Compile Data Set for Download or QSAR
Report error Found 169 Enz. Inhib. hit(s) with Target = 'COP9 signalosome complex subunit 5'
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514114BDBM50514114(CHEMBL4528101)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of CSN5 (unknown origin) using fluorescence-labeled CRL substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514114BDBM50514114(CHEMBL4528101)
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514115BDBM50514115(CHEMBL4447716)
Affinity DataIC50: 60nMAssay Description:Inhibition of CSN5 (unknown origin) using fluorescence-labeled CRL substrate by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514115BDBM50514115(CHEMBL4447716)
Affinity DataIC50: 90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50060898BDBM50060898(5,8-dihydroxy-1,4-naphthoquinone | 5,8-Dihydroxy-[...)
Affinity DataIC50: 170nMAssay Description:Inhibition of N-terminal His6-tagged CSN5 (2 to 257 residues) (unknown origin) transfected in Transetta cells preincubated for 20 mins followed by N-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50033731BDBM50033731(5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...)
Affinity DataIC50: 190nMAssay Description:Inhibition of N-terminal His6-tagged CSN5 (2 to 257 residues) (unknown origin) transfected in Transetta cells preincubated for 20 mins followed by N-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 400994BDBM400994(US10005735, Compound 7)
Affinity DataIC50: 200nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659982BDBM50659982(CHEMBL6149563)
Affinity DataIC50: 250nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597697BDBM50597697(CHEBI:2578 | E103 | ALKANNIN)
Affinity DataIC50: 270nMAssay Description:Inhibition of N-terminal His6-tagged CSN5 (2 to 257 residues) (unknown origin) transfected in Transetta cells preincubated for 20 mins followed by N-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659975BDBM50659975(CHEMBL6145253)
Affinity DataIC50: 290nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264453BDBM50264453(CHEMBL4088568)
Affinity DataIC50: 300nMAssay Description:Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659970BDBM50659970(CHEMBL6162853)
Affinity DataIC50: 310nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659972BDBM50659972(CHEMBL6163084)
Affinity DataIC50: 310nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 401023BDBM401023(US10005735, Compound 21)
Affinity DataIC50: 350nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659965BDBM50659965(CHEMBL6163378)
Affinity DataIC50: 360nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50033731BDBM50033731(5,8-Dihydroxy-2-(1-hydroxy-4-methyl-pent-3-enyl)-[...)
Affinity DataIC50: 410nMAssay Description:Inhibition of N-terminal His6-tagged CSN5 (2 to 257 residues) (unknown origin) transfected in Transetta cells preincubated for 20 mins followed by N-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50033741BDBM50033741(1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2...)
Affinity DataIC50: 430nMAssay Description:Inhibition of N-terminal His6-tagged CSN5 (2 to 257 residues) (unknown origin) transfected in Transetta cells preincubated for 20 mins followed by N-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 401020BDBM401020(US10005735, Compound 19)
Affinity DataIC50: 500nMAssay Description:In brief, this Rpn11 bioassay employs a fluorescent polarization readout based on the ability of the 26S proteasome to cleave the protein substrate i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2020
Entry Details
US Patent

TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264415BDBM50264415(CHEMBL4096289)
Affinity DataIC50: 500nMAssay Description:Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659973BDBM50659973(CHEMBL6120733)
Affinity DataIC50: 500nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264426BDBM50264426(CHEMBL4095913)
Affinity DataIC50: 500nMAssay Description:Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659978BDBM50659978(CHEMBL6160777)
Affinity DataIC50: 510nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659993BDBM50659993(CHEMBL6168758)
Affinity DataIC50: 600nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50033722BDBM50033722(CHEMBL9416 | Isobutyric acid (R)-1-(5,8-dihydroxy-...)
Affinity DataIC50: 600nMAssay Description:Inhibition of N-terminal His6-tagged CSN5 (2 to 257 residues) (unknown origin) transfected in Transetta cells preincubated for 20 mins followed by N-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659979BDBM50659979(CHEMBL6142730)
Affinity DataIC50: 660nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659961BDBM50659961(CHEMBL6142969)
Affinity DataIC50: 680nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659977BDBM50659977(CHEMBL6133980)
Affinity DataIC50: 790nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50597697BDBM50597697(CHEBI:2578 | E103 | ALKANNIN)
Affinity DataIC50: 800nMAssay Description:Inhibition of N-terminal His6-tagged CSN5 (2 to 257 residues) (unknown origin) transfected in Transetta cells preincubated for 20 mins followed by N-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50514115BDBM50514115(CHEMBL4447716)
Affinity DataIC50: 840nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659938BDBM50659938(CHEMBL6143669)
Affinity DataIC50: 860nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659971BDBM50659971(CHEMBL6164460)
Affinity DataIC50: 870nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50060898BDBM50060898(5,8-dihydroxy-1,4-naphthoquinone | 5,8-Dihydroxy-[...)
Affinity DataIC50: 910nMAssay Description:Inhibition of N-terminal His6-tagged CSN5 (2 to 257 residues) (unknown origin) transfected in Transetta cells preincubated for 20 mins followed by N-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659962BDBM50659962(CHEMBL6160437)
Affinity DataIC50: 940nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659976BDBM50659976(CHEMBL6171611)
Affinity DataIC50: 940nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659967BDBM50659967(CHEMBL6152696)
Affinity DataIC50: 980nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50033741BDBM50033741(1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2...)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of N-terminal His6-tagged CSN5 (2 to 257 residues) (unknown origin) transfected in Transetta cells preincubated for 20 mins followed by N-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659940BDBM50659940(CHEMBL6167716)
Affinity DataIC50: 1.12E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50033722BDBM50033722(CHEMBL9416 | Isobutyric acid (R)-1-(5,8-dihydroxy-...)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of N-terminal His6-tagged CSN5 (2 to 257 residues) (unknown origin) transfected in Transetta cells preincubated for 20 mins followed by N-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659974BDBM50659974(CHEMBL6149919)
Affinity DataIC50: 1.22E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659942BDBM50659942(CHEMBL6167782)
Affinity DataIC50: 1.23E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659966BDBM50659966(CHEMBL6142964)
Affinity DataIC50: 1.25E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659985BDBM50659985(CHEMBL6171018)
Affinity DataIC50: 1.25E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659937BDBM50659937(CHEMBL6142433)
Affinity DataIC50: 1.37E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659981BDBM50659981(CHEMBL6162339)
Affinity DataIC50: 1.42E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659956BDBM50659956(CHEMBL6142513)
Affinity DataIC50: 1.44E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659983BDBM50659983(CHEMBL6147975)
Affinity DataIC50: 1.48E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659935BDBM50659935(CHEMBL6145339)
Affinity DataIC50: 1.50E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659958BDBM50659958(CHEMBL6166228)
Affinity DataIC50: 1.57E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264491BDBM50264491(CHEMBL4101230)
Affinity DataIC50: 1.60E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetCOP9 signalosome complex subunit 5(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50264491BDBM50264491(CHEMBL4101230)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of CSN5 (unknown origin) using SCFskp2-Nedd8OG as substrate after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details Article
PubMed
Displayed 1 to 50 (of 169 total ) | Next | Last >>
Jump to: