BDBM50425732 ENZALUTAMIDE::US10053433, FC 4.129::US10806720, Compound Enzalutamide::US11230523, Compound Enzalutamide::US11648234, Compound Enzalutamide::US20230382870, Enzalutamide::Xtandi
SMILES CNC(=O)c1ccc(cc1F)N1C(=S)N(C(=O)C1(C)C)c1ccc(C#N)c(c1)C(F)(F)F
InChI Key InChIKey=WXCXUHSOUPDCQV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 96 hits for monomerid = 50425732
Affinity DataKd: 4nMAssay Description:Binding affinity to Androgen receptor LBD (unknown origin) assessed as dissociation constant by biolayer interferometry assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of AR transcriptional activity in human LNCaP cells harboring ARR2PB-eGFP incubated for 72 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Binding affinity to wild-type androgen receptor in human LNCaP cells assessed as inhibition constant incubated for 24 hrs by Cheng-Prusoff equation a...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Displacement of [18F]-FDHT from androgen receptor in human LNCAP/AR cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Antagonist activity at androgen receptor (unknown origin) in human LNCap-ARR2PB-eGFP cells by measuring fluorescence intensity measured after 3 days ...More data for this Ligand-Target Pair
Affinity DataKi: 28nMAssay Description:Antagonist activity at androgen receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Antagonist activity at androgen receptor in human LNCaP cells transfected with ARR2 PB-eGFP assessed as inhibition of DHT-induced transcriptional act...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:In vitro inhibition of [6,7-3H]-17beta-estradiol binding to human estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Displacement of [3H]methyltrienolone from wild-type androgen receptor in human LNCaP cells incubated for 24 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 49nMAssay Description:Displacement of [3H]R1881 from AR in human MDA-MB-453 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of full length AR transcriptional activity in human LNCAP cells harboring AR2PB-eGFP construct assessed as reduction in R1881-induced secr...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Antagonist activity at DHT-induced Androgen receptor in human LNCaP cells transfected with ARR2PB-eGFP incubated for 3 daysMore data for this Ligand-Target Pair
Affinity DataEC50: 62nMAssay Description:Agonist activity at VP16-AR F877L mutant (unknown origin) transfected in human HepG2 cells cotransfected with ARE-LUC incubated for 48 hrs by steady-...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Antagonist activity against human androgen receptor expressed in human LNCap cells trasfected with ARR2PB-eGFP cells incubated for 3 days by fluoresc...More data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Antagonist activity at androgen receptor in human LNCaP cells harboring eGFP/ARRIPB incubated for 3 days by fluorescence methodMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Binding affinity to GST-tagged AR ligand binding domain (unknown origin) measured after 4 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 86nMAssay Description:Inhibition of androgen receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of R1881-induced full length AR transcriptional activity in human LNCAP cells harboring AR2PB-eGFP construct after 72 hrs by fluorescence ...More data for this Ligand-Target Pair
Affinity DataIC50: 99nMAssay Description:Inhibition of DHT induced androgen receptor transcription in human LNCaP cells cotransfected with PSA-luc and renilla plasmid incubated for 24 hrs by...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Antagonist activity at Androgen receptor in human LNCaP cells transfected with ARR2PB-eGFP incubated for 3 days by synergy H1 microplate reader analy...More data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Antagonist activity at androgen receptor T877A mutant (unknown origin) expressed in HEK293 cells incubated for 24 hrs by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 112nMAssay Description:Antagonist activity at androgen receptor T877A mutant expressed in HEK293 cells assessed as reduction in DHT-induced transcriptional activation of an...More data for this Ligand-Target Pair
Affinity DataIC50: 117nMAssay Description:Antagonist activity at AR wild-type (unknown origin) transfected in human LNCAP cells cotransfected with ARE-LUC incubated for 20 to 24 hrs in presen...More data for this Ligand-Target Pair
Affinity DataIC50: 117nMAssay Description:Antagonist activity at wild type androgen receptor in castration-resistant human LNCaP cells assessed as inhibition of R1881-stimulated receptor tran...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of prostate specific antigen in human LNCaP cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Antagonist activity at Androgen receptor in human LNCaP cells expressing ARR2PB-eGFP incubated for 3 days by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Antagonist activity at DHT-induced Androgen receptor in human LNCaP cells expressing ARR2PB-eGFP incubated for 3 days by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 180nMAssay Description:Inhibition of DHT-induced androgen receptor transactivation in human LNCaP cells after 24 hrs by luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Affinity DataIC50: 183nMAssay Description:Antagonist activity at wildtype androgen receptor (unknown origin) transfected in HEK293 cells co-transfected with pGL4.35 assessed as inhibition of ...More data for this Ligand-Target Pair
Affinity DataIC50: 186nMAssay Description:Antagonist activity at AR in human LNCaP cells assessed as reduction in R1881-induced AR transcriptional activity preincubated for 60 mins followed b...More data for this Ligand-Target Pair
Affinity DataIC50: 186nMAssay Description:Antagonist activity at wild type Androgen receptor in human LNCaP cells in presence of R1881More data for this Ligand-Target Pair
Affinity DataIC50: 216nMAssay Description:Antagonist activity at human androgen receptor expressed in HEK-293 cells harboring GRE-LUC and CMV-renilla luciferase assessed as inhibition of tran...More data for this Ligand-Target Pair
Affinity DataIC50: 216nMAssay Description:Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of R1881-induced receptor transactivation after 24 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 216nMAssay Description:Antagonist activity at recombinant human AR expressed in HEK293 cells assessed as inhibition of R1881-induced transcriptional activity measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 216nMAssay Description:Antagonist activity at human androgen receptor expressed in HEK293 cells assessed as inhibition of R1881-induced receptor transactivation after 24 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 216nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
Affinity DataIC50: 216nMAssay Description:Antagonist activity at CMV-tagged full length wild type human AR expressed in HEK293 cells co-transfected with GRE-LUC and CMV-renilla LUC assessed a...More data for this Ligand-Target Pair
Affinity DataIC50: 216nMAssay Description:Methods: hAR-LBD (633-919) was cloned into pGex4t.1. Large scale GST-tagged AR-LBD was prepared and purified using a GST column. Recombinant AR-LBD w...More data for this Ligand-Target Pair
Affinity DataIC50: 218nMAssay Description:Reagents and instruments: radiolabeled dihydrotestosterone (DHT-d3) and unlabelled dihydrotestosterone (DHT) purchased from Sigma-Aldrich (St. Louis,...More data for this Ligand-Target Pair
Affinity DataIC50: 219nMAssay Description:Inhibition of androgen receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Antagonist activity at DHT-induced Androgen receptor W741C mutant in human PC-3 cells transfected with ARR2PB-Luc by Dual-Luciferase Reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 294nMAssay Description:Displacement of fluormone-DHT green from His/GST-tagged rat AR ligand binding domain after 4 to 8 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Antagonist activity at Androgen receptor in human LNCaP cells expressing ARR2PB-eGFP assessed as inhibition of secreted PSA level by Western blot ana...More data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Inhibition of androgen receptor in human VCaP cells expressing GRE-2-TATA-Luc co-expressing firefly luciferase incubated for 24 hrs in presence of DH...More data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Antagonist activity at wild type Androgen receptor in human PC-3 cells expressing ARR2PB-eGFP incubated for 3 days by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 361nMAssay Description:Antagonist activity at GAL4 DBD-fused androgen receptor LBD (unknown origin) transfected in UAS-bla GripTite 293 cells assessed as inhibition of R188...More data for this Ligand-Target Pair
Affinity DataIC50: 361nMAssay Description:Antagonist activity at rat androgen receptor fused with DNA-binding domain of GAL4 expressed in AR-UAS-bla GripTite 293 cells assessed as inhibition ...More data for this Ligand-Target Pair
Affinity DataIC50: 384nMAssay Description:Antagonist activity at androgen receptor T878A mutant (unknown origin) transfected in HEK293 cells co-transfected with ARR2PB-pGL-basic plasmid prein...More data for this Ligand-Target Pair
Affinity DataIC50: 401nMAssay Description:Antagonist activity at Androgen receptor W742C mutant expressed in human PC-3 cells co-expressing ARR2PB-luc by Dual-Luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 420nMAssay Description:Antagonist activity at full length human androgen receptor expressed in mammalian expression system measured after 22 to 24 hrs by luciferase reporte...More data for this Ligand-Target Pair