Compile Data Set for Download or QSAR
Report error Found 121 Enz. Inhib. hit(s) with Target = 'Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial'
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581306BDBM581306(US11504368, Example 24 | (2S)-2-[(5-{[(2,4-diamino...)
Affinity DataIC50: 3nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581300BDBM581300(US11504368, Example 18 | (2S)-2-[(6-cyclopropoxy-5...)
Affinity DataIC50: 3nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581317BDBM581317(US11504368, Example 35 | (2S)-2-[(5-{[(2,4-diamino...)
Affinity DataIC50: 5nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50509364BDBM50509364(CHEMBL4463968)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50509364BDBM50509364(CHEMBL4463968)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of NKG2D (unknown origin)/ULBP6 (unknown origin) protein-protein interaction by cell-based TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581313BDBM581313(US11504368, Example 31 | (2S)-2-[(5-{[(2,4-diamino...)
Affinity DataIC50: 8nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50509346BDBM50509346(CHEMBL4470947)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581288BDBM581288(US11504368, Example 6 | (2S)-2-[(5-{[(2,4-diamino-...)
Affinity DataIC50: 10nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581298BDBM581298(US11504368, Example 16 | (2S)-4- [(benzenesulfonyl...)
Affinity DataIC50: 11nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581286BDBM581286(US11504368, Example 4 | (2S)-2-[(5-{[(2,4-diamino-...)
Affinity DataIC50: 12nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581314BDBM581314(US11504368, Example 32 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 13nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581308BDBM581308(US11504368, Example 26 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 14nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581287BDBM581287(US11504368, Example 5 | (2S)-2-[(3-chloro-5-{[(2,4...)
Affinity DataIC50: 15nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581294BDBM581294(US11504368, Example 12 | (2S)-2-cyclohexyl-2-[(5-{...)
Affinity DataIC50: 17nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50509358BDBM50509358(CHEMBL4534641)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581285BDBM581285(US11504368, Example 3 | (2S)-2-[(5-{[(2,4-diamino-...)
Affinity DataIC50: 19nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50509362BDBM50509362(CHEMBL4483030)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50655327BDBM50655327(CHEMBL6133989)
Affinity DataIC50: 22nMAssay Description:Inhibition of NKG2D (unknown origin)/ULBP6 (unknown origin) protein-protein interaction by cell-based TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581297BDBM581297(US11504368, Example 15 | (2S)-2-[(5-{[(2,4-diamino...)
Affinity DataIC50: 23nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581283BDBM581283(US11504368, Example 1 | (2S)-2-[(5-{[(2,4-diamino-...)
Affinity DataIC50: 24nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50123588BDBM50123588(CHEMBL297258)
Affinity DataKi:  29nMAssay Description:Competitive inhibition of human FolD dehydrogenase activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2016
Entry Details Article
PubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581307BDBM581307(US11504368, Example 25 | (2R)-2-[(4S)-4-carboxy-4-...)
Affinity DataIC50: 30nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581299BDBM581299(US11504368, Example 17 | (2S)-2-[(5-{[(2,4-diamino...)
Affinity DataIC50: 32nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50509354BDBM50509354(CHEMBL4542665)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581296BDBM581296(US11504368, Example 14 | (2S)-2-[(5-{[(2,4-diamino...)
Affinity DataIC50: 36nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50509356BDBM50509356(CHEMBL4584730)
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50509360BDBM50509360(CHEMBL4538356)
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50655334BDBM50655334(CHEMBL6103492)
Affinity DataIC50: 40nMAssay Description:Inhibition of NKG2D (unknown origin)/ULBP6 (unknown origin) protein-protein interaction by cell-based TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581305BDBM581305(US11504368, Example 23 | (2S)-2-[(4S)-4-carboxy-4-...)
Affinity DataIC50: 43nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581311BDBM581311(US11504368, Example 29 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 44nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581293BDBM581293(US11504368, Example 11 | (2S)-3-cyclopentyl-2-[(5-...)
Affinity DataIC50: 46nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581292BDBM581292(US11504368, Example 10 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 47nMAssay Description:Inhibition of NKG2D (unknown origin)/ULBP6 (unknown origin) protein-protein interaction by cell-based TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50509353BDBM50509353(CHEMBL4546647)
Affinity DataIC50: 48nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581292BDBM581292(US11504368, Example 10 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 49nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50509350BDBM50509350(CHEMBL4441993)
Affinity DataIC50: 49nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581291BDBM581291(US11504368, Example 9 | (2S)-2-({5-[2-(2,4-diamino...)
Affinity DataIC50: 53nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50509351BDBM50509351(CHEMBL4460077)
Affinity DataIC50: 53nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581316BDBM581316(US11504368, Example 34 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 60nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581309BDBM581309(US11504368, Example 27 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 65nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50655332BDBM50655332(CHEMBL6159806)
Affinity DataIC50: 66nMAssay Description:Inhibition of NKG2D (unknown origin)/ULBP6 (unknown origin) protein-protein interaction by cell-based TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581284BDBM581284(US11504368, Example 2 | (2S)-2-[(5-{[(2,4-diamino-...)
Affinity DataIC50: 68nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581301BDBM581301(US11504368, Example 19 | (2S)-2-({3-chloro-5-[2-(2...)
Affinity DataIC50: 72nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50655325BDBM50655325(CHEMBL3622702)
Affinity DataIC50: 80nMAssay Description:Inhibition of NKG2D (unknown origin)/ULBP6 (unknown origin) protein-protein interaction by cell-based TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50655325BDBM50655325(CHEMBL3622702)
Affinity DataIC50: 80nMAssay Description:Inhibition of NKG2D (unknown origin)/ULBP6 (unknown origin) protein-protein interaction by cell-based TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPDB
In Depth
Date in BDB:
6/4/2026
Entry Details PubMedPDB3D3D Structure (crystal)
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50509355BDBM50509355(CHEMBL4551634)
Affinity DataIC50: 89nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50655333BDBM50655333(CHEMBL6102973)
Affinity DataIC50: 90nMAssay Description:Inhibition of NKG2D (unknown origin)/ULBP6 (unknown origin) protein-protein interaction by cell-based TR-FRET assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581310BDBM581310(US11504368, Example 28 | (2S)-2-[(4S)-4-carboxy-4-...)
Affinity DataIC50: 92nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581315BDBM581315(US11504368, Example 33 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 92nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 581295BDBM581295(US11504368, Example 13 | (2S)-2-({5-[2-(2,4-diamin...)
Affinity DataIC50: 103nMAssay Description:To determine the IC50 value of a compound, an 11-concentration dose-response curve with 3-fold difference in concentration between assay points was g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2023
Entry Details
US Patent

TargetBifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial(Human)
Thomas Helledays Stiftelse FÖR Medicinsk Forskning

US Patent
LigandChemical structure of BindingDB Monomer ID 50509359BDBM50509359(CHEMBL4474051)
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant MTHFD2 (unknown origin) using THF as substrate incubated for 30 mins in presence of NADMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
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