BDBM637687 US11834440, Compound RF-1B

SMILES FC(F)CCOc1cc(F)c([C@H]2CC(=O)N2c2ccc3[nH]cnc3c2)c(F)c1

InChI Key InChIKey=GURVAWDLVHIGNH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 637687   

TargetGlutaminyl-peptide cyclotransferase-like protein(Human)
Tongji University Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 637687BDBM637687(US11834440, Compound RF-1B)
Affinity DataKi:  0.200nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Tongji University Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 637687BDBM637687(US11834440, Compound RF-1B)
Affinity DataKi:  2.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetGlutaminyl-peptide cyclotransferase-like protein(Human)
Tongji University Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 637687BDBM637687(US11834440, Compound RF-1B)
Affinity DataIC50: 13.5nMAssay Description:Preparation of working solution: 2×Glutaminyl Cyclase substrate was diluted in assay buffer to 5 M. 2×enzyme solution and QPCTL was diluted in assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
US Patent