Compile Data Set for Download or QSAR
Report error Found 66 Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase, H3 lysine-36 specific'
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 712326BDBM712326(US20250011329, Compound III-35)
Affinity DataIC50: 1nMAssay Description:A reaction mixture was prepared by adding oligonucleosomes from Chicken (0.05 mg/ml) to freshly prepared reaction buffer containing 50 mM Tris-HCl (p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/22/2025
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50106497BDBM50106497(NSC-663284 | 6-Chloro-7-(2-morpholin-4-yl-ethylami...)
Affinity DataIC50: 110nMAssay Description:Inhibition of NSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50106497BDBM50106497(NSC-663284 | 6-Chloro-7-(2-morpholin-4-yl-ethylami...)
Affinity DataIC50: 110nMAssay Description:Inhibition of N-terminal polyhistidine-tagged recombinant human NSD1 (1538 to 2696 residues) expressed in baculovirus infected insect cell using SAM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50106497BDBM50106497(NSC-663284 | 6-Chloro-7-(2-morpholin-4-yl-ethylami...)
Affinity DataIC50: 150nMAssay Description:Inhibition of NSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 567822BDBM567822(US11420970, Example 23)
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant NSD1 incubated for 2 hrs by AlphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50627886BDBM50627886(CHEMBL5438312)
Affinity DataIC50: 214nMAssay Description:Inhibition of human recombinant NSD1 incubated for 2 hrs by AlphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 567828BDBM567828(US11420970, Example 29)
Affinity DataIC50: 225nMAssay Description:Inhibition of human recombinant NSD1 incubated for 2 hrs by AlphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 567825BDBM567825(US11420970, Example 26)
Affinity DataIC50: 248nMAssay Description:Inhibition of human recombinant NSD1 incubated for 2 hrs by AlphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 567831BDBM567831(US11420970, Example 32)
Affinity DataIC50: 270nMAssay Description:Inhibition of human recombinant NSD1 incubated for 2 hrs by AlphaLISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50653202BDBM50653202(CHEMBL2028187)
Affinity DataIC50: 340nMAssay Description:Inhibition of KDR autophosphorylation by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50616733BDBM50616733(CHEMBL5422549)
Affinity DataIC50: 690nMAssay Description:Inhibition of NSD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 588052BDBM588052((2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human NSD1 using Nucleosomes and [3H]SAM as substrate incubated for 30 mins to 1 hr by HotSpot kinase assayMore data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50590375BDBM50590375(CHEMBL5187396)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human NSD1 using Nucleosomes and [3H]SAM as substrate incubated for 30 mins to 1 hr by HotSpot kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50627887BDBM50627887(CHEMBL5438496)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to NSD1 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50608077BDBM50608077(CHEMBL5270736)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of NSD1 (unknown origin) measured after 16 hrs by MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 83922BDBM83922(cid_164676 | 1,6,6-trimethyl-8,9-dihydro-7H-naphth...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of KDR autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50015214BDBM50015214(N-(4-Hydroxy-phenyl)-acetamide | 6-chloro-2-methox...)
Affinity DataKd:  1.40E+3nMAssay Description:Binding affinity to NSD1 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50608077BDBM50608077(CHEMBL5270736)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of N-terminal hexa-histidine tagged NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50660430BDBM50660430(CHEMBL6170408)
Affinity DataIC50: 1.50E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 71542BDBM71542(Primaquine bisphosphate | N4-(6-methoxy-8-quinolin...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 24776BDBM24776(1,4-dihydronaphthalene-1,4-dione | 1,4-Naphthoquin...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50162774BDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of N-terminal polyhistidine-tagged recombinant human NSD1 (1538 to 2696 residues) expressed in baculovirus infected insect cell using SAM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50587736BDBM50587736(PYRVINIUM | CHEBI:8687 | Pyrvinium | Pyrvinium (ca...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50106497BDBM50106497(NSC-663284 | 6-Chloro-7-(2-morpholin-4-yl-ethylami...)
Affinity DataIC50: 2.60E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 51317BDBM51317(1,6-dimethylnaphtho[1,2-g][1]benzofuran-10,11-dion...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 57938BDBM57938(cid_160254 | MLS001049002 | (1R)-1,6,6-trimethyl-2...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of COT by cell-based HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 22985BDBM22985(Aralen | Chlorochin | CHLOROQUINE PHOSPHATE | Chlo...)
Affinity DataKd:  4.70E+3nMAssay Description:Binding affinity to NSD1 (unknown origin) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50855BDBM50855(ALPHA-ERGOCRYPTINE | MLS000069839 | SMR000058703 |...)
Affinity DataIC50: 4.90E+3nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50012070BDBM50012070(CHEMBL295316 | plumbagin | 5-hydroxy-2-methylnapht...)
Affinity DataIC50: 5.70E+3nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50608077BDBM50608077(CHEMBL5270736)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of NSD1 (unknown origin) methyltransferase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50608077BDBM50608077(CHEMBL5270736)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of NSD1 (unknown origin) measured after 4 hrs by MS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50608077BDBM50608077(CHEMBL5270736)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of N-terminal hexa-histidine tagged NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli incubated for 4...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50653203BDBM50653203(CHEMBL6149804)
Affinity DataIC50: 5.90E+3nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50622285BDBM50622285(CHEMBL5401398)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NSD1 (unknown origin) using histone peptide/SAM as substrate by AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 378802BDBM378802(US10266526, Compound 985 | N-(1-((1-(4-chlorobenzy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NSD1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 378654BDBM378654(US10266526, Compound 792 | N-{1-[(1-benzyl-1H-pyra...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NSD1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50652922BDBM50652922(CHEMBL5678791)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NSD1 (unknown origin) methyltransferase activity measuredMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50608076BDBM50608076(CHEMBL5281547)
Affinity DataKd:  1.04E+4nMAssay Description:Inhibition of NSD1 (unknown origin) by ITC assay assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50608076BDBM50608076(CHEMBL5281547)
Affinity DataKd:  1.04E+4nMAssay Description:Binding affinity to hexa-histidine tagged NSD1 SET domain (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50324210BDBM50324210((3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of N-terminal polyhistidine-tagged recombinant human NSD1 (1538 to 2696 residues) expressed in baculovirus infected insect cell using SAM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50388091BDBM50388091(CHEMBL2058156)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of N-terminal polyhistidine-tagged recombinant human NSD1 (1538 to 2696 residues) expressed in baculovirus infected insect cell using SAM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50336799BDBM50336799(Suramin hexasodium | Germanin | suramin | 8,8'-[Ca...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of KDR autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50315537BDBM50315537(chaetocin | CHEMBL1089316)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of KDR autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50179360BDBM50179360(CHEMBL3040216)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human NSD1 overexpressed in Escherichia coli BL21(DE3) using nucleosome as substrate by SPA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50315537BDBM50315537(chaetocin | CHEMBL1089316)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human NSD1 overexpressed in Escherichia coli BL21(DE3) using nucleosome as substrate by SPA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50572749BDBM50572749(CHEMBL4854710)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NSD1 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by AlphaLISA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50627885BDBM50627885(CHEMBL5407230)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of N-terminal hexa-histidine tagged NSD1 SET domain (1852 to 2105 residues) (unknown origin) expressed in Escherichia coli incubated for 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50378739BDBM50378739(SINEFUNGIN | jm2c00120, Sinefungin)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of KDR autophosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50378739BDBM50378739(SINEFUNGIN | jm2c00120, Sinefungin)
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of human NSD1 overexpressed in Escherichia coli BL21(DE3) using nucleosome as substrate by SPA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
K36 Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 50608076BDBM50608076(CHEMBL5281547)
Affinity DataIC50: 6.60E+4nMAssay Description:Positive allosteric modulation of rat mGlu1 receptor assessed as potentiation of glutamate-induced calcium mobiliztion by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
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