BDBM4651 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,3-triazol-1-yl)ethoxy]quinazolin-4-amine::ZD4190

SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCn1ccnn1

InChI Key InChIKey=YBTGTVGEKMZEQX-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 4651   

TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4651BDBM4651(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,...)
Affinity DataIC50: 30nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4651BDBM4651(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,...)
Affinity DataIC50: 30nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4651BDBM4651(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,...)
Affinity DataIC50: 30nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Xi'an Jiaotong University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 4651BDBM4651(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,...)
Affinity DataIC50: 50nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 4651BDBM4651(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,...)
Affinity DataIC50: 400nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 4651BDBM4651(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,...)
Affinity DataIC50: 700nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 4651BDBM4651(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,...)
Affinity DataIC50: 700nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 4651BDBM4651(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,...)
Affinity DataIC50: 1.00E+5nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandChemical structure of BindingDB Monomer ID 4651BDBM4651(N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(1H-1,2,...)
Affinity DataIC50: 1.00E+5nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed