BDBM714897 US20250026748, Compound 61::US20260022114, Compound 115

SMILES Cc1nnc(Cn2cc(-c3cc(C(F)(F)F)ccc3Cl)c(C(=O)Nc3nnc(C#CC4CC4)s3)cc2=O)o1

InChI Key InChIKey=IQRLPAWCYCGFTM-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 714897   

TargetDNA polymerase theta(Human)
Repare Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 714897BDBM714897(US20250026748, Compound 61 | US20260022114, Compou...)
Affinity DataIC50: 0.25nMAssay Description:PolQ ATPase enzyme (1-894) at 0.5 nM is incubated with a 10-point concentration response of inhibitors for 15 min at rt in the following buffer: 50 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/30/2025
Entry Details
US Patent

TargetDNA polymerase theta [1-894](Homo sapiens (Human))
Repare Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 714897BDBM714897(US20250026748, Compound 61 | US20260022114, Compou...)
Affinity DataIC50: 0.25nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent

TargetDNA polymerase theta [1-894](Homo sapiens (Human))
Repare Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 714897BDBM714897(US20250026748, Compound 61 | US20260022114, Compou...)
Affinity DataIC50: 0.25nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/3/2026
Entry Details US Patent