BDBM650786 US20240043448, Example 1a

SMILES CC(C)c1nccc2OCCCOc3cccc(F)c3-c3nc4n(-c12)c(=O)nc(N1CCN(C[C@@H]1C)C(=O)C=C)c4cc3F

InChI Key InChIKey=NGWCUDJECVMIEJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 650786   

TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 650786BDBM650786(US20240043448, Example 1a)
Affinity DataIC50: 11nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent

TargetGTPase KRas(Human)
Merck & Co.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 650786BDBM650786(US20240043448, Example 1a)
Affinity DataIC50: 11nMAssay Description:Inhibition of CSF1R phosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed
TargetGTPase KRas(Human)
Merck & Co.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 650786BDBM650786(US20240043448, Example 1a)
Affinity DataIC50: 21nMAssay Description:Inhibition of CSF1R phosphorylation by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details PubMed