BDBM660740 Synthesis of (R)-3-(((1-((6-chloropyridin-3-yl)amino)isoquinolin-6-yl)oxy)methyl)tetrahydrofuran-3-carbonitrile and (S)-3-(((1-((6-chloropyridin-3-yl)amino)isoquinolin-6-yl)oxy)methyl)tetrahydrofuran-3-carbonitrile::US20240101531, Example 125

SMILES Clc1ccc(Nc2nccc3cc(OC[C@@]4(CCOC4)C#N)ccc23)cn1

InChI Key InChIKey=BIQGLLGFUISFEX-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 660740   

TargetVoltage-gated potassium channel, KQT; KCNQ2(Kv7.2)/KCNQ3(Kv7.3)(Human)
Xenon Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 660740BDBM660740(Synthesis of (R)-3-(((1-((6-chloropyridin-3-yl)ami...)
Affinity DataEC50: <1.00E+3nMAssay Description:This potassium flux assay employs the cell-permeable, potassium-sensitive dye, IPG-2 AM, to quantify potassium ion flux through potassium channels.In...More data for this Ligand-Target Pair
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Date in BDB:
6/11/2024
Entry Details
US Patent