BDBM669469 US11964990, Example 11

SMILES CC%11(C)CC(c1ccc(Cl)cc1)=C%10CN9CCN(c8ccc(C(=O)NS(=O)(=O)c4cnc(OC[C@@]3(F)CC[C@@H](N2CCOCC2)CC3)c(Cl)c4)c(N7CCCOc6nc5[nH]ccc5cc67)c8)C[C@H]9COCCCO[C@@H]%10C%11

InChI Key InChIKey=ZDNLAUJRAPAGAA-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 669469   

TargetApoptosis regulator Bcl-2(Human)
Abbvie

US Patent
LigandChemical structure of BindingDB Monomer ID 669469BDBM669469(US11964990, Example 11 | US20250066388, Example 11...)
Affinity DataKi:  0.936nMAssay Description:The samples were then mixed on a shaker for 1 minute and equilibrated for an additional 3 hours at room temperature. For each assay plate, a probe/an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Abbvie

US Patent
LigandChemical structure of BindingDB Monomer ID 669469BDBM669469(US11964990, Example 11 | US20250066388, Example 11...)
Affinity DataKi:  0.936nMAssay Description:[Bcl-2 protein or Bcl-xL protein], [Probe], [Antibody],Protein Probe nM nM Antibody nMGST- F-Bak 1 100 Tb-anti- 1Bcl- Acetyl-(SEQ GST 2 ID NO: 3)-NH2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2024
Entry Details
US Patent

TargetApoptosis regulator Bcl-2(Human)
Abbvie

US Patent
LigandChemical structure of BindingDB Monomer ID 669469BDBM669469(US11964990, Example 11 | US20250066388, Example 11...)
Affinity DataKi:  0.936nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details US Patent

TargetBcl-2-like protein 1(Human)
Abbvie

US Patent
LigandChemical structure of BindingDB Monomer ID 669469BDBM669469(US11964990, Example 11 | US20250066388, Example 11...)
Affinity DataKi:  17.3nMAssay Description:[Bcl-2 protein or Bcl-xL protein], [Probe], [Antibody],Protein Probe nM nM Antibody nMGST- F-Bak 1 100 Tb-anti- 1Bcl- Acetyl-(SEQ GST 2 ID NO: 3)-NH2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/13/2024
Entry Details
US Patent

TargetBcl-2-like protein 1(Human)
Abbvie

US Patent
LigandChemical structure of BindingDB Monomer ID 669469BDBM669469(US11964990, Example 11 | US20250066388, Example 11...)
Affinity DataKi:  17.3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details US Patent

TargetBcl-2-like protein 1(Human)
Abbvie

US Patent
LigandChemical structure of BindingDB Monomer ID 669469BDBM669469(US11964990, Example 11 | US20250066388, Example 11...)
Affinity DataKi:  17.3nMAssay Description:The samples were then mixed on a shaker for 1 minute and equilibrated for an additional 3 hours at room temperature. For each assay plate, a probe/an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2025
Entry Details
US Patent