BDBM652864 1-(6-(4-(5-methyl-1H- indazol-4-yl)-5,6,7,8- tetrahydro-2- quinazolinyl)-2,6- diazaspiro[3.4]octan-2- yl)-2-propen-1-one::US20240059703, Example 1-17

SMILES Cc1ccc2[nH]ncc2c1-c1nc(nc2CCCCc12)N1CCC2(CN(C2)C(=O)C=C)C1

InChI Key InChIKey=JSPWKFIWAQUZOZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652864   

TargetGTPase KRas(Human)
Amgen Research

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 652864BDBM652864(US20240059703, Example 1-17 | 1-(6-(4-(5-methyl-1H...)
Affinity DataIC50: 3.83E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 652864BDBM652864(US20240059703, Example 1-17 | 1-(6-(4-(5-methyl-1H...)
Affinity DataIC50: 5.76E+3nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent