Compile Data Set for Download or QSAR
Report error Found 32 Enz. Inhib. hit(s) with Target = 'DNA-binding protein Ikaros'
TargetDNA-binding protein Ikaros/Protein cereblon(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50476157BDBM50476157(CHEMBL6074489)
Affinity DataEC50:  35nMAssay Description:Inhibition of TRKA (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526273BDBM526273(2-(2,6-dioxopiperidin-3-yl)-5-(((1S,2S)-2- (ethyla...)
Affinity DataEC50:  51nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros/Protein cereblon(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 730416BDBM730416(US20250122166, Compound 7)
Affinity DataEC50:  120nMAssay Description:Inhibition of TIE2 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526270BDBM526270(US11185537, Compound Mix)
Affinity DataEC50:  120nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526271BDBM526271(2-(2,6-dioxopiperidin-3- yl)-5-(methyl((1S,2S)-2- ...)
Affinity DataEC50:  290nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526278BDBM526278(3-(4-fluoro-5-(methyl((1S,2S)-2- (methylamino)cycl...)
Affinity DataEC50:  570nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526270BDBM526270(US11185537, Compound Mix)
Affinity DataEC50:  630nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros/Protein cereblon(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 292744BDBM292744(US20260014133, Compound 5)
Affinity DataEC50:  650nMAssay Description:Inhibition of TRKB (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526281BDBM526281(5-(((1S,2S)-2- (dimethylamino)cyclohexyl) (methyl)...)
Affinity DataEC50:  2.37E+3nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526272BDBM526272(5-(((1S,2S)-2-aminocyclohexyl) (methyl)amino)- 2-(...)
Affinity DataEC50:  5.20E+3nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros/Protein cereblon(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50557457BDBM50557457(CHEMBL4742712)
Affinity DataEC50: >1.00E+4nMAssay Description:Protac activity at CRBN/IKZF1 (unknown origin) assessed as IKZF1 degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 525983BDBM525983(3-(5-(methyl((1R,2R)-2- (methylamino)cyclohexyl)am...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526283BDBM526283(US11185537, Compound 1-148)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526006BDBM526006(3-(5-(((1S,2S)-2- (benzylamino)cyclohexyl)amino)-1...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526274BDBM526274(2-(2,6-dioxopiperidin-3- yl)-5-(methyl((1S,2S)-2- ...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526275BDBM526275(5-(((1S,2S)-2- (benzylamino)cyclohexyl) (methyl)am...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526276BDBM526276(2-(2,6-dioxopiperidin-3-yl)-5- (methyl((1S,2S)-2- ...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526253BDBM526253(3-(5-(((1S,2S)-2-(ethylamino) cyclohexyl)amino)- 1...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526277BDBM526277(2-(2,6-dioxopiperidin-3-yl)-5- (methyl((1S,2S)-2-(...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526265BDBM526265(3-(5-(((1S,2S)-2- (isopropylamino)cyclohexyl)amino...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526266BDBM526266(3-(5-(ethyl((1S,2S)-2- (ethylamino)cyclohexyl) ami...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526279BDBM526279(2-(2,6-dioxopiperidin-3- yl)-5-(methyl((1S,2S)-2- ...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526267BDBM526267(3-(5-(((1S,2S)-2- ((cyclohexylmethyl)amino) cycloh...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526280BDBM526280(3-(5-(((1S,2S)-2- (methylamino)cyclohexyl)amino)-1...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526268BDBM526268(3-(1-oxo-5-(((1S,2S)-2-(piperidin-1- yl)cyclopenty...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526269BDBM526269(3-(5-(((1S,2S)-2- (isobutylamino)cyclohexyl)amino)...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 525977BDBM525977(3-(5-(((1S,2S)-2- hydroxycyclohexyl)amino)-1- oxoi...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526282BDBM526282(5-(((1S,2S)-2- (dimethylamino)cyclohexyl)amino)-2-...)
Affinity DataEC50: >3.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526078BDBM526078(US11185537, Compound I-9 | US11185537, Compound I-...)
Affinity DataEC50: >5.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526123BDBM526123(3-(5-(((1S,2S)-2- (benzyl(methyl)amino)cyclohexyl)...)
Affinity DataEC50: >5.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526131BDBM526131(3-(5-(((1S,2S)-2- aminocyclohexyl)amino)-1- oxoiso...)
Affinity DataEC50: >5.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent

TargetDNA-binding protein Ikaros(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 526078BDBM526078(US11185537, Compound I-9 | US11185537, Compound I-...)
Affinity DataEC50: >5.00E+4nMAssay Description:The Prolabel system from DiscoverX was used to develop high-throughput and quantitative assays to measure changes in IKZF1, IKZF2, and GSPT1 protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2022
Entry Details
US Patent