Compile Data Set for Download or QSAR
Report error Found 195 Enz. Inhib. hit(s) with Target = 'DNA topoisomerase 4 subunit A'
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24616BDBM24616(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-7-(pyri...)
Affinity DataKi:  7nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24617BDBM24617(3-ethyl-1-[7-(3-fluoropyridin-2-yl)-5-(1-methyl-2-...)
Affinity DataKi:  11nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24615BDBM24615(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-7-(1H-p...)
Affinity DataKi:  12nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Staphylococcus aureus (strain NCTC 8325 / PS 47))
Vertex Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 50393079BDBM50393079(CHEMBL2152855 | US9040542, 23)
Affinity DataKi:  12nMAssay Description:The conversion of ATP to ADP by S. aureus TopoIV enzyme is coupled to the conversion of NADH to NAD+, and the progress of the reaction is measured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24609BDBM24609(3-ethyl-1-[7-(pyridin-2-yl)-5-(pyridin-3-yl)-1H-1,...)
Affinity DataKi:  14nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24611BDBM24611(3-ethyl-1-[7-(3-fluoropyridin-2-yl)-5-(pyridin-3-y...)
Affinity DataKi:  23nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24606BDBM24606(methyl 2-[(ethylcarbamoyl)amino]-5-(pyridin-3-yl)-...)
Affinity DataKi:  35nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50518915BDBM50518915(CHEMBL4583368)
Affinity DataIC50: 40nMAssay Description:Inhibition of Staphylococcus aureus ATCC 29213 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 737448BDBM737448(US20250136618, Compound 4)
Affinity DataIC50: 44nMAssay Description:E. coli topoisomerase IV decatenation activity and its inhibition was assayed using a kit procured from Inpiralis (D4002) and the kit protocol was ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2025
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 737446BDBM737446(US20250136618, Compound 2)
Affinity DataIC50: 45nMAssay Description:E. coli topoisomerase IV decatenation activity and its inhibition was assayed using a kit procured from Inpiralis (D4002) and the kit protocol was ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2025
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24608BDBM24608(3-ethyl-1-[7-(1H-pyrazol-1-yl)-5-(pyridin-3-yl)-1H...)
Affinity DataKi:  46nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 595423BDBM595423(US11590142, Compound 13 | US20250136618, Compound ...)
Affinity DataIC50: 50nMAssay Description:E. coli topoisomerase IV decatenation activity and its inhibition was assayed using a kit procured from Inpiralis (D4002) and the kit protocol was ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2025
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50518940BDBM50518940(CHEMBL4541988)
Affinity DataIC50: 50nMAssay Description:Inhibition of Staphylococcus aureus ATCC 29213 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 737447BDBM737447(US20250136618, Compound 3)
Affinity DataIC50: 50nMAssay Description:E. coli topoisomerase IV decatenation activity and its inhibition was assayed using a kit procured from Inpiralis (D4002) and the kit protocol was ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2025
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24614BDBM24614(3-ethyl-1-[7-(1H-pyrazol-1-yl)-5-(pyrimidin-5-yl)-...)
Affinity DataKi:  58nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 737454BDBM737454(US20250136618, Compound 10)
Affinity DataIC50: 78nMAssay Description:E. coli topoisomerase IV decatenation activity and its inhibition was assayed using a kit procured from Inpiralis (D4002) and the kit protocol was ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2025
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24601BDBM24601(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-6-fluor...)
Affinity DataKi:  78nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 737453BDBM737453(US20250136618, Compound 9)
Affinity DataIC50: 91nMAssay Description:E. coli topoisomerase IV decatenation activity and its inhibition was assayed using a kit procured from Inpiralis (D4002) and the kit protocol was ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2025
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50518948BDBM50518948(CHEMBL4574863)
Affinity DataIC50: 100nMAssay Description:Inhibition of Staphylococcus aureus ATCC 29213 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50518915BDBM50518915(CHEMBL4583368)
Affinity DataIC50: 100nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50518948BDBM50518948(CHEMBL4574863)
Affinity DataIC50: 100nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50518940BDBM50518940(CHEMBL4541988)
Affinity DataIC50: 100nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 282BDBM282(Coumarin-Based, DNA Gyrase Inhibitor | (3R,4S,5R,6...)
Affinity DataKi:  110nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 737449BDBM737449(US20250136618, Compound 5)
Affinity DataIC50: 110nMAssay Description:E. coli topoisomerase IV decatenation activity and its inhibition was assayed using a kit procured from Inpiralis (D4002) and the kit protocol was ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2025
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 737450BDBM737450(US20250136618, Compound 6)
Affinity DataIC50: 130nMAssay Description:E. coli topoisomerase IV decatenation activity and its inhibition was assayed using a kit procured from Inpiralis (D4002) and the kit protocol was ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/3/2025
Entry Details
US Patent

TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24607BDBM24607(2-[(ethylcarbamoyl)amino]-N-methyl-5-(pyridin-3-yl...)
Affinity DataKi:  150nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50518924BDBM50518924(CHEMBL4533152)
Affinity DataIC50: 200nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178928BDBM50178928(7-(3-(aminomethyl)phenyl)-9-cyclopropyl-6-fluorois...)
Affinity DataIC50: 200nMAssay Description:Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50518911BDBM50518911(CHEMBL4530328)
Affinity DataIC50: 300nMAssay Description:Inhibition of Staphylococcus aureus ATCC 29213 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50518924BDBM50518924(CHEMBL4533152)
Affinity DataIC50: 300nMAssay Description:Inhibition of Staphylococcus aureus ATCC 29213 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178917BDBM50178917(CHEMBL430 | 7-(3-(aminomethyl)-4-(methoxyimino)pyr...)
Affinity DataIC50: 300nMAssay Description:Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus subsp. aureus Mu50)
Daiichi Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474900BDBM50474900(CHEMBL365638)
Affinity DataIC50: 312nMAssay Description:Inhibitory concentration against Staphylococcus aureus DNA topoisomerase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24612BDBM24612(1-[7-(benzyloxy)-5-(pyridin-3-yl)-1H-1,3-benzodiaz...)
Affinity DataKi:  390nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50518911BDBM50518911(CHEMBL4530328)
Affinity DataIC50: 400nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus subsp. aureus Mu50)
Daiichi Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474895BDBM50474895(CHEMBL186870)
Affinity DataIC50: 412nMAssay Description:Inhibitory concentration against Staphylococcus aureus DNA topoisomerase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178926BDBM50178926(9-cyclopropyl-6-fluoro-7-(piperazin-1-yl)isothiazo...)
Affinity DataIC50: 500nMAssay Description:Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178912BDBM50178912(9-cyclopropyl-6-fluoro-7-(pyridin-3-yl)isothiazolo...)
Affinity DataIC50: 500nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus subsp. aureus Mu50)
Daiichi Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474901BDBM50474901(CHEMBL360168)
Affinity DataIC50: 668nMAssay Description:Inhibitory concentration against Staphylococcus aureus DNA topoisomerase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24613BDBM24613(3-ethyl-1-[6-methoxy-5-(2-methoxypyrimidin-5-yl)-1...)
Affinity DataKi:  680nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A/B(Escherichia coli (strain K12))
Vertex Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 24602BDBM24602(3-ethyl-1-[6-fluoro-5-(pyridin-3-yl)-1H-1,3-benzod...)
Affinity DataKi:  680nMAssay Description:Enzymatic hydrolysis of ATP to ADP was coupled to the conversion of NADH to NAD+. The decrease in NADH absorbance was monitored at 340 nm for 20 min ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2008
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50178913BDBM50178913(7-(6-(aminomethyl)pyridin-3-yl)-9-cyclopropyl-6-fl...)
Affinity DataIC50: 700nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50518928BDBM50518928(CHEMBL4544202)
Affinity DataIC50: 700nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus subsp. aureus Mu50)
Daiichi Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474899BDBM50474899(CHEMBL187796)
Affinity DataIC50: 716nMAssay Description:Inhibitory concentration against Staphylococcus aureus DNA topoisomerase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus subsp. aureus Mu50)
Daiichi Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474896BDBM50474896(CHEMBL184167)
Affinity DataIC50: 733nMAssay Description:Inhibitory concentration against Staphylococcus aureus DNA topoisomerase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50131428BDBM50131428(CHEMBL32 | 1-Cyclopropyl-6-fluoro-8-methoxy-7-(oct...)
Affinity DataIC50: 800nMAssay Description:Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus)
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50131428BDBM50131428(CHEMBL32 | 1-Cyclopropyl-6-fluoro-8-methoxy-7-(oct...)
Affinity DataIC50: 800nMAssay Description:Inhibitory activity against Staphylococcus aureus ATCC 29213 wild type Topo 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus subsp. aureus Mu50)
Daiichi Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474898BDBM50474898(CHEMBL363725)
Affinity DataIC50: 809nMAssay Description:Inhibitory concentration against Staphylococcus aureus DNA topoisomerase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Staphylococcus aureus subsp. aureus Mu50)
Daiichi Pharmaceutical

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50474897BDBM50474897(CHEMBL184489)
Affinity DataIC50: 847nMAssay Description:Inhibitory concentration against Staphylococcus aureus DNA topoisomerase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50518918BDBM50518918(CHEMBL4569403)
Affinity DataIC50: 900nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 4 subunit A(Escherichia coli (strain K12))
Angelini

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50518922BDBM50518922(CHEMBL4441397)
Affinity DataIC50: 900nMAssay Description:Inhibition of Escherichia coli ATCC 25922 DNA topoisomerase 4 subunit ParC assessed as reduction in decatenation of kinetoplast DNA incubated for 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
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