Compile Data Set for Download or QSAR
Report error Found 734 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 11'
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 130909BDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human MLK3 using myelin basic protein as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505541BDBM50505541(CHEMBL4465866)
Affinity DataKd:  3nMAssay Description:Binding affinity to recombinant N-terminal His-FLAG-GST-tagged MAP3K11 (unknown origin) (99 to 398 residues) expressed in baculovirus infected Sf9 in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 354724BDBM354724(US9814704, Example 1 | BDBM356235)
Affinity DataIC50: 3nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human MLK3 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505542BDBM50505542(CHEMBL4576489)
Affinity DataKd:  4nMAssay Description:Binding affinity to recombinant N-terminal His-FLAG-GST-tagged MAP3K11 (unknown origin) (99 to 398 residues) expressed in baculovirus infected Sf9 in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791933BDBM791933( (S)-6-bromo-2-(2,5-dimethyl-1-(4-morpholinophenyl...)
Affinity DataIC50: 4nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791934BDBM791934(US12545673, Example 2)
Affinity DataIC50: 4nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 6760BDBM6760(CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human N-terminal HA-tagged wild type MLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 6760BDBM6760(CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal HA-tagged recombinant wild-type human MLK3 overexpressed in HEK293A cells preincubated for 10 mins followed by [gamma-32P]AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791935BDBM791935(US12545673, Example 3)
Affinity DataIC50: 5nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of human MLK3 using MBP as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791937BDBM791937(US12545673, Example 5)
Affinity DataIC50: 6nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 24942BDBM24942(methyl (15S,16R,18R)-10,23-bis[(ethylsulfanyl)meth...)
Affinity DataIC50: 6nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins in presence of [33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791938BDBM791938(US12545673, Example 6)
Affinity DataIC50: 6nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791939BDBM791939(US12545673, Example 7)
Affinity DataIC50: 6nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50620990BDBM50620990(CHEMBL5403058)
Affinity DataIC50: 6nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50620994BDBM50620994(CHEMBL5397520)
Affinity DataIC50: 6nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50458548BDBM50458548(CHEMBL4218417)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant GST-tagged full length human MLK3 KD expressed in baculovirus using myelin basic protein as substrate preincubated for 15 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50441571BDBM50441571(CHEMBL2436982 | US9814704, Example 18 | US10485800...)
Affinity DataIC50: 7nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791940BDBM791940(US12545673, Example 8)
Affinity DataIC50: 7nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 792005BDBM792005(US12545673, Example 77)
Affinity DataIC50: 7nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791942BDBM791942(US12545673, Example 10)
Affinity DataIC50: 7nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791943BDBM791943(US12545673, Example 11)
Affinity DataIC50: 7nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 792014BDBM792014(US12545673, Example 86)
Affinity DataIC50: 7nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791944BDBM791944(US12545673, Example 12)
Affinity DataIC50: 7nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 792007BDBM792007(US12545673, Example 79)
Affinity DataIC50: 7nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791945BDBM791945(US12545673, Example 13)
Affinity DataIC50: 7nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50620999BDBM50620999(CHEMBL5417152)
Affinity DataIC50: 8nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 792012BDBM792012(US12545673, Example 84)
Affinity DataIC50: 8nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 792009BDBM792009(US12545673, Example 81)
Affinity DataIC50: 9nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50441570BDBM50441570(CHEMBL2436976 | US9814704, Example 17 | US10485800...)
Affinity DataIC50: 9nMAssay Description:Inhibition of MLK3 (unknown origin) after 20 mins by scintillation counting analysis in presence of [33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791941BDBM791941(US12545673, Example 9)
Affinity DataIC50: 10nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50108295BDBM50108295(Indolocarbazole analogue | CHEMBL288817)
Affinity DataIC50: 11nMAssay Description:Inhibition of Mixed lineage kinase 3 (MLK3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791948BDBM791948(6-bromo-2-(1-(2-chlorophenyl)-2,5-dimethyl-1H-pyrr...)
Affinity DataIC50: 11nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50621000BDBM50621000(CHEMBL5436267)
Affinity DataIC50: 11nMAssay Description:Inhibition of human MLK3 by ATP-competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 60665BDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542 |...)
Affinity DataKd:  11nMAssay Description:Binding constant for MLK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 792013BDBM792013(US12545673, Example 85)
Affinity DataIC50: 11nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 60665BDBM60665(US9145414, R406 | US9212178, R406 | BDBM50249542 |...)
Affinity DataKd:  11nMAssay Description:Binding affinity to human MLK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50108296BDBM50108296(Indolocarbazole analogue | CHEMBL289772)
Affinity DataIC50: 11nMAssay Description:Inhibition of Mixed lineage kinase 3 (MLK3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50108293BDBM50108293(Indolocarbazole analogue | CHEMBL277817)
Affinity DataIC50: 11nMAssay Description:Inhibition of Mixed lineage kinase 3 (MLK3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791949BDBM791949(3-(3-(6-bromo-7-(((S)-1-(ethylsulfonyl) pyrrolidin...)
Affinity DataIC50: 12nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 792011BDBM792011(US12545673, Example 83)
Affinity DataIC50: 12nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 14186BDBM14186(3,13-diazahexacyclo[14.8.0.0^{2,10}.0^{4,9}.0^{11,...)
Affinity DataIC50: 12nMAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791950BDBM791950(US12545673, Example 18)
Affinity DataIC50: 13nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791997BDBM791997(US12545673, Example 69)
Affinity DataIC50: 13nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 792015BDBM792015(US12545673, Example 87)
Affinity DataIC50: 13nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 6760BDBM6760(CHEMBL281948 | methyl (15S,16R,18R)-16-hydroxy-15-...)
Affinity DataIC50: 13nMAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2007
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 791936BDBM791936(US12545673, Example 4)
Affinity DataIC50: 13nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 792010BDBM792010(3-(3-(6-bromo-7-(((S)-1-(ethylsulfonyl)pyrrolidine...)
Affinity DataIC50: 14nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
Center for Lymphoid Malignancies

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 792026BDBM792026(US12545673, Example 98)
Affinity DataIC50: 14nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/22/2026
Entry Details US Patent

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