BDBM77573 2-chlorobenzoic acid [[amino-(5-nitro-2-thiazolyl)methylidene]amino] ester::2-chlorobenzoic acid [[amino-(5-nitrothiazol-2-yl)methylene]amino] ester::MLS000859516::O2-(2-chlorobenzoyl)-5-nitro-1,3-thiazole-2-carbohydroximamide::SMR000461293::[[amino-(5-nitro-1,3-thiazol-2-yl)methylidene]amino] 2-chlorobenzoate::[[azanyl-(5-nitro-1,3-thiazol-2-yl)methylidene]amino] 2-chloranylbenzoate::cid_2743682

SMILES CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C(=O)C3CC3)C4)n[nH]c2c1

InChI Key InChIKey=UKCYXJSMXMIPPN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 77573   

TargetBDNF/NT-3 growth factors receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77573BDBM77573(cyclopropyl (2-(6-(2-ethyl-5-fluoro-4-hydroxypheny...)
Affinity DataIC50: 4.16nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77573BDBM77573(cyclopropyl (2-(6-(2-ethyl-5-fluoro-4-hydroxypheny...)
Affinity DataIC50: 4.21nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77573BDBM77573(cyclopropyl (2-(6-(2-ethyl-5-fluoro-4-hydroxypheny...)
Affinity DataIC50: 5.91nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77573BDBM77573(cyclopropyl (2-(6-(2-ethyl-5-fluoro-4-hydroxypheny...)
Affinity DataIC50: 12.2nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent