BDBM631035 (S)-N-((R or S)-(3- chloro-2,4- difluorophenyl)(2- (2,2,2- trifluoroethoxy)thiazol- 5-yl)methyl)-2- oxoimidazolidine-4- carboxamide::US11802122, Example 35A::US11802122, Example 35B

SMILES O=C3NC[C@@H](C(=O)N[C@@H](c1cnc(OCC(F)(F)F)s1)c2ccc(F)c(Cl)c2F)N3

InChI Key InChIKey=ALMNSEVIEVBIQP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 631035   

TargetSodium channel protein type 8 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 631035BDBM631035(US11802122, Example 35A | (S)-N-((R or S)-(3- chlo...)
Affinity DataIC50: 2.40nMAssay Description:The following buffers were used for the Qube recordings: External buffer for NaV1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2023
Entry Details
US Patent