BDBM660999 1-(1-((1-((2-chloropyrimidin-5- yl)amino)isoquinolin-6- yl)oxy)ethyl)cyclopropane-1- carbonitrile::US20240101531, Example 385

SMILES CC(Oc1ccc2c(Nc3cnc(Cl)nc3)nccc2c1)C1(CC1)C#N

InChI Key InChIKey=VCKMIYOIGVPAQO-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 660999   

TargetVoltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3)(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 660999BDBM660999(1-(1-((1-((2-chloropyrimidin-5- yl)amino)isoquinol...)
Affinity DataEC50: <1.00E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2024
Entry Details
US Patent