BDBM747191 (5-aminopyrimidin-2-yl)(6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3- b]indol-2-yl)methanone::US20250179079, Compound 30

SMILES Nc1cnc(C(=O)N2CCc3[nH]c4c(Cl)c(Cl)ccc4c3C2)nc1

InChI Key InChIKey=KPBYCQKTWKXQGH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 747191   

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747191BDBM747191((5-aminopyrimidin-2-yl)(6,7-dichloro-1,3,4,5-tetra...)
Affinity DataIC50: 220nMAssay Description:Inhibition of full length human SGLT1 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrs by cell-based topcount scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747191BDBM747191((5-aminopyrimidin-2-yl)(6,7-dichloro-1,3,4,5-tetra...)
Affinity DataIC50: 226nMAssay Description:Certain compounds of the present disclosure were tested for their h-cGAS inhibition activity using the methodology reported in Lama et al., “Developm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/30/2025
Entry Details
US Patent

TargetCyclic GMP-AMP synthase(Human)
Ventus Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 747191BDBM747191((5-aminopyrimidin-2-yl)(6,7-dichloro-1,3,4,5-tetra...)
Affinity DataIC50: 2.88E+3nMAssay Description:Inhibition of full length human SGLT2 assessed as methyl-alpha-D-[U-14C]glucopyranoside uptake after 1.5 hrs by cell-based topcount scintillation cou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed