Compile Data Set for Download or QSAR
Report error Found 204 Enz. Inhib. hit(s) with Target = 'Dual specificity mitogen-activated protein kinase kinase 7'
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50553869BDBM50553869(CHEMBL4764965)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal 6XHis-tagged recombinant MKK7 (117 to 423 residues) (unknown origin) expressed in Escherichia coli BL21-DE3 preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 130909BDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human MKK7 using JNK (K55M) as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559800BDBM50559800(CHEMBL3329977)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of MEK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594444BDBM50594444(CHEMBL5174214)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal 6XHis-tagged recombinant MKK7 (117 to 423 residues) (unknown origin) expressed in Escherichia coli BL21-DE3 preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594445BDBM50594445(CHEMBL5195838)
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal 6XHis-tagged recombinant MKK7 (117 to 423 residues) (unknown origin) expressed in Escherichia coli BL21-DE3 preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 293025BDBM293025(1-(6-{1H-pyrazolo[3,4-c]pyridin-3-yl}-2,3-dihydroi...)
Affinity DataIC50: 4.80nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50553870BDBM50553870(CHEMBL4749823)
Affinity DataIC50: 5nMAssay Description:Inhibition of MAP2K7 (unknown origin) using JNK peptide KFMMTPYVVTR incubated for 30 mins measured by multimode reader based ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50553870BDBM50553870(CHEMBL4749823)
Affinity DataIC50: 5nMAssay Description:Inhibition of MEK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 293043BDBM293043(3-[1-(prop-2-enoyl)-2,3-dihydroindol-6-yl]-1H-inda...)
Affinity DataIC50: 6nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50206444BDBM50206444(CHEMBL3901151)
Affinity DataIC50: 6nMAssay Description:Inhibition of MEK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50553869BDBM50553869(CHEMBL4764965)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of MAP2K7 (unknown origin) using JNK peptide KFMMTPYVVTR incubated for 30 mins measured by multimode reader based ADP-glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 293041BDBM293041(1-(ethenesulfonyl)-6-{1H-pyrazolo[3,4-b]pyridin-3-...)
Affinity DataIC50: 7.70nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 293028BDBM293028(1-[6-(6-methyl-1H-indazol-3-yl)-2,3-dihydroindol-1...)
Affinity DataKd:  7.80nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615119BDBM50615119(CHEMBL5284723)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant full-length MEK7 using JNK1 as substrate incubated for 30 mins followed by ATP addition measured after 1 hr by ADP Gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50559801BDBM50559801(CHEMBL4787266)
Affinity DataIC50: 14nMAssay Description:Inhibition of MEK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 293038BDBM293038(1-[6-(1H-indazol-3-yl)-2,3-dihydroindol-1-yl]prop-...)
Affinity DataIC50: 19nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 293028BDBM293028(1-[6-(6-methyl-1H-indazol-3-yl)-2,3-dihydroindol-1...)
Affinity DataIC50: 23nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31085BDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataKd:  27nMAssay Description:Binding constant for MKK7 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  30nMAssay Description:Binding constant for MKK7 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50258966BDBM50258966(CHEMBL4071151)
Affinity DataIC50: 30nMAssay Description:Inhibition of N-terminal 6XHis-tagged recombinant MKK7 (117 to 423 residues) (unknown origin) expressed in Escherichia coli BL21-DE3 preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 293027BDBM293027(1-(6-{1H-pyrazolo[4,3-c]pyridin-3-yl}-2,3-dihydroi...)
Affinity DataIC50: 30nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594446BDBM50594446(CHEMBL5169325)
Affinity DataIC50: 30nMAssay Description:Inhibition of N-terminal 6XHis-tagged recombinant MKK7 (117 to 423 residues) (unknown origin) expressed in Escherichia coli BL21-DE3 preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615123BDBM50615123(CHEMBL5283781)
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant full-length MEK7 using JNK1 as substrate incubated for 30 mins followed by ATP addition measured after 1 hr by ADP Gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615102BDBM50615102(CHEMBL5271442)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant full-length MEK7 using JNK1 as substrate incubated for 30 mins followed by ATP addition measured after 1 hr by ADP Gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615113BDBM50615113(CHEMBL5267499)
Affinity DataIC50: 66nMAssay Description:Inhibition of human recombinant full-length MEK7 using JNK1 as substrate incubated for 30 mins followed by ATP addition measured after 1 hr by ADP Gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 293029BDBM293029((2E)-4-[6-(1H-indazol-3-yl)-2,3-dihydroindol-1-yl]...)
Affinity DataIC50: 70nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 293036BDBM293036(1-[7-(6-methyl-1H-indazol-3-yl)-3,4-dihydro-2H-qui...)
Affinity DataKd:  71nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615120BDBM50615120(CHEMBL5279577)
Affinity DataIC50: 74nMAssay Description:Inhibition of human recombinant full-length MEK7 using JNK1 as substrate incubated for 30 mins followed by ATP addition measured after 1 hr by ADP Gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50308060BDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  80nMAssay Description:Binding constant for MKK7 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 293042BDBM293042(1-(7-fluoro-6-{1H-pyrazolo[3,4-b]pyridin-3-yl}-2,3...)
Affinity DataIC50: 88nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 293026BDBM293026(1-[4-(1H-indazol-3-yl)-2,3-dihydroindol-1-yl]prop-...)
Affinity DataIC50: 92nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50577689BDBM50577689(CHEMBL4866649)
Affinity DataIC50: 96nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK7 expressed in Sf21 cells using JNK1 as substrate pre-incubated for 30 mins foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50553869BDBM50553869(CHEMBL4764965)
Affinity DataEC50: <100nMAssay Description:Inhibition of N-terminal 6XHis-tagged recombinant MKK7 (117 to 423 residues) in human U2OS assessed as reduction in c-Jun phosphorylation level incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4779BDBM4779(cid_156414 | PD0183805 | CHEMBL545315 | CHEMBL3196...)
Affinity DataKd:  110nMAssay Description:Binding constant for MKK7 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615122BDBM50615122(CHEMBL5267684)
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant full-length MEK7 using JNK1 as substrate incubated for 30 mins followed by ATP addition measured after 1 hr by ADP Gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615118BDBM50615118(CHEMBL5271266)
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant full-length MEK7 using JNK1 as substrate incubated for 30 mins followed by ATP addition measured after 1 hr by ADP Gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 293037BDBM293037(1-[6-(1H-indazol-3-yl)-2,3-dihydro-1,4-benzoxazin-...)
Affinity DataIC50: 140nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 293036BDBM293036(1-[7-(6-methyl-1H-indazol-3-yl)-3,4-dihydro-2H-qui...)
Affinity DataIC50: 160nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 293040BDBM293040(US20260015351, Compound 15-B)
Affinity DataIC50: 160nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 293030BDBM293030((2E)-4-(dimethylamino)-1-[6-(1H-indazol-3-yl)-2,3-...)
Affinity DataIC50: 180nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2026
Entry Details
US Patent

TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50269615BDBM50269615(CHEMBL4095253)
Affinity DataIC50: 189nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MKK7beta (2 to end residues) expressed in Escherichia coli preincubated for 5 mins followed by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50504351BDBM50504351(CHEMBL100206)
Affinity DataIC50: 230nMAssay Description:Inhibition of MEK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50504351BDBM50504351(CHEMBL100206)
Affinity DataKd:  230nMAssay Description:Binding affinity to MKK7 (unknown origin) expressed in HEK293 cells assessed as dissociation constant by kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615109BDBM50615109(CHEMBL5282673)
Affinity DataIC50: 260nMAssay Description:Inhibition of human recombinant full-length MEK7 using JNK1 as substrate incubated for 30 mins followed by ATP addition measured after 1 hr by ADP Gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615129BDBM50615129(CHEMBL5277855)
Affinity DataIC50: 260nMAssay Description:Inhibition of human recombinant full-length MEK7 using JNK1 as substrate incubated for 30 mins followed by ATP addition measured after 1 hr by ADP Gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 31085BDBM31085(cid_11409972 | 1-[4-[(4-ethylpiperazin-1-yl)methyl...)
Affinity DataIC50: 260nMAssay Description:Inhibition of human recombinant full-length MEK7 using JNK1 as substrate incubated for 30 mins followed by ATP addition measured after 1 hr by ADP Gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50594445BDBM50594445(CHEMBL5195838)
Affinity DataEC50:  265nMAssay Description:Inhibition of N-terminal 6XHis-tagged recombinant MKK7 (117 to 423 residues) in human U2OS assessed as reduction in c-Jun phosphorylation level incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615110BDBM50615110(CHEMBL5271906)
Affinity DataIC50: 270nMAssay Description:Inhibition of human recombinant full-length MEK7 using JNK1 as substrate incubated for 30 mins followed by ATP addition measured after 1 hr by ADP Gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50505541BDBM50505541(CHEMBL4465866)
Affinity DataKd:  293nMAssay Description:Binding affinity to recombinant human full-length N-terminal GST-tagged MAP2K7 (1 to 419 residues) expressed in baculovirus expression system using J...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Human)
Weizmann Institute of Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50615128BDBM50615128(CHEMBL5272546)
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant full-length MEK7 using JNK1 as substrate incubated for 30 mins followed by ATP addition measured after 1 hr by ADP Gl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
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