BDBM290431 CAS No.:1352792-74-5::RDEA3170::US10100016, Verinurad (RDEA3170)::US10266493, Example 2C::US10919858, Example 2C::US20240116873, Compound Verinuard::US9856239, 41

SMILES CC(C)(Sc1ccncc1-c1ccc(C#N)c2ccccc12)C(O)=O

InChI Key InChIKey=YYBOLPLTQDKXPM-UHFFFAOYSA-N

Data  10 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 290431   

TargetSolute carrier family 22 member 12(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 290431BDBM290431(RDEA3170 | US10100016, Verinurad (RDEA3170) | CAS ...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human URAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 290431BDBM290431(RDEA3170 | US10100016, Verinurad (RDEA3170) | CAS ...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human URT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 290431BDBM290431(RDEA3170 | US10100016, Verinurad (RDEA3170) | CAS ...)
Affinity DataIC50: 25nMAssay Description:Inhibition of human URAT1 expressed in HEK293T cells by assessed as [14C]urate uptake preincubated for 5 mins followed by [14C]urate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 290431BDBM290431(RDEA3170 | US10100016, Verinurad (RDEA3170) | CAS ...)
Affinity DataIC50: 25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSolute carrier family 22 member 12(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 290431BDBM290431(RDEA3170 | US10100016, Verinurad (RDEA3170) | CAS ...)
Affinity DataEC50:  25nMAssay Description:HEK293 human embryonic kidney cells (ATCC #CRL-1573) were propagated in EMEM tissue culture medium as described by ATCC in an atmosphere of 5% C02 an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 290431BDBM290431(RDEA3170 | US10100016, Verinurad (RDEA3170) | CAS ...)
Affinity DataEC50:  26nMAssay Description:HEK293 human embryonic kidney cells (ATCC# CRL-1573) were propagated in EMEM tissue culture medium as described by ATCC in an atmosphere of 5% CO2 an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 290431BDBM290431(RDEA3170 | US10100016, Verinurad (RDEA3170) | CAS ...)
Affinity DataIC50: 50nMAssay Description:Inhibition of human URAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2019
Entry Details Article
PubMed
TargetSolute carrier family 22 member 12(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 290431BDBM290431(RDEA3170 | US10100016, Verinurad (RDEA3170) | CAS ...)
Affinity DataIC50: 54.5nMAssay Description:Experimental results: The compounds had no obvious inhibitory effect on the drug transporter OAT3, and when the compounds were used clinically in com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 290431BDBM290431(RDEA3170 | US10100016, Verinurad (RDEA3170) | CAS ...)
Affinity DataIC50: 100nMAssay Description:Human kidney embryonic cells HEK-293T were grown in a petri dish (diameter=10 cm) containing DMEM and 10% of bovine fetal serum culture solution, and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2019
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 290431BDBM290431(RDEA3170 | US10100016, Verinurad (RDEA3170) | CAS ...)
Affinity DataIC50: 100nMAssay Description:Human kidney embryonic cells HEK-293T were grown in a petri dish (diameter=10 cm) containing DMEM and 10% of bovine fetal serum culture solution, and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2019
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 290431BDBM290431(RDEA3170 | US10100016, Verinurad (RDEA3170) | CAS ...)
Affinity DataIC50: 113nMAssay Description:Human embryonic kidney cells (HEK293) was incubated in DMEM tissue culture medium, at 37° C., under 5% CO2 and 95% air atmosphere. TransIT-293 transf...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2019
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 290431BDBM290431(RDEA3170 | US10100016, Verinurad (RDEA3170) | CAS ...)
Affinity DataIC50: 130nMAssay Description:Inhibition of human URAT1 stably overexpressing in human HEK293 cells assessed as inhibition of 14C-uric acid uptake preincubated for 30 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 290431BDBM290431(RDEA3170 | US10100016, Verinurad (RDEA3170) | CAS ...)
Affinity DataIC50: 170nMAssay Description:Inhibition of URAT1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSolute carrier family 22 member 12(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 290431BDBM290431(RDEA3170 | US10100016, Verinurad (RDEA3170) | CAS ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Human kidney embryonic cells HEK-293T were grown in a petri dish (diameter=10 cm) containing DMEM and 10% of bovine fetal serum culture solution, and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2019
Entry Details
US Patent