Compile Data Set for Download or QSAR
Report error Found 283 Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2 [A677G]'
TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788002BDBM788002(N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-y...)
Affinity DataIC50: 0.140nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50647217BDBM50647217(CHEMBL5598486 | US12473298, Compound 66)
Affinity DataIC50: 0.140nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 787996BDBM787996(N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-y...)
Affinity DataIC50: 0.170nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788059BDBM788059(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.180nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 787983BDBM787983(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.200nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788046BDBM788046(5-(1'-(cyclopropylmethyl)-2-oxospiro[dihydroindole...)
Affinity DataIC50: 0.210nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 787987BDBM787987(2-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin...)
Affinity DataIC50: 0.210nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788008BDBM788008(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.210nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 39644BDBM39644(3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-N-((4-met...)
Affinity DataIC50: 0.210nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In Depth
Date in BDB:
8/17/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50647215BDBM50647215(CHEMBL5597893 | US12473298, Compound 7)
Affinity DataIC50: 0.220nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 39678BDBM39678(5-(5-acrylamidoisoindolin-2-yl)-N-((4,6-dimethyl-2...)
Affinity DataIC50: 0.230nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In Depth
Date in BDB:
8/17/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788020BDBM788020(3-((2,2-dimethyltetrahydro-2H-pyran-4-yl)(ethyl)am...)
Affinity DataIC50: 0.230nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788012BDBM788012(3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-N-((4-met...)
Affinity DataIC50: 0.240nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 39669BDBM39669(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.240nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In Depth
Date in BDB:
8/17/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 39700BDBM39700(5-(3,3-dimethyl-1-morpholino-2,3-dihydro-1H-indan-...)
Affinity DataIC50: 0.260nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In Depth
Date in BDB:
8/17/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788011BDBM788011(3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-N-((4-met...)
Affinity DataIC50: 0.260nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788051BDBM788051(5-(1-acetyl-2',3',5',6'-tetrahydrospiro[dihydroind...)
Affinity DataIC50: 0.260nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788081BDBM788081(N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.270nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788026BDBM788026(2-chloro-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-...)
Affinity DataIC50: 0.280nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788075BDBM788075(N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.280nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 39705BDBM39705(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.280nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In Depth
Date in BDB:
8/17/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 787985BDBM787985(3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-5-(6-fluo...)
Affinity DataIC50: 0.290nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 787991BDBM787991(N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-y...)
Affinity DataIC50: 0.290nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 787995BDBM787995(N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-y...)
Affinity DataIC50: 0.290nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788034BDBM788034(2-chloro-N-((4,6-dimethyl-2-carbonyl-1,2-dihydropy...)
Affinity DataIC50: 0.310nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788039BDBM788039(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.310nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50647216BDBM50647216(CHEMBL5596557 | US12473298, Compound 86)
Affinity DataIC50: 0.310nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50647226BDBM50647226(CHEMBL5598282 | US12595267, Compound 29)
Affinity DataIC50: 0.310nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/17/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788006BDBM788006(N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-y...)
Affinity DataIC50: 0.330nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/17/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 787982BDBM787982(3-(ethyl(piperidin-4-yl)amino)-N-((4-methoxy-6-met...)
Affinity DataIC50: 0.330nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788088BDBM788088(3-(Ethyl(tetrahydro-2H-pyran-4-yl)amino)-N-((4-met...)
Affinity DataIC50: 0.330nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788028BDBM788028(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.330nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788052BDBM788052(5-(1-trifluoroacetyl-2',3',5',6'-tetrahydrospiro[d...)
Affinity DataIC50: 0.330nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 787989BDBM787989(N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-y...)
Affinity DataIC50: 0.340nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788014BDBM788014(3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-5-(1'-iso...)
Affinity DataIC50: 0.340nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788087BDBM788087(5-(1'-(Cyclopropylmethyl)-2-oxospiro[dihydroindole...)
Affinity DataIC50: 0.340nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 39674BDBM39674(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.340nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In Depth
Date in BDB:
8/17/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788016BDBM788016(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.340nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 39661BDBM39661(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.340nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In Depth
Date in BDB:
8/17/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 787993BDBM787993(3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-5-(5-fluo...)
Affinity DataIC50: 0.350nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 50647214BDBM50647214(CHEMBL5596732 | US12473298, Compound 72)
Affinity DataIC50: 0.350nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 39637BDBM39637(4'-(4-cyanotetrahydro-2H-pyran-4-yl)-N-((4,6-dimet...)
Affinity DataIC50: 0.350nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In Depth
Date in BDB:
8/17/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788010BDBM788010(Methyl 6-(3-(((4,6-dimethyl-2-carbonyl-1,2-dihydro...)
Affinity DataIC50: 0.350nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788035BDBM788035(N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-y...)
Affinity DataIC50: 0.350nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788009BDBM788009(Methyl 6-(3-(((4,6-dimethyl-2-carbonyl-1,2-dihydro...)
Affinity DataIC50: 0.360nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788030BDBM788030(2-chloro-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin...)
Affinity DataIC50: 0.360nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 39643BDBM39643(N-((4,6-dimethyl-2-carbonyl-1,2-dihydropyridin-3-y...)
Affinity DataIC50: 0.360nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In Depth
Date in BDB:
8/17/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 39652BDBM39652(3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-N-((4-met...)
Affinity DataIC50: 0.360nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In Depth
Date in BDB:
8/17/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G](Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 788040BDBM788040(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.360nMAssay Description:According to the specification, test buffer was used to dilute the enzyme complex, methyl donor S-adenosylmethionine (SAM) (Sigma, Art. No. A7007), p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/8/2026
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2 [A677G]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Synergy Pharmaceutical Sciences Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 39690BDBM39690(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: 0.370nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (SBMRI, San Diego, CA) NIH Molecular Libraries Screen...More data for this Ligand-Target Pair
Target InfoPDB
GoogleScholar
In Depth
Date in BDB:
8/17/2026
Entry Details
US Patent

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