BDBM697332 US20240316047, Example 115

SMILES CS(=O)(=O)Nc1cc(Cl)cc(NC(=O)c2cc(cs2)-c2c(F)cccc2F)c1

InChI Key InChIKey=SODRTJBHGVEHSD-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 697332   

TargetATP-dependent RNA helicase A(Human)
Accent Therapeutics, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 697332BDBM697332(US20240316047, Example 115)
Affinity DataEC50:  74nMAssay Description:Inhibition of human DHX9 using double-stranded RNA and ATP as substrate pre-incubated for 15 mins followed by substrate addition and measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetATP-dependent RNA helicase A(Human)
Accent Therapeutics, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 697332BDBM697332(US20240316047, Example 115)
Affinity DataIC50: 74.3nMAssay Description:Recombinant DHX9-Human recombinant DHX9 protein was custom ordered from Viva.RNA substrateĀ—Oligos for double-stranded RNA substrate were custom order...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/28/2025
Entry Details
US Patent

TargetATP-dependent RNA helicase A(Human)
Accent Therapeutics, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 697332BDBM697332(US20240316047, Example 115)
Affinity DataEC50:  410nMAssay Description:Inhibition of DHX9 in human PBMC assessed as target engagement by measuring circBRIP1 incubated for 24 hrs by Taqman qPCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed