BDBM652103 (3S,4S) or (3R,4R) 4-(4-{2-[(1- cyclopropyl-5-methyl-1H-pyrazol- 4-yl)amino]-6-methylquinazolin- 7-yl}piperidin-1-yl)-4- methyloxolan-3-ol::US12540131, Ex-2.38

SMILES Cc1cc2cnc(Nc3cnn(C4CC4)c3C)nc2cc1C1CCN([C@@]2(C)COC[C@H]2O)CC1

InChI Key InChIKey=NEGKLSXDQMNMTO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652103   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652103BDBM652103((3S,4S) or (3R,4R) 4-(4-{2-[(1- cyclopropyl-5-meth...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details
US Patent