BDBM730416 US20250122166, Compound 7

SMILES O=C1CCC(N2Cc3c(CNC(=O)c4ccc(F)cc4)cccc3C2=O)C(=O)N1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 730416   

TargetDNA-binding protein Ikaros/Protein cereblon(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 730416BDBM730416(US20250122166, Compound 7)
Affinity DataEC50:  120nMAssay Description:Inhibition of TIE2 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetCereblon/Casein kinase I alpha(Human)
St. Jude Children's Research Hospital

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 730416BDBM730416(US20250122166, Compound 7)
Affinity DataEC50:  260nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cells using NADPH assessed as conversion of cortisone to cortisol by cell-based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetProtein cereblon(Human)
ST. JUDE CHILDREN''S RESEARCH HOSPITAL, INC.

US Patent
LigandChemical structure of BindingDB Monomer ID 730416BDBM730416(US20250122166, Compound 7)
Affinity DataIC50: 5.50E+3nMAssay Description:In this competitive fluorescent polarization assay Cy5 conjugated lenalidomide analog (Cy5—O-Len)1 was used as a fluorescent probe. 6XHis-CRBN-DDB1 p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent