BDBM652109 (R)(3S,4S) or (R)(3R,4R) or (S)(3S,4S) or (S)(3R,4R) 4-[4-(2- {[1-(2,2-difluorocyclopropyl)-5- methyl-1H-pyrazol-4-yl]amino}-6- methylquinazolin-7-yl)piperidin-1- yl]-4-methyloxolan-3-ol::US12540131, Ex-2.44

SMILES Cc1cc2cnc(Nc3cnn(C4CC4(F)F)c3C)nc2cc1C1CCN([C@@]2(C)COC[C@H]2O)CC1

InChI Key InChIKey=VPXCWLNEMAORLW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652109   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652109BDBM652109((R)(3S,4S) or (R)(3R,4R) or (S)(3S,4S) or (S)(3R,4...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details
US Patent