BDBM50447561 CHEMBL3105156

SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)NCc2ccc(cc2)C(=O)Nc3cccnc3

InChI Key InChIKey=NGQPRVWTFNBUHA-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50447561   

TargetNicotinamide phosphoribosyltransferase(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50447561BDBM50447561(CHEMBL3105156)
Affinity DataIC50: 19nMAssay Description:Inhibition of full length C-terminal His6-tagged human NAMPT expressed in Escherichia coli Rosetta (DE3) cells using PRPP/NAM as substrate/cofactor p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide phosphoribosyltransferase(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50447561BDBM50447561(CHEMBL3105156)
Affinity DataIC50: 19nMAssay Description:Inhibition of NAMPT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNicotinamide phosphoribosyltransferase(Human)
Genentech

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50447561BDBM50447561(CHEMBL3105156)
Affinity DataIC50: 24nMAssay Description:Inhibition of NAMPT in human A2780 cells assessed as reduction in NAD level after 48 hrs by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSolute carrier family 2, facilitated glucose transporter member 1(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50447561BDBM50447561(CHEMBL3105156)
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed