Compile Data Set for Download or QSAR
Report error Found 72 Enz. Inhib. hit(s) with Target = 'Coiled-coil domain-containing protein 6'
TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653234BDBM50653234(CHEMBL6132745)
Affinity DataIC50: 0.100nMAssay Description:Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653230BDBM50653230(CHEMBL6120359)
Affinity DataIC50: 0.100nMAssay Description:Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 716172BDBM716172(US12209085, Example 215)
Affinity DataIC50: 0.160nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
US Patent

TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653248BDBM50653248(CHEMBL6133093)
Affinity DataIC50: 0.200nMAssay Description:Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653236BDBM50653236(CHEMBL6083074)
Affinity DataIC50: 0.240nMAssay Description:Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 716173BDBM716173(US12209085, Example 194)
Affinity DataIC50: 0.260nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
US Patent

TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653235BDBM50653235(CHEMBL6078603)
Affinity DataIC50: 0.290nMAssay Description:Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50382959BDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of CCDC6-RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 625349BDBM625349(US20230322769, Compound 67 | US20230322769, Compou...)
Affinity DataIC50: 0.340nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50601766BDBM50601766(CHEMBL5171764 | US20250387388, Compound Pralsetini...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant CCDC6-RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 625352BDBM625352(US20230322769, Compound 65)
Affinity DataIC50: 0.520nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 716174BDBM716174(US12209085, Example 214)
Affinity DataIC50: 0.600nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 716171BDBM716171(US12209085, Example 4)
Affinity DataIC50: 0.600nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
US Patent

TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653253BDBM50653253(CHEMBL6143118)
Affinity DataIC50: 0.630nMAssay Description:Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514844BDBM50514844(CHEMBL4473213)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of CCDC6/RET in human LC2/ad cells assessed as reduction in cell proliferation supplemented with fresh medium containing compound for ever...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514844BDBM50514844(CHEMBL4473213)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of CCDC6/RET in human TPC1 cells assessed as reduction in cell proliferation supplemented with fresh medium containing compound for every ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 716170BDBM716170(US12209085, Example 3)
Affinity DataIC50: 0.800nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 716112BDBM716112(US12209085, Example 1 | US20250115576, Example 7)
Affinity DataIC50: 0.870nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
US Patent

TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653231BDBM50653231(CHEMBL6091882)
Affinity DataIC50: 0.970nMAssay Description:Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 625351BDBM625351(US20230322769, Compound 70 | US20230322769, Compou...)
Affinity DataIC50: 1.02nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 625348BDBM625348(US20230322769, Compound 66 | US20230322769, Compou...)
Affinity DataIC50: 1.13nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50623616BDBM50623616(CHEMBL5430810)
Affinity DataIC50: 1.60nMAssay Description:Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 296429BDBM296429(US10112942, Example 163 | US10112942, Example 183 ...)
Affinity DataIC50: 2.07nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 625338BDBM625338(US20230322769, Compound 20)
Affinity DataIC50: 2.14nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 625346BDBM625346(US20230322769, Compound 51)
Affinity DataIC50: 2.15nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653247BDBM50653247(CHEMBL6114884)
Affinity DataIC50: 2.20nMAssay Description:Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653250BDBM50653250(CHEMBL6132683)
Affinity DataIC50: 2.20nMAssay Description:Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 2579BDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human N-terminal GST-HIS6 fused CCDC6-RET fusion protein (Met1 to Ser503 residues) expressed in Sf9 insect cells using TRK-C-derived pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653232BDBM50653232(CHEMBL6102816)
Affinity DataIC50: 2.40nMAssay Description:Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 625350BDBM625350(US20230322769, Compound 68 | US20230322769, Compou...)
Affinity DataIC50: 2.54nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 625337BDBM625337(US20230322769, Compound 17)
Affinity DataIC50: 2.61nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 625367BDBM625367(US20230322769, Compound 94 | US20230322769, Compou...)
Affinity DataIC50: 3nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50641289BDBM50641289(CHEMBL5572034)
Affinity DataIC50: 3nMAssay Description:Inhibition of CCDC6-RET (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 625369BDBM625369(US20230322769, Compound 89)
Affinity DataIC50: 3.04nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 625342BDBM625342(US20230322769, Compound 32)
Affinity DataIC50: 3.13nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 716175BDBM716175(US12209085, Example 268)
Affinity DataIC50: 3.16nMAssay Description:1. Experimental Purpose:The inhibitory activities of the series of compounds against Ret wt, VEGFR2, CCDC6-RET, Ret M918T, Ret V804L, and Ret V804M w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2025
Entry Details
US Patent

TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653242BDBM50653242(CHEMBL6141799)
Affinity DataIC50: 3.40nMAssay Description:Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 625335BDBM625335(US20230322769, Compound 16)
Affinity DataIC50: 3.65nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653241BDBM50653241(CHEMBL6078524)
Affinity DataIC50: 4.20nMAssay Description:Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 435010BDBM435010(US10584114, Compound 130 | US11279688, Compound 13...)
Affinity DataIC50: 4.20nMAssay Description:Displacement of radioligand from human recombinant adenosine A3 receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 625348BDBM625348(US20230322769, Compound 66 | US20230322769, Compou...)
Affinity DataIC50: 4.44nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 625358BDBM625358(US20230322769, Compound 78)
Affinity DataIC50: 4.60nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653221BDBM50653221(CHEMBL6078080)
Affinity DataIC50: 4.80nMAssay Description:Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50538514BDBM50538514(CHEMBL4644274)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of CCDC6/RET (unknown origin) transfected in human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50556136BDBM50556136(CHEMBL4790634)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human N-terminal GST-HIS6 fused CCDC6-RET fusion protein (Met1 to Ser503 residues) expressed in Sf9 insect cells using TRK-C-derived pe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 625350BDBM625350(US20230322769, Compound 68 | US20230322769, Compou...)
Affinity DataIC50: 6.01nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50653246BDBM50653246(CHEMBL6143967)
Affinity DataIC50: 6.10nMAssay Description:Displacement of radioligand from human recombinant adenosine A2B receptor at 21 degC after 60 mins by cell-based microplate scintillation countingMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50538517BDBM50538517(CHEMBL4639022)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of CCDC6/RET (unknown origin) transfected in human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCoiled-coil domain-containing protein 6(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50382959BDBM50382959(CEP-32496 | CHEMBL2029988 | US9730937, Example 261)
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant CCDC6-RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 625347BDBM625347(US20230322769, Compound 55)
Affinity DataIC50: 7.45nMAssay Description:The activity assay method for the above kinases was established by homogeneous time-resolved fluorescence (HTRF), and the inhibitory activity of the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

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