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Report error Found 54 Enz. Inhib. hit(s) with Target = 'NADPH oxidase 5'
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50206334BDBM50206334(Diphenylene iodonium chloride | dibenziodolium chl...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human NOX5 expressed in HEK293 cells assessed as inhibition of ionomycin-induced hydrogen peroxide production pretreated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359525BDBM50359525(CHEMBL1927146)
Affinity DataKi:  360nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628591BDBM50628591(Setanaxib | GKT-137831 | GKT-831 | SETANAXIB)
Affinity DataKi:  410nMAssay Description:Binding affinity to human NOX5 assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359523BDBM50359523(CHEMBL1927147)
Affinity DataKi:  414nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359529BDBM50359529(CHEMBL1927150)
Affinity DataKi:  475nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359522BDBM50359522(CHEMBL1927160)
Affinity DataKi:  490nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359519BDBM50359519(CHEMBL1927157)
Affinity DataKi:  543nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50606914BDBM50606914(CHEMBL5218591)
Affinity DataIC50: 570nMAssay Description:Inhibition of human NOX5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 318940BDBM318940(US10173988, Compound inventive)
Affinity DataIC50: 570nMAssay Description:Inhibition of NOX5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359530BDBM50359530(CHEMBL1927151)
Affinity DataKi:  585nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359524BDBM50359524(CHEMBL1927145)
Affinity DataKi:  590nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359520BDBM50359520(CHEMBL1927158)
Affinity DataKi:  610nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359528BDBM50359528(CHEMBL1927149)
Affinity DataKi:  615nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359527BDBM50359527(CHEMBL1927148)
Affinity DataKi:  670nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359533BDBM50359533(CHEMBL1927154)
Affinity DataKi:  690nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359521BDBM50359521(CHEMBL1927159)
Affinity DataKi:  690nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 34233BDBM34233(EBSELEN | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebse...)
Affinity DataEC50:  700nMAssay Description:Inhibition of NOX5 (unknown origin) transfected in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359532BDBM50359532(CHEMBL1927153)
Affinity DataKi:  730nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359531BDBM50359531(CHEMBL1927152)
Affinity DataKi:  740nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359534BDBM50359534(CHEMBL1927155)
Affinity DataKi:  955nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359518BDBM50359518(CHEMBL1927156)
Affinity DataKi:  1.15E+3nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50359526BDBM50359526(CHEMBL1926690)
Affinity DataKi:  1.43E+3nMAssay Description:Antagonist activity at human NOX5 assessed as inhibition of ROS production after 20 mins by cell-free amplex red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628589BDBM50628589(CHEMBL4210329)
Affinity DataIC50: 1.80E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50661973BDBM50661973(CHEMBL6173563)
Affinity DataIC50: 2.06E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50628589BDBM50628589(CHEMBL4210329)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human NOX5 transfected in HEK cells assessed as PMA-induced hydrogen peroxide production pre-incubated for 10 mins and measured after 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50071058BDBM50071058(CHEMBL301982 | cid_4274774 | (2R,4aS,6aS,12bR,14aS...)
Affinity DataIC50: 3.13E+3nMAssay Description:Inhibition of human NOX5 expressed in HEK293 cells assessed as inhibition of ionomycin-induced hydrogen peroxide production pretreated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50661972BDBM50661972(CHEMBL6141807)
Affinity DataIC50: 4.72E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50661969BDBM50661969(CHEMBL6148605)
Affinity DataIC50: 5.20E+3nMMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50661967BDBM50661967(CHEMBL6151297)
Affinity DataIC50: 6.50E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50497263BDBM50497263(CHEMBL3347554)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of full length human NOX5 transfected in HEK cells assessed as inhibition of ionomycin-stimulated ROS generation by chemiluminescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50661971BDBM50661971(CHEMBL6149257)
Affinity DataIC50: 1.43E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50497257BDBM50497257(CHEMBL3347502)
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of full length human NOX5 transfected in HEK cells assessed as inhibition of ionomycin-stimulated ROS generation by chemiluminescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50497268BDBM50497268(CHEMBL3347491)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of full length human NOX5 transfected in HEK cells assessed as inhibition of ionomycin-stimulated ROS generation by chemiluminescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50661966BDBM50661966(CHEMBL6144069)
Affinity DataIC50: 2.80E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50497272BDBM50497272(CHEMBL3347543)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of full length human NOX5 transfected in HEK cells assessed as inhibition of ionomycin-stimulated ROS generation by chemiluminescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50497262BDBM50497262(CHEMBL3347492)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of full length human NOX5 transfected in HEK cells assessed as inhibition of ionomycin-stimulated ROS generation by chemiluminescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
Glucox Biotech

US Patent
LigandChemical structure of BindingDB Monomer ID 50330722BDBM50330722(2-(2-chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)...)
Affinity DataIC50: 4.40E+4nMAssay Description:Reactive oxygen produced in whole cells or in membrane preparation of Nox1, Nox3, Nox4, Nox5 and xanthine oxidase and glucose oxidase were determined...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2025
Entry Details
US Patent

TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50661974BDBM50661974(CHEMBL6164691)
Affinity DataIC50: 4.66E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50497265BDBM50497265(CHEMBL3347503)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of full length human NOX5 transfected in HEK cells assessed as inhibition of ionomycin-stimulated ROS generation by chemiluminescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50497261BDBM50497261(CHEMBL3347549)
Affinity DataIC50: 7.90E+4nMAssay Description:Inhibition of full length human NOX5 transfected in HEK cells assessed as inhibition of ionomycin-stimulated ROS generation by chemiluminescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50630371BDBM50630371(CHEMBL5410142)
Affinity DataIC50: 9.40E+4nMAssay Description:Inhibition of NOX5 (unknown origin) transfected in HEK cells assessed as reduction in PMA/ionomycin-stimulated H2O2 production preincubated for 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50630348BDBM50630348(CHEMBL5419067)
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of NOX5 (unknown origin) transfected in HEK cells assessed as reduction in PMA/ionomycin-stimulated H2O2 production preincubated for 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50497273BDBM50497273(CHEMBL3347583)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length human NOX5 transfected in HEK cells assessed as inhibition of ionomycin-stimulated ROS generation by chemiluminescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50497269BDBM50497269(CHEMBL3347584)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length human NOX5 transfected in HEK cells assessed as inhibition of ionomycin-stimulated ROS generation by chemiluminescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50497259BDBM50497259(CHEMBL3347542)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length human NOX5 transfected in HEK cells assessed as inhibition of ionomycin-stimulated ROS generation by chemiluminescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50661968BDBM50661968(CHEMBL6159950)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50497271BDBM50497271(CHEMBL3347550)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length human NOX5 transfected in HEK cells assessed as inhibition of ionomycin-stimulated ROS generation by chemiluminescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50661970BDBM50661970(CHEMBL6161357)
Affinity DataIC50: 1.00E+5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50497258BDBM50497258(CHEMBL3347566)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length human NOX5 transfected in HEK cells assessed as inhibition of ionomycin-stimulated ROS generation by chemiluminescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
TargetNADPH oxidase 5(Human)
TBA

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50497267BDBM50497267(CHEMBL3347501)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of full length human NOX5 transfected in HEK cells assessed as inhibition of ionomycin-stimulated ROS generation by chemiluminescence assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMed
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