Azd 5363 | Azd-5363 | AZC5363 | AZD...)
Affinity DataIC50: 3nMAssay Description:Inhibition of AKT phosphorylation in human MDA-MB-231 incubated for 18 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50633613BDBM50633613(CHEMBL5411976)
Affinity DataIC50: 3nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50633616BDBM50633616(CHEMBL5424195)
Affinity DataIC50: 3nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50633617BDBM50633617(CHEMBL5408522)
Affinity DataIC50: 3nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50633603BDBM50633603(CHEMBL5419204)
Affinity DataIC50: 3nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50637391BDBM50637391(CHEMBL5556059)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of AKT in human SW620 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 182529BDBM182529(US9145392, 230)
Affinity DataIC50: 4nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182519BDBM182519(US9145392, 220)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182390BDBM182390(US9145392, 91)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50593633BDBM50593633(Miransertib | Arq-092 | ARQ 092 | ARQ 092 FREE BAS...)
Affinity DataIC50: 5nMAssay Description:Inhibition of AKT (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 182413BDBM182413(US9145392, 114)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182307BDBM182307(US9145392, 8)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50572155BDBM50572155(CHEMBL4876889)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50550739BDBM50550739(CHEMBL4788683)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of human AKT assessed as inhibition of substrate phosphorylation using AKTide-2T as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50633625BDBM50633625(CHEMBL5406570)
Affinity DataIC50: 9nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 182372BDBM182372(US9145392, 73)
Affinity DataIC50: 9.10nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182381BDBM182381(US9145392, 82)
Affinity DataIC50: 12nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50633623BDBM50633623(CHEMBL5430524)
Affinity DataIC50: 14nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50633622BDBM50633622(CHEMBL5422741)
Affinity DataIC50: 15nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 182377BDBM182377(US9145392, 78)
Affinity DataIC50: 16nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50633621BDBM50633621(CHEMBL5424291)
Affinity DataIC50: 18nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50528415BDBM50528415(CHEMBL4457064)
Affinity DataIC50: 21nMAssay Description:Inhibition of Akt in human LNCaP cells assessed as reduction in PRAS40 phosphorylation at T246 residue after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 182518BDBM182518(US9145392, 219)
Affinity DataIC50: 23nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50633611BDBM50633611(CHEMBL5424735)
Affinity DataIC50: 28nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50528416BDBM50528416(CHEMBL4440965)
Affinity DataIC50: 44nMAssay Description:Inhibition of Akt in human LNCaP cells assessed as reduction in PRAS40 phosphorylation at T246 residue after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50609380BDBM50609380(CHEMBL5269374)
Affinity DataIC50: 66nMAssay Description:Inhibition of AKT (unknown origin) by by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50609291BDBM50609291(CHEMBL5281874)
Affinity DataIC50: 75nMAssay Description:Inhibition of Akt phosphorylation in human HCT-116 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50633605BDBM50633605(CHEMBL5436038)
Affinity DataIC50: 78nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 182337BDBM182337(US9145392, 38)
Affinity DataIC50: 84nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50633604BDBM50633604(CHEMBL5404456)
Affinity DataIC50: 115nMAssay Description:Inhibition of AKT phosphorylation in human SK-BR-3 cells harboring wildtype PI3Kalpha incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 182356BDBM182356(US9145392, 57)
Affinity DataIC50: 140nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50633624BDBM50633624(CHEMBL5409207)
Affinity DataIC50: 144nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50188913BDBM50188913(N-((S)-1-amino-3-(2,4-dichlorophenyl)propan-2-yl)-...)
Affinity DataEC50:  160nMAssay Description:Activity against AKT-mediated PRAS40 T246P phosphorylation in human DOV13 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50633607BDBM50633607(CHEMBL5440814)
Affinity DataIC50: 179nMAssay Description:Inhibition of AKT phosphorylation in human T47D cells harboring PI3Kalpha H1047R mutant incubated for 24 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 53484BDBM53484(MLS001207496 | [(E)-2-[5-(1,3-benzothiazol-2-yl)-3...)
Affinity DataIC50: 200nMAssay Description:Inhibition of AKT in human bortezomib-resistant ANBL6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one sol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50609379BDBM50609379(CHEMBL5270720)
Affinity DataIC50: 207nMAssay Description:Inhibition of AKT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 182367BDBM182367(US9145392, 68)
Affinity DataIC50: 230nMAssay Description:Inhibition of Akt (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 53484BDBM53484(MLS001207496 | [(E)-2-[5-(1,3-benzothiazol-2-yl)-3...)
Affinity DataIC50: 250nMAssay Description:Inhibition of AKT in human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
Displayed 1 to 50 (of 143 total ) | Next | Last >>
Jump to: