Compile Data Set for Download or QSAR
Report error Found 1478 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 11'
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50105327BDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of human HDAC11More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2016
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50101331BDBM50101331(CHEMBL3329621)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of HDAC11 (unknown origin) incubated for 3 hrs in presence of BSA and DTT by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50101330BDBM50101330(CHEMBL3329622)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of HDAC11 (unknown origin) incubated for 3 hrs in presence of BSA and DTT by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50354086BDBM50354086(FK-228 | Istodax | ROMIDEPSIN)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HDAC11 (unknown origin) incubated for 3 hrs in presence of BSA and DTT by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50135746BDBM50135746((3S,14S,15S)-6-Ethylidene-12-((R)-isopropyl)-3-iso...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of JAK2 (unknown origin) assessed as reduction of EPO-induced STAT5 phosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 19151BDBM19151(Depsipeptide | (1S,4S,7Z,10S,16E,21R)-7-ethylidene...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50048864BDBM50048864(CHEMBL3310505)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50105327BDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50105327BDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of p53 (unknown origin) phosphorylation at Ser15 by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50105327BDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human HDAC11 expressed in baculovirus infected sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50649001BDBM50649001(CHEMBL5618885)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50273535BDBM50273535(CHEMBL4130288 | US11535607, Example 18-1)
Affinity DataIC50: 1nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027494BDBM50027494(CHEMBL3356916)
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC11 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 29589BDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50273525BDBM50273525(CHEMBL4128972 | US11535607, Example 18-2)
Affinity DataIC50: 2nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50273553BDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50: 2nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50273522BDBM50273522(CHEMBL4127743 | US11535607, Example 12-1)
Affinity DataIC50: 2nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667368BDBM50667368(CHEMBL6189220)
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50304782BDBM50304782(N-hydroxy-2-(4-(naphthalen-2-ylsulfonyl)piperazin-...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human HDAC11More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 29589BDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human recombinant HDAC11 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50273526BDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 29589BDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataIC50: 3nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50273520BDBM50273520(CHEMBL4127735 | US11535607, Example 22-3)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50273553BDBM50273553(CHEMBL4127020 | US10508088, ID HDTK028 | US1153560...)
Affinity DataIC50: 3nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
US Patent

TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 421500BDBM421500(US10538496, Compound 1-1 | US10508088, Example 1-1...)
Affinity DataIC50: 3nMAssay Description:This example describes in vitro inhibition properties of exemplary HDAC11 inhibitors for various HDACs. HDAC inhibition assays were performed using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
US Patent

TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50273526BDBM50273526(CHEMBL4126661 | US11535607, Example 22-8)
Affinity DataIC50: 3nMAssay Description:Agonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027495BDBM50027495(CHEMBL3356917)
Affinity DataIC50: 3nMAssay Description:Inhibition of HDAC11 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50020912BDBM50020912(Largazole Thiol)
Affinity DataIC50: 3nMAssay Description:Inhibition of HDAC11 (unknown origin) incubated for 3 hrs in presence of BSA and in absence of DTT by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2016
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 29589BDBM29589(Panobinostat | Faridak | LBH-589B | LBH-589 | US10...)
Affinity DataKi:  3.5nMAssay Description:Competitive inhibition of HDAC11 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50005711BDBM50005711(GNF-Pf-1011 | CHEBI:46024 | TRICHOSTATIN | Trichos...)
Affinity DataIC50: 3.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027521BDBM50027521(CHEMBL3356925)
Affinity DataIC50: 4nMAssay Description:Inhibition of HDAC11 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50665249BDBM50665249(CHEMBL6174342)
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 19149BDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 4nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50353234BDBM50353234(CHEMBL1830537)
Affinity DataKi:  4.20nMAssay Description:Competitive inhibition of HDAC11 using KI-104 as substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50188961BDBM50188961(CHEMBL3622533)
Affinity DataIC50: 5nMAssay Description:Inhibition of HDAC11 (unknown origin) by color de Lys colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027648BDBM50027648(CHEMBL3356526)
Affinity DataIC50: 5nMAssay Description:Inhibition of HDAC11 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50273538BDBM50273538(CHEMBL4127894 | US11535607, Example 22-6)
Affinity DataIC50: 5nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027501BDBM50027501(CHEMBL3356923)
Affinity DataIC50: 5nMAssay Description:Inhibition of HDAC11 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50190155BDBM50190155(CHEMBL6091984)
Affinity DataIC50: 5.10nMAssay Description:Agonistic activity in CHO-hFollicle stimulating hormone receptor cell-based cAMP accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50188961BDBM50188961(CHEMBL3622533)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of full length human recombinant HDAC11 expressed in baculovirus infected insect Sf9 cells using Ac-peptide-AMC as substrate assessed as r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2017
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50188961BDBM50188961(CHEMBL3622533)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50188961BDBM50188961(CHEMBL3622533)
Affinity DataIC50: 5.40nMAssay Description:Agonist activity at mouse androgen receptor assessed as inhibition of transactivation after 24 hrs by cell-based luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50188961BDBM50188961(CHEMBL3622533)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of HDAC11 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50405632BDBM50405632(CHEMBL5278968)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human HDAC11 by fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 19428BDBM19428(NVP-LAQ824 | (2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl...)
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human HDAC11 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2011
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50027602BDBM50027602(CHEMBL3356523)
Affinity DataIC50: 6nMAssay Description:Inhibition of HDAC11 (unknown origin) using fluorogenic tetrapeptide RHKK(Ac) substrate by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50273554BDBM50273554(CHEMBL4129134 | US11535607, Example 22-2)
Affinity DataIC50: 6nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50273551BDBM50273551(CHEMBL4129143 | US11535607, Example 45-1)
Affinity DataIC50: 7nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50273549BDBM50273549(CHEMBL4129266 | US11535607, Example 15-1)
Affinity DataIC50: 7nMAssay Description:Inhibition of full length recombinant human HDAC11 expressed in baculoviral expression system using FAM-RHKK as substrate by electrophoretic mobility...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2020
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50658547BDBM50658547(CHEMBL6148436)
Affinity DataIC50: 7.60nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
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