BDBM77568 2-(4-methyl-phenyl)-3-hydroxy-4(1H)-quinolinone-7-carboxylic acid N-(4-methylbenzyl)-amide::2-(4-methylphenyl)-N-[(4-methylphenyl)methyl]-3-oxidanyl-4-oxidanylidene-1H-quinoline-7-carboxamide::3-hydroxy-2-(4-methylphenyl)-N-[(4-methylphenyl)methyl]-4-oxo-1H-quinoline-7-carboxamide::3-hydroxy-4-keto-N-(4-methylbenzyl)-2-(p-tolyl)-1H-quinoline-7-carboxamide::MLS000888928::SMR000453630::cid_16745860

SMILES CCOC(=O)N1Cc2nc(-c3n[nH]c4cc(-c5cc(F)c(O)cc5CC)ccc34)[nH]c2C1

InChI Key InChIKey=SKXWAJCAKXURHC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 77568   

TargetHigh affinity nerve growth factor receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77568BDBM77568(Ethyl 2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-i...)
Affinity DataIC50: 11.4nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetNT-3 growth factor receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77568BDBM77568(Ethyl 2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-i...)
Affinity DataIC50: 13.1nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77568BDBM77568(Ethyl 2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-i...)
Affinity DataIC50: 98.8nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent