BDBM50575072 BLU-111362::BLU-554::BLU111362::Fisogatinib::US20240199625, Compound BLU554::X-439161::X439161

SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2nc(N[C@@H]3COCC[C@@H]3NC(=O)C=C)ncc2c1

InChI Key InChIKey=MGZKYOAQVGSSGC-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50575072   

TargetFibroblast growth factor receptor 4(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 3nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of FGFR4 (445 to 753 residues) (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 5nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of FGFR4 (unknown origin) using TK as substrate incubated for 1 hr in presence of biotin/ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 5.98nMAssay Description:Compound preparation: Add 45 μL of DMSO to 5 μL of stock solution at a concentration of 10 mM to prepare the solution LY2874455 at 1000 M; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 4(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of FGFR4 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 53nMAssay Description:Inhibition of FGFR4 (unknown origin) by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 150nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 493nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 500nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetFibroblast growth factor receptor 1(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 591nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 624nMAssay Description:Compound preparation: Add 45 μL of DMSO to 5 μL of stock solution at a concentration of 10 mM to prepare the solution LY2874455 at 1000 M; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2024
Entry Details
US Patent

TargetFibroblast growth factor receptor 1(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 624nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 950nMAssay Description:Inhibition of wild type FGFR1 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of wild type FGFR2 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of wild type FGFR3 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 4(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of FGFR4 V550L mutant (unknown origin) at 1 uM using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 2(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 1.84E+3nMAssay Description:Inhibition of FGFR1 (unknown origin) by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2022
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of FGFR2 (unknown origin) by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of CYP2C8 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Jingzhou Hospital Affiliated to Yangtze University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR3 (unknown origin) by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 2.18E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 2.42E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of hERG channel assessed as prolongation of QT interval by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using Midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50575072BDBM50575072(Fisogatinib | BLU-111362 | BLU-554 | BLU111362 | X...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed