Compile Data Set for Download or QSAR
Report error Found 5851 Enz. Inhib. hit(s) with Target = 'Heat shock protein HSP 90'
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 81917BDBM81917(BX-2819)
Affinity DataIC50: 0.0400nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 152279BDBM152279(US8993556, 3-{2-[4-(Dimethylamino)phenoxy]-4,6-dih...)
Affinity DataKd:  0.0430nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 152285BDBM152285(US8993556, N-[1-(4,4-Difluorocyclohexyl)piperidin-...)
Affinity DataKd:  0.0570nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 50442757BDBM50442757(CHEMBL2443026)
Affinity DataKd:  0.0570nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20926BDBM20926(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataKi:  0.0640nMAssay Description:Binding affinity to HSP90 under reducing conditions in presence of TECPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 152280BDBM152280(US8993556, 3-{2-[4-(Dimethylamino)phenoxy]-4,6-dih...)
Affinity DataKd:  0.0660nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 20926BDBM20926(5-[2,4-dihydroxy-5-(propan-2-yl)phenyl]-N-ethyl-4-...)
Affinity DataKi:  0.0690nMAssay Description:Binding affinity to HSP90 under non-reducing conditions in absence of TECPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 152283BDBM152283(US8993556, 5-{2-[4-(Dimethylamino)phenoxy]-4,6-dih...)
Affinity DataKd:  0.0790nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 152281BDBM152281(US8993556, 5-{2-[4-(Dimethylamino)phenoxy]-4,6-dih...)
Affinity DataKd:  0.0800nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 152287BDBM152287(US8993556, N-(1-Cyclohexylpiperidin-4-yl)-5-{2-[4-...)
Affinity DataKd:  0.0900nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 81916BDBM81916(lspropyl analog, 5)
Affinity DataIC50: 0.100nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 81914BDBM81914(Ethyl carbamate analog, 3)
Affinity DataIC50: 0.100nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 50442759BDBM50442759(CHEMBL2443138)
Affinity DataKd:  0.120nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Dezhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667112BDBM50667112(CHEMBL6168361)
Affinity DataIC50: 0.130nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Dezhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50005782BDBM50005782(ATI-13387X | ONALESPIB)
Affinity DataIC50: 0.130nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Dezhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667075BDBM50667075(CHEMBL6165710)
Affinity DataIC50: 0.160nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 152284BDBM152284(US8993556, N-[1-(Cyclohexylmethyl)piperidin-4-yl]-...)
Affinity DataKd:  0.188nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 50401333BDBM50401333(CHEMBL1230584)
Affinity DataKi:  0.200nMAssay Description:Binding affinity at recombinant Hsp90alpha incubated for 16 hrs by fluorescence polarization competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 81915BDBM81915(Ethyl analog, 4)
Affinity DataIC50: 0.200nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 50442758BDBM50442758(CHEMBL2443139)
Affinity DataKd:  0.218nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 152286BDBM152286(US8993556, 3-[2,4-Dihydroxy-6-(4-nitrophenoxy)phen...)
Affinity DataKd:  0.240nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 50362225BDBM50362225(CHEMBL1939381)
Affinity DataKd:  0.25nMAssay Description:Binding affinity to N-terminus biotinylated human Hsp90 alpha by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Dezhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667100BDBM50667100(CHEMBL6172500)
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 152277BDBM152277(US8993556, N-(1-Cyclohexylpiperidin-4-yl)-5-[2,4-d...)
Affinity DataKd:  0.300nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 81912BDBM81912(Resorcinol analog, 1 | DC23)
Affinity DataIC50: 0.300nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Dezhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667069BDBM50667069(CHEMBL6176585)
Affinity DataIC50: 0.310nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Dezhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667067BDBM50667067(CHEMBL6175808)
Affinity DataIC50: 0.320nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Dezhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667051BDBM50667051(CHEMBL6167852)
Affinity DataIC50: 0.320nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 50495248BDBM50495248(CHEMBL3104281)
Affinity DataKd:  0.330nMAssay Description:Binding affinity to human biotinylated N-terminal Hsp90alpha (9 to 236) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50357454BDBM50357454(CHEMBL1917878)
Affinity DataKd:  0.350nMAssay Description:Binding affinity to human Hsp90beta after overnight incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 50442760BDBM50442760(CHEMBL2443044)
Affinity DataKd:  0.350nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 50362226BDBM50362226(CHEMBL1939380)
Affinity DataKd:  0.380nMAssay Description:Binding affinity to N-terminus biotinylated human Hsp90 alpha by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 152282BDBM152282(US8993556, 5-{2-[4-(Dimethylamino)phenoxy]-4,6-dih...)
Affinity DataKd:  0.423nMpH: 7.6Assay Description:The evaluation of the binding affinity (KD) of the compounds of formula (I) to the HSP90 protein was done using Biacore T100.His-HSP90 N-term domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2015
Entry Details
US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 50495254BDBM50495254(CHEMBL3104273)
Affinity DataKd:  0.430nMAssay Description:Binding affinity to human biotinylated N-terminal Hsp90alpha (9 to 236) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Dezhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667074BDBM50667074(CHEMBL6164902)
Affinity DataIC50: 0.450nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 50495250BDBM50495250(CHEMBL3104277)
Affinity DataKd:  0.460nMAssay Description:Binding affinity to human biotinylated N-terminal Hsp90alpha (9 to 236) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Dezhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667050BDBM50667050(CHEMBL6167303)
Affinity DataIC50: 0.460nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Dezhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667107BDBM50667107(CHEMBL6175551)
Affinity DataIC50: 0.460nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 50645078BDBM50645078(CHEMBL5574581)
Affinity DataKd:  0.480nMAssay Description:Binding affinity to human N-terminal his tagged Hsp90alpha (1 to 241 residues) expressed in Escherichia coli (DE3) strain assessed as dissociation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 50495245BDBM50495245(CHEMBL3104289)
Affinity DataKd:  0.480nMAssay Description:Binding affinity to human biotinylated N-terminal Hsp90alpha (9 to 236) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 81913BDBM81913(Unsubstituted phenyl ring analog, 2)
Affinity DataIC50: 0.5nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Dezhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667108BDBM50667108(CHEMBL6170870)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 50362220BDBM50362220(CHEMBL1939379)
Affinity DataKd:  0.520nMAssay Description:Binding affinity to N-terminus biotinylated human Hsp90 alpha by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Dezhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667097BDBM50667097(CHEMBL6170534)
Affinity DataIC50: 0.530nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Dezhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667109BDBM50667109(CHEMBL6177673)
Affinity DataIC50: 0.530nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Dezhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667103BDBM50667103(CHEMBL6170473)
Affinity DataIC50: 0.530nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Dezhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50482743BDBM50482743(CHEMBL1215467)
Affinity DataKd:  0.540nMAssay Description:Binding affinity to human N-terminal ATPase domain of Hsp90 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock protein HSP 90-alpha/90-beta(Human)
Dezhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50593502BDBM50593502(CHEMBL1215539)
Affinity DataKd:  0.540nMAssay Description:Inhibition of HSP90 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 50314505BDBM50314505(CHEMBL6092104)
Affinity DataIC50: 0.540nMAssay Description:Antagonist activity at human recombinant TRPV1 assessed as inhibition of capsaicin-induced in intracellular calcium levels by cell-based FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Human)
Bayer Healthcare

LigandChemical structure of BindingDB Monomer ID 50495244BDBM50495244(CHEMBL3104276)
Affinity DataKd:  0.540nMAssay Description:Binding affinity to human biotinylated N-terminal Hsp90alpha (9 to 236) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
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