BDBM783346 6-(4-fluorobenzyl)-1- (2-((2R,5R)-2-(((R)-4- (2-(1-(3-((R)-4- (((2R,5R)-1-(2-(6-(4- fluorobenzyl)-3,3- dimethyl-5-oxo- 2,3,4,5-tetrahydro-1H- pyrrolo[3,2-b]pyridin- 1-yl)-2-oxoethyl)-5- methylpiperazin-2- yl)methyl)-3- methylpiperazin-1-yl)- 3-oxopropyl)-1H-1,2,3- triazol-4-yl)ethyl)-2- methylpiperazin-1- yl)methyl)-5- methylpiperazin-1- yl)acetyl)-3,3- dimethyl-1,2,3,4- tetrahydro-5H- pyrrolo[3,2-b]pyridin- 5-one::US20250326771, Compound 154

SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3[nH]c(=O)c(Cc4ccc(F)cc4)cc32)[C@@H](CN2CCN(CCc3cn(CCC(=O)N4CCN(C[C@H]5CN[C@H](C)CN5CC(=O)N5CC(C)(C)c6[nH]c(=O)c(Cc7ccc(F)cc7)cc65)[C@H](C)C4)nn3)C[C@H]2C)CN1

InChI Key InChIKey=MVWURGXHGZJSJK-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 783346   

TargetE3 ubiquitin-protein ligase XIAP [265-330](Human)
Viiv Healthcare

US Patent
LigandChemical structure of BindingDB Monomer ID 783346BDBM783346(6-(4-fluorobenzyl)-1- (2-((2R,5R)-2-(((R)-4- (2-(1...)
Affinity DataIC50: 15.8nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetBaculoviral IAP repeat-containing protein 3 [255-322](Human)
Viiv Healthcare

US Patent
LigandChemical structure of BindingDB Monomer ID 783346BDBM783346(6-(4-fluorobenzyl)-1- (2-((2R,5R)-2-(((R)-4- (2-(1...)
Affinity DataIC50: 15.8nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetBaculoviral IAP repeat-containing protein 2 [269-336](Human)
Viiv Healthcare

US Patent
LigandChemical structure of BindingDB Monomer ID 783346BDBM783346(6-(4-fluorobenzyl)-1- (2-((2R,5R)-2-(((R)-4- (2-(1...)
Affinity DataIC50: 15.8nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetBaculoviral IAP repeat-containing protein 3 [169-235](Human)
Viiv Healthcare

US Patent
LigandChemical structure of BindingDB Monomer ID 783346BDBM783346(6-(4-fluorobenzyl)-1- (2-((2R,5R)-2-(((R)-4- (2-(1...)
Affinity DataIC50: 2.58E+3nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetBaculoviral IAP repeat-containing protein 2 [184-250](Human)
Viiv Healthcare

US Patent
LigandChemical structure of BindingDB Monomer ID 783346BDBM783346(6-(4-fluorobenzyl)-1- (2-((2R,5R)-2-(((R)-4- (2-(1...)
Affinity DataIC50: 2.58E+3nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase XIAP [163-230](Human)
Viiv Healthcare

US Patent
LigandChemical structure of BindingDB Monomer ID 783346BDBM783346(6-(4-fluorobenzyl)-1- (2-((2R,5R)-2-(((R)-4- (2-(1...)
Affinity DataIC50: 3.57E+4nMAssay Description:The BIR domain binding assays are FRET based competition assays that utilize His-tagged versions of each of the BIR2 and BIR3 domains from cIAP1, cIA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
2/11/2026
Entry Details
US Patent