BDBM77566 2-Methyl-4-(5-nitro-furan-2-yl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylic acid ethyl ester::2-methyl-4-(5-nitro-2-furanyl)-5-oxo-1,4-dihydroindeno[1,2-b]pyridine-3-carboxylic acid ethyl ester::5-keto-2-methyl-4-(5-nitro-2-furyl)-1,4-dihydroindeno[1,2-b]pyridine-3-carboxylic acid ethyl ester::MLS000780303::SMR000420486::cid_2886681::ethyl 2-methyl-4-(5-nitrofuran-2-yl)-5-oxidanylidene-1,4-dihydroindeno[1,2-b]pyridine-3-carboxylate::ethyl 2-methyl-4-(5-nitrofuran-2-yl)-5-oxo-1,4-dihydroindeno[1,2-b]pyridine-3-carboxylate

SMILES CCc1cc(O)c(F)cc1-c1ccc2c(-c3nc4c([nH]3)CN(C3CC(O)CCN3C(=O)N3CCC(O)CC3N3Cc5nc(-c6n[nH]c7cc(-c8cc(F)c(O)cc8CC)ccc67)[nH]c5C3)C4)n[nH]c2c1

InChI Key InChIKey=OXMLYHSYUJYPFT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 77566   

TargetNT-3 growth factor receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77566BDBM77566((2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazo...)
Affinity DataIC50: 0.570nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77566BDBM77566((2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazo...)
Affinity DataIC50: 0.830nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77566BDBM77566((2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazo...)
Affinity DataIC50: 0.990nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

TargetBDNF/NT-3 growth factors receptor(Human)
Medinno Pharmaceutical Technology (Zhuhai) Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 77566BDBM77566((2-(6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazo...)
Affinity DataIC50: 3.37nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent