BDBM747194 (6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)(5-((2- (dimethylamino)ethyl)(methyl)amino)pyrimidin-2-yl)methanone::US20250179079, Compound 33

SMILES CN(C)CCN(C)c1cnc(C(=O)N2CCc3[nH]c4c(Cl)c(Cl)ccc4c3C2)nc1

InChI Key

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 747194   

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL

LigandBDBM747194((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)Copy SMILES

Affinity DataIC50: 170nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
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TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL

LigandBDBM747194((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)Copy SMILES

Affinity DataIC50: 177nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
9/30/2025
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL

LigandBDBM747194((6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]i...)Copy SMILES

Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
Copy reaction URL