BDBM652116 (R)(3S,4S) or (R)(3R,4R) or (S)(3S,4S) or (S)(3R,4R) 4-[4-(6- chloro-2-{[1-(2,2- difluorocyclopropyl)-5-methyl- 1H-pyrazol-4- yl]amino}quinazolin-7- yl)piperidin-1-yl]-4- methyloxolan-3-ol::US12540131, Ex-2.51

SMILES Cc1c(Nc2ncc3cc(Cl)c(C4CCN([C@@]5(C)COC[C@H]5O)CC4)cc3n2)cnn1C1CC1(F)F

InChI Key InChIKey=VFCYOTBJVABSBY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652116   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652116BDBM652116((R)(3S,4S) or (R)(3R,4R) or (S)(3S,4S) or (S)(3R,4...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details
US Patent