BDBM652105 (R)(3S,4S) or (R)(3R,4R) or (S)(3S,4S) or (S)(3R,4R) 4-[4-(2- {[5-chloro-1-(2,2- difluorocyclopropyl)-1H-pyrazol- 4-yl]amino}-6-methylquinazolin- 7-yl)piperidin-1-yl]-4- methyloxolan-3-ol::US12540131, Ex-2.40

SMILES Cc1cc2cnc(Nc3cnn(C4CC4(F)F)c3Cl)nc2cc1C1CCN([C@@]2(C)COC[C@H]2O)CC1

InChI Key InChIKey=ZWZQQXMSJUPGJP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652105   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652105BDBM652105((R)(3S,4S) or (R)(3R,4R) or (S)(3S,4S) or (S)(3R,4...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details
US Patent