Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with Target = 'High mobility group protein B1'
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50271261BDBM50271261(CHEMBL4129393)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to recombinant HMGB1 box A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50271261BDBM50271261(CHEMBL4129393)
Affinity DataKd:  1.5nMAssay Description:Binding affinity to recombinant HMGB1 box B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 66082BDBM66082(SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...)
Affinity DataKd:  24nMAssay Description:Binding affinity to N-terminal 6His-tagged HMGB1 Bj region (88 to 181 residues) (unknown origin) expressed in Escherichia coli JM109 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652793BDBM50652793(CHEMBL5653589)
Affinity DataKd:  50nMAssay Description:Binding affinity to human HMGB1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50241354BDBM50241354(Quercetin 3-O-beta-D-glucoside | quercetin 3-O-glu...)
Affinity DataKd:  100nMAssay Description:Agonist activity against S1P1 receptor by cell based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654254BDBM50654254(CALYCOSIN)
Affinity DataKd:  120nMAssay Description:Agonist activity against S1P1 receptor by cell based FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654256BDBM50654256(CHEMBL6133033)
Affinity DataKd:  187nMAssay Description:Agonist activity against S1P1 receptor by cell based FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50217942BDBM50217942(3-Rhamnoglucosylquercetin | cid_5280805 | CHEMBL22...)
Affinity DataKd:  260nMAssay Description:Agonist activity against S1P1 receptor by cell based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 66082BDBM66082(SMR000449324 | MLS001401431 | (2S)-2-[[4-[[2,4-bis...)
Affinity DataKd:  500nMAssay Description:Binding affinity to N-terminal 6His-tagged HMGB1 AI region (1 to 87 residues) (unknown origin) expressed in Escherichia coli JM109 by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575112BDBM50575112(CHEMBL4875121)
Affinity DataKd:  800nMAssay Description:Binding affinity to 6His-tagged HMGB1 (unknown origin) incubated for 15 mins by MST analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575107BDBM50575107(CHEMBL4867183)
Affinity DataKd:  800nMAssay Description:Binding affinity to 6His-tagged HMGB1 BoxA (unknown origin) incubated for 15 mins by MST analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575107BDBM50575107(CHEMBL4867183)
Affinity DataKd:  800nMAssay Description:Binding affinity to 6His-tagged HMGB1 (unknown origin) incubated for 15 mins by MST analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056920BDBM50056920(5-(3-carboxy-4-hydroxy-5-methylbenzyl)-2-hydroxy-3...)
Affinity DataKd:  900nMAssay Description:Agonist activity against S1P1 receptor by cell based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 26193BDBM26193(salicylic acid | 2-Hydroxybenzoate, I | CHEMBL424 ...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to recombinant HMGB1 box A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 22360BDBM22360(2-(acetyloxy)benzoic acid | 2-(acetyloxy)benzoate ...)
Affinity DataKd:  1.00E+3nMAssay Description:Agonist activity against S1P3 receptor by cell based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 26193BDBM26193(salicylic acid | 2-Hydroxybenzoate, I | CHEMBL424 ...)
Affinity DataKd:  1.00E+3nMAssay Description:Agonist activity against S1P1 receptor by cell based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 26193BDBM26193(salicylic acid | 2-Hydroxybenzoate, I | CHEMBL424 ...)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to recombinant HMGB1 box B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654253BDBM50654253(CHEMBL114721)
Affinity DataKd:  1.20E+3nMAssay Description:Agonist activity against S1P1 receptor by cell based FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575114BDBM50575114(CHEMBL4858278)
Affinity DataKd:  1.90E+3nMAssay Description:Binding affinity to 6His-tagged HMGB1 (unknown origin) incubated for 15 mins by MST analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50652792BDBM50652792(CHEMBL3752910)
Affinity DataKd:  3.01E+3nMAssay Description:Binding affinity to human HMGB1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654255BDBM50654255(CHEMBL1615534)
Affinity DataKd:  4.50E+3nMAssay Description:Agonist activity against S1P1 receptor by cell based FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575109BDBM50575109(CHEMBL4860199)
Affinity DataKd:  5.80E+3nMAssay Description:Binding affinity to 6His-tagged HMGB1 (unknown origin) incubated for 15 mins by MST analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575108BDBM50575108(CHEMBL4858896)
Affinity DataKd:  8.60E+3nMAssay Description:Binding affinity to 6His-tagged HMGB1 (unknown origin) incubated for 15 mins by MST analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575111BDBM50575111(CHEMBL4850898)
Affinity DataKd:  9.90E+3nMAssay Description:Binding affinity to 6His-tagged HMGB1 (unknown origin) incubated for 15 mins by MST analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50365463BDBM50365463(CHEMBL1232461)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HMGB1 (unknown origin) incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654252BDBM50654252(CHEMBL6145593)
Affinity DataKd:  1.25E+4nMAssay Description:Agonist activity against S1P1 receptor by cell based FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50657171BDBM50657171(CHEMBL6144182)
Affinity DataKd:  1.25E+4nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575117BDBM50575117(CHEMBL4853693)
Affinity DataKd:  1.40E+4nMAssay Description:Binding affinity to 6His-tagged HMGB1 (unknown origin) incubated for 15 mins by MST analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  1.60E+4nMAssay Description:Agonist activity against S1P1 receptor by cell based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575107BDBM50575107(CHEMBL4867183)
Affinity DataKd:  1.70E+4nMAssay Description:Binding affinity to 6His-tagged HMGB1 BoxB (unknown origin) incubated for 15 mins by MST analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575113BDBM50575113(CHEMBL4853073)
Affinity DataKd:  2.20E+4nMAssay Description:Binding affinity to 6His-tagged HMGB1 (unknown origin) incubated for 15 mins by MST analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575110BDBM50575110(CHEMBL4864623)
Affinity DataKd:  2.62E+4nMAssay Description:Binding affinity to 6His-tagged HMGB1 (unknown origin) incubated for 15 mins by MST analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575115BDBM50575115(CHEMBL4859744)
Affinity DataKd: >8.00E+4nMAssay Description:Binding affinity to 6His-tagged HMGB1 (unknown origin) incubated for 15 mins by MST analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50185127BDBM50185127(30-hydroxy-11,30-dioxoolean-12-en-3beta-yl (2-O-be...)
Affinity DataKd:  8.70E+4nMAssay Description:Binding affinity to recombinant HMGB1 B box region (90 to 175 residues) (unknown origin) expressed Escherichia coli after 5 mins by fluorescence-base...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50185127BDBM50185127(30-hydroxy-11,30-dioxoolean-12-en-3beta-yl (2-O-be...)
Affinity DataKd:  1.03E+5nMAssay Description:Binding affinity to recombinant HMGB1 A box region (1 to 89 residues) (unknown origin) expressed Escherichia coli after 5 mins by fluorescence-based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2020
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50185127BDBM50185127(30-hydroxy-11,30-dioxoolean-12-en-3beta-yl (2-O-be...)
Affinity DataKd:  1.50E+5nMAssay Description:Binding affinity to HMGB1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50185127BDBM50185127(30-hydroxy-11,30-dioxoolean-12-en-3beta-yl (2-O-be...)
Affinity DataKd:  1.50E+5nMAssay Description:Binding affinity to full-length N-terminal 6His-tagged HMGB1 (unknown origin) by NMR spectraMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575116BDBM50575116(CHEMBL4858354)
Affinity DataKd:  1.60E+5nMAssay Description:Binding affinity to 6His-tagged HMGB1 (unknown origin) incubated for 15 mins by MST analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50056920BDBM50056920(5-(3-carboxy-4-hydroxy-5-methylbenzyl)-2-hydroxy-3...)
Affinity DataKd:  9.00E+5nMAssay Description:Binding affinity to full-length N-terminal 6His-tagged HMGB1 (unknown origin) by NMR spectraMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetHigh mobility group protein B1(Human)
The Feinstein Institute For Medical Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50240510BDBM50240510(CHEMBL898 | DIFLUNISAL)
Affinity DataKd:  1.60E+6nMAssay Description:Binding affinity to full-length N-terminal 6His-tagged HMGB1 (unknown origin) by NMR spectraMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed