BDBM77581 MLS001205299::N-[(4-methylphenyl)-(8-oxidanylquinolin-7-yl)methyl]propanamide::N-[(8-Hydroxy-quinolin-7-yl)-p-tolyl-methyl]-propionamide::N-[(8-hydroxy-7-quinolinyl)-(4-methylphenyl)methyl]propanamide::N-[(8-hydroxy-7-quinolyl)-(p-tolyl)methyl]propionamide::N-[(8-hydroxyquinolin-7-yl)-(4-methylphenyl)methyl]propanamide::SMR000516557::cid_2876744

SMILES CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)N3CC(O)C3)C4)n[nH]c2c1

InChI Key InChIKey=VINGTFWNMOXCNQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 77581   

TargetNT-3 growth factor receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77581BDBM77581((2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazo...)
Affinity DataIC50: 0.590nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77581BDBM77581((2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazo...)
Affinity DataIC50: 0.890nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77581BDBM77581((2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazo...)
Affinity DataIC50: 1.04nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77581BDBM77581((2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazo...)
Affinity DataIC50: 3.43nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent