BDBM652122 US12540131, Ex-2.57::{3-[4-({6-chloro-7-[1-(3- methyloxetan-3-yl)piperidin-4- yl]quinazolin-2-yl}amino)-1H- pyrazol-1-yl]bicyclo[1.1.1]pentan- 1-yl}methanol

SMILES CC1(N2CCC(c3cc4nc(Nc5cnn(C67CC(CO)(C6)C7)c5)ncc4cc3Cl)CC2)COC1

InChI Key InChIKey=LJNAUYLAWQKMQX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652122   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652122BDBM652122({3-[4-({6-chloro-7-[1-(3- methyloxetan-3-yl)piperi...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details
US Patent