BDBM77580 MLS001210781::N-[(2,4-Dichloro-phenyl)-(8-hydroxy-quinolin-7-yl)-methyl]-isobutyramide::N-[(2,4-dichlorophenyl)-(8-hydroxy-7-quinolinyl)methyl]-2-methylpropanamide::N-[(2,4-dichlorophenyl)-(8-hydroxy-7-quinolyl)methyl]-2-methyl-propionamide::N-[(2,4-dichlorophenyl)-(8-hydroxyquinolin-7-yl)methyl]-2-methylpropanamide::N-[(2,4-dichlorophenyl)-(8-oxidanylquinolin-7-yl)methyl]-2-methyl-propanamide::SMR000517139::cid_2920814

SMILES CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)N(C)C)C4)n[nH]c2c1

InChI Key InChIKey=GUGJXJDURCSDQV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 77580   

TargetNT-3 growth factor receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77580BDBM77580(2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol...)
Affinity DataIC50: 0.720nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77580BDBM77580(2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol...)
Affinity DataIC50: 2.21nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77580BDBM77580(2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol...)
Affinity DataIC50: 2.93nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent