BDBM654305 US11912686, Compound 251

SMILES C[C@@H](OC(=O)Nc1c(nnn1C)-c1ccc(NC(=O)c2cnc(nc2)C(F)(F)F)cn1)c1cc(F)cnc1F

InChI Key InChIKey=VHSVUMBZCLBMNY-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 654305   

TargetLysophosphatidic acid receptor 1(Human)
Gilead Sciences Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 654305BDBM654305(US11912686, Compound 251)
Affinity DataEC50:  8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetLysophosphatidic acid receptor 1(Human)
Gilead Sciences Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 654305BDBM654305(US11912686, Compound 251)
Affinity DataEC50:  12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetLysophosphatidic acid receptor 1(Human)
Gilead Sciences Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 654305BDBM654305(US11912686, Compound 251)
Affinity DataEC50:  12nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetLysophosphatidic acid receptor 1(Human)
Gilead Sciences Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 654305BDBM654305(US11912686, Compound 251)
Affinity DataEC50:  34nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetLysophosphatidic acid receptor 1(Human)
Gilead Sciences Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 654305BDBM654305(US11912686, Compound 251)
Affinity DataEC50:  38.5nMAssay Description:CHO-K1 EDG2 cells (DiscoverX cat #93-0644C2) expressing human LPAR1 (NM_001401.3) were seeded in a total volume of 25 μL of Dulbecco's Modif...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2024
Entry Details
US Patent

TargetLysophosphatidic acid receptor 1(Human)
Gilead Sciences Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 654305BDBM654305(US11912686, Compound 251)
Affinity DataKi:  60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSolute carrier organic anion transporter family member 1B1(Human)
Gilead Sciences Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 654305BDBM654305(US11912686, Compound 251)
Affinity DataIC50: 1.30E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetSolute carrier organic anion transporter family member 1B3(Human)
Gilead Sciences Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 654305BDBM654305(US11912686, Compound 251)
Affinity DataIC50: 1.50E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetBile salt export pump(Human)
Gilead Sciences Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 654305BDBM654305(US11912686, Compound 251)
Affinity DataIC50: 2.20E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed