BDBM653297 1-(6-(3-fluoro-4-(3- hydroxy-1- naphthalenyl)-7,7- dimethyl-7,8-dihydro- 5H-pyrano[4,3- b]pyridin-2-yl)-2,6- diazaspiro[3.4]octan-2- yl)-2-propen-1-one::US20240059703, Example 14-68::US20240059703, Example 14-69::US20240059703, Example 14-70

SMILES CC1(C)Cc2nc(N3CCC4(CN(C4)C(=O)C=C)C3)c(F)c(c2CO1)-c1cc(O)cc2ccccc12

InChI Key InChIKey=PEGXZPYERRZQCH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 653297   

LigandChemical structure of BindingDB Monomer ID 653297BDBM653297(US20240059703, Example 14-68 | US20240059703, Exam...)
Affinity DataIC50: 50nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetGTPase KRas(Human)
Amgen Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 653297BDBM653297(US20240059703, Example 14-68 | US20240059703, Exam...)
Affinity DataIC50: 62nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 653297BDBM653297(US20240059703, Example 14-68 | US20240059703, Exam...)
Affinity DataIC50: 68nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 653297BDBM653297(US20240059703, Example 14-68 | US20240059703, Exam...)
Affinity DataIC50: 1.70E+4nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent