BDBM651257 6-[3-Fluoro-4-(morpholin-4-yl)phenyl]-4,5-dihydropyridazin-3(2H)-one::US11897867, Example 25

SMILES Fc1cc(ccc1N1CCOCC1)C1=NNC(=O)CC1

InChI Key InChIKey=VFMKZXBOOXFNQI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 651257   

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Bayer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 651257BDBM651257(US11897867, Example 25 | 6-[3-Fluoro-4-(morpholin-...)
Affinity DataIC50: 160nMAssay Description:The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2024
Entry Details
US Patent

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 651257BDBM651257(US11897867, Example 25 | 6-[3-Fluoro-4-(morpholin-...)
Affinity DataIC50: 190nMAssay Description:Agonist activity at RoRc (unknown origin) expressed in HEK293 cells assessed as transcriptional activity by GAL4 NR reporter cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2026
Entry Details PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Broad Institute of MIT and Harvard

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 651257BDBM651257(US11897867, Example 25 | 6-[3-Fluoro-4-(morpholin-...)
Affinity DataIC50: 210nMAssay Description:The commercially available 3H-cAMP Scintillation Proximity Assay (SPA, Perkin Elmer) system was used for enzyme inhibition studies. For the determina...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2024
Entry Details
US Patent