Compile Data Set for Download or QSAR
Report error Found 620 Enz. Inhib. hit(s) with Target = 'CDK6/cyclin D1'
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 467013BDBM467013((-)-6-(2,2-difluoroethyl)-8-[(1R*,2R*)-2-hydroxy-2...)
Affinity DataKi:  0.0640nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370121BDBM370121(6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcy...)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of non-phosphorylated CDK6/Cyclin D1 (unknown origin) assessed as reduction in production of ADP using 5-FAM-RRRFRPASPLRGPPK peptide as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370121BDBM370121(6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcy...)
Affinity DataKi:  0.110nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370121BDBM370121(6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcy...)
Affinity DataKi:  0.110nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 467012BDBM467012((+)-6-(2,2-difluoroethyl)-8-[(1R*,2R*)-2-hydroxy-2...)
Affinity DataKi:  0.130nMAssay Description:Inhibition of non-phosphorylated CDK6/Cyclin D1 (unknown origin) assessed as reduction in production of ADP using 5-FAM-RRRFRPASPLRGPPK peptide as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370233BDBM370233(US10233188, Example 120 | US10800783, Example 120 ...)
Affinity DataKi:  0.180nMAssay Description:Inhibition of non-phosphorylated CDK6/Cyclin D1 (unknown origin) assessed as reduction in production of ADP using 5-FAM-RRRFRPASPLRGPPK peptide as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370256BDBM370256(US10233188, Example 143 | BDBM467151)
Affinity DataKi:  0.190nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50609166BDBM50609166(CHEMBL5280928)
Affinity DataKi:  0.200nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 6309BDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370205BDBM370205(US10233188, Example 92 | US10800783, Example 92 | ...)
Affinity DataKi:  0.240nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370248BDBM370248((8-cyclopentyl-2-{[1-(methylsulfonyl)piperidin-4-y...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370140BDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)
Affinity DataKi:  0.310nMAssay Description:Inhibition of non-phosphorylated CDK6/Cyclin D1 (unknown origin) assessed as reduction in production of ADP using 5-FAM-RRRFRPASPLRGPPK peptide as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370133BDBM370133(US10233188, Example 22 | US10800783, Example 22 | ...)
Affinity DataKi:  0.330nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621179BDBM621179(US20230303564, Compound 21)
Affinity DataIC50: 0.340nMAssay Description:Preparation of Kinase Buffer: The composition of the buffer: 50 mM of hydroxyethylpiperazine ethanesulfonic acid solution at pH 7.5, 1 mM of ethylene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370140BDBM370140(US10233188, Example 29 | US10800783, Example 29 | ...)
Affinity DataKi:  0.360nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370120BDBM370120(6-chloro-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]...)
Affinity DataKi:  0.370nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50644906BDBM50644906(CHEMBL5574087)
Affinity DataIC50: 0.390nMAssay Description:Inhibition of CDK6/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110183BDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of human CDK6/cyclin D1 preincubated with compound for 20 mins followed by [33P]ATP addition and measured after 2 hrs by filter binding me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 6309BDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of human CDK6/cyclin D1 preincubated with compound for 20 mins followed by [33P]ATP addition and measured after 2 hrs by filter binding me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621183BDBM621183(US20230303564, Compound 25)
Affinity DataIC50: 0.460nMAssay Description:Preparation of Kinase Buffer: The composition of the buffer: 50 mM of hydroxyethylpiperazine ethanesulfonic acid solution at pH 7.5, 1 mM of ethylene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50637886BDBM50637886(Culmerciclib)
Affinity DataIC50: 0.490nMAssay Description:Inhibition of CDK6/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50644904BDBM50644904(CHEMBL5583721)
Affinity DataIC50: 0.520nMAssay Description:Inhibition of CDK6/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621178BDBM621178(US20230303564, Compound 20)
Affinity DataIC50: 0.560nMAssay Description:Preparation of Kinase Buffer: The composition of the buffer: 50 mM of hydroxyethylpiperazine ethanesulfonic acid solution at pH 7.5, 1 mM of ethylene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50644907BDBM50644907(CHEMBL5566684)
Affinity DataIC50: 0.730nMAssay Description:Inhibition of CDK6/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 611019BDBM611019(US10626107, Example A crystal form of compound WX_...)
Affinity DataIC50: 0.800nMAssay Description:The standard Lance Ultra method was performed by a 10 μL enzyme reaction system containing 0.3 nM CDK4/cyclin D1 protein, 50 nM ULight-4E-BP1 po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621172BDBM621172(US20230303564, Compound 8 | US20230303564, Compoun...)
Affinity DataIC50: 0.810nMAssay Description:Preparation of Kinase Buffer: The composition of the buffer: 50 mM of hydroxyethylpiperazine ethanesulfonic acid solution at pH 7.5, 1 mM of ethylene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370314BDBM370314(US10233188, Example 201 | BDBM467209)
Affinity DataKi:  0.850nMAssay Description:Inhibition of non-phosphorylated CDK6/Cyclin D1 (unknown origin) assessed as reduction in production of ADP using 5-FAM-RRRFRPASPLRGPPK peptide as su...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50609169BDBM50609169(CHEMBL5275378)
Affinity DataKi:  0.860nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370112BDBM370112(8-cyclopentyl-2-{[1-(methylsulfonyl)piperidin-4-yl...)
Affinity DataKi:  0.880nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370203BDBM370203(US10233188, Example 90 | US10800783, Example 90 | ...)
Affinity DataKi:  0.880nMAssay Description:Inhibition of non-phosphorylated CDK6/Cyclin D1 (unknown origin) assessed as reduction in production of ADP using 5-FAM-RRRFRPASPLRGPPK peptide as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50644905BDBM50644905(CHEMBL5570615)
Affinity DataIC50: 0.890nMAssay Description:Inhibition of CDK6/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370258BDBM370258(US10233188, Example 145 | BDBM467153)
Affinity DataKi:  0.920nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370239BDBM370239(US10233188, Example 126 | US10800783, Example 126 ...)
Affinity DataKi:  0.960nMAssay Description:Inhibition of non-phosphorylated CDK6/Cyclin D1 (unknown origin) assessed as reduction in production of ADP using 5-FAM-RRRFRPASPLRGPPK peptide as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 6309BDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 0.980nMAssay Description:The standard Lance Ultra method was performed by a 10 μL enzyme reaction system containing 0.3 nM CDK4/cyclin D1 protein, 50 nM ULight-4E-BP1 po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 6309BDBM6309(8-cyclopentyl-6-acetyl-5-methyl-2-{[5-(piperazin-1...)
Affinity DataIC50: 0.990nMAssay Description:Inhibition of CDK6/Cyclin D1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 513519BDBM513519(US11091485, Compound I-1)
Affinity DataIC50: 1nMAssay Description:Potency determination of biochemical kinase inhibition test. Kinase activity test and IC50 determination. Firstly, 10 ng of recombinant CDK4/Cyclin D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 513536BDBM513536(US11091485, Compound I-17)
Affinity DataIC50: 1nMAssay Description:Potency determination of biochemical kinase inhibition test. Kinase activity test and IC50 determination. Firstly, 10 ng of recombinant CDK4/Cyclin D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 513528BDBM513528(US11091485, Compound I-9)
Affinity DataIC50: 1nMAssay Description:Potency determination of biochemical kinase inhibition test. Kinase activity test and IC50 determination. Firstly, 10 ng of recombinant CDK4/Cyclin D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 513552BDBM513552(US11091485, Compound I-33)
Affinity DataIC50: 1nMAssay Description:Potency determination of biochemical kinase inhibition test. Kinase activity test and IC50 determination. Firstly, 10 ng of recombinant CDK4/Cyclin D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 513520BDBM513520(US11091485, Compound I-2)
Affinity DataIC50: 1nMAssay Description:Potency determination of biochemical kinase inhibition test. Kinase activity test and IC50 determination. Firstly, 10 ng of recombinant CDK4/Cyclin D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 513553BDBM513553(US11091485, Compound I-34)
Affinity DataIC50: 1nMAssay Description:Potency determination of biochemical kinase inhibition test. Kinase activity test and IC50 determination. Firstly, 10 ng of recombinant CDK4/Cyclin D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 513524BDBM513524(US11091485, Compound I-5)
Affinity DataIC50: 1nMAssay Description:Potency determination of biochemical kinase inhibition test. Kinase activity test and IC50 determination. Firstly, 10 ng of recombinant CDK4/Cyclin D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 513550BDBM513550(US11091485, Compound I-31)
Affinity DataIC50: 1nMAssay Description:Potency determination of biochemical kinase inhibition test. Kinase activity test and IC50 determination. Firstly, 10 ng of recombinant CDK4/Cyclin D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 513527BDBM513527(US11091485, Compound I-8)
Affinity DataIC50: 1nMAssay Description:Potency determination of biochemical kinase inhibition test. Kinase activity test and IC50 determination. Firstly, 10 ng of recombinant CDK4/Cyclin D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2022
Entry Details
US Patent

TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370113BDBM370113(8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-{[1-(m...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 621177BDBM621177(US20230303564, Compound 19)
Affinity DataIC50: 1.15nMAssay Description:Preparation of Kinase Buffer: The composition of the buffer: 50 mM of hydroxyethylpiperazine ethanesulfonic acid solution at pH 7.5, 1 mM of ethylene...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370130BDBM370130(US10233188, Example 19 | US10800783, Example 19 | ...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50609168BDBM50609168(CHEMBL5277190)
Affinity DataKi:  1.20nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50110183BDBM50110183(Abemaciclib | LY-2835219 | US10696678, Example LY2...)
Affinity DataIC50: 1.22nMAssay Description:The standard Lance Ultra method was performed by a 10 μL enzyme reaction system containing 0.3 nM CDK4/cyclin D1 protein, 50 nM ULight-4E-BP1 po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/8/2023
Entry Details
US Patent

TargetCDK6/cyclin D1(Human)
Pfizer

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 370277BDBM370277(US10233188, Example 164 | BDBM467172)
Affinity DataKi:  1.30nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) assessed as reduction in substrate peptide phosphorylation using DYRKtide peptide as substrate preincub...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
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