BDBM789959 (17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hexahydro-8H-3,5- ethenotripyrazolo[3,4-f:3'',4''-j:4$#8243;,3$#8243;- n][1,4]oxazacyclopentadecine::US20250353864, Example 43

SMILES Cc1nn(C)c2c1/C=C/c1n[nH]c3ccc(cc13)-c1cnn(C)c1OCCN(C)C2

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 789959   

TargetDual specificity protein kinase CLK1(Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 789959BDBM789959((17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hex...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetDual specificity protein kinase CLK2(Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 789959BDBM789959((17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hex...)
Affinity DataIC50: 0.140nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetDual specificity protein kinase CLK4(Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 789959BDBM789959((17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hex...)
Affinity DataIC50: 0.25nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 789959BDBM789959((17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hex...)
Affinity DataIC50: 13.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 789959BDBM789959((17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hex...)
Affinity DataIC50: 34.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-745,751-1210](Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 789959BDBM789959((17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hex...)
Affinity DataIC50: 74.8nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-745,751-1210,C797S](Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 789959BDBM789959((17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hex...)
Affinity DataIC50: 133nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 789959BDBM789959((17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hex...)
Affinity DataIC50: 144nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetDual specificity protein kinase CLK3(Homo sapiens)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 789959BDBM789959((17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hex...)
Affinity DataIC50: 236nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor [1-770,'NPG',771-1210](Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 789959BDBM789959((17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hex...)
Affinity DataIC50: 541nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Blossomhill Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 789959BDBM789959((17E)-8,12,14,16-tetramethyl- 2,10,11,12,13,14-hex...)
Affinity DataIC50: 543nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
3/11/2026
Entry Details
US Patent